Putative lipase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative lipase

Gene product:

lipase, putative

Species:

Leishmania braziliensis

UniProt:

A4HJN0_LEIBR

TriTrypDb:

LbrM.31.2750 , LBRM2903_310037200

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 9, no: 9
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HJN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJN0

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	19
GO:0008152	metabolic process	1	19
GO:0044238	primary metabolic process	2	19
GO:0071704	organic substance metabolic process	2	19

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004806	triglyceride lipase activity	5	9
GO:0016298	lipase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0052689	carboxylic ester hydrolase activity	4	10
GO:0004620	phospholipase activity	5	1
GO:0008970	phospholipase A1 activity	5	1
GO:0052739	phosphatidylserine 1-acylhydrolase activity	5	1
GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.172
CLV_C14_Caspase3-7	215	219	PF00656	0.143
CLV_NRD_NRD_1	62	64	PF00675	0.405
CLV_NRD_NRD_1	9	11	PF00675	0.309
CLV_PCSK_KEX2_1	9	11	PF00082	0.321
CLV_PCSK_SKI1_1	63	67	PF00082	0.408
DOC_MAPK_DCC_7	229	238	PF00069	0.143
DOC_PP1_RVXF_1	62	69	PF00149	0.224
DOC_PP4_FxxP_1	241	244	PF00568	0.231
DOC_USP7_MATH_1	146	150	PF00917	0.171
DOC_USP7_MATH_1	163	167	PF00917	0.277
DOC_USP7_MATH_1	228	232	PF00917	0.325
DOC_USP7_MATH_1	312	316	PF00917	0.282
DOC_USP7_MATH_1	75	79	PF00917	0.314
DOC_USP7_MATH_2	352	358	PF00917	0.345
DOC_WW_Pin1_4	89	94	PF00397	0.260
LIG_14-3-3_CanoR_1	162	168	PF00244	0.216
LIG_14-3-3_CanoR_1	266	274	PF00244	0.227
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_Clathr_ClatBox_1	358	362	PF01394	0.274
LIG_EH1_1	172	180	PF00400	0.143
LIG_FHA_1	184	190	PF00498	0.318
LIG_FHA_1	206	212	PF00498	0.216
LIG_FHA_1	21	27	PF00498	0.322
LIG_FHA_1	254	260	PF00498	0.236
LIG_FHA_1	353	359	PF00498	0.285
LIG_FHA_1	50	56	PF00498	0.390
LIG_FHA_2	238	244	PF00498	0.295
LIG_FHA_2	332	338	PF00498	0.395
LIG_GBD_Chelix_1	3	11	PF00786	0.308
LIG_LIR_Apic_2	139	144	PF02991	0.226
LIG_LIR_Apic_2	240	244	PF02991	0.239
LIG_LIR_Gen_1	166	176	PF02991	0.238
LIG_LIR_Gen_1	184	189	PF02991	0.348
LIG_LIR_Gen_1	281	291	PF02991	0.324
LIG_LIR_Gen_1	354	364	PF02991	0.348
LIG_LIR_Nem_3	137	143	PF02991	0.236
LIG_LIR_Nem_3	166	172	PF02991	0.243
LIG_LIR_Nem_3	184	188	PF02991	0.279
LIG_LIR_Nem_3	281	287	PF02991	0.303
LIG_LIR_Nem_3	354	359	PF02991	0.362
LIG_LIR_Nem_3	71	76	PF02991	0.258
LIG_LIR_Nem_3	92	98	PF02991	0.353
LIG_LYPXL_SIV_4	163	171	PF13949	0.143
LIG_MYND_1	275	279	PF01753	0.160
LIG_NRBOX	28	34	PF00104	0.298
LIG_Pex14_1	141	145	PF04695	0.194
LIG_PTB_Apo_2	245	252	PF02174	0.238
LIG_SH2_CRK	164	168	PF00017	0.327
LIG_SH2_CRK	169	173	PF00017	0.328
LIG_SH2_CRK	349	353	PF00017	0.253
LIG_SH2_CRK	356	360	PF00017	0.263
LIG_SH2_CRK	73	77	PF00017	0.321
LIG_SH2_GRB2like	101	104	PF00017	0.327
LIG_SH2_PTP2	284	287	PF00017	0.270
LIG_SH2_SRC	284	287	PF00017	0.225
LIG_SH2_STAP1	185	189	PF00017	0.244
LIG_SH2_STAP1	319	323	PF00017	0.322
LIG_SH2_STAP1	356	360	PF00017	0.239
LIG_SH2_STAT5	185	188	PF00017	0.311
LIG_SH2_STAT5	239	242	PF00017	0.238
LIG_SH2_STAT5	250	253	PF00017	0.239
LIG_SH2_STAT5	284	287	PF00017	0.295
LIG_SH2_STAT5	329	332	PF00017	0.269
LIG_SH2_STAT5	363	366	PF00017	0.257
LIG_SH2_STAT5	67	70	PF00017	0.218
LIG_SH2_STAT5	73	76	PF00017	0.242
LIG_SH3_3	272	278	PF00018	0.222
LIG_SH3_3	282	288	PF00018	0.261
LIG_SUMO_SIM_par_1	23	28	PF11976	0.298
LIG_SUMO_SIM_par_1	234	240	PF11976	0.338
LIG_SUMO_SIM_par_1	357	362	PF11976	0.363
LIG_TRFH_1	349	353	PF08558	0.372
LIG_TYR_ITIM	167	172	PF00017	0.170
LIG_TYR_ITIM	327	332	PF00017	0.265
LIG_UBA3_1	37	44	PF00899	0.306
LIG_WRC_WIRS_1	238	243	PF05994	0.249
MOD_CDK_SPxxK_3	89	96	PF00069	0.205
MOD_CK1_1	16	22	PF00069	0.654
MOD_CK1_1	86	92	PF00069	0.276
MOD_CK2_1	174	180	PF00069	0.275
MOD_CK2_1	209	215	PF00069	0.152
MOD_CK2_1	237	243	PF00069	0.274
MOD_CK2_1	304	310	PF00069	0.319
MOD_CK2_1	331	337	PF00069	0.345
MOD_CK2_1	75	81	PF00069	0.244
MOD_Cter_Amidation	61	64	PF01082	0.377
MOD_GlcNHglycan	111	114	PF01048	0.508
MOD_GlcNHglycan	224	227	PF01048	0.398
MOD_GlcNHglycan	70	73	PF01048	0.425
MOD_GlcNHglycan	85	88	PF01048	0.506
MOD_GSK3_1	16	23	PF00069	0.585
MOD_GSK3_1	183	190	PF00069	0.310
MOD_GSK3_1	205	212	PF00069	0.209
MOD_GSK3_1	217	224	PF00069	0.167
MOD_GSK3_1	249	256	PF00069	0.265
MOD_GSK3_1	314	321	PF00069	0.326
MOD_N-GLC_1	102	107	PF02516	0.441
MOD_N-GLC_1	209	214	PF02516	0.473
MOD_N-GLC_1	252	257	PF02516	0.509
MOD_N-GLC_1	305	310	PF02516	0.455
MOD_N-GLC_1	57	62	PF02516	0.533
MOD_N-GLC_1	89	94	PF02516	0.498
MOD_N-GLC_2	152	154	PF02516	0.507
MOD_NEK2_1	109	114	PF00069	0.251
MOD_NEK2_1	125	130	PF00069	0.268
MOD_NEK2_1	187	192	PF00069	0.261
MOD_NEK2_1	20	25	PF00069	0.192
MOD_NEK2_1	237	242	PF00069	0.277
MOD_NEK2_1	265	270	PF00069	0.291
MOD_NEK2_1	280	285	PF00069	0.308
MOD_NEK2_1	37	42	PF00069	0.306
MOD_NEK2_1	68	73	PF00069	0.266
MOD_NEK2_2	163	168	PF00069	0.271
MOD_NEK2_2	183	188	PF00069	0.306
MOD_NEK2_2	314	319	PF00069	0.286
MOD_PK_1	44	50	PF00069	0.299
MOD_PKA_2	125	131	PF00069	0.230
MOD_PKA_2	265	271	PF00069	0.225
MOD_Plk_1	204	210	PF00069	0.288
MOD_Plk_1	217	223	PF00069	0.298
MOD_Plk_2-3	174	180	PF00069	0.143
MOD_Plk_4	174	180	PF00069	0.231
MOD_Plk_4	183	189	PF00069	0.325
MOD_Plk_4	21	27	PF00069	0.350
MOD_Plk_4	254	260	PF00069	0.230
MOD_Plk_4	314	320	PF00069	0.289
MOD_Plk_4	354	360	PF00069	0.234
MOD_Plk_4	44	50	PF00069	0.498
MOD_Plk_4	75	81	PF00069	0.279
MOD_ProDKin_1	89	95	PF00069	0.254
TRG_DiLeu_BaEn_1	354	359	PF01217	0.194
TRG_ENDOCYTIC_2	111	114	PF00928	0.307
TRG_ENDOCYTIC_2	164	167	PF00928	0.262
TRG_ENDOCYTIC_2	169	172	PF00928	0.263
TRG_ENDOCYTIC_2	173	176	PF00928	0.264
TRG_ENDOCYTIC_2	185	188	PF00928	0.338
TRG_ENDOCYTIC_2	284	287	PF00928	0.312
TRG_ENDOCYTIC_2	329	332	PF00928	0.254
TRG_ENDOCYTIC_2	356	359	PF00928	0.376
TRG_ENDOCYTIC_2	73	76	PF00928	0.270
TRG_ER_diArg_1	367	370	PF00400	0.395
TRG_ER_diArg_1	9	11	PF00400	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0D0	Leptomonas seymouri	55%	100%
A0A0S4IJE8	Bodo saltans	33%	100%
A0A0S4J5D7	Bodo saltans	38%	100%
A0A0S4JTA1	Bodo saltans	38%	100%
A0A1X0NZH3	Trypanosomatidae	37%	88%
A0A1X0P001	Trypanosomatidae	36%	100%
A0A3Q8IFI3	Leishmania donovani	60%	100%
A0A3Q8IG97	Leishmania donovani	32%	100%
A0A422NPJ5	Trypanosoma rangeli	34%	75%
A4HLK7	Leishmania braziliensis	35%	100%
A4I6H7	Leishmania infantum	32%	100%
A4I752	Leishmania infantum	60%	100%
C9ZME7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B246	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
P19515	Rhizomucor miehei	33%	100%
P61871	Rhizopus niveus	31%	95%
P61872	Rhizopus oryzae	31%	95%
Q4Q615	Leishmania major	59%	100%
Q4Q6I0	Leishmania major	34%	100%
Q9BHD5	Leishmania major	39%	100%
Q9XTR8	Caenorhabditis elegans	25%	100%
V5B761	Trypanosoma cruzi	38%	100%