Ferredoxin, 2fe-2s-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ferredoxin, 2fe-2s-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJN3_LEIBR

TriTrypDb:

LbrM.31.2830 , LBRM2903_310037500

Length:

145

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 17
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HJN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJN3

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	20
GO:0008152	metabolic process	1	20
GO:0009987	cellular process	1	20
GO:0022900	electron transport chain	4	20
GO:0044237	cellular metabolic process	2	20
GO:0140647	P450-containing electron transport chain	5	20

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	20
GO:0051536	iron-sulfur cluster binding	3	20
GO:0051537	2 iron, 2 sulfur cluster binding	4	20
GO:0051540	metal cluster binding	2	20
GO:0003824	catalytic activity	1	2
GO:0009055	electron transfer activity	3	2
GO:0016491	oxidoreductase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.581
CLV_PCSK_KEX2_1	2	4	PF00082	0.570
CLV_PCSK_SKI1_1	138	142	PF00082	0.381
DEG_APCC_DBOX_1	14	22	PF00400	0.431
DEG_Nend_UBRbox_1	1	4	PF02207	0.646
DEG_SCF_FBW7_1	123	130	PF00400	0.492
DEG_SCF_FBW7_1	24	30	PF00400	0.534
DOC_CKS1_1	124	129	PF01111	0.370
DOC_CKS1_1	24	29	PF01111	0.426
DOC_CKS1_1	31	36	PF01111	0.347
DOC_CYCLIN_yCln2_LP_2	14	20	PF00134	0.430
DOC_PP2B_LxvP_1	14	17	PF13499	0.419
DOC_PP4_FxxP_1	51	54	PF00568	0.263
DOC_USP7_MATH_1	127	131	PF00917	0.401
DOC_USP7_MATH_1	27	31	PF00917	0.645
DOC_USP7_MATH_1	55	59	PF00917	0.170
DOC_USP7_MATH_1	79	83	PF00917	0.252
DOC_USP7_UBL2_3	38	42	PF12436	0.375
DOC_USP7_UBL2_3	90	94	PF12436	0.226
DOC_WW_Pin1_4	123	128	PF00397	0.413
DOC_WW_Pin1_4	23	28	PF00397	0.500
DOC_WW_Pin1_4	30	35	PF00397	0.458
LIG_14-3-3_CanoR_1	2	8	PF00244	0.522
LIG_14-3-3_CanoR_1	28	34	PF00244	0.511
LIG_FHA_1	114	120	PF00498	0.315
LIG_FHA_1	139	145	PF00498	0.512
LIG_FHA_1	8	14	PF00498	0.630
LIG_FHA_1	81	87	PF00498	0.364
LIG_FHA_2	45	51	PF00498	0.305
LIG_LIR_Apic_2	29	34	PF02991	0.415
LIG_LIR_Apic_2	50	54	PF02991	0.266
LIG_LIR_Nem_3	91	96	PF02991	0.306
LIG_MYND_1	16	20	PF01753	0.395
LIG_PDZ_Class_2	140	145	PF00595	0.356
LIG_SH2_CRK	31	35	PF00017	0.458
LIG_SH2_CRK	4	8	PF00017	0.516
LIG_SH2_NCK_1	31	35	PF00017	0.548
LIG_SH2_STAT5	87	90	PF00017	0.245
LIG_SH3_3	131	137	PF00018	0.403
LIG_SH3_3	14	20	PF00018	0.399
LIG_TRAF2_1	100	103	PF00917	0.342
LIG_UBA3_1	59	68	PF00899	0.410
MOD_CDK_SPK_2	23	28	PF00069	0.384
MOD_CDK_SPxK_1	30	36	PF00069	0.500
MOD_CK1_1	30	36	PF00069	0.520
MOD_CK2_1	127	133	PF00069	0.332
MOD_CK2_1	97	103	PF00069	0.300
MOD_GlcNHglycan	128	132	PF01048	0.378
MOD_GSK3_1	123	130	PF00069	0.360
MOD_GSK3_1	23	30	PF00069	0.499
MOD_GSK3_1	3	10	PF00069	0.552
MOD_GSK3_1	40	47	PF00069	0.257
MOD_NEK2_1	113	118	PF00069	0.375
MOD_NEK2_1	88	93	PF00069	0.377
MOD_OFUCOSY	78	84	PF10250	0.309
MOD_PIKK_1	40	46	PF00454	0.207
MOD_PKA_1	2	8	PF00069	0.408
MOD_PKA_2	2	8	PF00069	0.475
MOD_PKA_2	27	33	PF00069	0.489
MOD_Plk_1	114	120	PF00069	0.314
MOD_Plk_4	55	61	PF00069	0.341
MOD_ProDKin_1	123	129	PF00069	0.413
MOD_ProDKin_1	23	29	PF00069	0.500
MOD_ProDKin_1	30	36	PF00069	0.452
MOD_SUMO_for_1	67	70	PF00179	0.182
MOD_SUMO_rev_2	108	116	PF00179	0.283
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.385
TRG_ENDOCYTIC_2	4	7	PF00928	0.653
TRG_ER_diArg_1	1	3	PF00400	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W3	Leptomonas seymouri	55%	100%
A0A0N0P799	Leptomonas seymouri	42%	88%
A0A0N1HYR7	Leptomonas seymouri	49%	99%
A0A0N1HZ74	Leptomonas seymouri	36%	83%
A0A0N1I5P4	Leptomonas seymouri	72%	100%
A0A0N1ILD8	Leptomonas seymouri	48%	85%
A0A0N1PE81	Leptomonas seymouri	52%	100%
A0A0S4J024	Bodo saltans	53%	94%
A0A1X0NSB1	Trypanosomatidae	37%	81%
A0A3Q8IIS3	Leishmania donovani	77%	100%
A0A3R7MK78	Trypanosoma rangeli	50%	89%
A0A3R7NM96	Trypanosoma rangeli	33%	76%
A0A3S7WZQ5	Leishmania donovani	35%	83%
A0A3S7X4S6	Leishmania donovani	44%	91%
A0A3S7X4U4	Leishmania donovani	43%	80%
A0A3S7X4W8	Leishmania donovani	54%	100%
A4HEW1	Leishmania braziliensis	36%	77%
A4HJN2	Leishmania braziliensis	42%	100%
A4HJN4	Leishmania braziliensis	57%	92%
A4HJN8	Leishmania braziliensis	56%	100%
A4HJN9	Leishmania braziliensis	46%	81%
A4I234	Leishmania infantum	35%	83%
A4I755	Leishmania infantum	44%	91%
A4I756	Leishmania infantum	77%	100%
A4I757	Leishmania infantum	52%	100%
A4I758	Leishmania infantum	42%	80%
C9ZRX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	81%
E9AY84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	83%
E9B248	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	91%
E9B249	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
E9B250	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9B251	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	80%
P00257	Bos taurus	35%	78%
P00258	Sus scrofa	35%	78%
P00259	Pseudomonas putida	38%	100%
P0A9R4	Escherichia coli (strain K12)	37%	100%
P0A9R5	Escherichia coli O157:H7	37%	100%
P0A9R6	Shigella flexneri	37%	100%
P10109	Homo sapiens	36%	79%
P13216	Gallus gallus	34%	100%
P24483	Rattus norvegicus	35%	77%
P29330	Ovis aries	36%	100%
P37098	Caulobacter vibrioides (strain ATCC 19089 / CB15)	32%	100%
P37193	Drosophila melanogaster	35%	84%
P46656	Mus musculus	35%	77%
P80306	Rhodobacter capsulatus	38%	100%
Q05B51	Bos taurus	36%	78%
Q12184	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	84%
Q1RJ69	Rickettsia bellii (strain RML369-C)	41%	100%
Q4Q610	Leishmania major	41%	100%
Q4Q611	Leishmania major	50%	100%
Q4Q612	Leishmania major	77%	100%
Q4Q613	Leishmania major	44%	100%
Q4Q989	Leishmania major	35%	100%
Q4UKL2	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	45%	100%
Q5S3I4	Stenotrophomonas maltophilia	37%	100%
Q6P4F2	Homo sapiens	35%	78%
Q8S904	Arabidopsis thaliana	34%	74%
Q8SV19	Encephalitozoon cuniculi (strain GB-M1)	31%	100%
Q8SZA8	Drosophila melanogaster	36%	95%
Q92J08	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	44%	100%
Q9AKC4	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	44%	100%
Q9AKH1	Rickettsia rickettsii	45%	100%
Q9AKM6	Rickettsia montanensis	45%	100%
Q9M0V0	Arabidopsis thaliana	33%	74%
Q9ZDW6	Rickettsia prowazekii (strain Madrid E)	44%	100%
X5CFH4	Rhizorhabdus wittichii (strain DC-6 / KACC 16600)	41%	100%
X5CWH9	Rhizorhabdus wittichii (strain DC-6 / KACC 16600)	37%	100%