Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJK0_LEIBR

TriTrypDb:

LbrM.31.2440 , LBRM2903_310034000

Length:

772

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJK0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.586
CLV_NRD_NRD_1	150	152	PF00675	0.826
CLV_NRD_NRD_1	194	196	PF00675	0.798
CLV_NRD_NRD_1	316	318	PF00675	0.518
CLV_NRD_NRD_1	470	472	PF00675	0.781
CLV_NRD_NRD_1	557	559	PF00675	0.549
CLV_NRD_NRD_1	578	580	PF00675	0.663
CLV_NRD_NRD_1	81	83	PF00675	0.827
CLV_PCSK_FUR_1	192	196	PF00082	0.799
CLV_PCSK_KEX2_1	11	13	PF00082	0.840
CLV_PCSK_KEX2_1	144	146	PF00082	0.668
CLV_PCSK_KEX2_1	149	151	PF00082	0.670
CLV_PCSK_KEX2_1	194	196	PF00082	0.662
CLV_PCSK_KEX2_1	315	317	PF00082	0.421
CLV_PCSK_KEX2_1	557	559	PF00082	0.549
CLV_PCSK_KEX2_1	81	83	PF00082	0.848
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.840
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.581
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.421
CLV_PCSK_PC7_1	145	151	PF00082	0.579
CLV_PCSK_SKI1_1	194	198	PF00082	0.620
CLV_PCSK_SKI1_1	299	303	PF00082	0.509
CLV_PCSK_SKI1_1	378	382	PF00082	0.599
CLV_PCSK_SKI1_1	461	465	PF00082	0.591
CLV_PCSK_SKI1_1	82	86	PF00082	0.830
CLV_Separin_Metazoa	223	227	PF03568	0.563
DEG_APCC_DBOX_1	315	323	PF00400	0.429
DEG_APCC_DBOX_1	413	421	PF00400	0.564
DEG_COP1_1	436	445	PF00400	0.561
DEG_SCF_FBW7_1	756	761	PF00400	0.543
DEG_SCF_FBW7_2	596	603	PF00400	0.794
DEG_SPOP_SBC_1	758	762	PF00917	0.540
DOC_CKS1_1	389	394	PF01111	0.565
DOC_CKS1_1	597	602	PF01111	0.801
DOC_CKS1_1	86	91	PF01111	0.668
DOC_MAPK_gen_1	315	324	PF00069	0.446
DOC_MAPK_gen_1	42	50	PF00069	0.502
DOC_MAPK_gen_1	557	565	PF00069	0.408
DOC_MAPK_MEF2A_6	558	567	PF00069	0.411
DOC_PP2B_LxvP_1	765	768	PF13499	0.512
DOC_PP2B_LxvP_1	95	98	PF13499	0.850
DOC_PP4_FxxP_1	16	19	PF00568	0.779
DOC_USP7_MATH_1	167	171	PF00917	0.803
DOC_USP7_MATH_1	180	184	PF00917	0.627
DOC_USP7_MATH_1	202	206	PF00917	0.645
DOC_USP7_MATH_1	325	329	PF00917	0.527
DOC_USP7_MATH_1	380	384	PF00917	0.802
DOC_USP7_MATH_1	489	493	PF00917	0.629
DOC_USP7_MATH_1	616	620	PF00917	0.646
DOC_USP7_MATH_1	758	762	PF00917	0.540
DOC_USP7_MATH_2	49	55	PF00917	0.553
DOC_USP7_UBL2_3	71	75	PF12436	0.751
DOC_WW_Pin1_4	117	122	PF00397	0.707
DOC_WW_Pin1_4	157	162	PF00397	0.563
DOC_WW_Pin1_4	178	183	PF00397	0.754
DOC_WW_Pin1_4	3	8	PF00397	0.562
DOC_WW_Pin1_4	326	331	PF00397	0.553
DOC_WW_Pin1_4	352	357	PF00397	0.572
DOC_WW_Pin1_4	388	393	PF00397	0.665
DOC_WW_Pin1_4	428	433	PF00397	0.731
DOC_WW_Pin1_4	441	446	PF00397	0.516
DOC_WW_Pin1_4	487	492	PF00397	0.551
DOC_WW_Pin1_4	582	587	PF00397	0.549
DOC_WW_Pin1_4	596	601	PF00397	0.803
DOC_WW_Pin1_4	631	636	PF00397	0.538
DOC_WW_Pin1_4	680	685	PF00397	0.759
DOC_WW_Pin1_4	743	748	PF00397	0.704
DOC_WW_Pin1_4	752	757	PF00397	0.495
DOC_WW_Pin1_4	82	87	PF00397	0.831
LIG_14-3-3_CanoR_1	106	110	PF00244	0.585
LIG_14-3-3_CanoR_1	145	153	PF00244	0.571
LIG_14-3-3_CanoR_1	210	216	PF00244	0.579
LIG_14-3-3_CanoR_1	226	232	PF00244	0.504
LIG_14-3-3_CanoR_1	317	323	PF00244	0.435
LIG_14-3-3_CanoR_1	348	356	PF00244	0.561
LIG_14-3-3_CanoR_1	382	388	PF00244	0.552
LIG_14-3-3_CanoR_1	537	545	PF00244	0.650
LIG_14-3-3_CanoR_1	640	646	PF00244	0.762
LIG_14-3-3_CanoR_1	657	666	PF00244	0.586
LIG_14-3-3_CanoR_1	727	735	PF00244	0.609
LIG_14-3-3_CanoR_1	81	85	PF00244	0.781
LIG_BRCT_BRCA1_1	608	612	PF00533	0.758
LIG_eIF4E_1	733	739	PF01652	0.694
LIG_FHA_1	118	124	PF00498	0.708
LIG_FHA_1	434	440	PF00498	0.703
LIG_FHA_1	504	510	PF00498	0.535
LIG_FHA_1	599	605	PF00498	0.555
LIG_FHA_1	624	630	PF00498	0.652
LIG_FHA_1	649	655	PF00498	0.663
LIG_FHA_1	668	674	PF00498	0.476
LIG_FHA_1	691	697	PF00498	0.665
LIG_FHA_1	760	766	PF00498	0.577
LIG_FHA_2	13	19	PF00498	0.803
LIG_FHA_2	133	139	PF00498	0.583
LIG_FHA_2	22	28	PF00498	0.546
LIG_FHA_2	367	373	PF00498	0.733
LIG_FHA_2	464	470	PF00498	0.588
LIG_FHA_2	542	548	PF00498	0.666
LIG_FHA_2	65	71	PF00498	0.681
LIG_FHA_2	726	732	PF00498	0.693
LIG_GBD_Chelix_1	216	224	PF00786	0.572
LIG_LIR_Apic_2	15	19	PF02991	0.790
LIG_LIR_Apic_2	607	611	PF02991	0.567
LIG_LIR_Gen_1	29	37	PF02991	0.679
LIG_LIR_Nem_3	162	168	PF02991	0.561
LIG_LIR_Nem_3	29	34	PF02991	0.525
LIG_NRBOX	308	314	PF00104	0.415
LIG_NRBOX	734	740	PF00104	0.536
LIG_PDZ_Class_1	767	772	PF00595	0.499
LIG_Pex14_1	608	612	PF04695	0.583
LIG_Pex14_2	499	503	PF04695	0.750
LIG_SH2_CRK	31	35	PF00017	0.556
LIG_SH2_GRB2like	678	681	PF00017	0.559
LIG_SH2_STAP1	31	35	PF00017	0.673
LIG_SH2_STAT3	552	555	PF00017	0.654
LIG_SH2_STAT5	733	736	PF00017	0.794
LIG_SH3_2	98	103	PF14604	0.819
LIG_SH3_3	110	116	PF00018	0.721
LIG_SH3_3	327	333	PF00018	0.569
LIG_SH3_3	424	430	PF00018	0.623
LIG_SH3_3	439	445	PF00018	0.614
LIG_SH3_3	592	598	PF00018	0.770
LIG_SH3_3	608	614	PF00018	0.569
LIG_SH3_3	83	89	PF00018	0.769
LIG_SH3_3	94	100	PF00018	0.651
LIG_SH3_CIN85_PxpxPR_1	98	103	PF14604	0.566
LIG_SUMO_SIM_anti_2	760	768	PF11976	0.528
LIG_TRAF2_1	182	185	PF00917	0.596
LIG_TRAF2_1	369	372	PF00917	0.713
LIG_TRAF2_1	544	547	PF00917	0.417
LIG_TRAF2_1	67	70	PF00917	0.593
LIG_UBA3_1	220	228	PF00899	0.622
LIG_WRC_WIRS_1	13	18	PF05994	0.809
LIG_WW_3	100	104	PF00397	0.813
MOD_CDC14_SPxK_1	329	332	PF00782	0.579
MOD_CDC14_SPxK_1	490	493	PF00782	0.539
MOD_CDK_SPK_2	352	357	PF00069	0.572
MOD_CDK_SPK_2	388	393	PF00069	0.665
MOD_CDK_SPxK_1	326	332	PF00069	0.558
MOD_CDK_SPxK_1	487	493	PF00069	0.551
MOD_CK1_1	137	143	PF00069	0.763
MOD_CK1_1	183	189	PF00069	0.794
MOD_CK1_1	233	239	PF00069	0.652
MOD_CK1_1	293	299	PF00069	0.808
MOD_CK1_1	328	334	PF00069	0.575
MOD_CK1_1	383	389	PF00069	0.670
MOD_CK1_1	431	437	PF00069	0.593
MOD_CK1_1	467	473	PF00069	0.768
MOD_CK1_1	541	547	PF00069	0.678
MOD_CK1_1	585	591	PF00069	0.548
MOD_CK1_1	639	645	PF00069	0.812
MOD_CK1_1	659	665	PF00069	0.487
MOD_CK1_1	713	719	PF00069	0.595
MOD_CK1_1	726	732	PF00069	0.537
MOD_CK1_1	743	749	PF00069	0.494
MOD_CK2_1	21	27	PF00069	0.654
MOD_CK2_1	267	273	PF00069	0.531
MOD_CK2_1	366	372	PF00069	0.686
MOD_CK2_1	38	44	PF00069	0.417
MOD_CK2_1	431	437	PF00069	0.807
MOD_CK2_1	463	469	PF00069	0.590
MOD_CK2_1	525	531	PF00069	0.584
MOD_CK2_1	537	543	PF00069	0.474
MOD_CK2_1	64	70	PF00069	0.670
MOD_CK2_1	662	668	PF00069	0.809
MOD_CK2_1	734	740	PF00069	0.565
MOD_CK2_1	757	763	PF00069	0.649
MOD_Cter_Amidation	79	82	PF01082	0.597
MOD_DYRK1A_RPxSP_1	178	182	PF00069	0.586
MOD_DYRK1A_RPxSP_1	428	432	PF00069	0.552
MOD_DYRK1A_RPxSP_1	82	86	PF00069	0.786
MOD_GlcNHglycan	110	113	PF01048	0.842
MOD_GlcNHglycan	178	181	PF01048	0.839
MOD_GlcNHglycan	235	238	PF01048	0.698
MOD_GlcNHglycan	249	252	PF01048	0.651
MOD_GlcNHglycan	292	295	PF01048	0.752
MOD_GlcNHglycan	385	388	PF01048	0.798
MOD_GlcNHglycan	433	436	PF01048	0.559
MOD_GlcNHglycan	493	496	PF01048	0.610
MOD_GlcNHglycan	540	543	PF01048	0.711
MOD_GlcNHglycan	592	595	PF01048	0.549
MOD_GlcNHglycan	641	644	PF01048	0.724
MOD_GlcNHglycan	661	664	PF01048	0.523
MOD_GlcNHglycan	70	74	PF01048	0.624
MOD_GlcNHglycan	712	715	PF01048	0.701
MOD_GlcNHglycan	718	721	PF01048	0.764
MOD_GlcNHglycan	742	745	PF01048	0.548
MOD_GlcNHglycan	77	80	PF01048	0.673
MOD_GSK3_1	130	137	PF00069	0.666
MOD_GSK3_1	172	179	PF00069	0.735
MOD_GSK3_1	232	239	PF00069	0.686
MOD_GSK3_1	289	296	PF00069	0.522
MOD_GSK3_1	352	359	PF00069	0.640
MOD_GSK3_1	362	369	PF00069	0.684
MOD_GSK3_1	383	390	PF00069	0.574
MOD_GSK3_1	431	438	PF00069	0.801
MOD_GSK3_1	441	448	PF00069	0.552
MOD_GSK3_1	463	470	PF00069	0.720
MOD_GSK3_1	483	490	PF00069	0.605
MOD_GSK3_1	527	534	PF00069	0.775
MOD_GSK3_1	537	544	PF00069	0.646
MOD_GSK3_1	644	651	PF00069	0.731
MOD_GSK3_1	65	72	PF00069	0.672
MOD_GSK3_1	658	665	PF00069	0.533
MOD_GSK3_1	709	716	PF00069	0.724
MOD_GSK3_1	723	730	PF00069	0.547
MOD_GSK3_1	754	761	PF00069	0.570
MOD_N-GLC_1	116	121	PF02516	0.575
MOD_N-GLC_1	456	461	PF02516	0.600
MOD_N-GLC_1	483	488	PF02516	0.638
MOD_N-GLC_1	525	530	PF02516	0.592
MOD_NEK2_1	197	202	PF00069	0.683
MOD_NEK2_1	227	232	PF00069	0.637
MOD_NEK2_1	30	35	PF00069	0.462
MOD_NEK2_1	483	488	PF00069	0.568
MOD_NEK2_1	625	630	PF00069	0.560
MOD_NEK2_1	649	654	PF00069	0.557
MOD_NEK2_2	380	385	PF00069	0.592
MOD_PIKK_1	180	186	PF00454	0.680
MOD_PIKK_1	21	27	PF00454	0.698
MOD_PIKK_1	230	236	PF00454	0.678
MOD_PIKK_1	367	373	PF00454	0.751
MOD_PIKK_1	445	451	PF00454	0.599
MOD_PIKK_1	51	57	PF00454	0.597
MOD_PIKK_1	531	537	PF00454	0.830
MOD_PIKK_1	606	612	PF00454	0.580
MOD_PIKK_1	65	71	PF00454	0.547
MOD_PK_1	318	324	PF00069	0.441
MOD_PK_1	580	586	PF00069	0.552
MOD_PKA_1	144	150	PF00069	0.578
MOD_PKA_2	105	111	PF00069	0.582
MOD_PKA_2	144	150	PF00069	0.578
MOD_PKA_2	197	203	PF00069	0.585
MOD_PKA_2	209	215	PF00069	0.531
MOD_PKA_2	616	622	PF00069	0.565
MOD_PKA_2	639	645	PF00069	0.560
MOD_PKA_2	656	662	PF00069	0.502
MOD_PKA_2	726	732	PF00069	0.537
MOD_PKA_2	80	86	PF00069	0.574
MOD_PKB_1	36	44	PF00069	0.442
MOD_Plk_1	261	267	PF00069	0.796
MOD_Plk_1	649	655	PF00069	0.645
MOD_Plk_4	105	111	PF00069	0.582
MOD_Plk_4	167	173	PF00069	0.804
MOD_Plk_4	293	299	PF00069	0.556
MOD_Plk_4	422	428	PF00069	0.611
MOD_Plk_4	625	631	PF00069	0.545
MOD_Plk_4	734	740	PF00069	0.536
MOD_ProDKin_1	117	123	PF00069	0.616
MOD_ProDKin_1	157	163	PF00069	0.563
MOD_ProDKin_1	178	184	PF00069	0.756
MOD_ProDKin_1	3	9	PF00069	0.563
MOD_ProDKin_1	326	332	PF00069	0.558
MOD_ProDKin_1	352	358	PF00069	0.576
MOD_ProDKin_1	388	394	PF00069	0.665
MOD_ProDKin_1	428	434	PF00069	0.731
MOD_ProDKin_1	441	447	PF00069	0.517
MOD_ProDKin_1	487	493	PF00069	0.551
MOD_ProDKin_1	582	588	PF00069	0.549
MOD_ProDKin_1	596	602	PF00069	0.802
MOD_ProDKin_1	631	637	PF00069	0.538
MOD_ProDKin_1	680	686	PF00069	0.761
MOD_ProDKin_1	743	749	PF00069	0.707
MOD_ProDKin_1	752	758	PF00069	0.484
MOD_ProDKin_1	82	88	PF00069	0.832
MOD_SUMO_rev_2	137	146	PF00179	0.581
MOD_SUMO_rev_2	46	54	PF00179	0.600
TRG_DiLeu_BaEn_1	669	674	PF01217	0.548
TRG_ENDOCYTIC_2	165	168	PF00928	0.556
TRG_ENDOCYTIC_2	31	34	PF00928	0.673
TRG_ER_diArg_1	149	151	PF00400	0.837
TRG_ER_diArg_1	192	195	PF00400	0.815
TRG_ER_diArg_1	571	574	PF00400	0.451
TRG_NLS_MonoCore_2	314	319	PF00514	0.417
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIP7	Leishmania donovani	48%	85%
A4I6Z7	Leishmania infantum	48%	85%
E9B218	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	90%
Q4Q643	Leishmania major	46%	100%