Putative 3,2-trans-enoyl-CoA isomerase,mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3,2-trans-enoyl-CoA isomerase, mitochondrial precursor, putative

Species:

Leishmania braziliensis

UniProt:

A4HJL5_LEIBR

TriTrypDb:

LbrM.31.2600 , LBRM2903_310035500

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	4
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4HJL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJL5

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0006635	fatty acid beta-oxidation	6	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009062	fatty acid catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0016042	lipid catabolic process	4	2
GO:0016054	organic acid catabolic process	4	2
GO:0019395	fatty acid oxidation	5	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0030258	lipid modification	4	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0034440	lipid oxidation	5	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044242	cellular lipid catabolic process	4	2
GO:0044248	cellular catabolic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	2
GO:0046395	carboxylic acid catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0072329	monocarboxylic acid catabolic process	6	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	19
GO:0004165	delta(3)-delta(2)-enoyl-CoA isomerase activity	5	12
GO:0016853	isomerase activity	2	19
GO:0016860	intramolecular oxidoreductase activity	3	12
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	4	12
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	5	4
GO:0016491	oxidoreductase activity	2	4
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	4
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	4
GO:0004300	enoyl-CoA hydratase activity	5	2
GO:0016829	lyase activity	2	2
GO:0016835	carbon-oxygen lyase activity	3	2
GO:0016836	hydro-lyase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.568
CLV_NRD_NRD_1	297	299	PF00675	0.321
CLV_NRD_NRD_1	309	311	PF00675	0.299
CLV_NRD_NRD_1	341	343	PF00675	0.623
CLV_NRD_NRD_1	67	69	PF00675	0.521
CLV_PCSK_KEX2_1	2	4	PF00082	0.568
CLV_PCSK_KEX2_1	297	299	PF00082	0.320
CLV_PCSK_KEX2_1	311	313	PF00082	0.299
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.196
CLV_PCSK_PC7_1	293	299	PF00082	0.299
CLV_PCSK_SKI1_1	319	323	PF00082	0.196
CLV_PCSK_SKI1_1	84	88	PF00082	0.367
CLV_Separin_Metazoa	294	298	PF03568	0.196
CLV_Separin_Metazoa	65	69	PF03568	0.572
DEG_APCC_DBOX_1	297	305	PF00400	0.306
DEG_Nend_UBRbox_1	1	4	PF02207	0.583
DEG_SPOP_SBC_1	4	8	PF00917	0.666
DOC_CYCLIN_RxL_1	237	248	PF00134	0.317
DOC_MAPK_gen_1	204	213	PF00069	0.252
DOC_PP2B_LxvP_1	220	223	PF13499	0.391
DOC_PP2B_LxvP_1	23	26	PF13499	0.635
DOC_PP2B_LxvP_1	282	285	PF13499	0.389
DOC_PP4_FxxP_1	167	170	PF00568	0.320
DOC_USP7_MATH_1	4	8	PF00917	0.555
DOC_USP7_MATH_1	95	99	PF00917	0.300
DOC_USP7_UBL2_3	200	204	PF12436	0.196
DOC_WW_Pin1_4	245	250	PF00397	0.320
LIG_14-3-3_CanoR_1	280	285	PF00244	0.415
LIG_14-3-3_CanoR_1	29	36	PF00244	0.670
LIG_14-3-3_CanoR_1	78	86	PF00244	0.414
LIG_BRCT_BRCA1_1	99	103	PF00533	0.313
LIG_deltaCOP1_diTrp_1	159	167	PF00928	0.320
LIG_FHA_1	118	124	PF00498	0.346
LIG_FHA_1	17	23	PF00498	0.556
LIG_FHA_1	200	206	PF00498	0.187
LIG_FHA_1	268	274	PF00498	0.196
LIG_LIR_Apic_2	166	170	PF02991	0.319
LIG_LIR_Gen_1	102	112	PF02991	0.322
LIG_LIR_Gen_1	151	162	PF02991	0.312
LIG_LIR_Gen_1	279	288	PF02991	0.320
LIG_LIR_Gen_1	299	305	PF02991	0.138
LIG_LIR_Gen_1	314	324	PF02991	0.286
LIG_LIR_Nem_3	102	107	PF02991	0.322
LIG_LIR_Nem_3	151	157	PF02991	0.310
LIG_LIR_Nem_3	159	164	PF02991	0.311
LIG_LIR_Nem_3	279	284	PF02991	0.320
LIG_LYPXL_SIV_4	274	282	PF13949	0.447
LIG_PCNA_PIPBox_1	327	336	PF02747	0.389
LIG_PCNA_yPIPBox_3	327	340	PF02747	0.343
LIG_Pex14_2	153	157	PF04695	0.320
LIG_SH2_STAT5	230	233	PF00017	0.320
LIG_SH2_STAT5	300	303	PF00017	0.411
LIG_SH2_STAT5	333	336	PF00017	0.367
LIG_SH3_3	139	145	PF00018	0.447
LIG_SH3_3	218	224	PF00018	0.406
LIG_SH3_3	282	288	PF00018	0.327
LIG_SH3_3	318	324	PF00018	0.362
LIG_SH3_3	61	67	PF00018	0.577
LIG_SxIP_EBH_1	121	135	PF03271	0.333
LIG_TRAF2_1	116	119	PF00917	0.435
LIG_TRAF2_1	156	159	PF00917	0.309
LIG_TRAF2_1	265	268	PF00917	0.477
LIG_WW_3	65	69	PF00397	0.572
MOD_CK1_1	7	13	PF00069	0.691
MOD_CK2_1	113	119	PF00069	0.396
MOD_CK2_1	153	159	PF00069	0.374
MOD_CMANNOS	110	113	PF00535	0.320
MOD_GlcNHglycan	126	129	PF01048	0.367
MOD_GlcNHglycan	133	136	PF01048	0.320
MOD_GlcNHglycan	150	153	PF01048	0.216
MOD_GlcNHglycan	19	22	PF01048	0.671
MOD_GSK3_1	113	120	PF00069	0.341
MOD_GSK3_1	124	131	PF00069	0.297
MOD_GSK3_1	3	10	PF00069	0.647
MOD_N-GLC_1	213	218	PF02516	0.325
MOD_N-GLC_1	79	84	PF02516	0.321
MOD_NEK2_1	153	158	PF00069	0.320
MOD_NEK2_1	213	218	PF00069	0.317
MOD_NEK2_1	233	238	PF00069	0.138
MOD_PIKK_1	29	35	PF00454	0.710
MOD_PK_1	280	286	PF00069	0.415
MOD_PKA_1	311	317	PF00069	0.196
MOD_PKA_1	68	74	PF00069	0.620
MOD_PKA_2	148	154	PF00069	0.216
MOD_PKA_2	311	317	PF00069	0.196
MOD_Plk_1	267	273	PF00069	0.456
MOD_Plk_2-3	267	273	PF00069	0.340
MOD_Plk_4	128	134	PF00069	0.339
MOD_ProDKin_1	245	251	PF00069	0.320
MOD_SUMO_rev_2	116	123	PF00179	0.413
TRG_DiLeu_BaEn_2	71	77	PF01217	0.573
TRG_ENDOCYTIC_2	192	195	PF00928	0.447
TRG_ENDOCYTIC_2	230	233	PF00928	0.320
TRG_ENDOCYTIC_2	300	303	PF00928	0.411
TRG_ER_diArg_1	1	3	PF00400	0.563
TRG_ER_diArg_1	296	298	PF00400	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4C8	Leptomonas seymouri	71%	98%
A0A0N1PBS2	Leptomonas seymouri	31%	100%
A0A0S4IKH3	Bodo saltans	56%	99%
A0A0S4JA19	Bodo saltans	34%	100%
A0A1X0NRI1	Trypanosomatidae	53%	93%
A0A3Q8IE71	Leishmania donovani	35%	100%
A0A3S7X4R5	Leishmania donovani	77%	100%
A0A3S7X4T7	Leishmania donovani	75%	100%
A0A422N418	Trypanosoma rangeli	57%	99%
A0A422NUW6	Trypanosoma rangeli	31%	100%
A4HH09	Leishmania braziliensis	34%	100%
A4HJK3	Leishmania braziliensis	99%	100%
A4HJK8	Leishmania braziliensis	93%	100%
A4I438	Leishmania infantum	32%	100%
A4I708	Leishmania infantum	76%	100%
A4I738	Leishmania infantum	72%	98%
C9ZKS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZME0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	73%
C9ZWP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	96%
E9ADK3	Leishmania major	33%	100%
E9AE93	Leishmania major	24%	100%
E9AM78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B226	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E9B233	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
O34893	Bacillus subtilis (strain 168)	22%	100%
O35459	Mus musculus	24%	100%
O75521	Homo sapiens	24%	87%
P14604	Rattus norvegicus	24%	100%
P23965	Rattus norvegicus	37%	100%
P30084	Homo sapiens	25%	100%
P34559	Caenorhabditis elegans	24%	100%
P42125	Mus musculus	37%	100%
P42126	Homo sapiens	36%	100%
P76082	Escherichia coli (strain K12)	24%	100%
P95279	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	100%
Q0AVM1	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	26%	100%
Q1ZXF1	Dictyostelium discoideum	28%	100%
Q3MIE0	Rattus norvegicus	28%	100%
Q3TLP5	Mus musculus	27%	100%
Q4Q628	Leishmania major	72%	100%
Q4Q636	Leishmania major	77%	100%
Q58DM8	Bos taurus	25%	100%
Q5R646	Pongo abelii	24%	100%
Q869N6	Dictyostelium discoideum	27%	100%
Q8BH95	Mus musculus	26%	100%
V5B2L9	Trypanosoma cruzi	54%	88%
V5BK92	Trypanosoma cruzi	34%	100%