Fungal_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJM0_LEIBR

TriTrypDb:

LbrM.31.2650 , LBRM2903_310036100

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.789
CLV_NRD_NRD_1	445	447	PF00675	0.550
CLV_PCSK_KEX2_1	445	447	PF00082	0.550
CLV_PCSK_SKI1_1	156	160	PF00082	0.556
DEG_APCC_DBOX_1	469	477	PF00400	0.607
DEG_APCC_DBOX_1	480	488	PF00400	0.606
DEG_SCF_FBW7_1	391	397	PF00400	0.564
DEG_SCF_FBW7_2	468	475	PF00400	0.599
DEG_SPOP_SBC_1	345	349	PF00917	0.576
DEG_SPOP_SBC_1	63	67	PF00917	0.783
DOC_CDC14_PxL_1	247	255	PF14671	0.745
DOC_CDC14_PxL_1	300	308	PF14671	0.748
DOC_CKS1_1	372	377	PF01111	0.547
DOC_CKS1_1	391	396	PF01111	0.562
DOC_CKS1_1	40	45	PF01111	0.650
DOC_CKS1_1	469	474	PF01111	0.606
DOC_CYCLIN_yCln2_LP_2	241	247	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	373	379	PF00134	0.728
DOC_MAPK_FxFP_2	512	515	PF00069	0.598
DOC_MAPK_MEF2A_6	41	49	PF00069	0.721
DOC_PP2B_LxvP_1	373	376	PF13499	0.677
DOC_PP2B_LxvP_1	465	468	PF13499	0.561
DOC_PP4_FxxP_1	191	194	PF00568	0.816
DOC_PP4_FxxP_1	431	434	PF00568	0.600
DOC_PP4_FxxP_1	512	515	PF00568	0.598
DOC_USP7_MATH_1	322	326	PF00917	0.754
DOC_USP7_MATH_1	345	349	PF00917	0.752
DOC_USP7_MATH_1	351	355	PF00917	0.496
DOC_USP7_MATH_1	63	67	PF00917	0.716
DOC_USP7_UBL2_3	415	419	PF12436	0.723
DOC_WW_Pin1_4	134	139	PF00397	0.581
DOC_WW_Pin1_4	178	183	PF00397	0.738
DOC_WW_Pin1_4	190	195	PF00397	0.666
DOC_WW_Pin1_4	220	225	PF00397	0.634
DOC_WW_Pin1_4	240	245	PF00397	0.687
DOC_WW_Pin1_4	371	376	PF00397	0.702
DOC_WW_Pin1_4	387	392	PF00397	0.704
DOC_WW_Pin1_4	39	44	PF00397	0.647
DOC_WW_Pin1_4	468	473	PF00397	0.591
DOC_WW_Pin1_4	78	83	PF00397	0.700
DOC_WW_Pin1_4	95	100	PF00397	0.672
LIG_14-3-3_CanoR_1	162	168	PF00244	0.757
LIG_14-3-3_CanoR_1	261	270	PF00244	0.689
LIG_14-3-3_CanoR_1	31	36	PF00244	0.562
LIG_14-3-3_CanoR_1	396	403	PF00244	0.829
LIG_14-3-3_CanoR_1	413	421	PF00244	0.605
LIG_14-3-3_CanoR_1	76	80	PF00244	0.627
LIG_BRCT_BRCA1_1	163	167	PF00533	0.532
LIG_BRCT_BRCA1_1	202	206	PF00533	0.561
LIG_BRCT_BRCA1_1	379	383	PF00533	0.565
LIG_deltaCOP1_diTrp_1	450	459	PF00928	0.527
LIG_deltaCOP1_diTrp_1	495	504	PF00928	0.477
LIG_deltaCOP1_diTrp_1	51	60	PF00928	0.666
LIG_EVH1_1	432	436	PF00568	0.586
LIG_EVH1_1	465	469	PF00568	0.558
LIG_FHA_1	123	129	PF00498	0.750
LIG_FHA_1	460	466	PF00498	0.568
LIG_FHA_2	17	23	PF00498	0.732
LIG_FHA_2	309	315	PF00498	0.664
LIG_FHA_2	46	52	PF00498	0.695
LIG_FXI_DFP_1	511	515	PF00024	0.648
LIG_Integrin_RGD_1	23	25	PF01839	0.824
LIG_LIR_Apic_2	188	194	PF02991	0.810
LIG_LIR_Apic_2	510	515	PF02991	0.466
LIG_LIR_Apic_2	57	63	PF02991	0.725
LIG_LIR_Gen_1	495	505	PF02991	0.508
LIG_LIR_Gen_1	522	533	PF02991	0.651
LIG_LIR_Nem_3	203	208	PF02991	0.561
LIG_LIR_Nem_3	450	455	PF02991	0.523
LIG_LIR_Nem_3	495	500	PF02991	0.511
LIG_LIR_Nem_3	501	507	PF02991	0.518
LIG_LIR_Nem_3	522	528	PF02991	0.652
LIG_LYPXL_yS_3	303	306	PF13949	0.753
LIG_MLH1_MIPbox_1	202	206	PF16413	0.561
LIG_MYND_3	250	254	PF01753	0.739
LIG_NRBOX	420	426	PF00104	0.571
LIG_PCNA_PIPBox_1	184	193	PF02747	0.549
LIG_Pex14_2	427	431	PF04695	0.600
LIG_Rb_pABgroove_1	506	514	PF01858	0.619
LIG_SH2_SRC	278	281	PF00017	0.745
LIG_SH2_STAP1	163	167	PF00017	0.743
LIG_SH2_STAP1	171	175	PF00017	0.661
LIG_SH2_STAP1	455	459	PF00017	0.543
LIG_SH2_STAT5	190	193	PF00017	0.624
LIG_SH2_STAT5	205	208	PF00017	0.754
LIG_SH2_STAT5	249	252	PF00017	0.675
LIG_SH2_STAT5	278	281	PF00017	0.619
LIG_SH2_STAT5	420	423	PF00017	0.583
LIG_SH3_2	391	396	PF14604	0.562
LIG_SH3_2	434	439	PF14604	0.607
LIG_SH3_3	281	287	PF00018	0.777
LIG_SH3_3	369	375	PF00018	0.810
LIG_SH3_3	37	43	PF00018	0.664
LIG_SH3_3	388	394	PF00018	0.625
LIG_SH3_3	399	405	PF00018	0.566
LIG_SH3_3	430	436	PF00018	0.597
LIG_SH3_3	463	469	PF00018	0.571
LIG_SH3_CIN85_PxpxPR_1	434	439	PF14604	0.607
LIG_SUMO_SIM_par_1	268	274	PF11976	0.459
LIG_SUMO_SIM_par_1	44	51	PF11976	0.676
LIG_TRAF2_1	310	313	PF00917	0.750
LIG_TRAF2_1	441	444	PF00917	0.549
LIG_WW_3	436	440	PF00397	0.605
LIG_WW_3	467	471	PF00397	0.585
MOD_CDK_SPxK_1	390	396	PF00069	0.562
MOD_CDK_SPxK_1	78	84	PF00069	0.572
MOD_CDK_SPxxK_3	220	227	PF00069	0.562
MOD_CK1_1	122	128	PF00069	0.716
MOD_CK1_1	14	20	PF00069	0.651
MOD_CK1_1	271	277	PF00069	0.464
MOD_CK1_1	364	370	PF00069	0.722
MOD_CK1_1	390	396	PF00069	0.711
MOD_CK1_1	75	81	PF00069	0.699
MOD_CK2_1	308	314	PF00069	0.665
MOD_CK2_1	444	450	PF00069	0.468
MOD_CK2_1	45	51	PF00069	0.725
MOD_CK2_1	64	70	PF00069	0.493
MOD_GlcNHglycan	264	267	PF01048	0.653
MOD_GlcNHglycan	322	325	PF01048	0.584
MOD_GlcNHglycan	349	352	PF01048	0.714
MOD_GlcNHglycan	353	356	PF01048	0.594
MOD_GlcNHglycan	358	361	PF01048	0.570
MOD_GlcNHglycan	364	367	PF01048	0.539
MOD_GlcNHglycan	380	383	PF01048	0.665
MOD_GlcNHglycan	385	388	PF01048	0.709
MOD_GlcNHglycan	397	400	PF01048	0.798
MOD_GlcNHglycan	55	59	PF01048	0.787
MOD_GlcNHglycan	77	80	PF01048	0.757
MOD_GlcNHglycan	93	96	PF01048	0.727
MOD_GSK3_1	14	21	PF00069	0.576
MOD_GSK3_1	170	177	PF00069	0.733
MOD_GSK3_1	219	226	PF00069	0.639
MOD_GSK3_1	304	311	PF00069	0.720
MOD_GSK3_1	343	350	PF00069	0.809
MOD_GSK3_1	356	363	PF00069	0.740
MOD_GSK3_1	383	390	PF00069	0.822
MOD_GSK3_1	41	48	PF00069	0.721
MOD_GSK3_1	415	422	PF00069	0.593
MOD_GSK3_1	91	98	PF00069	0.726
MOD_N-GLC_1	117	122	PF02516	0.714
MOD_N-GLC_1	185	190	PF02516	0.667
MOD_N-GLC_1	304	309	PF02516	0.822
MOD_N-GLC_1	377	382	PF02516	0.553
MOD_NEK2_1	219	224	PF00069	0.806
MOD_NEK2_1	293	298	PF00069	0.727
MOD_NEK2_1	356	361	PF00069	0.579
MOD_NEK2_1	377	382	PF00069	0.707
MOD_NEK2_1	383	388	PF00069	0.690
MOD_NEK2_1	45	50	PF00069	0.671
MOD_PIKK_1	185	191	PF00454	0.801
MOD_PIKK_1	293	299	PF00454	0.725
MOD_PIKK_1	336	342	PF00454	0.634
MOD_PK_1	209	215	PF00069	0.532
MOD_PKA_2	14	20	PF00069	0.673
MOD_PKA_2	161	167	PF00069	0.787
MOD_PKA_2	2	8	PF00069	0.601
MOD_PKA_2	30	36	PF00069	0.681
MOD_PKA_2	395	401	PF00069	0.833
MOD_PKA_2	444	450	PF00069	0.480
MOD_PKA_2	75	81	PF00069	0.747
MOD_Plk_1	185	191	PF00069	0.801
MOD_Plk_1	523	529	PF00069	0.465
MOD_Plk_2-3	119	125	PF00069	0.547
MOD_Plk_2-3	308	314	PF00069	0.700
MOD_Plk_4	245	251	PF00069	0.653
MOD_Plk_4	271	277	PF00069	0.657
MOD_Plk_4	31	37	PF00069	0.697
MOD_Plk_4	41	47	PF00069	0.703
MOD_Plk_4	64	70	PF00069	0.684
MOD_ProDKin_1	134	140	PF00069	0.584
MOD_ProDKin_1	178	184	PF00069	0.738
MOD_ProDKin_1	190	196	PF00069	0.665
MOD_ProDKin_1	220	226	PF00069	0.634
MOD_ProDKin_1	240	246	PF00069	0.684
MOD_ProDKin_1	371	377	PF00069	0.704
MOD_ProDKin_1	387	393	PF00069	0.702
MOD_ProDKin_1	39	45	PF00069	0.648
MOD_ProDKin_1	468	474	PF00069	0.596
MOD_ProDKin_1	78	84	PF00069	0.700
MOD_ProDKin_1	95	101	PF00069	0.673
MOD_SUMO_rev_2	248	258	PF00179	0.479
MOD_SUMO_rev_2	307	316	PF00179	0.570
MOD_SUMO_rev_2	416	421	PF00179	0.701
TRG_ENDOCYTIC_2	205	208	PF00928	0.814
TRG_ENDOCYTIC_2	303	306	PF00928	0.700
TRG_ER_diArg_1	445	448	PF00400	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC95	Leptomonas seymouri	50%	91%
A0A3Q8IST7	Leishmania donovani	73%	99%
A4I742	Leishmania infantum	73%	99%
E9B236	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
Q4Q625	Leishmania major	70%	100%
V5BBS4	Trypanosoma cruzi	36%	100%