Putative p-nitrophenylphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p-nitrophenylphosphatase, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HJL8_LEIBR

TriTrypDb:

LbrM.31.2630 , LBRM2903_310035600

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJL8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	19	23	PF00082	0.414
CLV_PCSK_SKI1_1	96	100	PF00082	0.320
DEG_ODPH_VHL_1	131	142	PF01847	0.396
DOC_CYCLIN_RxL_1	93	103	PF00134	0.479
DOC_MAPK_gen_1	73	81	PF00069	0.505
DOC_PP1_RVXF_1	49	56	PF00149	0.451
DOC_PP2B_LxvP_1	165	168	PF13499	0.371
DOC_USP7_MATH_1	155	159	PF00917	0.469
DOC_USP7_MATH_1	217	221	PF00917	0.447
DOC_USP7_MATH_1	241	245	PF00917	0.503
DOC_WW_Pin1_4	13	18	PF00397	0.461
DOC_WW_Pin1_4	233	238	PF00397	0.634
DOC_WW_Pin1_4	3	8	PF00397	0.443
LIG_14-3-3_CanoR_1	175	183	PF00244	0.581
LIG_Actin_WH2_2	200	217	PF00022	0.432
LIG_Clathr_ClatBox_1	22	26	PF01394	0.462
LIG_FHA_1	135	141	PF00498	0.384
LIG_FHA_1	151	157	PF00498	0.493
LIG_FHA_1	4	10	PF00498	0.521
LIG_FHA_2	192	198	PF00498	0.421
LIG_FHA_2	78	84	PF00498	0.519
LIG_LIR_Apic_2	158	163	PF02991	0.492
LIG_LIR_Apic_2	233	238	PF02991	0.569
LIG_LIR_Gen_1	208	218	PF02991	0.423
LIG_LIR_Nem_3	208	214	PF02991	0.429
LIG_NRBOX	94	100	PF00104	0.505
LIG_NRP_CendR_1	243	245	PF00754	0.454
LIG_SH2_CRK	218	222	PF00017	0.448
LIG_SH2_CRK	235	239	PF00017	0.628
LIG_SH2_NCK_1	85	89	PF00017	0.493
LIG_SH2_STAP1	151	155	PF00017	0.513
LIG_SH2_STAP1	89	93	PF00017	0.471
LIG_SH2_STAT5	235	238	PF00017	0.575
LIG_SH2_STAT5	45	48	PF00017	0.458
LIG_SH3_1	235	241	PF00018	0.410
LIG_SH3_2	238	243	PF14604	0.437
LIG_SH3_3	11	17	PF00018	0.496
LIG_SH3_3	127	133	PF00018	0.517
LIG_SH3_3	160	166	PF00018	0.420
LIG_SH3_3	235	241	PF00018	0.580
LIG_SUMO_SIM_par_1	21	26	PF11976	0.315
LIG_TRAF2_1	105	108	PF00917	0.529
LIG_TRAF2_1	80	83	PF00917	0.513
LIG_TYR_ITIM	18	23	PF00017	0.367
LIG_TYR_ITIM	216	221	PF00017	0.451
LIG_UBA3_1	67	74	PF00899	0.529
MOD_CDC14_SPxK_1	16	19	PF00782	0.479
MOD_CDK_SPxK_1	13	19	PF00069	0.475
MOD_CK2_1	77	83	PF00069	0.519
MOD_GlcNHglycan	157	160	PF01048	0.434
MOD_GlcNHglycan	86	89	PF01048	0.254
MOD_GSK3_1	54	61	PF00069	0.457
MOD_N-GLC_1	58	63	PF02516	0.258
MOD_Plk_1	58	64	PF00069	0.458
MOD_Plk_2-3	191	197	PF00069	0.486
MOD_Plk_2-3	77	83	PF00069	0.529
MOD_ProDKin_1	13	19	PF00069	0.461
MOD_ProDKin_1	233	239	PF00069	0.637
MOD_ProDKin_1	3	9	PF00069	0.434
MOD_SUMO_rev_2	70	76	PF00179	0.404
TRG_ENDOCYTIC_2	20	23	PF00928	0.359
TRG_ENDOCYTIC_2	218	221	PF00928	0.449
TRG_NES_CRM1_1	197	208	PF08389	0.376
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.204

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P266	Leptomonas seymouri	39%	72%
A0A0N1P9E3	Leptomonas seymouri	74%	86%
A0A0S4IZ46	Bodo saltans	42%	73%
A4HJL7	Leishmania braziliensis	100%	67%
A4I740	Leishmania infantum	40%	72%
A6NDG6	Homo sapiens	28%	76%
D3ZDK7	Rattus norvegicus	30%	76%
E9B234	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	67%
P0DKC3	Arabidopsis thaliana	31%	68%
P0DKC4	Arabidopsis thaliana	31%	68%
Q2T9S4	Bos taurus	28%	76%
Q8CHP8	Mus musculus	30%	76%
Q8GWU0	Arabidopsis thaliana	30%	81%