Putative 3,2-trans-enoyl-CoA isomerase,mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3,2-trans-enoyl-CoA isomerase, mitochondrial precursor, putative

Species:

Leishmania braziliensis

UniProt:

A4HJK5_LEIBR

TriTrypDb:

LbrM.31.2490 , LBRM2903_310034500

Length:

184

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJK5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004165	delta(3)-delta(2)-enoyl-CoA isomerase activity	5	2
GO:0016853	isomerase activity	2	2
GO:0016860	intramolecular oxidoreductase activity	3	2
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.231
CLV_NRD_NRD_1	182	184	PF00675	0.463
CLV_PCSK_KEX2_1	138	140	PF00082	0.231
CLV_PCSK_PC7_1	134	140	PF00082	0.231
DEG_APCC_DBOX_1	138	146	PF00400	0.231
DEG_Nend_Nbox_1	1	3	PF02207	0.231
DOC_CYCLIN_RxL_1	78	89	PF00134	0.231
DOC_PP2B_LxvP_1	123	126	PF13499	0.231
DOC_PP2B_LxvP_1	61	64	PF13499	0.231
DOC_PP4_FxxP_1	8	11	PF00568	0.231
DOC_USP7_MATH_1	126	130	PF00917	0.231
DOC_WW_Pin1_4	86	91	PF00397	0.231
LIG_14-3-3_CanoR_1	121	126	PF00244	0.451
LIG_FHA_1	157	163	PF00498	0.231
LIG_LIR_Apic_2	7	11	PF02991	0.231
LIG_LIR_Gen_1	120	126	PF02991	0.231
LIG_LIR_Gen_1	140	146	PF02991	0.173
LIG_LIR_Gen_1	155	165	PF02991	0.370
LIG_LIR_Nem_3	120	125	PF02991	0.231
LIG_LIR_Nem_3	155	161	PF02991	0.370
LIG_LYPXL_SIV_4	115	123	PF13949	0.231
LIG_PCNA_PIPBox_1	168	177	PF02747	0.231
LIG_PCNA_yPIPBox_3	168	181	PF02747	0.231
LIG_Pex14_2	157	161	PF04695	0.231
LIG_SH2_CRK	71	75	PF00017	0.231
LIG_SH2_STAP1	153	157	PF00017	0.231
LIG_SH2_STAP1	71	75	PF00017	0.231
LIG_SH2_STAT5	141	144	PF00017	0.231
LIG_SH2_STAT5	174	177	PF00017	0.231
LIG_SH2_STAT5	73	76	PF00017	0.231
LIG_SH3_3	159	165	PF00018	0.348
LIG_SH3_3	59	65	PF00018	0.231
LIG_TRAF2_1	106	109	PF00917	0.231
LIG_TRAF2_1	147	150	PF00917	0.231
MOD_CK2_1	103	109	PF00069	0.231
MOD_CK2_1	144	150	PF00069	0.231
MOD_GSK3_1	152	159	PF00069	0.284
MOD_N-GLC_1	54	59	PF02516	0.231
MOD_NEK2_1	54	59	PF00069	0.406
MOD_NEK2_1	74	79	PF00069	0.231
MOD_PIKK_1	156	162	PF00454	0.231
MOD_PK_1	121	127	PF00069	0.231
MOD_Plk_1	108	114	PF00069	0.241
MOD_Plk_2-3	103	109	PF00069	0.231
MOD_ProDKin_1	86	92	PF00069	0.231
TRG_ENDOCYTIC_2	141	144	PF00928	0.231
TRG_ENDOCYTIC_2	33	36	PF00928	0.231
TRG_ENDOCYTIC_2	71	74	PF00928	0.231
TRG_ER_diArg_1	137	139	PF00400	0.231

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z0	Leptomonas seymouri	25%	69%
A0A1X0P9A2	Trypanosomatidae	29%	69%
A0A3Q8IIZ5	Leishmania donovani	27%	69%
A0QJH8	Mycobacterium avium (strain 104)	31%	72%
A1KN36	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	30%	70%
A4HHN0	Leishmania braziliensis	26%	69%
A4I4U5	Leishmania infantum	27%	69%
A5U753	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	30%	70%
C9ZLJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	69%
E9AE93	Leishmania major	25%	69%
E9ALJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	69%
P76082	Escherichia coli (strain K12)	27%	72%
P9WNN2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	30%	70%
P9WNN3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	70%
Q0AVM1	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	29%	71%
Q1ZXF1	Dictyostelium discoideum	30%	66%
Q73VC7	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	31%	72%
Q7TXE1	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	30%	70%
V5DTT7	Trypanosoma cruzi	27%	69%