Uridine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Uridine kinase

Gene product:

uridine kinase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJN1_LEIBR

TriTrypDb:

LbrM.31.2760 , LBRM2903_310037300

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HJN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJN1

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006220	pyrimidine nucleotide metabolic process	5	4
GO:0006221	pyrimidine nucleotide biosynthetic process	6	4
GO:0006222	UMP biosynthetic process	8	4
GO:0006241	CTP biosynthetic process	8	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006753	nucleoside phosphate metabolic process	4	4
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	4

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004849	uridine kinase activity	7	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0017076	purine nucleotide binding	4	6
GO:0019205	nucleobase-containing compound kinase activity	5	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.475
CLV_NRD_NRD_1	143	145	PF00675	0.382
CLV_PCSK_FUR_1	144	148	PF00082	0.275
CLV_PCSK_KEX2_1	143	145	PF00082	0.286
CLV_PCSK_KEX2_1	146	148	PF00082	0.276
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.242
CLV_PCSK_SKI1_1	107	111	PF00082	0.275
CLV_PCSK_SKI1_1	143	147	PF00082	0.278
CLV_PCSK_SKI1_1	77	81	PF00082	0.275
DOC_CKS1_1	133	138	PF01111	0.564

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6V6	Leptomonas seymouri	74%	95%
A0A0S4JJ70	Bodo saltans	27%	85%
A0A3S7X4U8	Leishmania donovani	62%	68%
A0AIU6	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	41%	100%
A0KKF8	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	54%	98%
A0KW26	Shewanella sp. (strain ANA-3)	56%	99%
A0Q140	Clostridium novyi (strain NT)	42%	100%
A0RIZ3	Bacillus thuringiensis (strain Al Hakam)	44%	99%
A1JTX4	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	53%	99%
A1QYG8	Borrelia turicatae (strain 91E135)	45%	100%

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