Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJK4_LEIBR

TriTrypDb:

LbrM.31.2480 , LBRM2903_310034400

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.567
CLV_C14_Caspase3-7	338	342	PF00656	0.575
CLV_C14_Caspase3-7	346	350	PF00656	0.536
CLV_C14_Caspase3-7	9	13	PF00656	0.646
CLV_NRD_NRD_1	114	116	PF00675	0.623
CLV_NRD_NRD_1	233	235	PF00675	0.652
CLV_PCSK_KEX2_1	114	116	PF00082	0.564
CLV_PCSK_KEX2_1	233	235	PF00082	0.652
CLV_PCSK_SKI1_1	115	119	PF00082	0.618
CLV_PCSK_SKI1_1	440	444	PF00082	0.618
DOC_CDC14_PxL_1	38	46	PF14671	0.570
DOC_CKS1_1	17	22	PF01111	0.551
DOC_SPAK_OSR1_1	272	276	PF12202	0.560
DOC_USP7_MATH_1	100	104	PF00917	0.530
DOC_USP7_MATH_1	130	134	PF00917	0.681
DOC_USP7_MATH_1	277	281	PF00917	0.578
DOC_USP7_MATH_1	300	304	PF00917	0.712
DOC_USP7_MATH_1	32	36	PF00917	0.658
DOC_USP7_MATH_1	335	339	PF00917	0.574
DOC_USP7_MATH_1	358	362	PF00917	0.586
DOC_USP7_MATH_1	67	71	PF00917	0.696
DOC_USP7_MATH_1	92	96	PF00917	0.578
DOC_WW_Pin1_4	16	21	PF00397	0.537
DOC_WW_Pin1_4	161	166	PF00397	0.581
DOC_WW_Pin1_4	280	285	PF00397	0.536
DOC_WW_Pin1_4	344	349	PF00397	0.665
DOC_WW_Pin1_4	354	359	PF00397	0.695
DOC_WW_Pin1_4	400	405	PF00397	0.624
DOC_WW_Pin1_4	60	65	PF00397	0.626
DOC_WW_Pin1_4	94	99	PF00397	0.660
LIG_14-3-3_CanoR_1	114	123	PF00244	0.617
LIG_14-3-3_CanoR_1	272	276	PF00244	0.630
LIG_14-3-3_CanoR_1	37	42	PF00244	0.623
LIG_14-3-3_CanoR_1	51	55	PF00244	0.604
LIG_Actin_WH2_2	415	432	PF00022	0.579
LIG_BIR_II_1	1	5	PF00653	0.577
LIG_BIR_III_4	221	225	PF00653	0.540
LIG_BRCT_BRCA1_1	369	373	PF00533	0.622
LIG_BRCT_BRCA1_1	39	43	PF00533	0.510
LIG_Clathr_ClatBox_1	58	62	PF01394	0.605
LIG_FHA_1	168	174	PF00498	0.520
LIG_FHA_1	24	30	PF00498	0.600
LIG_FHA_1	303	309	PF00498	0.544
LIG_FHA_1	54	60	PF00498	0.692
LIG_FHA_2	153	159	PF00498	0.578
LIG_FHA_2	9	15	PF00498	0.681
LIG_LIR_Gen_1	121	131	PF02991	0.566
LIG_LIR_Gen_1	370	379	PF02991	0.706
LIG_LIR_LC3C_4	56	61	PF02991	0.664
LIG_LIR_Nem_3	121	126	PF02991	0.567
LIG_LIR_Nem_3	177	181	PF02991	0.632
LIG_LIR_Nem_3	202	208	PF02991	0.600
LIG_LIR_Nem_3	416	422	PF02991	0.633
LIG_Pex14_1	156	160	PF04695	0.603
LIG_Pex14_2	45	49	PF04695	0.534
LIG_SH2_NCK_1	38	42	PF00017	0.578
LIG_SH2_STAT5	154	157	PF00017	0.594
LIG_SH2_STAT5	160	163	PF00017	0.594
LIG_SH3_3	123	129	PF00018	0.576
LIG_SH3_3	401	407	PF00018	0.588
LIG_SH3_3	58	64	PF00018	0.641
LIG_SUMO_SIM_anti_2	56	63	PF11976	0.615
LIG_SUMO_SIM_par_1	283	288	PF11976	0.537
LIG_SUMO_SIM_par_1	56	63	PF11976	0.615
LIG_TRAF2_1	267	270	PF00917	0.620
LIG_UBA3_1	321	329	PF00899	0.558
LIG_WW_3	435	439	PF00397	0.712
MOD_CDC14_SPxK_1	403	406	PF00782	0.596
MOD_CDK_SPxK_1	400	406	PF00069	0.598
MOD_CDK_SPxxK_3	344	351	PF00069	0.568
MOD_CK1_1	150	156	PF00069	0.590
MOD_CK1_1	189	195	PF00069	0.626
MOD_CK1_1	2	8	PF00069	0.678
MOD_CK1_1	271	277	PF00069	0.557
MOD_CK1_1	280	286	PF00069	0.497
MOD_CK1_1	296	302	PF00069	0.619
MOD_CK1_1	303	309	PF00069	0.550
MOD_CK1_1	357	363	PF00069	0.699
MOD_CK1_1	368	374	PF00069	0.552
MOD_CK1_1	400	406	PF00069	0.648
MOD_CK1_1	50	56	PF00069	0.722
MOD_CK2_1	405	411	PF00069	0.707
MOD_GlcNHglycan	102	105	PF01048	0.581
MOD_GlcNHglycan	132	135	PF01048	0.679
MOD_GlcNHglycan	165	168	PF01048	0.691
MOD_GlcNHglycan	29	32	PF01048	0.768
MOD_GlcNHglycan	295	298	PF01048	0.601
MOD_GlcNHglycan	337	340	PF01048	0.589
MOD_GlcNHglycan	360	363	PF01048	0.646
MOD_GlcNHglycan	39	42	PF01048	0.567
MOD_GlcNHglycan	94	97	PF01048	0.675
MOD_GSK3_1	130	137	PF00069	0.622
MOD_GSK3_1	144	151	PF00069	0.620
MOD_GSK3_1	15	22	PF00069	0.625
MOD_GSK3_1	161	168	PF00069	0.558
MOD_GSK3_1	181	188	PF00069	0.649
MOD_GSK3_1	23	30	PF00069	0.633
MOD_GSK3_1	292	299	PF00069	0.561
MOD_GSK3_1	300	307	PF00069	0.696
MOD_GSK3_1	308	315	PF00069	0.582
MOD_GSK3_1	335	342	PF00069	0.581
MOD_GSK3_1	354	361	PF00069	0.812
MOD_GSK3_1	377	384	PF00069	0.694
MOD_GSK3_1	405	412	PF00069	0.746
MOD_N-GLC_1	303	308	PF02516	0.648
MOD_N-GLC_1	417	422	PF02516	0.584
MOD_NEK2_1	152	157	PF00069	0.783
MOD_NEK2_1	23	28	PF00069	0.697
MOD_NEK2_1	324	329	PF00069	0.664
MOD_NEK2_1	429	434	PF00069	0.678
MOD_PIKK_1	24	30	PF00454	0.554
MOD_PIKK_1	324	330	PF00454	0.558
MOD_PIKK_1	394	400	PF00454	0.619
MOD_PIKK_1	405	411	PF00454	0.610
MOD_PIKK_1	50	56	PF00454	0.651
MOD_PIKK_1	65	71	PF00454	0.590
MOD_PKA_2	147	153	PF00069	0.606
MOD_PKA_2	271	277	PF00069	0.587
MOD_PKA_2	409	415	PF00069	0.681
MOD_PKA_2	429	435	PF00069	0.609
MOD_PKA_2	47	53	PF00069	0.700
MOD_Plk_1	148	154	PF00069	0.540
MOD_Plk_1	268	274	PF00069	0.584
MOD_Plk_1	303	309	PF00069	0.582
MOD_Plk_1	365	371	PF00069	0.548
MOD_Plk_2-3	135	141	PF00069	0.571
MOD_Plk_4	139	145	PF00069	0.653
MOD_Plk_4	19	25	PF00069	0.696
MOD_Plk_4	204	210	PF00069	0.552
MOD_Plk_4	304	310	PF00069	0.531
MOD_Plk_4	368	374	PF00069	0.535
MOD_ProDKin_1	16	22	PF00069	0.537
MOD_ProDKin_1	161	167	PF00069	0.578
MOD_ProDKin_1	280	286	PF00069	0.536
MOD_ProDKin_1	344	350	PF00069	0.666
MOD_ProDKin_1	354	360	PF00069	0.692
MOD_ProDKin_1	400	406	PF00069	0.624
MOD_ProDKin_1	60	66	PF00069	0.625
MOD_ProDKin_1	94	100	PF00069	0.659
MOD_SUMO_rev_2	103	111	PF00179	0.536
MOD_SUMO_rev_2	346	352	PF00179	0.710
TRG_ER_diArg_1	113	115	PF00400	0.568
TRG_ER_diArg_1	169	172	PF00400	0.507
TRG_ER_diArg_1	437	440	PF00400	0.607
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ50	Leptomonas seymouri	33%	98%
A0A3S7X4S8	Leishmania donovani	53%	100%
A4HJK7	Leishmania braziliensis	98%	100%
A4I706	Leishmania infantum	53%	100%
E9B224	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
Q4Q638	Leishmania major	51%	100%