Putative p-nitrophenylphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p-nitrophenylphosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HJL7_LEIBR

TriTrypDb:

LbrM.31.2620 , LBRM2903_310035600

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJL7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	274	276	PF00675	0.259
CLV_PCSK_KEX2_1	274	276	PF00082	0.371
CLV_PCSK_SKI1_1	19	23	PF00082	0.336
CLV_PCSK_SKI1_1	289	293	PF00082	0.172
CLV_PCSK_SKI1_1	96	100	PF00082	0.315
DEG_ODPH_VHL_1	131	142	PF01847	0.337
DOC_CYCLIN_RxL_1	286	295	PF00134	0.239
DOC_CYCLIN_RxL_1	93	103	PF00134	0.416
DOC_MAPK_gen_1	73	81	PF00069	0.413
DOC_PP1_RVXF_1	287	293	PF00149	0.172
DOC_PP1_RVXF_1	49	56	PF00149	0.422
DOC_PP2B_LxvP_1	165	168	PF13499	0.321
DOC_USP7_MATH_1	155	159	PF00917	0.472
DOC_USP7_MATH_1	217	221	PF00917	0.361
DOC_USP7_UBL2_3	289	293	PF12436	0.168
DOC_WW_Pin1_4	13	18	PF00397	0.461
DOC_WW_Pin1_4	233	238	PF00397	0.483
DOC_WW_Pin1_4	3	8	PF00397	0.444
LIG_14-3-3_CanoR_1	175	183	PF00244	0.513
LIG_14-3-3_CanoR_1	310	317	PF00244	0.249
LIG_Actin_WH2_2	200	217	PF00022	0.295
LIG_FHA_1	135	141	PF00498	0.382
LIG_FHA_1	151	157	PF00498	0.465
LIG_FHA_1	234	240	PF00498	0.495
LIG_FHA_1	310	316	PF00498	0.276
LIG_FHA_1	345	351	PF00498	0.461
LIG_FHA_1	4	10	PF00498	0.471
LIG_FHA_2	192	198	PF00498	0.248
LIG_FHA_2	241	247	PF00498	0.337
LIG_FHA_2	78	84	PF00498	0.510
LIG_LIR_Apic_2	158	163	PF02991	0.448
LIG_LIR_Apic_2	233	238	PF02991	0.388
LIG_LIR_Gen_1	208	218	PF02991	0.321
LIG_LIR_Nem_3	208	214	PF02991	0.328
LIG_NRBOX	94	100	PF00104	0.416
LIG_SH2_CRK	218	222	PF00017	0.359
LIG_SH2_CRK	235	239	PF00017	0.363
LIG_SH2_NCK_1	85	89	PF00017	0.517
LIG_SH2_STAP1	151	155	PF00017	0.439
LIG_SH2_STAP1	89	93	PF00017	0.455
LIG_SH2_STAT5	235	238	PF00017	0.398
LIG_SH2_STAT5	353	356	PF00017	0.419
LIG_SH2_STAT5	45	48	PF00017	0.427
LIG_SH3_3	11	17	PF00018	0.365
LIG_SH3_3	127	133	PF00018	0.483
LIG_SH3_3	160	166	PF00018	0.458
LIG_SH3_3	244	250	PF00018	0.424
LIG_SUMO_SIM_par_1	325	330	PF11976	0.278
LIG_TRAF2_1	105	108	PF00917	0.456
LIG_TRAF2_1	300	303	PF00917	0.423
LIG_TRAF2_1	80	83	PF00917	0.504
LIG_TYR_ITIM	18	23	PF00017	0.275
LIG_TYR_ITIM	216	221	PF00017	0.362
LIG_UBA3_1	67	74	PF00899	0.455
MOD_CDC14_SPxK_1	16	19	PF00782	0.352
MOD_CDK_SPxK_1	13	19	PF00069	0.349
MOD_CK1_1	263	269	PF00069	0.353
MOD_CK2_1	327	333	PF00069	0.259
MOD_CK2_1	77	83	PF00069	0.510
MOD_Cter_Amidation	272	275	PF01082	0.377
MOD_GlcNHglycan	157	160	PF01048	0.380
MOD_GlcNHglycan	265	268	PF01048	0.324
MOD_GlcNHglycan	329	332	PF01048	0.291
MOD_GlcNHglycan	86	89	PF01048	0.224
MOD_GSK3_1	263	270	PF00069	0.330
MOD_GSK3_1	318	325	PF00069	0.238
MOD_GSK3_1	54	61	PF00069	0.426
MOD_N-GLC_1	318	323	PF02516	0.168
MOD_N-GLC_1	58	63	PF02516	0.229
MOD_NEK2_1	327	332	PF00069	0.249
MOD_PKA_2	309	315	PF00069	0.254
MOD_Plk_1	58	64	PF00069	0.429
MOD_Plk_2-3	191	197	PF00069	0.372
MOD_Plk_2-3	77	83	PF00069	0.450
MOD_Plk_4	260	266	PF00069	0.296
MOD_Plk_4	322	328	PF00069	0.313
MOD_ProDKin_1	13	19	PF00069	0.463
MOD_ProDKin_1	233	239	PF00069	0.475
MOD_ProDKin_1	3	9	PF00069	0.435
MOD_SUMO_for_1	292	295	PF00179	0.249
MOD_SUMO_rev_2	70	76	PF00179	0.370
TRG_ENDOCYTIC_2	20	23	PF00928	0.264
TRG_ENDOCYTIC_2	218	221	PF00928	0.409
TRG_ER_diArg_1	274	276	PF00400	0.259
TRG_NES_CRM1_1	197	208	PF08389	0.260
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.247

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P266	Leptomonas seymouri	39%	100%
A0A0S4IZ46	Bodo saltans	45%	100%
A0A3Q8IFQ8	Leishmania donovani	87%	88%
A0A422N412	Trypanosoma rangeli	54%	98%
A4HJL8	Leishmania braziliensis	100%	100%
A4I739	Leishmania infantum	87%	88%
A4I740	Leishmania infantum	42%	100%
A6NDG6	Homo sapiens	29%	100%
C9ZWP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	94%
D3ZDK7	Rattus norvegicus	30%	100%
E9B234	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
P0DKC3	Arabidopsis thaliana	31%	100%
P0DKC4	Arabidopsis thaliana	31%	100%
P19881	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P34492	Caenorhabditis elegans	27%	69%
P46351	Paenibacillus thiaminolyticus	25%	88%
Q00472	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q2FIE5	Staphylococcus aureus (strain USA300)	24%	100%
Q2FZX0	Staphylococcus aureus (strain NCTC 8325 / PS 47)	24%	100%
Q2T9S4	Bos taurus	29%	100%
Q3ZBF9	Bos taurus	30%	100%
Q4L4U2	Staphylococcus haemolyticus (strain JCSC1435)	22%	100%
Q4Q627	Leishmania major	86%	100%
Q5F4B1	Gallus gallus	27%	100%
Q5HHF6	Staphylococcus aureus (strain COL)	24%	100%
Q6GAZ7	Staphylococcus aureus (strain MSSA476)	24%	100%
Q6GIF9	Staphylococcus aureus (strain MRSA252)	24%	100%
Q7A1D4	Staphylococcus aureus (strain MW2)	24%	100%
Q7A6K4	Staphylococcus aureus (strain N315)	24%	100%
Q8CHP8	Mus musculus	30%	100%
Q8GWU0	Arabidopsis thaliana	31%	100%
Q96GD0	Homo sapiens	30%	100%
Q99VE8	Staphylococcus aureus (strain Mu50 / ATCC 700699)	24%	100%
V5D2X9	Trypanosoma cruzi	53%	83%