Zinc transporter-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HJM3_LEIBR

TriTrypDb:

LbrM.31.2680 , LBRM2903_310036400

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4HJM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJM3

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006829	zinc ion transport	8	1
GO:0009987	cellular process	1	1
GO:0030001	metal ion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071577	zinc ion transmembrane transport	6	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098662	inorganic cation transmembrane transport	5	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0022857	transmembrane transporter activity	2	12
GO:0005385	zinc ion transmembrane transporter activity	7	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1
GO:0046873	metal ion transmembrane transporter activity	5	1
GO:0046915	transition metal ion transmembrane transporter activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.410
CLV_C14_Caspase3-7	390	394	PF00656	0.461
CLV_NRD_NRD_1	51	53	PF00675	0.293
CLV_PCSK_KEX2_1	51	53	PF00082	0.291
CLV_PCSK_SKI1_1	331	335	PF00082	0.286
CLV_PCSK_SKI1_1	56	60	PF00082	0.241
CLV_TASPASE1	360	366	PF01112	0.419
DOC_ANK_TNKS_1	122	129	PF00023	0.426
DOC_CYCLIN_RxL_1	328	336	PF00134	0.311
DOC_MAPK_MEF2A_6	180	187	PF00069	0.395
DOC_PP4_FxxP_1	16	19	PF00568	0.526
DOC_USP7_MATH_1	162	166	PF00917	0.269
DOC_USP7_MATH_1	17	21	PF00917	0.662
DOC_USP7_MATH_1	176	180	PF00917	0.317
DOC_USP7_MATH_1	254	258	PF00917	0.498
DOC_USP7_MATH_1	316	320	PF00917	0.302
DOC_USP7_MATH_1	388	392	PF00917	0.581
DOC_WW_Pin1_4	26	31	PF00397	0.559
DOC_WW_Pin1_4	342	347	PF00397	0.510
DOC_WW_Pin1_4	428	433	PF00397	0.620
LIG_14-3-3_CanoR_1	116	120	PF00244	0.465
LIG_14-3-3_CanoR_1	409	417	PF00244	0.455
LIG_AP2alpha_2	315	317	PF02296	0.387
LIG_BIR_II_1	1	5	PF00653	0.735
LIG_BRCT_BRCA1_1	318	322	PF00533	0.256
LIG_BRCT_BRCA1_1	402	406	PF00533	0.430
LIG_FHA_1	139	145	PF00498	0.327
LIG_FHA_1	149	155	PF00498	0.226
LIG_FHA_1	328	334	PF00498	0.284
LIG_FHA_1	410	416	PF00498	0.462
LIG_FHA_1	7	13	PF00498	0.731
LIG_FHA_1	73	79	PF00498	0.352
LIG_FHA_1	85	91	PF00498	0.318
LIG_FHA_2	32	38	PF00498	0.632
LIG_FHA_2	431	437	PF00498	0.630
LIG_LIR_Apic_2	13	19	PF02991	0.533
LIG_LIR_Gen_1	135	145	PF02991	0.272
LIG_LIR_Gen_1	29	36	PF02991	0.614
LIG_LIR_Gen_1	315	325	PF02991	0.299
LIG_LIR_Gen_1	348	358	PF02991	0.493
LIG_LIR_Gen_1	376	387	PF02991	0.476
LIG_LIR_Nem_3	135	140	PF02991	0.269
LIG_LIR_Nem_3	141	145	PF02991	0.267
LIG_LIR_Nem_3	146	152	PF02991	0.226
LIG_LIR_Nem_3	29	35	PF02991	0.564
LIG_LIR_Nem_3	315	320	PF02991	0.332
LIG_LIR_Nem_3	336	341	PF02991	0.443
LIG_LIR_Nem_3	348	354	PF02991	0.568
LIG_LIR_Nem_3	376	382	PF02991	0.485
LIG_Pex14_2	65	69	PF04695	0.312
LIG_PTB_Apo_2	294	301	PF02174	0.317
LIG_PTB_Phospho_1	294	300	PF10480	0.317
LIG_RPA_C_Fungi	46	58	PF08784	0.494
LIG_SH2_PTP2	32	35	PF00017	0.360
LIG_SH2_PTP2	379	382	PF00017	0.388
LIG_SH2_SRC	306	309	PF00017	0.387
LIG_SH2_STAP1	152	156	PF00017	0.328
LIG_SH2_STAP1	306	310	PF00017	0.304
LIG_SH2_STAP1	99	103	PF00017	0.277
LIG_SH2_STAT5	201	204	PF00017	0.286
LIG_SH2_STAT5	294	297	PF00017	0.287
LIG_SH2_STAT5	32	35	PF00017	0.602
LIG_SH2_STAT5	379	382	PF00017	0.391
LIG_SUMO_SIM_anti_2	178	185	PF11976	0.311
LIG_SUMO_SIM_anti_2	82	88	PF11976	0.252
LIG_SUMO_SIM_par_1	129	135	PF11976	0.267
LIG_SUMO_SIM_par_1	362	369	PF11976	0.365
LIG_TYR_ITIM	349	354	PF00017	0.343
LIG_Vh1_VBS_1	181	199	PF01044	0.225
MOD_CK1_1	132	138	PF00069	0.274
MOD_CK1_1	257	263	PF00069	0.352
MOD_CK2_1	31	37	PF00069	0.523
MOD_CK2_1	43	49	PF00069	0.496
MOD_GlcNHglycan	1	4	PF01048	0.695
MOD_GlcNHglycan	164	167	PF01048	0.422
MOD_GlcNHglycan	220	224	PF01048	0.229
MOD_GlcNHglycan	256	259	PF01048	0.421
MOD_GlcNHglycan	350	354	PF01048	0.355
MOD_GlcNHglycan	375	378	PF01048	0.438
MOD_GlcNHglycan	389	393	PF01048	0.382
MOD_GlcNHglycan	402	405	PF01048	0.294
MOD_GlcNHglycan	426	429	PF01048	0.570
MOD_GlcNHglycan	45	48	PF01048	0.479
MOD_GlcNHglycan	75	78	PF01048	0.355
MOD_GSK3_1	202	209	PF00069	0.325
MOD_GSK3_1	211	218	PF00069	0.311
MOD_GSK3_1	302	309	PF00069	0.255
MOD_GSK3_1	323	330	PF00069	0.255
MOD_GSK3_1	341	348	PF00069	0.439
MOD_GSK3_1	424	431	PF00069	0.544
MOD_GSK3_1	6	13	PF00069	0.709
MOD_GSK3_1	95	102	PF00069	0.348
MOD_N-GLC_1	327	332	PF02516	0.249
MOD_NEK2_1	202	207	PF00069	0.308
MOD_NEK2_1	211	216	PF00069	0.329
MOD_NEK2_1	327	332	PF00069	0.286
MOD_NEK2_1	341	346	PF00069	0.349
MOD_NEK2_1	79	84	PF00069	0.254
MOD_NEK2_2	167	172	PF00069	0.171
MOD_NEK2_2	306	311	PF00069	0.307
MOD_PIKK_1	252	258	PF00454	0.171
MOD_PKA_1	51	57	PF00069	0.395
MOD_PKA_2	115	121	PF00069	0.325
MOD_PKA_2	408	414	PF00069	0.337
MOD_PKA_2	51	57	PF00069	0.385
MOD_Plk_1	306	312	PF00069	0.307
MOD_Plk_1	349	355	PF00069	0.244
MOD_Plk_1	37	43	PF00069	0.485
MOD_Plk_2-3	37	43	PF00069	0.485
MOD_Plk_4	126	132	PF00069	0.289
MOD_Plk_4	138	144	PF00069	0.263
MOD_Plk_4	195	201	PF00069	0.311
MOD_Plk_4	306	312	PF00069	0.231
MOD_Plk_4	316	322	PF00069	0.247
MOD_ProDKin_1	26	32	PF00069	0.453
MOD_ProDKin_1	342	348	PF00069	0.392
MOD_ProDKin_1	428	434	PF00069	0.543
MOD_SUMO_rev_2	49	59	PF00179	0.376
TRG_DiLeu_BaEn_1	55	60	PF01217	0.365
TRG_ENDOCYTIC_2	32	35	PF00928	0.569
TRG_ENDOCYTIC_2	351	354	PF00928	0.325
TRG_ENDOCYTIC_2	379	382	PF00928	0.328
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYQ8	Leptomonas seymouri	66%	99%
A0A0N1I8K4	Leptomonas seymouri	33%	96%
A0A1X0P593	Trypanosomatidae	24%	74%
A0A3Q8IDA3	Leishmania donovani	23%	73%
A0A3Q8IGB8	Leishmania donovani	81%	98%
A4HFQ2	Leishmania braziliensis	24%	67%
A4I2S7	Leishmania infantum	23%	73%
A4I745	Leishmania infantum	81%	98%
A4IFD7	Bos taurus	24%	100%
C9ZME5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	94%
C9ZWN8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	95%
D0A5Y6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AZ30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	73%
E9B239	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%
O13918	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
O14863	Homo sapiens	26%	100%
O35149	Mus musculus	27%	100%
O55174	Rattus norvegicus	27%	100%
P0CE46	Rattus norvegicus	30%	100%
P20107	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P32798	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P75757	Escherichia coli (strain K12)	25%	100%
P97441	Mus musculus	29%	100%
Q08E25	Bos taurus	29%	100%
Q2HJ10	Mus musculus	29%	100%
Q3UVU3	Mus musculus	23%	94%
Q4Q622	Leishmania major	81%	100%
Q4R6K2	Macaca fascicularis	22%	88%
Q54QU8	Dictyostelium discoideum	32%	82%
Q5BJM8	Rattus norvegicus	24%	100%
Q5I020	Xenopus laevis	32%	100%
Q5MNV6	Gallus gallus	27%	100%
Q5R617	Pongo abelii	29%	100%
Q5XHB4	Xenopus tropicalis	31%	100%
Q60738	Mus musculus	22%	88%
Q62720	Rattus norvegicus	23%	87%
Q66D85	Yersinia pseudotuberculosis serotype I (strain IP32953)	22%	100%
Q688R1	Oryza sativa subsp. japonica	33%	100%
Q6D7E5	Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)	24%	100%
Q6DBM8	Arabidopsis thaliana	28%	100%
Q6QIX3	Rattus norvegicus	29%	100%
Q6XR72	Homo sapiens	24%	91%
Q83SA2	Shigella flexneri	26%	100%
Q8BGG0	Mus musculus	29%	100%
Q8H329	Oryza sativa subsp. japonica	26%	100%
Q8IWU4	Homo sapiens	30%	100%
Q8NEW0	Homo sapiens	25%	100%
Q8X400	Escherichia coli O157:H7	25%	100%
Q8Z8B6	Salmonella typhi	25%	100%
Q8ZGY6	Yersinia pestis	23%	100%
Q8ZQT3	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	100%
Q99726	Homo sapiens	30%	100%
Q9JKN1	Mus musculus	25%	100%
Q9LXS1	Arabidopsis thaliana	30%	100%
Q9M271	Arabidopsis thaliana	30%	100%
Q9TTF3	Bos taurus	25%	100%
Q9Y6M5	Homo sapiens	23%	87%
Q9ZT63	Arabidopsis thaliana	31%	100%
V5AMB7	Trypanosoma cruzi	55%	94%
V5BV32	Trypanosoma cruzi	35%	100%
V5DHF7	Trypanosoma cruzi	22%	82%