Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJM2_LEIBR

TriTrypDb:

LbrM.31.2670 , LBRM2903_310036300

Length:

830

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.545
CLV_C14_Caspase3-7	163	167	PF00656	0.794
CLV_NRD_NRD_1	145	147	PF00675	0.640
CLV_NRD_NRD_1	163	165	PF00675	0.729
CLV_NRD_NRD_1	250	252	PF00675	0.560
CLV_NRD_NRD_1	277	279	PF00675	0.735
CLV_NRD_NRD_1	402	404	PF00675	0.768
CLV_NRD_NRD_1	409	411	PF00675	0.671
CLV_NRD_NRD_1	427	429	PF00675	0.583
CLV_NRD_NRD_1	468	470	PF00675	0.863
CLV_NRD_NRD_1	472	474	PF00675	0.803
CLV_NRD_NRD_1	476	478	PF00675	0.723
CLV_NRD_NRD_1	588	590	PF00675	0.821
CLV_NRD_NRD_1	684	686	PF00675	0.578
CLV_NRD_NRD_1	783	785	PF00675	0.850
CLV_PCSK_FUR_1	784	788	PF00082	0.839
CLV_PCSK_KEX2_1	145	147	PF00082	0.620
CLV_PCSK_KEX2_1	250	252	PF00082	0.560
CLV_PCSK_KEX2_1	277	279	PF00082	0.735
CLV_PCSK_KEX2_1	402	404	PF00082	0.763
CLV_PCSK_KEX2_1	409	411	PF00082	0.665
CLV_PCSK_KEX2_1	427	429	PF00082	0.583
CLV_PCSK_KEX2_1	472	474	PF00082	0.869
CLV_PCSK_KEX2_1	588	590	PF00082	0.808
CLV_PCSK_KEX2_1	684	686	PF00082	0.578
CLV_PCSK_KEX2_1	786	788	PF00082	0.834
CLV_PCSK_PC1ET2_1	786	788	PF00082	0.834
CLV_PCSK_SKI1_1	112	116	PF00082	0.578
CLV_PCSK_SKI1_1	583	587	PF00082	0.724
CLV_PCSK_SKI1_1	593	597	PF00082	0.586
CLV_PCSK_SKI1_1	673	677	PF00082	0.821
CLV_Separin_Metazoa	551	555	PF03568	0.593
DEG_APCC_KENBOX_2	516	520	PF00400	0.585
DEG_APCC_KENBOX_2	822	826	PF00400	0.503
DEG_Nend_UBRbox_3	1	3	PF02207	0.605
DEG_SCF_FBW7_1	376	381	PF00400	0.586
DEG_SCF_FBW7_1	505	512	PF00400	0.584
DEG_SPOP_SBC_1	102	106	PF00917	0.545
DEG_SPOP_SBC_1	509	513	PF00917	0.681
DEG_SPOP_SBC_1	661	665	PF00917	0.687
DEG_SPOP_SBC_1	770	774	PF00917	0.742
DOC_CKS1_1	292	297	PF01111	0.596
DOC_CKS1_1	506	511	PF01111	0.583
DOC_MAPK_DCC_7	577	587	PF00069	0.582
DOC_MAPK_gen_1	577	587	PF00069	0.582
DOC_MAPK_MEF2A_6	723	730	PF00069	0.572
DOC_MAPK_MEF2A_6	791	799	PF00069	0.541
DOC_MAPK_NFAT4_5	723	731	PF00069	0.573
DOC_PP2B_LxvP_1	245	248	PF13499	0.573
DOC_PP2B_LxvP_1	289	292	PF13499	0.706
DOC_PP2B_LxvP_1	816	819	PF13499	0.542
DOC_USP7_MATH_1	23	27	PF00917	0.614
DOC_USP7_MATH_1	279	283	PF00917	0.684
DOC_USP7_MATH_1	334	338	PF00917	0.730
DOC_USP7_MATH_1	369	373	PF00917	0.677
DOC_USP7_MATH_1	412	416	PF00917	0.864
DOC_USP7_MATH_1	479	483	PF00917	0.609
DOC_USP7_MATH_1	48	52	PF00917	0.694
DOC_USP7_MATH_1	501	505	PF00917	0.789
DOC_USP7_MATH_1	509	513	PF00917	0.774
DOC_USP7_MATH_1	560	564	PF00917	0.589
DOC_USP7_MATH_1	565	569	PF00917	0.572
DOC_USP7_MATH_1	57	61	PF00917	0.758
DOC_USP7_MATH_1	628	632	PF00917	0.656
DOC_USP7_MATH_1	659	663	PF00917	0.713
DOC_USP7_UBL2_3	470	474	PF12436	0.866
DOC_WW_Pin1_4	291	296	PF00397	0.606
DOC_WW_Pin1_4	374	379	PF00397	0.614
DOC_WW_Pin1_4	413	418	PF00397	0.618
DOC_WW_Pin1_4	505	510	PF00397	0.696
DOC_WW_Pin1_4	546	551	PF00397	0.692
DOC_WW_Pin1_4	570	575	PF00397	0.851
DOC_WW_Pin1_4	608	613	PF00397	0.820
DOC_WW_Pin1_4	637	642	PF00397	0.618
DOC_WW_Pin1_4	653	658	PF00397	0.766
DOC_WW_Pin1_4	667	672	PF00397	0.587
LIG_14-3-3_CanoR_1	188	194	PF00244	0.757
LIG_14-3-3_CanoR_1	234	244	PF00244	0.686
LIG_14-3-3_CanoR_1	250	258	PF00244	0.655
LIG_14-3-3_CanoR_1	284	290	PF00244	0.680
LIG_14-3-3_CanoR_1	389	395	PF00244	0.802
LIG_14-3-3_CanoR_1	409	417	PF00244	0.649
LIG_14-3-3_CanoR_1	427	432	PF00244	0.785
LIG_14-3-3_CanoR_1	483	491	PF00244	0.761
LIG_14-3-3_CanoR_1	542	546	PF00244	0.621
LIG_14-3-3_CanoR_1	761	766	PF00244	0.820
LIG_14-3-3_CanoR_1	771	779	PF00244	0.681
LIG_14-3-3_CanoR_1	84	89	PF00244	0.757
LIG_Actin_WH2_2	384	399	PF00022	0.564
LIG_BRCT_BRCA1_1	334	338	PF00533	0.691
LIG_BRCT_BRCA1_1	425	429	PF00533	0.583
LIG_BRCT_BRCA1_1	436	440	PF00533	0.530
LIG_BRCT_BRCA1_1	455	459	PF00533	0.573
LIG_BRCT_BRCA1_1	663	667	PF00533	0.825
LIG_CSL_BTD_1	654	657	PF09270	0.825
LIG_EH1_1	21	29	PF00400	0.537
LIG_FHA_1	284	290	PF00498	0.694
LIG_FHA_1	519	525	PF00498	0.587
LIG_FHA_1	567	573	PF00498	0.736
LIG_FHA_1	644	650	PF00498	0.758
LIG_FHA_1	774	780	PF00498	0.598
LIG_FHA_1	8	14	PF00498	0.763
LIG_FHA_2	133	139	PF00498	0.587
LIG_FHA_2	234	240	PF00498	0.573
LIG_FHA_2	30	36	PF00498	0.750
LIG_FHA_2	620	626	PF00498	0.590
LIG_FHA_2	645	651	PF00498	0.585
LIG_LIR_Gen_1	181	187	PF02991	0.554
LIG_LIR_Gen_1	323	331	PF02991	0.561
LIG_LIR_Gen_1	426	436	PF02991	0.574
LIG_LIR_Gen_1	672	681	PF02991	0.785
LIG_LIR_Gen_1	800	810	PF02991	0.556
LIG_LIR_Nem_3	181	185	PF02991	0.553
LIG_LIR_Nem_3	323	328	PF02991	0.559
LIG_LIR_Nem_3	426	432	PF02991	0.578
LIG_LIR_Nem_3	672	677	PF02991	0.782
LIG_MYND_1	637	641	PF01753	0.567
LIG_Pex14_2	58	62	PF04695	0.781
LIG_SH2_CRK	116	120	PF00017	0.739
LIG_SH2_CRK	325	329	PF00017	0.567
LIG_SH2_SRC	116	119	PF00017	0.587
LIG_SH2_SRC	127	130	PF00017	0.513
LIG_SH2_STAP1	127	131	PF00017	0.558
LIG_SH2_STAP1	325	329	PF00017	0.567
LIG_SH2_STAT5	220	223	PF00017	0.795
LIG_SH2_STAT5	31	34	PF00017	0.813
LIG_SH2_STAT5	590	593	PF00017	0.654
LIG_SH2_STAT5	803	806	PF00017	0.557
LIG_SH3_2	468	473	PF14604	0.613
LIG_SH3_3	289	295	PF00018	0.591
LIG_SH3_3	465	471	PF00018	0.674
LIG_SH3_3	49	55	PF00018	0.645
LIG_SH3_3	503	509	PF00018	0.585
LIG_SH3_3	569	575	PF00018	0.754
LIG_SH3_3	606	612	PF00018	0.817
LIG_SH3_3	635	641	PF00018	0.737
LIG_SH3_3	651	657	PF00018	0.590
LIG_SH3_3	699	705	PF00018	0.572
LIG_SH3_4	470	477	PF00018	0.861
LIG_SUMO_SIM_par_1	793	798	PF11976	0.539
LIG_TRAF2_1	491	494	PF00917	0.598
LIG_TRFH_1	429	433	PF08558	0.567
LIG_UBA3_1	815	823	PF00899	0.542
LIG_WRC_WIRS_1	182	187	PF05994	0.556
LIG_WRC_WIRS_1	567	572	PF05994	0.599
LIG_WW_1	348	351	PF00397	0.573
MOD_CDK_SPxK_1	667	673	PF00069	0.818
MOD_CDK_SPxxK_3	570	577	PF00069	0.598
MOD_CK1_1	149	155	PF00069	0.829
MOD_CK1_1	174	180	PF00069	0.656
MOD_CK1_1	181	187	PF00069	0.678
MOD_CK1_1	189	195	PF00069	0.820
MOD_CK1_1	205	211	PF00069	0.552
MOD_CK1_1	233	239	PF00069	0.570
MOD_CK1_1	253	259	PF00069	0.659
MOD_CK1_1	265	271	PF00069	0.771
MOD_CK1_1	282	288	PF00069	0.541
MOD_CK1_1	332	338	PF00069	0.761
MOD_CK1_1	363	369	PF00069	0.577
MOD_CK1_1	4	10	PF00069	0.792
MOD_CK1_1	413	419	PF00069	0.851
MOD_CK1_1	423	429	PF00069	0.645
MOD_CK1_1	443	449	PF00069	0.692
MOD_CK1_1	452	458	PF00069	0.756
MOD_CK1_1	482	488	PF00069	0.866
MOD_CK1_1	499	505	PF00069	0.573
MOD_CK1_1	544	550	PF00069	0.752
MOD_CK1_1	563	569	PF00069	0.645
MOD_CK1_1	619	625	PF00069	0.849
MOD_CK1_1	662	668	PF00069	0.818
MOD_CK1_1	679	685	PF00069	0.555
MOD_CK1_1	71	77	PF00069	0.622
MOD_CK1_1	716	722	PF00069	0.843
MOD_CK1_1	742	748	PF00069	0.825
MOD_CK1_1	763	769	PF00069	0.782
MOD_CK2_1	132	138	PF00069	0.565
MOD_CK2_1	207	213	PF00069	0.565
MOD_CK2_1	233	239	PF00069	0.570
MOD_CK2_1	330	336	PF00069	0.566
MOD_CK2_1	573	579	PF00069	0.843
MOD_CK2_1	596	602	PF00069	0.695
MOD_CK2_1	697	703	PF00069	0.682
MOD_CK2_1	721	727	PF00069	0.662
MOD_CK2_1	74	80	PF00069	0.821
MOD_CK2_1	746	752	PF00069	0.803
MOD_DYRK1A_RPxSP_1	546	550	PF00069	0.605
MOD_GlcNHglycan	105	108	PF01048	0.553
MOD_GlcNHglycan	152	155	PF01048	0.708
MOD_GlcNHglycan	173	176	PF01048	0.639
MOD_GlcNHglycan	19	22	PF01048	0.587
MOD_GlcNHglycan	204	207	PF01048	0.667
MOD_GlcNHglycan	245	248	PF01048	0.771
MOD_GlcNHglycan	281	284	PF01048	0.749
MOD_GlcNHglycan	332	335	PF01048	0.741
MOD_GlcNHglycan	362	365	PF01048	0.699
MOD_GlcNHglycan	367	370	PF01048	0.773
MOD_GlcNHglycan	404	408	PF01048	0.855
MOD_GlcNHglycan	412	415	PF01048	0.768
MOD_GlcNHglycan	465	468	PF01048	0.814
MOD_GlcNHglycan	499	502	PF01048	0.626
MOD_GlcNHglycan	55	58	PF01048	0.676
MOD_GlcNHglycan	598	601	PF01048	0.692
MOD_GlcNHglycan	657	660	PF01048	0.821
MOD_GlcNHglycan	678	681	PF01048	0.646
MOD_GlcNHglycan	699	702	PF01048	0.566
MOD_GlcNHglycan	723	726	PF01048	0.826
MOD_GlcNHglycan	73	76	PF01048	0.519
MOD_GlcNHglycan	747	751	PF01048	0.624
MOD_GlcNHglycan	768	771	PF01048	0.749
MOD_GlcNHglycan	780	783	PF01048	0.572
MOD_GlcNHglycan	80	84	PF01048	0.699
MOD_GlcNHglycan	93	96	PF01048	0.685
MOD_GSK3_1	1	8	PF00069	0.722
MOD_GSK3_1	132	139	PF00069	0.717
MOD_GSK3_1	146	153	PF00069	0.713
MOD_GSK3_1	174	181	PF00069	0.695
MOD_GSK3_1	192	199	PF00069	0.822
MOD_GSK3_1	201	208	PF00069	0.668
MOD_GSK3_1	221	228	PF00069	0.561
MOD_GSK3_1	252	259	PF00069	0.656
MOD_GSK3_1	279	286	PF00069	0.765
MOD_GSK3_1	330	337	PF00069	0.673
MOD_GSK3_1	365	372	PF00069	0.670
MOD_GSK3_1	374	381	PF00069	0.611
MOD_GSK3_1	412	419	PF00069	0.815
MOD_GSK3_1	423	430	PF00069	0.578
MOD_GSK3_1	434	441	PF00069	0.665
MOD_GSK3_1	449	456	PF00069	0.771
MOD_GSK3_1	479	486	PF00069	0.733
MOD_GSK3_1	496	503	PF00069	0.569
MOD_GSK3_1	505	512	PF00069	0.678
MOD_GSK3_1	53	60	PF00069	0.792
MOD_GSK3_1	566	573	PF00069	0.813
MOD_GSK3_1	604	611	PF00069	0.629
MOD_GSK3_1	616	623	PF00069	0.770
MOD_GSK3_1	64	71	PF00069	0.606
MOD_GSK3_1	644	651	PF00069	0.807
MOD_GSK3_1	653	660	PF00069	0.660
MOD_GSK3_1	661	668	PF00069	0.538
MOD_GSK3_1	675	682	PF00069	0.668
MOD_GSK3_1	742	749	PF00069	0.818
MOD_GSK3_1	759	766	PF00069	0.538
MOD_GSK3_1	769	776	PF00069	0.675
MOD_GSK3_1	79	86	PF00069	0.757
MOD_LATS_1	481	487	PF00433	0.614
MOD_N-GLC_1	147	152	PF02516	0.589
MOD_N-GLC_1	271	276	PF02516	0.762
MOD_N-GLC_1	329	334	PF02516	0.565
MOD_N-GLC_1	360	365	PF02516	0.540
MOD_N-GLC_1	417	422	PF02516	0.631
MOD_N-GLC_1	479	484	PF02516	0.842
MOD_N-GLC_1	518	523	PF02516	0.585
MOD_N-GLC_1	560	565	PF02516	0.704
MOD_N-GLC_1	620	625	PF02516	0.596
MOD_NEK2_1	1	6	PF00069	0.756
MOD_NEK2_1	136	141	PF00069	0.642
MOD_NEK2_1	17	22	PF00069	0.575
MOD_NEK2_1	196	201	PF00069	0.793
MOD_NEK2_1	207	212	PF00069	0.658
MOD_NEK2_1	221	226	PF00069	0.547
MOD_NEK2_1	252	257	PF00069	0.807
MOD_NEK2_1	273	278	PF00069	0.731
MOD_NEK2_1	303	308	PF00069	0.786
MOD_NEK2_1	510	515	PF00069	0.589
MOD_NEK2_1	58	63	PF00069	0.617
MOD_NEK2_1	696	701	PF00069	0.819
MOD_NEK2_1	731	736	PF00069	0.718
MOD_NEK2_1	739	744	PF00069	0.800
MOD_NEK2_2	541	546	PF00069	0.607
MOD_NEK2_2	628	633	PF00069	0.570
MOD_PIKK_1	119	125	PF00454	0.539
MOD_PIKK_1	303	309	PF00454	0.732
MOD_PIKK_1	544	550	PF00454	0.760
MOD_PK_1	483	489	PF00069	0.867
MOD_PKA_1	250	256	PF00069	0.555
MOD_PKA_1	402	408	PF00069	0.725
MOD_PKA_1	427	433	PF00069	0.572
MOD_PKA_2	144	150	PF00069	0.597
MOD_PKA_2	211	217	PF00069	0.571
MOD_PKA_2	233	239	PF00069	0.595
MOD_PKA_2	250	256	PF00069	0.738
MOD_PKA_2	283	289	PF00069	0.776
MOD_PKA_2	402	408	PF00069	0.664
MOD_PKA_2	427	433	PF00069	0.736
MOD_PKA_2	449	455	PF00069	0.558
MOD_PKA_2	482	488	PF00069	0.866
MOD_PKA_2	541	547	PF00069	0.606
MOD_PKA_2	760	766	PF00069	0.645
MOD_PKA_2	770	776	PF00069	0.705
MOD_PKA_2	83	89	PF00069	0.735
MOD_Plk_1	127	133	PF00069	0.591
MOD_Plk_1	221	227	PF00069	0.800
MOD_Plk_1	230	236	PF00069	0.812
MOD_Plk_1	253	259	PF00069	0.632
MOD_Plk_1	271	277	PF00069	0.765
MOD_Plk_1	444	450	PF00069	0.572
MOD_Plk_1	563	569	PF00069	0.590
MOD_Plk_1	713	719	PF00069	0.757
MOD_Plk_2-3	321	327	PF00069	0.583
MOD_Plk_4	520	526	PF00069	0.584
MOD_Plk_4	58	64	PF00069	0.528
MOD_Plk_4	644	650	PF00069	0.583
MOD_ProDKin_1	291	297	PF00069	0.607
MOD_ProDKin_1	374	380	PF00069	0.615
MOD_ProDKin_1	413	419	PF00069	0.617
MOD_ProDKin_1	505	511	PF00069	0.698
MOD_ProDKin_1	546	552	PF00069	0.686
MOD_ProDKin_1	570	576	PF00069	0.852
MOD_ProDKin_1	608	614	PF00069	0.824
MOD_ProDKin_1	637	643	PF00069	0.620
MOD_ProDKin_1	653	659	PF00069	0.766
MOD_ProDKin_1	667	673	PF00069	0.587
MOD_SUMO_rev_2	354	363	PF00179	0.553
MOD_SUMO_rev_2	437	446	PF00179	0.759
TRG_DiLeu_BaLyEn_6	581	586	PF01217	0.583
TRG_DiLeu_BaLyEn_6	726	731	PF01217	0.573
TRG_ENDOCYTIC_2	182	185	PF00928	0.555
TRG_ENDOCYTIC_2	325	328	PF00928	0.565
TRG_ENDOCYTIC_2	803	806	PF00928	0.557
TRG_ER_diArg_1	250	252	PF00400	0.562
TRG_ER_diArg_1	277	279	PF00400	0.642
TRG_ER_diArg_1	394	397	PF00400	0.804
TRG_ER_diArg_1	409	411	PF00400	0.622
TRG_ER_diArg_1	427	429	PF00400	0.583
TRG_ER_diArg_1	471	473	PF00400	0.869
TRG_ER_diArg_1	587	589	PF00400	0.809
TRG_ER_diArg_1	684	686	PF00400	0.578
TRG_NLS_MonoCore_2	468	473	PF00514	0.866
TRG_NLS_MonoCore_2	783	788	PF00514	0.842
TRG_NLS_MonoExtC_3	468	473	PF00514	0.866
TRG_NLS_MonoExtC_3	784	790	PF00514	0.832
TRG_NLS_MonoExtN_4	468	473	PF00514	0.613
TRG_NLS_MonoExtN_4	784	789	PF00514	0.835
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	729	733	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGI6	Leishmania donovani	61%	100%
A4I744	Leishmania infantum	61%	100%
E9B238	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4Q623	Leishmania major	58%	100%