HEAT repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJL0_LEIBR

TriTrypDb:

LbrM.31.2540 , LBRM2903_310034800

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJL0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0000774	adenyl-nucleotide exchange factor activity	3	1
GO:0005488	binding	1	1
GO:0017076	purine nucleotide binding	4	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0036094	small molecule binding	2	1
GO:0060590	ATPase regulator activity	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:0098772	molecular function regulator activity	1	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	325	329	PF00656	0.473
CLV_NRD_NRD_1	451	453	PF00675	0.357
CLV_PCSK_KEX2_1	451	453	PF00082	0.354
CLV_PCSK_KEX2_1	91	93	PF00082	0.390
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.425
CLV_PCSK_SKI1_1	315	319	PF00082	0.390
CLV_PCSK_SKI1_1	365	369	PF00082	0.335
CLV_PCSK_SKI1_1	406	410	PF00082	0.353
CLV_PCSK_SKI1_1	80	84	PF00082	0.487
CLV_PCSK_SKI1_1	91	95	PF00082	0.428
DEG_APCC_DBOX_1	79	87	PF00400	0.546
DEG_SCF_FBW7_1	186	192	PF00400	0.498
DOC_CKS1_1	111	116	PF01111	0.423
DOC_CKS1_1	186	191	PF01111	0.504
DOC_CYCLIN_RxL_1	312	319	PF00134	0.362
DOC_CYCLIN_RxL_1	91	101	PF00134	0.419
DOC_CYCLIN_yCln2_LP_2	213	219	PF00134	0.431
DOC_MAPK_gen_1	451	457	PF00069	0.311
DOC_MAPK_gen_1	91	98	PF00069	0.479
DOC_PP1_RVXF_1	92	99	PF00149	0.464
DOC_PP2B_LxvP_1	213	216	PF13499	0.329
DOC_USP7_MATH_1	171	175	PF00917	0.678
DOC_USP7_MATH_1	37	41	PF00917	0.678
DOC_USP7_MATH_1	376	380	PF00917	0.457
DOC_USP7_MATH_1	47	51	PF00917	0.724
DOC_USP7_MATH_1	60	64	PF00917	0.714
DOC_USP7_MATH_1	82	86	PF00917	0.493
DOC_WW_Pin1_4	110	115	PF00397	0.453
DOC_WW_Pin1_4	185	190	PF00397	0.521
DOC_WW_Pin1_4	412	417	PF00397	0.492
DOC_WW_Pin1_4	45	50	PF00397	0.551
DOC_WW_Pin1_4	54	59	PF00397	0.592
LIG_14-3-3_CanoR_1	103	111	PF00244	0.450
LIG_14-3-3_CanoR_1	151	160	PF00244	0.423
LIG_14-3-3_CanoR_1	257	267	PF00244	0.400
LIG_14-3-3_CanoR_1	269	274	PF00244	0.239
LIG_14-3-3_CanoR_1	312	318	PF00244	0.464
LIG_14-3-3_CanoR_1	71	79	PF00244	0.502
LIG_AP2alpha_1	454	458	PF02296	0.294
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_Clathr_ClatBox_1	97	101	PF01394	0.468
LIG_deltaCOP1_diTrp_1	129	137	PF00928	0.436
LIG_DLG_GKlike_1	269	276	PF00625	0.268
LIG_FHA_1	308	314	PF00498	0.424
LIG_FHA_2	103	109	PF00498	0.541
LIG_FHA_2	111	117	PF00498	0.488
LIG_FHA_2	175	181	PF00498	0.698
LIG_FHA_2	24	30	PF00498	0.581
LIG_FHA_2	314	320	PF00498	0.435
LIG_FHA_2	323	329	PF00498	0.447
LIG_FHA_2	439	445	PF00498	0.525
LIG_IRF3_LxIS_1	158	163	PF10401	0.370
LIG_LIR_Gen_1	136	143	PF02991	0.380
LIG_LIR_Gen_1	74	84	PF02991	0.531
LIG_LIR_Nem_3	349	355	PF02991	0.504
LIG_LIR_Nem_3	456	461	PF02991	0.318
LIG_LIR_Nem_3	74	79	PF02991	0.524
LIG_NRBOX	272	278	PF00104	0.396
LIG_Pex14_1	133	137	PF04695	0.387
LIG_Pex14_2	454	458	PF04695	0.294
LIG_SH2_CRK	352	356	PF00017	0.488
LIG_SH2_STAT5	372	375	PF00017	0.391
LIG_SH3_3	108	114	PF00018	0.470
LIG_SH3_3	348	354	PF00018	0.376
LIG_SH3_3	41	47	PF00018	0.670
LIG_SH3_3	83	89	PF00018	0.490
LIG_SH3_5	72	76	PF00018	0.491
LIG_SUMO_SIM_anti_2	201	207	PF11976	0.248
LIG_SUMO_SIM_anti_2	301	310	PF11976	0.454
LIG_SUMO_SIM_par_1	158	163	PF11976	0.429
LIG_SUMO_SIM_par_1	243	250	PF11976	0.355
LIG_TRAF2_1	113	116	PF00917	0.507
LIG_TRAF2_1	181	184	PF00917	0.560
LIG_TRAF2_1	344	347	PF00917	0.605
LIG_TRAF2_1	379	382	PF00917	0.528
MOD_CK1_1	174	180	PF00069	0.543
MOD_CK1_1	185	191	PF00069	0.492
MOD_CK1_1	2	8	PF00069	0.610
MOD_CK1_1	265	271	PF00069	0.312
MOD_CK1_1	393	399	PF00069	0.490
MOD_CK2_1	102	108	PF00069	0.551
MOD_CK2_1	110	116	PF00069	0.443
MOD_CK2_1	174	180	PF00069	0.540
MOD_CK2_1	23	29	PF00069	0.577
MOD_CK2_1	313	319	PF00069	0.565
MOD_CK2_1	341	347	PF00069	0.672
MOD_CK2_1	376	382	PF00069	0.501
MOD_CK2_1	71	77	PF00069	0.487
MOD_GlcNHglycan	153	156	PF01048	0.415
MOD_GlcNHglycan	162	165	PF01048	0.544
MOD_GlcNHglycan	209	212	PF01048	0.300
MOD_GlcNHglycan	301	304	PF01048	0.487
MOD_GlcNHglycan	31	34	PF01048	0.658
MOD_GlcNHglycan	339	342	PF01048	0.669
MOD_GlcNHglycan	374	377	PF01048	0.379
MOD_GlcNHglycan	39	42	PF01048	0.750
MOD_GlcNHglycan	4	7	PF01048	0.583
MOD_GlcNHglycan	49	52	PF01048	0.641
MOD_GSK3_1	174	181	PF00069	0.701
MOD_GSK3_1	185	192	PF00069	0.537
MOD_GSK3_1	25	32	PF00069	0.559
MOD_GSK3_1	253	260	PF00069	0.527
MOD_GSK3_1	265	272	PF00069	0.331
MOD_GSK3_1	307	314	PF00069	0.340
MOD_GSK3_1	333	340	PF00069	0.611
MOD_GSK3_1	368	375	PF00069	0.378
MOD_GSK3_1	45	52	PF00069	0.619
MOD_N-GLC_1	101	106	PF02516	0.573
MOD_N-GLC_1	258	263	PF02516	0.427
MOD_N-GLC_1	396	401	PF02516	0.317
MOD_N-GLC_2	13	15	PF02516	0.503
MOD_NEK2_1	160	165	PF00069	0.574
MOD_NEK2_1	298	303	PF00069	0.542
MOD_NEK2_1	311	316	PF00069	0.408
MOD_NEK2_1	322	327	PF00069	0.455
MOD_NEK2_1	355	360	PF00069	0.420
MOD_NEK2_1	368	373	PF00069	0.350
MOD_NEK2_1	438	443	PF00069	0.464
MOD_OFUCOSY	388	394	PF10250	0.291
MOD_PKA_2	102	108	PF00069	0.430
MOD_PKA_2	268	274	PF00069	0.269
MOD_PKA_2	311	317	PF00069	0.545
MOD_Plk_1	182	188	PF00069	0.540
MOD_Plk_1	226	232	PF00069	0.270
MOD_Plk_1	396	402	PF00069	0.317
MOD_Plk_4	192	198	PF00069	0.363
MOD_Plk_4	262	268	PF00069	0.460
MOD_Plk_4	269	275	PF00069	0.418
MOD_Plk_4	292	298	PF00069	0.412
MOD_Plk_4	368	374	PF00069	0.246
MOD_Plk_4	422	428	PF00069	0.336
MOD_ProDKin_1	110	116	PF00069	0.449
MOD_ProDKin_1	185	191	PF00069	0.509
MOD_ProDKin_1	412	418	PF00069	0.491
MOD_ProDKin_1	45	51	PF00069	0.554
MOD_ProDKin_1	54	60	PF00069	0.591
TRG_DiLeu_BaEn_2	449	455	PF01217	0.416
TRG_DiLeu_BaEn_4	381	387	PF01217	0.375
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.438
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.372
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.417
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.493
TRG_ENDOCYTIC_2	352	355	PF00928	0.474
TRG_ENDOCYTIC_2	76	79	PF00928	0.524
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXH6	Leptomonas seymouri	47%	100%
A0A3S7X4Q0	Leishmania donovani	65%	100%
A4I710	Leishmania infantum	65%	100%
E9B228	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4Q634	Leishmania major	66%	100%
V5BA98	Trypanosoma cruzi	27%	100%