Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJK2_LEIBR

TriTrypDb:

LbrM.31.2460 , LBRM2903_310034200

Length:

477

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJK2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.643
CLV_NRD_NRD_1	25	27	PF00675	0.816
CLV_NRD_NRD_1	294	296	PF00675	0.682
CLV_NRD_NRD_1	361	363	PF00675	0.588
CLV_NRD_NRD_1	367	369	PF00675	0.578
CLV_NRD_NRD_1	448	450	PF00675	0.415
CLV_PCSK_KEX2_1	24	26	PF00082	0.818
CLV_PCSK_KEX2_1	294	296	PF00082	0.712
CLV_PCSK_KEX2_1	361	363	PF00082	0.588
CLV_PCSK_KEX2_1	367	369	PF00082	0.578
CLV_PCSK_KEX2_1	448	450	PF00082	0.413
CLV_PCSK_PC7_1	290	296	PF00082	0.566
CLV_PCSK_SKI1_1	188	192	PF00082	0.641
CLV_PCSK_SKI1_1	377	381	PF00082	0.560
CLV_PCSK_SKI1_1	460	464	PF00082	0.378
DEG_APCC_DBOX_1	117	125	PF00400	0.553
DEG_COP1_1	425	435	PF00400	0.601
DOC_MAPK_gen_1	448	456	PF00069	0.412
DOC_MAPK_gen_1	460	469	PF00069	0.334
DOC_MAPK_gen_1	50	59	PF00069	0.599
DOC_MAPK_HePTP_8	47	59	PF00069	0.519
DOC_MAPK_MEF2A_6	50	59	PF00069	0.518
DOC_PP2B_LxvP_1	74	77	PF13499	0.551
DOC_PP2B_LxvP_1	82	85	PF13499	0.608
DOC_USP7_MATH_1	112	116	PF00917	0.668
DOC_USP7_MATH_1	137	141	PF00917	0.737
DOC_USP7_MATH_1	209	213	PF00917	0.539
DOC_USP7_MATH_1	285	289	PF00917	0.692
DOC_USP7_MATH_1	35	39	PF00917	0.547
DOC_USP7_MATH_1	384	388	PF00917	0.656
DOC_USP7_MATH_1	48	52	PF00917	0.491
DOC_WW_Pin1_4	10	15	PF00397	0.551
DOC_WW_Pin1_4	110	115	PF00397	0.658
DOC_WW_Pin1_4	189	194	PF00397	0.653
DOC_WW_Pin1_4	263	268	PF00397	0.540
DOC_WW_Pin1_4	431	436	PF00397	0.644
LIG_14-3-3_CanoR_1	146	152	PF00244	0.645
LIG_14-3-3_CanoR_1	217	225	PF00244	0.644
LIG_14-3-3_CanoR_1	294	299	PF00244	0.708
LIG_14-3-3_CanoR_1	30	34	PF00244	0.721
LIG_14-3-3_CanoR_1	337	345	PF00244	0.667
LIG_14-3-3_CanoR_1	377	384	PF00244	0.607
LIG_14-3-3_CanoR_1	412	417	PF00244	0.561
LIG_14-3-3_CanoR_1	44	48	PF00244	0.564
LIG_BRCT_BRCA1_1	282	286	PF00533	0.552
LIG_BRCT_BRCA1_1	354	358	PF00533	0.556
LIG_BRCT_BRCA1_1	412	416	PF00533	0.630
LIG_BRCT_BRCA1_1	427	431	PF00533	0.457
LIG_CtBP_PxDLS_1	254	258	PF00389	0.527
LIG_EVH1_1	82	86	PF00568	0.554
LIG_FHA_1	105	111	PF00498	0.615
LIG_FHA_1	139	145	PF00498	0.679
LIG_FHA_1	197	203	PF00498	0.551
LIG_FHA_1	264	270	PF00498	0.540
LIG_FHA_1	295	301	PF00498	0.699
LIG_FHA_1	378	384	PF00498	0.557
LIG_FHA_2	146	152	PF00498	0.645
LIG_FHA_2	163	169	PF00498	0.538
LIG_FHA_2	274	280	PF00498	0.684
LIG_LIR_Gen_1	130	138	PF02991	0.605
LIG_LIR_Gen_1	434	443	PF02991	0.538
LIG_LIR_Nem_3	130	136	PF02991	0.571
LIG_LIR_Nem_3	297	301	PF02991	0.524
LIG_LIR_Nem_3	434	440	PF02991	0.685
LIG_LIR_Nem_3	54	59	PF02991	0.513
LIG_PCNA_yPIPBox_3	447	460	PF02747	0.386
LIG_Pex14_1	319	323	PF04695	0.542
LIG_PTAP_UEV_1	113	118	PF05743	0.570
LIG_SH2_CRK	133	137	PF00017	0.616
LIG_SH2_NCK_1	133	137	PF00017	0.646
LIG_SH2_PTP2	56	59	PF00017	0.508
LIG_SH2_STAP1	281	285	PF00017	0.548
LIG_SH2_STAT3	142	145	PF00017	0.531
LIG_SH2_STAT5	133	136	PF00017	0.677
LIG_SH2_STAT5	142	145	PF00017	0.588
LIG_SH2_STAT5	56	59	PF00017	0.508
LIG_SH3_3	111	117	PF00018	0.623
LIG_SH3_3	391	397	PF00018	0.569
LIG_SH3_3	429	435	PF00018	0.596
LIG_SH3_3	69	75	PF00018	0.649
LIG_SH3_3	80	86	PF00018	0.639
LIG_SUMO_SIM_anti_2	247	252	PF11976	0.525
LIG_UBA3_1	269	274	PF00899	0.542
MOD_CK1_1	13	19	PF00069	0.587
MOD_CK1_1	162	168	PF00069	0.600
MOD_CK1_1	192	198	PF00069	0.710
MOD_CK1_1	226	232	PF00069	0.582
MOD_CK1_1	268	274	PF00069	0.629
MOD_CK1_1	275	281	PF00069	0.662
MOD_CK1_1	288	294	PF00069	0.647
MOD_CK1_1	326	332	PF00069	0.628
MOD_CK1_1	38	44	PF00069	0.599
MOD_CK1_1	387	393	PF00069	0.539
MOD_CK1_1	408	414	PF00069	0.649
MOD_CK1_1	425	431	PF00069	0.481
MOD_CK2_1	145	151	PF00069	0.651
MOD_CK2_1	162	168	PF00069	0.535
MOD_CK2_1	194	200	PF00069	0.558
MOD_CK2_1	209	215	PF00069	0.537
MOD_CK2_1	241	247	PF00069	0.671
MOD_CK2_1	326	332	PF00069	0.545
MOD_CK2_1	84	90	PF00069	0.823
MOD_Cter_Amidation	365	368	PF01082	0.558
MOD_GlcNHglycan	114	117	PF01048	0.575
MOD_GlcNHglycan	259	262	PF01048	0.760
MOD_GlcNHglycan	325	328	PF01048	0.596
MOD_GlcNHglycan	340	343	PF01048	0.579
MOD_GlcNHglycan	355	358	PF01048	0.559
MOD_GlcNHglycan	37	40	PF01048	0.596
MOD_GlcNHglycan	386	389	PF01048	0.544
MOD_GlcNHglycan	424	427	PF01048	0.592
MOD_GSK3_1	100	107	PF00069	0.748
MOD_GSK3_1	13	20	PF00069	0.745
MOD_GSK3_1	167	174	PF00069	0.666
MOD_GSK3_1	188	195	PF00069	0.575
MOD_GSK3_1	219	226	PF00069	0.547
MOD_GSK3_1	24	31	PF00069	0.646
MOD_GSK3_1	253	260	PF00069	0.773
MOD_GSK3_1	268	275	PF00069	0.675
MOD_GSK3_1	281	288	PF00069	0.664
MOD_GSK3_1	290	297	PF00069	0.593
MOD_GSK3_1	322	329	PF00069	0.636
MOD_GSK3_1	34	41	PF00069	0.566
MOD_GSK3_1	408	415	PF00069	0.564
MOD_GSK3_1	418	425	PF00069	0.589
MOD_GSK3_1	84	91	PF00069	0.618
MOD_LATS_1	471	477	PF00433	0.414
MOD_N-GLC_1	408	413	PF02516	0.664
MOD_N-GLC_2	61	63	PF02516	0.504
MOD_N-GLC_2	97	99	PF02516	0.801
MOD_NEK2_1	1	6	PF00069	0.685
MOD_NEK2_1	138	143	PF00069	0.526
MOD_NEK2_1	257	262	PF00069	0.537
MOD_NEK2_1	270	275	PF00069	0.554
MOD_NEK2_1	323	328	PF00069	0.569
MOD_NEK2_1	338	343	PF00069	0.618
MOD_NEK2_1	410	415	PF00069	0.684
MOD_NEK2_1	422	427	PF00069	0.590
MOD_NMyristoyl	1	7	PF02799	0.687
MOD_PIKK_1	285	291	PF00454	0.685
MOD_PIKK_1	29	35	PF00454	0.569
MOD_PIKK_1	304	310	PF00454	0.658
MOD_PKA_1	24	30	PF00069	0.776
MOD_PKA_1	294	300	PF00069	0.715
MOD_PKA_2	145	151	PF00069	0.651
MOD_PKA_2	231	237	PF00069	0.547
MOD_PKA_2	24	30	PF00069	0.748
MOD_PKA_2	294	300	PF00069	0.746
MOD_PKA_2	332	338	PF00069	0.810
MOD_PKA_2	384	390	PF00069	0.627
MOD_PKA_2	43	49	PF00069	0.526
MOD_PKB_1	375	383	PF00069	0.557
MOD_Plk_1	418	424	PF00069	0.589
MOD_Plk_2-3	259	265	PF00069	0.541
MOD_Plk_4	131	137	PF00069	0.568
MOD_Plk_4	241	247	PF00069	0.523
MOD_Plk_4	265	271	PF00069	0.686
MOD_ProDKin_1	10	16	PF00069	0.553
MOD_ProDKin_1	110	116	PF00069	0.658
MOD_ProDKin_1	189	195	PF00069	0.652
MOD_ProDKin_1	263	269	PF00069	0.540
MOD_ProDKin_1	431	437	PF00069	0.641
TRG_DiLeu_BaEn_4	445	451	PF01217	0.535
TRG_ENDOCYTIC_2	133	136	PF00928	0.650
TRG_ENDOCYTIC_2	56	59	PF00928	0.508
TRG_ER_diArg_1	24	26	PF00400	0.677
TRG_ER_diArg_1	360	362	PF00400	0.569
TRG_ER_diArg_1	367	369	PF00400	0.537
TRG_ER_diArg_1	373	376	PF00400	0.517
TRG_ER_diArg_1	448	450	PF00400	0.415
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	448	452	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4Q7	Leishmania donovani	55%	98%
A4I703	Leishmania infantum	56%	98%
E9B221	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	98%
Q4Q641	Leishmania major	54%	100%