Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJK1_LEIBR

TriTrypDb:

LbrM.31.2450 , LBRM2903_310034100

Length:

767

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.520
CLV_C14_Caspase3-7	160	164	PF00656	0.554
CLV_C14_Caspase3-7	51	55	PF00656	0.529
CLV_NRD_NRD_1	261	263	PF00675	0.593
CLV_NRD_NRD_1	279	281	PF00675	0.691
CLV_NRD_NRD_1	401	403	PF00675	0.591
CLV_NRD_NRD_1	624	626	PF00675	0.545
CLV_NRD_NRD_1	656	658	PF00675	0.571
CLV_PCSK_FUR_1	654	658	PF00082	0.573
CLV_PCSK_KEX2_1	279	281	PF00082	0.736
CLV_PCSK_KEX2_1	400	402	PF00082	0.591
CLV_PCSK_KEX2_1	582	584	PF00082	0.720
CLV_PCSK_KEX2_1	626	628	PF00082	0.534
CLV_PCSK_KEX2_1	656	658	PF00082	0.571
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.720
CLV_PCSK_PC1ET2_1	626	628	PF00082	0.534
CLV_PCSK_SKI1_1	255	259	PF00082	0.637
CLV_PCSK_SKI1_1	317	321	PF00082	0.638
CLV_PCSK_SKI1_1	583	587	PF00082	0.649
CLV_PCSK_SKI1_1	751	755	PF00082	0.547
CLV_Separin_Metazoa	288	292	PF03568	0.579
DEG_APCC_KENBOX_2	757	761	PF00400	0.526
DEG_SCF_FBW7_1	219	226	PF00400	0.535
DEG_SCF_FBW7_1	230	237	PF00400	0.548
DEG_SCF_FBW7_1	489	496	PF00400	0.581
DEG_SCF_FBW7_2	99	104	PF00400	0.549
DEG_SCF_TRCP1_1	163	169	PF00400	0.535
DEG_SPOP_SBC_1	257	261	PF00917	0.572
DEG_SPOP_SBC_1	484	488	PF00917	0.583
DEG_SPOP_SBC_1	565	569	PF00917	0.717
DEG_SPOP_SBC_1	570	574	PF00917	0.670
DOC_CKS1_1	220	225	PF01111	0.530
DOC_CKS1_1	33	38	PF01111	0.563
DOC_MAPK_gen_1	582	588	PF00069	0.716
DOC_PIKK_1	759	767	PF02985	0.519
DOC_PP1_RVXF_1	56	62	PF00149	0.548
DOC_PP1_SILK_1	699	704	PF00149	0.691
DOC_PP2B_LxvP_1	218	221	PF13499	0.540
DOC_PP2B_LxvP_1	356	359	PF13499	0.703
DOC_USP7_MATH_1	130	134	PF00917	0.543
DOC_USP7_MATH_1	146	150	PF00917	0.608
DOC_USP7_MATH_1	223	227	PF00917	0.580
DOC_USP7_MATH_1	325	329	PF00917	0.687
DOC_USP7_MATH_1	376	380	PF00917	0.564
DOC_USP7_MATH_1	423	427	PF00917	0.690
DOC_USP7_MATH_1	565	569	PF00917	0.728
DOC_USP7_MATH_1	581	585	PF00917	0.673
DOC_USP7_MATH_1	670	674	PF00917	0.584
DOC_USP7_MATH_1	680	684	PF00917	0.558
DOC_USP7_MATH_1	722	726	PF00917	0.667
DOC_USP7_MATH_1	738	742	PF00917	0.490
DOC_USP7_MATH_1	89	93	PF00917	0.560
DOC_USP7_MATH_2	78	84	PF00917	0.638
DOC_USP7_UBL2_3	370	374	PF12436	0.657
DOC_USP7_UBL2_3	490	494	PF12436	0.609
DOC_USP7_UBL2_3	754	758	PF12436	0.676
DOC_WW_Pin1_4	166	171	PF00397	0.580
DOC_WW_Pin1_4	195	200	PF00397	0.577
DOC_WW_Pin1_4	202	207	PF00397	0.590
DOC_WW_Pin1_4	219	224	PF00397	0.568
DOC_WW_Pin1_4	230	235	PF00397	0.662
DOC_WW_Pin1_4	237	242	PF00397	0.693
DOC_WW_Pin1_4	245	250	PF00397	0.633
DOC_WW_Pin1_4	267	272	PF00397	0.762
DOC_WW_Pin1_4	32	37	PF00397	0.566
DOC_WW_Pin1_4	321	326	PF00397	0.622
DOC_WW_Pin1_4	335	340	PF00397	0.530
DOC_WW_Pin1_4	354	359	PF00397	0.542
DOC_WW_Pin1_4	383	388	PF00397	0.630
DOC_WW_Pin1_4	425	430	PF00397	0.838
DOC_WW_Pin1_4	454	459	PF00397	0.664
DOC_WW_Pin1_4	489	494	PF00397	0.632
DOC_WW_Pin1_4	542	547	PF00397	0.686
DOC_WW_Pin1_4	560	565	PF00397	0.538
DOC_WW_Pin1_4	577	582	PF00397	0.565
DOC_WW_Pin1_4	59	64	PF00397	0.727
DOC_WW_Pin1_4	638	643	PF00397	0.664
DOC_WW_Pin1_4	661	666	PF00397	0.738
DOC_WW_Pin1_4	676	681	PF00397	0.635
DOC_WW_Pin1_4	74	79	PF00397	0.480
DOC_WW_Pin1_4	85	90	PF00397	0.645
DOC_WW_Pin1_4	97	102	PF00397	0.693
LIG_14-3-3_CanoR_1	155	161	PF00244	0.714
LIG_14-3-3_CanoR_1	255	265	PF00244	0.687
LIG_14-3-3_CanoR_1	425	429	PF00244	0.601
LIG_14-3-3_CanoR_1	498	505	PF00244	0.585
LIG_14-3-3_CanoR_1	520	530	PF00244	0.575
LIG_14-3-3_CanoR_1	583	589	PF00244	0.820
LIG_14-3-3_CanoR_1	70	78	PF00244	0.541
LIG_14-3-3_CanoR_1	96	100	PF00244	0.656
LIG_Actin_WH2_2	213	231	PF00022	0.543
LIG_BRCT_BRCA1_1	303	307	PF00533	0.544
LIG_BRCT_BRCA1_1	350	354	PF00533	0.538
LIG_BRCT_BRCA1_1	67	71	PF00533	0.553
LIG_BRCT_BRCA1_1	724	728	PF00533	0.666
LIG_FHA_1	110	116	PF00498	0.537
LIG_FHA_1	167	173	PF00498	0.639
LIG_FHA_1	192	198	PF00498	0.570
LIG_FHA_1	231	237	PF00498	0.670
LIG_FHA_1	281	287	PF00498	0.578
LIG_FHA_1	351	357	PF00498	0.608
LIG_FHA_1	449	455	PF00498	0.653
LIG_FHA_1	48	54	PF00498	0.531
LIG_FHA_1	565	571	PF00498	0.821
LIG_FHA_1	89	95	PF00498	0.707
LIG_FHA_2	114	120	PF00498	0.525
LIG_FHA_2	158	164	PF00498	0.559
LIG_FHA_2	222	228	PF00498	0.539
LIG_FHA_2	283	289	PF00498	0.604
LIG_FHA_2	49	55	PF00498	0.531
LIG_FHA_2	520	526	PF00498	0.632
LIG_FHA_2	570	576	PF00498	0.579
LIG_FHA_2	585	591	PF00498	0.684
LIG_FHA_2	88	94	PF00498	0.557
LIG_LIR_Gen_1	179	188	PF02991	0.559
LIG_LIR_Gen_1	209	220	PF02991	0.562
LIG_LIR_Gen_1	304	315	PF02991	0.543
LIG_LIR_Gen_1	54	63	PF02991	0.537
LIG_LIR_Nem_3	179	183	PF02991	0.555
LIG_LIR_Nem_3	209	215	PF02991	0.561
LIG_LIR_Nem_3	304	310	PF02991	0.539
LIG_LIR_Nem_3	395	399	PF02991	0.556
LIG_LIR_Nem_3	54	59	PF02991	0.535
LIG_MYND_1	189	193	PF01753	0.564
LIG_PDZ_Class_3	762	767	PF00595	0.518
LIG_RPA_C_Fungi	737	749	PF08784	0.671
LIG_SH2_CRK	180	184	PF00017	0.558
LIG_SH2_NCK_1	180	184	PF00017	0.558
LIG_SH2_NCK_1	56	60	PF00017	0.537
LIG_SH2_STAP1	111	115	PF00017	0.596
LIG_SH2_STAT5	111	114	PF00017	0.576
LIG_SH2_STAT5	124	127	PF00017	0.597
LIG_SH2_STAT5	173	176	PF00017	0.534
LIG_SH2_STAT5	39	42	PF00017	0.553
LIG_SH3_1	291	297	PF00018	0.565
LIG_SH3_2	578	583	PF14604	0.567
LIG_SH3_3	204	210	PF00018	0.623
LIG_SH3_3	238	244	PF00018	0.733
LIG_SH3_3	246	252	PF00018	0.631
LIG_SH3_3	27	33	PF00018	0.593
LIG_SH3_3	290	296	PF00018	0.770
LIG_SH3_3	452	458	PF00018	0.697
LIG_SH3_3	540	546	PF00018	0.615
LIG_SH3_3	575	581	PF00018	0.566
LIG_SH3_3	639	645	PF00018	0.691
LIG_SH3_4	490	497	PF00018	0.578
LIG_SH3_4	754	761	PF00018	0.670
LIG_SUMO_SIM_anti_2	213	220	PF11976	0.539
LIG_SUMO_SIM_par_1	110	117	PF11976	0.533
LIG_SUMO_SIM_par_1	123	129	PF11976	0.496
LIG_SUMO_SIM_par_1	216	222	PF11976	0.550
LIG_TRFH_1	354	358	PF08558	0.548
MOD_CDC14_SPxK_1	205	208	PF00782	0.549
MOD_CDC14_SPxK_1	545	548	PF00782	0.694
MOD_CDC14_SPxK_1	580	583	PF00782	0.572
MOD_CDK_SPK_2	425	430	PF00069	0.838
MOD_CDK_SPK_2	489	494	PF00069	0.582
MOD_CDK_SPK_2	577	582	PF00069	0.565
MOD_CDK_SPK_2	641	646	PF00069	0.565
MOD_CDK_SPK_2	676	681	PF00069	0.581
MOD_CDK_SPxK_1	202	208	PF00069	0.559
MOD_CDK_SPxK_1	542	548	PF00069	0.689
MOD_CDK_SPxK_1	577	583	PF00069	0.568
MOD_CDK_SPxxK_3	267	274	PF00069	0.580
MOD_CDK_SPxxK_3	661	668	PF00069	0.565
MOD_CK1_1	114	120	PF00069	0.604
MOD_CK1_1	137	143	PF00069	0.627
MOD_CK1_1	149	155	PF00069	0.736
MOD_CK1_1	157	163	PF00069	0.718
MOD_CK1_1	270	276	PF00069	0.721
MOD_CK1_1	282	288	PF00069	0.605
MOD_CK1_1	324	330	PF00069	0.643
MOD_CK1_1	331	337	PF00069	0.619
MOD_CK1_1	350	356	PF00069	0.626
MOD_CK1_1	379	385	PF00069	0.679
MOD_CK1_1	386	392	PF00069	0.654
MOD_CK1_1	449	455	PF00069	0.616
MOD_CK1_1	475	481	PF00069	0.660
MOD_CK1_1	483	489	PF00069	0.679
MOD_CK1_1	521	527	PF00069	0.636
MOD_CK1_1	584	590	PF00069	0.657
MOD_CK1_1	606	612	PF00069	0.626
MOD_CK1_1	633	639	PF00069	0.771
MOD_CK1_1	641	647	PF00069	0.670
MOD_CK1_1	707	713	PF00069	0.688
MOD_CK1_1	85	91	PF00069	0.603
MOD_CK2_1	161	167	PF00069	0.706
MOD_CK2_1	275	281	PF00069	0.710
MOD_CK2_1	282	288	PF00069	0.717
MOD_CK2_1	569	575	PF00069	0.655
MOD_CK2_1	584	590	PF00069	0.725
MOD_CK2_1	6	12	PF00069	0.540
MOD_CK2_1	661	667	PF00069	0.726
MOD_CK2_1	711	717	PF00069	0.690
MOD_CK2_1	74	80	PF00069	0.693
MOD_CK2_1	87	93	PF00069	0.592
MOD_Cter_Amidation	623	626	PF01082	0.546
MOD_DYRK1A_RPxSP_1	425	429	PF00069	0.561
MOD_GlcNHglycan	163	166	PF01048	0.749
MOD_GlcNHglycan	22	25	PF01048	0.543
MOD_GlcNHglycan	327	330	PF01048	0.799
MOD_GlcNHglycan	350	353	PF01048	0.716
MOD_GlcNHglycan	367	370	PF01048	0.603
MOD_GlcNHglycan	406	409	PF01048	0.618
MOD_GlcNHglycan	441	444	PF01048	0.674
MOD_GlcNHglycan	448	451	PF01048	0.642
MOD_GlcNHglycan	482	485	PF01048	0.804
MOD_GlcNHglycan	583	586	PF01048	0.717
MOD_GlcNHglycan	608	611	PF01048	0.684
MOD_GlcNHglycan	635	638	PF01048	0.773
MOD_GlcNHglycan	649	652	PF01048	0.604
MOD_GlcNHglycan	8	11	PF01048	0.625
MOD_GlcNHglycan	84	87	PF01048	0.676
MOD_GSK3_1	103	110	PF00069	0.734
MOD_GSK3_1	113	120	PF00069	0.642
MOD_GSK3_1	130	137	PF00069	0.528
MOD_GSK3_1	146	153	PF00069	0.694
MOD_GSK3_1	157	164	PF00069	0.608
MOD_GSK3_1	191	198	PF00069	0.746
MOD_GSK3_1	20	27	PF00069	0.743
MOD_GSK3_1	202	209	PF00069	0.591
MOD_GSK3_1	219	226	PF00069	0.501
MOD_GSK3_1	230	237	PF00069	0.584
MOD_GSK3_1	270	277	PF00069	0.742
MOD_GSK3_1	301	308	PF00069	0.560
MOD_GSK3_1	319	326	PF00069	0.717
MOD_GSK3_1	331	338	PF00069	0.674
MOD_GSK3_1	350	357	PF00069	0.609
MOD_GSK3_1	372	379	PF00069	0.765
MOD_GSK3_1	404	411	PF00069	0.558
MOD_GSK3_1	425	432	PF00069	0.652
MOD_GSK3_1	439	446	PF00069	0.716
MOD_GSK3_1	449	456	PF00069	0.657
MOD_GSK3_1	475	482	PF00069	0.789
MOD_GSK3_1	485	492	PF00069	0.738
MOD_GSK3_1	493	500	PF00069	0.617
MOD_GSK3_1	509	516	PF00069	0.654
MOD_GSK3_1	542	549	PF00069	0.734
MOD_GSK3_1	552	559	PF00069	0.705
MOD_GSK3_1	560	567	PF00069	0.580
MOD_GSK3_1	577	584	PF00069	0.721
MOD_GSK3_1	65	72	PF00069	0.569
MOD_GSK3_1	676	683	PF00069	0.585
MOD_GSK3_1	703	710	PF00069	0.692
MOD_GSK3_1	743	750	PF00069	0.520
MOD_GSK3_1	80	87	PF00069	0.712
MOD_N-GLC_1	348	353	PF02516	0.569
MOD_N-GLC_1	379	384	PF02516	0.639
MOD_N-GLC_1	560	565	PF02516	0.663
MOD_N-GLC_1	659	664	PF02516	0.620
MOD_N-GLC_1	711	716	PF02516	0.689
MOD_N-GLC_2	15	17	PF02516	0.549
MOD_N-GLC_2	418	420	PF02516	0.557
MOD_N-GLC_2	497	499	PF02516	0.585
MOD_NEK2_1	103	108	PF00069	0.678
MOD_NEK2_1	109	114	PF00069	0.632
MOD_NEK2_1	161	166	PF00069	0.612
MOD_NEK2_1	301	306	PF00069	0.549
MOD_NEK2_1	365	370	PF00069	0.566
MOD_NEK2_1	394	399	PF00069	0.641
MOD_NEK2_1	448	453	PF00069	0.561
MOD_NEK2_1	513	518	PF00069	0.577
MOD_NEK2_1	566	571	PF00069	0.614
MOD_NEK2_1	603	608	PF00069	0.644
MOD_NEK2_1	630	635	PF00069	0.606
MOD_NEK2_1	669	674	PF00069	0.582
MOD_NEK2_1	685	690	PF00069	0.635
MOD_NEK2_1	692	697	PF00069	0.690
MOD_NEK2_1	702	707	PF00069	0.567
MOD_NEK2_1	71	76	PF00069	0.605
MOD_NEK2_1	84	89	PF00069	0.562
MOD_PIKK_1	103	109	PF00454	0.580
MOD_PIKK_1	117	123	PF00454	0.477
MOD_PIKK_1	305	311	PF00454	0.620
MOD_PIKK_1	386	392	PF00454	0.759
MOD_PIKK_1	513	519	PF00454	0.588
MOD_PK_1	697	703	PF00069	0.585
MOD_PKA_1	279	285	PF00069	0.590
MOD_PKA_1	703	709	PF00069	0.695
MOD_PKA_2	138	144	PF00069	0.591
MOD_PKA_2	147	153	PF00069	0.619
MOD_PKA_2	154	160	PF00069	0.632
MOD_PKA_2	279	285	PF00069	0.574
MOD_PKA_2	404	410	PF00069	0.553
MOD_PKA_2	424	430	PF00069	0.604
MOD_PKA_2	497	503	PF00069	0.592
MOD_PKA_2	509	515	PF00069	0.548
MOD_PKA_2	519	525	PF00069	0.568
MOD_PKA_2	66	72	PF00069	0.551
MOD_PKA_2	670	676	PF00069	0.745
MOD_PKA_2	680	686	PF00069	0.639
MOD_PKA_2	95	101	PF00069	0.653
MOD_PKB_1	29	37	PF00069	0.644
MOD_PKB_1	709	717	PF00069	0.526
MOD_Plk_1	301	307	PF00069	0.547
MOD_Plk_1	379	385	PF00069	0.640
MOD_Plk_1	48	54	PF00069	0.531
MOD_Plk_1	716	722	PF00069	0.665
MOD_Plk_4	192	198	PF00069	0.570
MOD_Plk_4	408	414	PF00069	0.551
MOD_Plk_4	443	449	PF00069	0.557
MOD_Plk_4	48	54	PF00069	0.610
MOD_Plk_4	509	515	PF00069	0.568
MOD_Plk_4	566	572	PF00069	0.581
MOD_Plk_4	611	617	PF00069	0.559
MOD_Plk_4	697	703	PF00069	0.695
MOD_Plk_4	711	717	PF00069	0.541
MOD_Plk_4	724	730	PF00069	0.634
MOD_ProDKin_1	166	172	PF00069	0.580
MOD_ProDKin_1	195	201	PF00069	0.576
MOD_ProDKin_1	202	208	PF00069	0.615
MOD_ProDKin_1	219	225	PF00069	0.565
MOD_ProDKin_1	230	236	PF00069	0.664
MOD_ProDKin_1	237	243	PF00069	0.690
MOD_ProDKin_1	245	251	PF00069	0.633
MOD_ProDKin_1	267	273	PF00069	0.760
MOD_ProDKin_1	32	38	PF00069	0.565
MOD_ProDKin_1	321	327	PF00069	0.624
MOD_ProDKin_1	335	341	PF00069	0.530
MOD_ProDKin_1	354	360	PF00069	0.540
MOD_ProDKin_1	383	389	PF00069	0.628
MOD_ProDKin_1	425	431	PF00069	0.840
MOD_ProDKin_1	454	460	PF00069	0.664
MOD_ProDKin_1	489	495	PF00069	0.632
MOD_ProDKin_1	542	548	PF00069	0.689
MOD_ProDKin_1	560	566	PF00069	0.540
MOD_ProDKin_1	577	583	PF00069	0.568
MOD_ProDKin_1	59	65	PF00069	0.727
MOD_ProDKin_1	638	644	PF00069	0.666
MOD_ProDKin_1	661	667	PF00069	0.738
MOD_ProDKin_1	676	682	PF00069	0.635
MOD_ProDKin_1	74	80	PF00069	0.481
MOD_ProDKin_1	85	91	PF00069	0.647
MOD_ProDKin_1	97	103	PF00069	0.691
MOD_SUMO_for_1	13	16	PF00179	0.542
MOD_SUMO_rev_2	226	231	PF00179	0.560
MOD_SUMO_rev_2	266	276	PF00179	0.597
TRG_DiLeu_BaEn_1	759	764	PF01217	0.519
TRG_ENDOCYTIC_2	180	183	PF00928	0.555
TRG_ENDOCYTIC_2	56	59	PF00928	0.539
TRG_ER_diArg_1	399	402	PF00400	0.544
TRG_ER_diArg_1	463	466	PF00400	0.570
TRG_ER_diArg_1	654	657	PF00400	0.575
TRG_ER_diArg_1	708	711	PF00400	0.529
TRG_NLS_MonoExtN_4	400	406	PF00514	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFQ0	Leishmania donovani	46%	100%
A4I6Z8	Leishmania infantum	46%	100%
E9B219	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
Q4Q642	Leishmania major	44%	99%