Ferredoxin, 2fe-2s-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ferredoxin, 2fe-2s-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJN4_LEIBR

TriTrypDb:

LbrM.31.2790 , LBRM2903_310037600

Length:

157

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 21
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HJN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJN4

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	24
GO:0008152	metabolic process	1	24
GO:0009987	cellular process	1	24
GO:0022900	electron transport chain	4	24
GO:0044237	cellular metabolic process	2	24
GO:0140647	P450-containing electron transport chain	5	24

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	24
GO:0051536	iron-sulfur cluster binding	3	24
GO:0051537	2 iron, 2 sulfur cluster binding	4	24
GO:0051540	metal cluster binding	2	24
GO:0003824	catalytic activity	1	3
GO:0009055	electron transfer activity	3	3
GO:0016491	oxidoreductase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.530
CLV_NRD_NRD_1	19	21	PF00675	0.581
CLV_PCSK_KEX2_1	107	109	PF00082	0.181
CLV_PCSK_KEX2_1	19	21	PF00082	0.567
CLV_PCSK_KEX2_1	56	58	PF00082	0.507
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.181
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.507
CLV_PCSK_SKI1_1	19	23	PF00082	0.590
DEG_Nend_Nbox_1	1	3	PF02207	0.394
DEG_SPOP_SBC_1	36	40	PF00917	0.650
DOC_ANK_TNKS_1	80	87	PF00023	0.181
DOC_USP7_MATH_1	110	114	PF00917	0.181
DOC_WW_Pin1_4	136	141	PF00397	0.536
LIG_14-3-3_CanoR_1	100	109	PF00244	0.181
LIG_14-3-3_CanoR_1	41	50	PF00244	0.533
LIG_Actin_WH2_2	63	79	PF00022	0.256
LIG_EVH1_1	22	26	PF00568	0.390
LIG_FHA_1	127	133	PF00498	0.325
LIG_FHA_1	137	143	PF00498	0.427
LIG_FHA_1	94	100	PF00498	0.379
LIG_FHA_2	58	64	PF00498	0.318
LIG_Integrin_isoDGR_2	154	156	PF01839	0.425
LIG_LIR_Nem_3	104	109	PF02991	0.325
LIG_Pex14_1	14	18	PF04695	0.374
LIG_PTB_Phospho_1	151	157	PF10480	0.392
LIG_SH2_CRK	18	22	PF00017	0.482
LIG_SH2_GRB2like	152	155	PF00017	0.379
LIG_SH2_SRC	152	155	PF00017	0.379
LIG_SH3_1	20	26	PF00018	0.392
LIG_SH3_3	106	112	PF00018	0.297
LIG_SH3_3	144	150	PF00018	0.437
LIG_SH3_3	20	26	PF00018	0.414
LIG_SH3_3	61	67	PF00018	0.371
LIG_TRAF2_1	112	115	PF00917	0.344
LIG_WW_3	24	28	PF00397	0.399
MOD_CK1_1	102	108	PF00069	0.326
MOD_CK2_1	110	116	PF00069	0.311
MOD_GlcNHglycan	101	104	PF01048	0.256
MOD_NEK2_1	101	106	PF00069	0.406
MOD_NEK2_1	37	42	PF00069	0.553
MOD_PKA_2	99	105	PF00069	0.181
MOD_Plk_1	127	133	PF00069	0.322
MOD_Plk_4	68	74	PF00069	0.361
MOD_ProDKin_1	136	142	PF00069	0.531
TRG_DiLeu_BaEn_1	6	11	PF01217	0.360
TRG_DiLeu_BaEn_4	115	121	PF01217	0.367
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.452
TRG_ENDOCYTIC_2	18	21	PF00928	0.632
TRG_ER_diArg_1	18	20	PF00400	0.560
TRG_ER_diArg_1	26	29	PF00400	0.608
TRG_NES_CRM1_1	137	148	PF08389	0.358
TRG_NES_CRM1_1	74	85	PF08389	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W3	Leptomonas seymouri	66%	100%
A0A0N1HYR7	Leptomonas seymouri	43%	100%
A0A0N1I5P4	Leptomonas seymouri	56%	100%
A0A0N1ILD8	Leptomonas seymouri	42%	92%
A0A0N1PE81	Leptomonas seymouri	51%	100%
A0A0S4J024	Bodo saltans	50%	100%
A0A3Q8IIS3	Leishmania donovani	57%	100%
A0A3R7MK78	Trypanosoma rangeli	43%	96%
A0A3R7NM96	Trypanosoma rangeli	39%	82%
A0A3S7X4S6	Leishmania donovani	40%	98%
A0A3S7X4U4	Leishmania donovani	39%	86%
A0A3S7X4W8	Leishmania donovani	71%	100%
A4HEW1	Leishmania braziliensis	32%	100%
A4HJN2	Leishmania braziliensis	44%	100%
A4HJN3	Leishmania braziliensis	57%	100%
A4HJN8	Leishmania braziliensis	96%	100%
A4HJN9	Leishmania braziliensis	41%	88%
A4I755	Leishmania infantum	40%	98%
A4I756	Leishmania infantum	57%	100%
A4I757	Leishmania infantum	71%	100%
A4I758	Leishmania infantum	38%	86%
E9B248	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	98%
E9B249	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E9B250	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E9B251	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	86%
P00257	Bos taurus	32%	84%
P00258	Sus scrofa	34%	84%
P13216	Gallus gallus	34%	100%
P29330	Ovis aries	31%	100%
P37193	Drosophila melanogaster	32%	91%
Q05B51	Bos taurus	35%	84%
Q08C57	Danio rerio	38%	81%
Q4Q610	Leishmania major	38%	100%
Q4Q611	Leishmania major	71%	100%
Q4Q612	Leishmania major	58%	100%
Q4Q613	Leishmania major	45%	100%
Q4UKL2	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	42%	100%
Q5FWQ0	Xenopus laevis	34%	81%
Q6P4F2	Homo sapiens	34%	84%
Q8S904	Arabidopsis thaliana	28%	80%
Q8SZA8	Drosophila melanogaster	32%	100%
Q9AKM6	Rickettsia montanensis	42%	100%
Q9CPW2	Mus musculus	36%	90%