WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJM1_LEIBR

TriTrypDb:

LbrM.31.2660 , LBRM2903_310036200

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJM1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	46	50	PF00656	0.485
CLV_MEL_PAP_1	294	300	PF00089	0.425
CLV_NRD_NRD_1	136	138	PF00675	0.598
CLV_NRD_NRD_1	22	24	PF00675	0.597
CLV_NRD_NRD_1	61	63	PF00675	0.328
CLV_NRD_NRD_1	84	86	PF00675	0.374
CLV_PCSK_KEX2_1	430	432	PF00082	0.398
CLV_PCSK_KEX2_1	6	8	PF00082	0.663
CLV_PCSK_KEX2_1	96	98	PF00082	0.477
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.420
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.696
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.477
CLV_PCSK_SKI1_1	120	124	PF00082	0.294
CLV_PCSK_SKI1_1	195	199	PF00082	0.455
CLV_PCSK_SKI1_1	237	241	PF00082	0.441
CLV_PCSK_SKI1_1	327	331	PF00082	0.322
CLV_PCSK_SKI1_1	40	44	PF00082	0.708
CLV_PCSK_SKI1_1	66	70	PF00082	0.356
DEG_APCC_DBOX_1	276	284	PF00400	0.260
DEG_Nend_UBRbox_1	1	4	PF02207	0.666
DEG_ODPH_VHL_1	157	168	PF01847	0.330
DOC_AGCK_PIF_1	295	300	PF00069	0.428
DOC_CKS1_1	383	388	PF01111	0.456
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.534
DOC_MAPK_gen_1	62	72	PF00069	0.238
DOC_MAPK_gen_1	85	93	PF00069	0.336
DOC_MAPK_MEF2A_6	203	210	PF00069	0.444
DOC_MAPK_MEF2A_6	213	222	PF00069	0.475
DOC_MAPK_MEF2A_6	277	285	PF00069	0.454
DOC_MIT_MIM_1	145	154	PF04212	0.419
DOC_PP1_RVXF_1	289	296	PF00149	0.382
DOC_PP2B_LxvP_1	132	135	PF13499	0.349
DOC_USP7_MATH_1	169	173	PF00917	0.465
DOC_USP7_MATH_1	258	262	PF00917	0.572
DOC_USP7_MATH_1	310	314	PF00917	0.392
DOC_USP7_MATH_1	36	40	PF00917	0.598
DOC_USP7_MATH_1	50	54	PF00917	0.554
DOC_USP7_MATH_1	64	68	PF00917	0.392
DOC_USP7_UBL2_3	2	6	PF12436	0.630
DOC_USP7_UBL2_3	237	241	PF12436	0.441
DOC_USP7_UBL2_3	88	92	PF12436	0.431
DOC_WW_Pin1_4	244	249	PF00397	0.502
DOC_WW_Pin1_4	283	288	PF00397	0.325
DOC_WW_Pin1_4	32	37	PF00397	0.651
DOC_WW_Pin1_4	362	367	PF00397	0.463
DOC_WW_Pin1_4	382	387	PF00397	0.446
DOC_WW_Pin1_4	394	399	PF00397	0.289
DOC_WW_Pin1_4	464	469	PF00397	0.439
LIG_14-3-3_CanoR_1	101	106	PF00244	0.439
LIG_14-3-3_CanoR_1	131	135	PF00244	0.358
LIG_14-3-3_CanoR_1	297	301	PF00244	0.411
LIG_Actin_WH2_2	384	402	PF00022	0.520
LIG_APCC_ABBA_1	165	170	PF00400	0.222
LIG_BRCT_BRCA1_1	412	416	PF00533	0.366
LIG_FHA_1	162	168	PF00498	0.496
LIG_FHA_1	225	231	PF00498	0.312
LIG_FHA_1	288	294	PF00498	0.486
LIG_FHA_1	332	338	PF00498	0.342
LIG_FHA_1	359	365	PF00498	0.449
LIG_FHA_2	219	225	PF00498	0.377
LIG_FHA_2	368	374	PF00498	0.495
LIG_FHA_2	42	48	PF00498	0.691
LIG_FHA_2	450	456	PF00498	0.329
LIG_LIR_Gen_1	296	306	PF02991	0.352
LIG_LIR_Gen_1	87	95	PF02991	0.476
LIG_LIR_LC3C_4	290	294	PF02991	0.214
LIG_LIR_LC3C_4	67	72	PF02991	0.289
LIG_LIR_Nem_3	296	301	PF02991	0.333
LIG_LIR_Nem_3	87	93	PF02991	0.482
LIG_NRP_CendR_1	481	482	PF00754	0.439
LIG_Pex14_2	89	93	PF04695	0.329
LIG_SH2_STAP1	303	307	PF00017	0.423
LIG_SH2_STAT5	111	114	PF00017	0.322
LIG_SH2_STAT5	441	444	PF00017	0.355
LIG_SH2_STAT5	90	93	PF00017	0.476
LIG_SH3_3	245	251	PF00018	0.487
LIG_SH3_3	304	310	PF00018	0.477
LIG_SH3_3	316	322	PF00018	0.485
LIG_SH3_3	53	59	PF00018	0.510
LIG_SUMO_SIM_anti_2	162	167	PF11976	0.218
LIG_SUMO_SIM_anti_2	227	232	PF11976	0.317
LIG_SUMO_SIM_anti_2	67	74	PF11976	0.356
LIG_SUMO_SIM_par_1	224	232	PF11976	0.359
LIG_SUMO_SIM_par_1	67	74	PF11976	0.285
LIG_TRAF2_1	262	265	PF00917	0.669
LIG_TRAF2_1	276	279	PF00917	0.363
LIG_WRC_WIRS_1	311	316	PF05994	0.316
MOD_CDC14_SPxK_1	397	400	PF00782	0.255
MOD_CDK_SPxK_1	382	388	PF00069	0.449
MOD_CDK_SPxK_1	394	400	PF00069	0.283
MOD_CDK_SPxxK_3	464	471	PF00069	0.439
MOD_CK1_1	193	199	PF00069	0.391
MOD_CK1_1	214	220	PF00069	0.479
MOD_CK1_1	26	32	PF00069	0.651
MOD_CK1_1	296	302	PF00069	0.426
MOD_CK1_1	417	423	PF00069	0.381
MOD_CK2_1	218	224	PF00069	0.457
MOD_CK2_1	258	264	PF00069	0.649
MOD_CK2_1	329	335	PF00069	0.371
MOD_CK2_1	367	373	PF00069	0.465
MOD_CK2_1	449	455	PF00069	0.474
MOD_CK2_1	9	15	PF00069	0.636
MOD_GlcNHglycan	114	117	PF01048	0.303
MOD_GlcNHglycan	195	198	PF01048	0.302
MOD_GlcNHglycan	260	263	PF01048	0.619
MOD_GlcNHglycan	269	272	PF01048	0.738
MOD_GlcNHglycan	304	307	PF01048	0.490
MOD_GlcNHglycan	31	34	PF01048	0.786
MOD_GlcNHglycan	443	446	PF01048	0.328
MOD_GlcNHglycan	52	55	PF01048	0.681
MOD_GlcNHglycan	66	69	PF01048	0.301
MOD_GSK3_1	214	221	PF00069	0.466
MOD_GSK3_1	23	30	PF00069	0.651
MOD_GSK3_1	283	290	PF00069	0.286
MOD_GSK3_1	32	39	PF00069	0.516
MOD_GSK3_1	358	365	PF00069	0.451
MOD_GSK3_1	367	374	PF00069	0.430
MOD_GSK3_1	390	397	PF00069	0.346
MOD_GSK3_1	41	48	PF00069	0.523
MOD_GSK3_1	410	417	PF00069	0.363
MOD_N-GLC_1	358	363	PF02516	0.604
MOD_NEK2_1	122	127	PF00069	0.307
MOD_NEK2_1	218	223	PF00069	0.295
MOD_NEK2_1	358	363	PF00069	0.572
MOD_NEK2_1	70	75	PF00069	0.435
MOD_NEK2_2	310	315	PF00069	0.402
MOD_PIKK_1	169	175	PF00454	0.329
MOD_PIKK_1	252	258	PF00454	0.490
MOD_PK_1	101	107	PF00069	0.374
MOD_PK_1	190	196	PF00069	0.349
MOD_PK_1	9	15	PF00069	0.624
MOD_PKA_1	23	29	PF00069	0.633
MOD_PKA_2	130	136	PF00069	0.596
MOD_PKA_2	267	273	PF00069	0.731
MOD_PKA_2	296	302	PF00069	0.426
MOD_PKA_2	449	455	PF00069	0.322
MOD_PKB_1	188	196	PF00069	0.326
MOD_PKB_1	7	15	PF00069	0.718
MOD_Plk_1	161	167	PF00069	0.439
MOD_Plk_1	190	196	PF00069	0.331
MOD_Plk_1	224	230	PF00069	0.337
MOD_Plk_4	161	167	PF00069	0.250
MOD_Plk_4	411	417	PF00069	0.351
MOD_ProDKin_1	244	250	PF00069	0.519
MOD_ProDKin_1	283	289	PF00069	0.320
MOD_ProDKin_1	32	38	PF00069	0.652
MOD_ProDKin_1	362	368	PF00069	0.466
MOD_ProDKin_1	382	388	PF00069	0.449
MOD_ProDKin_1	394	400	PF00069	0.283
MOD_ProDKin_1	464	470	PF00069	0.439
MOD_SUMO_for_1	387	390	PF00179	0.433
MOD_SUMO_rev_2	10	18	PF00179	0.490
TRG_DiLeu_BaEn_1	162	167	PF01217	0.360
TRG_ENDOCYTIC_2	90	93	PF00928	0.476
TRG_ER_diArg_1	187	190	PF00400	0.300
TRG_NLS_MonoExtC_3	136	142	PF00514	0.547
TRG_NLS_MonoExtC_3	5	11	PF00514	0.531
TRG_NLS_MonoExtN_4	135	141	PF00514	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5P1	Leptomonas seymouri	63%	100%
A0A0S4JK75	Bodo saltans	34%	100%
A0A1X0NFD4	Trypanosomatidae	38%	93%
A0A3Q8ICP9	Leishmania donovani	79%	94%
A0A3R7KS12	Trypanosoma rangeli	44%	100%
A4I743	Leishmania infantum	79%	94%
C9ZME4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	85%
C9ZWN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	85%
E9B237	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	93%
Q4Q624	Leishmania major	79%	100%
Q68FJ6	Xenopus laevis	23%	100%
V5B2M4	Trypanosoma cruzi	46%	100%