Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJM8_LEIBR

TriTrypDb:

LbrM.31.2730 , LBRM2903_310037000

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.521
CLV_C14_Caspase3-7	160	164	PF00656	0.632
CLV_C14_Caspase3-7	210	214	PF00656	0.529
CLV_NRD_NRD_1	181	183	PF00675	0.552
CLV_NRD_NRD_1	37	39	PF00675	0.621
CLV_PCSK_KEX2_1	181	183	PF00082	0.573
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.573
CLV_PCSK_SKI1_1	183	187	PF00082	0.656
CLV_PCSK_SKI1_1	206	210	PF00082	0.599
CLV_PCSK_SKI1_1	23	27	PF00082	0.613
DEG_SPOP_SBC_1	144	148	PF00917	0.469
DOC_CYCLIN_RxL_1	178	188	PF00134	0.539
DOC_MAPK_gen_1	74	81	PF00069	0.633
DOC_MAPK_MEF2A_6	74	81	PF00069	0.633
DOC_MAPK_NFAT4_5	74	82	PF00069	0.633
DOC_PP1_RVXF_1	1	8	PF00149	0.528
DOC_USP7_MATH_1	130	134	PF00917	0.526
DOC_USP7_MATH_1	138	142	PF00917	0.529
DOC_USP7_MATH_1	14	18	PF00917	0.483
DOC_USP7_MATH_1	143	147	PF00917	0.732
DOC_USP7_MATH_1	89	93	PF00917	0.568
LIG_14-3-3_CanoR_1	158	165	PF00244	0.485
LIG_14-3-3_CanoR_1	38	47	PF00244	0.629
LIG_APCC_ABBAyCdc20_2	182	188	PF00400	0.540
LIG_deltaCOP1_diTrp_1	153	159	PF00928	0.533
LIG_eIF4E_1	165	171	PF01652	0.439
LIG_FHA_1	19	25	PF00498	0.593
LIG_FHA_1	203	209	PF00498	0.447
LIG_FHA_1	29	35	PF00498	0.564
LIG_FHA_1	76	82	PF00498	0.523
LIG_FHA_2	190	196	PF00498	0.408
LIG_FHA_2	27	33	PF00498	0.635
LIG_FHA_2	95	101	PF00498	0.555
LIG_GBD_Chelix_1	167	175	PF00786	0.474
LIG_NRBOX	166	172	PF00104	0.389
LIG_PDZ_Class_3	216	221	PF00595	0.665
LIG_Pex14_1	155	159	PF04695	0.571
LIG_SH2_STAP1	165	169	PF00017	0.570
LIG_SH3_3	105	111	PF00018	0.752
LIG_SH3_3	83	89	PF00018	0.514
LIG_Sin3_3	168	175	PF02671	0.397
LIG_SUMO_SIM_anti_2	166	171	PF11976	0.582
LIG_SUMO_SIM_anti_2	49	54	PF11976	0.387
LIG_SUMO_SIM_par_1	168	173	PF11976	0.394
LIG_SUMO_SIM_par_1	23	33	PF11976	0.603
LIG_TRAF2_1	92	95	PF00917	0.458
LIG_TYR_ITIM	45	50	PF00017	0.619
LIG_UBA3_1	171	178	PF00899	0.619
MOD_CK1_1	109	115	PF00069	0.668
MOD_CK1_1	161	167	PF00069	0.585
MOD_CK1_1	207	213	PF00069	0.485
MOD_CK2_1	189	195	PF00069	0.470
MOD_CK2_1	89	95	PF00069	0.530
MOD_Cter_Amidation	179	182	PF01082	0.550
MOD_GlcNHglycan	140	143	PF01048	0.616
MOD_GlcNHglycan	16	19	PF01048	0.466
MOD_GSK3_1	106	113	PF00069	0.634
MOD_GSK3_1	14	21	PF00069	0.544
MOD_GSK3_1	157	164	PF00069	0.560
MOD_GSK3_1	23	30	PF00069	0.570
MOD_NEK2_1	116	121	PF00069	0.625
MOD_NEK2_1	151	156	PF00069	0.650
MOD_NEK2_1	170	175	PF00069	0.516
MOD_NEK2_2	75	80	PF00069	0.541
MOD_PIKK_1	18	24	PF00454	0.608
MOD_PK_1	106	112	PF00069	0.528
MOD_PK_1	158	164	PF00069	0.571
MOD_PKA_2	138	144	PF00069	0.542
MOD_PKA_2	157	163	PF00069	0.563
MOD_Plk_1	116	122	PF00069	0.675
MOD_Plk_4	151	157	PF00069	0.685
MOD_SUMO_rev_2	203	208	PF00179	0.473
TRG_DiLeu_BaEn_1	166	171	PF01217	0.401
TRG_DiLeu_BaEn_4	203	209	PF01217	0.422
TRG_ENDOCYTIC_2	47	50	PF00928	0.567
TRG_ER_diArg_1	182	185	PF00400	0.548
TRG_NLS_MonoCore_2	180	185	PF00514	0.550
TRG_NLS_MonoExtN_4	178	185	PF00514	0.542
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I730	Leptomonas seymouri	26%	100%
A0A0N1I8Q6	Leptomonas seymouri	45%	97%
A0A0N1PCW5	Leptomonas seymouri	36%	100%
A0A3Q8IF19	Leishmania donovani	78%	100%
A0A3Q8IKA6	Leishmania donovani	22%	100%
A0A3S5H7Q5	Leishmania donovani	36%	94%
A4HJM7	Leishmania braziliensis	37%	100%
A4HJM9	Leishmania braziliensis	23%	100%
A4I749	Leishmania infantum	36%	94%
A4I750	Leishmania infantum	78%	100%
A4I751	Leishmania infantum	22%	100%
E9B243	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	94%
E9B244	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E9B245	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
Q4Q617	Leishmania major	76%	100%