Ferredoxin 2fe-2s-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ferredoxin 2fe-2s-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJN2_LEIBR

TriTrypDb:

LbrM.31.2770 , LBRM2903_310037400

Length:

161

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJN2

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0022900	electron transport chain	4	9
GO:0044237	cellular metabolic process	2	9
GO:0140647	P450-containing electron transport chain	5	9

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0051536	iron-sulfur cluster binding	3	9
GO:0051537	2 iron, 2 sulfur cluster binding	4	9
GO:0051540	metal cluster binding	2	9
GO:0003824	catalytic activity	1	1
GO:0009055	electron transfer activity	3	1
GO:0016491	oxidoreductase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.556
CLV_PCSK_KEX2_1	14	16	PF00082	0.556
CLV_PCSK_SKI1_1	108	112	PF00082	0.196
CLV_PCSK_SKI1_1	8	12	PF00082	0.534
DOC_CKS1_1	44	49	PF01111	0.464
DOC_PP2B_LxvP_1	111	114	PF13499	0.348
DOC_PP4_FxxP_1	4	7	PF00568	0.436
DOC_USP7_MATH_1	13	17	PF00917	0.567
DOC_USP7_MATH_1	21	25	PF00917	0.421
DOC_WW_Pin1_4	138	143	PF00397	0.258
DOC_WW_Pin1_4	32	37	PF00397	0.622
DOC_WW_Pin1_4	39	44	PF00397	0.555
LIG_14-3-3_CanoR_1	133	140	PF00244	0.262
LIG_14-3-3_CanoR_1	14	18	PF00244	0.545
LIG_14-3-3_CanoR_1	31	36	PF00244	0.625
LIG_FHA_1	129	135	PF00498	0.262
LIG_FHA_1	139	145	PF00498	0.370
LIG_FHA_1	95	101	PF00498	0.297
LIG_FHA_2	70	76	PF00498	0.294
LIG_LIR_Nem_3	104	110	PF02991	0.258
LIG_RPA_C_Fungi	10	22	PF08784	0.422
LIG_SH2_CRK	107	111	PF00017	0.356
LIG_SH3_3	146	152	PF00018	0.386
LIG_SH3_3	33	39	PF00018	0.604
LIG_SH3_3	41	47	PF00018	0.637
LIG_UBA3_1	121	127	PF00899	0.356
LIG_UBA3_1	73	82	PF00899	0.356
MOD_CDK_SPxK_1	43	49	PF00069	0.520
MOD_CK1_1	132	138	PF00069	0.262
MOD_CK1_1	16	22	PF00069	0.436
MOD_CK1_1	25	31	PF00069	0.603
MOD_CK1_1	42	48	PF00069	0.577
MOD_CK2_1	112	118	PF00069	0.265
MOD_CK2_1	53	59	PF00069	0.447
MOD_CK2_1	69	75	PF00069	0.217
MOD_GlcNHglycan	18	21	PF01048	0.585
MOD_GlcNHglycan	25	28	PF01048	0.450
MOD_GSK3_1	128	135	PF00069	0.306
MOD_GSK3_1	21	28	PF00069	0.522
MOD_GSK3_1	38	45	PF00069	0.476
MOD_GSK3_1	89	96	PF00069	0.271
MOD_LATS_1	53	59	PF00433	0.479
MOD_N-GLC_1	129	134	PF02516	0.196
MOD_N-GLC_1	145	150	PF02516	0.238
MOD_NEK2_1	102	107	PF00069	0.196
MOD_NEK2_1	22	27	PF00069	0.550
MOD_NEK2_2	94	99	PF00069	0.262
MOD_OFUCOSY	93	98	PF10250	0.262
MOD_PKA_2	13	19	PF00069	0.434
MOD_PKA_2	132	138	PF00069	0.262
MOD_Plk_1	103	109	PF00069	0.311
MOD_Plk_1	129	135	PF00069	0.440
MOD_Plk_1	145	151	PF00069	0.435
MOD_Plk_1	61	67	PF00069	0.333
MOD_Plk_2-3	112	118	PF00069	0.367
MOD_Plk_4	69	75	PF00069	0.371
MOD_ProDKin_1	138	144	PF00069	0.258
MOD_ProDKin_1	32	38	PF00069	0.621
MOD_ProDKin_1	39	45	PF00069	0.550
MOD_SUMO_for_1	54	57	PF00179	0.467
MOD_SUMO_rev_2	56	63	PF00179	0.209
TRG_ENDOCYTIC_2	107	110	PF00928	0.359
TRG_NES_CRM1_1	75	86	PF08389	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W3	Leptomonas seymouri	43%	100%
A0A0N0P799	Leptomonas seymouri	62%	98%
A0A0N1HYR7	Leptomonas seymouri	43%	100%
A0A0N1I5P4	Leptomonas seymouri	47%	100%
A0A0N1ILD8	Leptomonas seymouri	39%	95%
A0A0N1PE81	Leptomonas seymouri	36%	100%
A0A0S4J024	Bodo saltans	55%	100%
A0A0S4JS28	Bodo saltans	38%	100%
A0A1X0NSB1	Trypanosomatidae	36%	89%
A0A3Q8IIS3	Leishmania donovani	43%	100%
A0A3R7MK78	Trypanosoma rangeli	62%	99%
A0A3S7X4S6	Leishmania donovani	79%	100%
A0A3S7X4U4	Leishmania donovani	41%	88%
A0A3S7X4W8	Leishmania donovani	44%	100%
A4HJN3	Leishmania braziliensis	42%	100%
A4HJN4	Leishmania braziliensis	44%	100%
A4HJN8	Leishmania braziliensis	45%	100%
A4HJN9	Leishmania braziliensis	40%	90%
A4I755	Leishmania infantum	79%	100%
A4I756	Leishmania infantum	43%	100%
A4I757	Leishmania infantum	44%	100%
A4I758	Leishmania infantum	41%	88%
C9ZRX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	90%
E9B248	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9B249	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9B250	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9B251	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	88%
P00257	Bos taurus	39%	87%
P13216	Gallus gallus	40%	100%
Q05B51	Bos taurus	36%	87%
Q4Q610	Leishmania major	36%	88%
Q4Q611	Leishmania major	45%	100%
Q4Q612	Leishmania major	43%	100%
Q4Q613	Leishmania major	81%	99%
Q4UKL2	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	47%	100%
Q6P4F2	Homo sapiens	36%	87%
Q8S904	Arabidopsis thaliana	36%	82%
Q8SV19	Encephalitozoon cuniculi (strain GB-M1)	39%	100%
Q9AKC4	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	46%	100%
Q9AKM6	Rickettsia montanensis	47%	100%
Q9M0V0	Arabidopsis thaliana	38%	82%
Q9ZDW6	Rickettsia prowazekii (strain Madrid E)	46%	100%