Helicase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

helicase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJL4_LEIBR

TriTrypDb:

LbrM.31.2590

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJL4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004386	helicase activity	2	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:0140657	ATP-dependent activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.702
CLV_NRD_NRD_1	229	231	PF00675	0.671
CLV_NRD_NRD_1	248	250	PF00675	0.405
CLV_NRD_NRD_1	89	91	PF00675	0.759
CLV_PCSK_KEX2_1	114	116	PF00082	0.833
CLV_PCSK_KEX2_1	141	143	PF00082	0.702
CLV_PCSK_KEX2_1	247	249	PF00082	0.727
CLV_PCSK_KEX2_1	25	27	PF00082	0.709
CLV_PCSK_KEX2_1	89	91	PF00082	0.759
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.833
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.709
CLV_PCSK_PC7_1	110	116	PF00082	0.844
CLV_PCSK_PC7_1	243	249	PF00082	0.709
CLV_PCSK_SKI1_1	124	128	PF00082	0.726
CLV_PCSK_SKI1_1	13	17	PF00082	0.529
CLV_PCSK_SKI1_1	141	145	PF00082	0.407
CLV_PCSK_SKI1_1	4	8	PF00082	0.718
CLV_Separin_Metazoa	57	61	PF03568	0.654
DEG_APCC_DBOX_1	248	256	PF00400	0.721
DEG_APCC_DBOX_1	3	11	PF00400	0.730
DEG_ODPH_VHL_1	252	265	PF01847	0.677
DOC_MAPK_DCC_7	247	257	PF00069	0.713
DOC_MAPK_gen_1	141	151	PF00069	0.708
DOC_MAPK_gen_1	230	238	PF00069	0.647
DOC_MAPK_gen_1	89	95	PF00069	0.779
DOC_MAPK_HePTP_8	139	151	PF00069	0.706
DOC_MAPK_MEF2A_6	142	151	PF00069	0.708
DOC_MAPK_MEF2A_6	237	246	PF00069	0.677
DOC_MAPK_MEF2A_6	4	11	PF00069	0.727
DOC_MAPK_NFAT4_5	4	12	PF00069	0.729
DOC_PP4_FxxP_1	347	350	PF00568	0.839
DOC_USP7_MATH_1	343	347	PF00917	0.817
DOC_WW_Pin1_4	157	162	PF00397	0.786
LIG_14-3-3_CanoR_1	196	200	PF00244	0.760
LIG_14-3-3_CanoR_1	225	232	PF00244	0.669
LIG_14-3-3_CanoR_1	4	10	PF00244	0.728
LIG_Actin_WH2_2	80	96	PF00022	0.756
LIG_APCC_ABBA_1	263	268	PF00400	0.638
LIG_APCC_ABBA_1	69	74	PF00400	0.789
LIG_APCC_ABBA_1	9	14	PF00400	0.729
LIG_FHA_1	202	208	PF00498	0.699
LIG_FHA_1	233	239	PF00498	0.636
LIG_FHA_1	258	264	PF00498	0.665
LIG_FHA_1	285	291	PF00498	0.798
LIG_FHA_1	300	306	PF00498	0.540
LIG_FHA_1	45	51	PF00498	0.671
LIG_FHA_1	6	12	PF00498	0.728
LIG_FHA_2	14	20	PF00498	0.684
LIG_FHA_2	330	336	PF00498	0.686
LIG_LIR_Apic_2	345	350	PF02991	0.833
LIG_LIR_Apic_2	63	67	PF02991	0.684
LIG_LIR_Gen_1	198	208	PF02991	0.715
LIG_LIR_Gen_1	268	277	PF02991	0.629
LIG_LIR_Nem_3	198	203	PF02991	0.723
LIG_LIR_Nem_3	264	269	PF02991	0.633
LIG_NRBOX	6	12	PF00104	0.728
LIG_PCNA_yPIPBox_3	310	319	PF02747	0.732
LIG_SH2_PTP2	64	67	PF00017	0.681
LIG_SH2_STAT5	130	133	PF00017	0.691
LIG_SH2_STAT5	269	272	PF00017	0.616
LIG_SH2_STAT5	64	67	PF00017	0.681
LIG_SH3_1	248	254	PF00018	0.729
LIG_SH3_2	188	193	PF14604	0.820
LIG_SH3_3	159	165	PF00018	0.792
LIG_SH3_3	170	176	PF00018	0.606
LIG_SH3_3	185	191	PF00018	0.565
LIG_SH3_3	248	254	PF00018	0.729
LIG_SH3_3	337	343	PF00018	0.719
LIG_SUMO_SIM_anti_2	122	129	PF11976	0.729
LIG_SUMO_SIM_par_1	122	129	PF11976	0.729
LIG_UBA3_1	127	133	PF00899	0.697
LIG_UBA3_1	207	211	PF00899	0.741
LIG_UBA3_1	238	245	PF00899	0.674
LIG_UBA3_1	31	37	PF00899	0.667
LIG_WW_1	152	155	PF00397	0.754
LIG_WW_3	78	82	PF00397	0.759
MOD_CK1_1	198	204	PF00069	0.717
MOD_CK1_1	271	277	PF00069	0.631
MOD_CK1_1	284	290	PF00069	0.568
MOD_CK1_1	296	302	PF00069	0.589
MOD_CK1_1	329	335	PF00069	0.689
MOD_CK2_1	13	19	PF00069	0.686
MOD_CK2_1	218	224	PF00069	0.704
MOD_CK2_1	325	331	PF00069	0.695
MOD_CK2_1	343	349	PF00069	0.508
MOD_GlcNHglycan	220	223	PF01048	0.691
MOD_GlcNHglycan	232	235	PF01048	0.416
MOD_GlcNHglycan	273	276	PF01048	0.628
MOD_GlcNHglycan	283	286	PF01048	0.605
MOD_GlcNHglycan	328	331	PF01048	0.688
MOD_GSK3_1	165	172	PF00069	0.784
MOD_GSK3_1	195	202	PF00069	0.753
MOD_GSK3_1	213	220	PF00069	0.446
MOD_GSK3_1	277	284	PF00069	0.715
MOD_GSK3_1	289	296	PF00069	0.601
MOD_GSK3_1	325	332	PF00069	0.695
MOD_GSK3_1	42	49	PF00069	0.671
MOD_NEK2_1	195	200	PF00069	0.762
MOD_NEK2_1	277	282	PF00069	0.695
MOD_NEK2_1	31	36	PF00069	0.661
MOD_NEK2_1	319	324	PF00069	0.686
MOD_NEK2_1	44	49	PF00069	0.444
MOD_NEK2_2	353	358	PF00069	0.831
MOD_NEK2_2	67	72	PF00069	0.767
MOD_OFUCOSY	223	228	PF10250	0.683
MOD_PIKK_1	313	319	PF00454	0.723
MOD_PIKK_1	329	335	PF00454	0.408
MOD_PK_1	42	48	PF00069	0.670
MOD_PKA_1	230	236	PF00069	0.641
MOD_PKA_2	195	201	PF00069	0.761
MOD_PKA_2	224	230	PF00069	0.673
MOD_PKA_2	257	263	PF00069	0.664
MOD_PKA_2	296	302	PF00069	0.799
MOD_PKA_2	93	99	PF00069	0.818
MOD_Plk_1	13	19	PF00069	0.686
MOD_Plk_1	353	359	PF00069	0.834
MOD_Plk_4	134	140	PF00069	0.685
MOD_Plk_4	169	175	PF00069	0.796
MOD_Plk_4	195	201	PF00069	0.761
MOD_Plk_4	203	209	PF00069	0.569
MOD_Plk_4	46	52	PF00069	0.679
MOD_Plk_4	5	11	PF00069	0.723
MOD_ProDKin_1	157	163	PF00069	0.791
MOD_SUMO_rev_2	96	103	PF00179	0.839
TRG_DiLeu_BaEn_1	122	127	PF01217	0.735
TRG_ENDOCYTIC_2	269	272	PF00928	0.616
TRG_ER_diArg_1	140	142	PF00400	0.708
TRG_ER_diArg_1	246	249	PF00400	0.719
TRG_ER_diArg_1	357	360	PF00400	0.848
TRG_ER_diArg_1	89	91	PF00400	0.759
TRG_Pf-PMV_PEXEL_1	124	129	PF00026	0.722