Protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kinase

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJJ8_LEIBR

TriTrypDb:

LbrM.31.2420 , LBRM2903_310033700

Length:

918

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJJ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	666	670	PF00656	0.663
CLV_C14_Caspase3-7	715	719	PF00656	0.812
CLV_C14_Caspase3-7	741	745	PF00656	0.608
CLV_MEL_PAP_1	777	783	PF00089	0.644
CLV_NRD_NRD_1	205	207	PF00675	0.602
CLV_NRD_NRD_1	276	278	PF00675	0.734
CLV_NRD_NRD_1	34	36	PF00675	0.773
CLV_NRD_NRD_1	403	405	PF00675	0.585
CLV_NRD_NRD_1	489	491	PF00675	0.643
CLV_NRD_NRD_1	620	622	PF00675	0.690
CLV_NRD_NRD_1	676	678	PF00675	0.650
CLV_NRD_NRD_1	779	781	PF00675	0.673
CLV_NRD_NRD_1	789	791	PF00675	0.666
CLV_NRD_NRD_1	885	887	PF00675	0.582
CLV_PCSK_KEX2_1	205	207	PF00082	0.602
CLV_PCSK_KEX2_1	276	278	PF00082	0.625
CLV_PCSK_KEX2_1	33	35	PF00082	0.847
CLV_PCSK_KEX2_1	334	336	PF00082	0.824
CLV_PCSK_KEX2_1	403	405	PF00082	0.585
CLV_PCSK_KEX2_1	46	48	PF00082	0.634
CLV_PCSK_KEX2_1	489	491	PF00082	0.643
CLV_PCSK_KEX2_1	533	535	PF00082	0.592
CLV_PCSK_KEX2_1	676	678	PF00082	0.650
CLV_PCSK_KEX2_1	779	781	PF00082	0.728
CLV_PCSK_KEX2_1	789	791	PF00082	0.776
CLV_PCSK_KEX2_1	885	887	PF00082	0.582
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.847
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.824
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.634
CLV_PCSK_PC1ET2_1	533	535	PF00082	0.592
CLV_PCSK_SKI1_1	408	412	PF00082	0.588
CLV_PCSK_SKI1_1	557	561	PF00082	0.569
CLV_PCSK_SKI1_1	82	86	PF00082	0.608
CLV_PCSK_SKI1_1	886	890	PF00082	0.524
DEG_Nend_UBRbox_2	1	3	PF02207	0.618
DEG_SPOP_SBC_1	121	125	PF00917	0.749
DEG_SPOP_SBC_1	230	234	PF00917	0.599
DOC_CKS1_1	258	263	PF01111	0.577
DOC_CYCLIN_RxL_1	892	902	PF00134	0.522
DOC_PP1_RVXF_1	80	86	PF00149	0.594
DOC_PP2B_LxvP_1	314	317	PF13499	0.561
DOC_PP2B_LxvP_1	375	378	PF13499	0.583
DOC_PP4_FxxP_1	258	261	PF00568	0.772
DOC_PP4_FxxP_1	300	303	PF00568	0.718
DOC_PP4_MxPP_1	281	284	PF00568	0.649
DOC_USP7_MATH_1	134	138	PF00917	0.700
DOC_USP7_MATH_1	140	144	PF00917	0.731
DOC_USP7_MATH_1	163	167	PF00917	0.583
DOC_USP7_MATH_1	192	196	PF00917	0.735
DOC_USP7_MATH_1	384	388	PF00917	0.623
DOC_USP7_MATH_1	406	410	PF00917	0.592
DOC_USP7_MATH_1	448	452	PF00917	0.596
DOC_USP7_MATH_1	506	510	PF00917	0.806
DOC_USP7_MATH_1	573	577	PF00917	0.562
DOC_USP7_MATH_1	858	862	PF00917	0.614
DOC_USP7_MATH_1	91	95	PF00917	0.675
DOC_WW_Pin1_4	105	110	PF00397	0.547
DOC_WW_Pin1_4	11	16	PF00397	0.777
DOC_WW_Pin1_4	219	224	PF00397	0.756
DOC_WW_Pin1_4	235	240	PF00397	0.535
DOC_WW_Pin1_4	257	262	PF00397	0.576
DOC_WW_Pin1_4	356	361	PF00397	0.832
DOC_WW_Pin1_4	39	44	PF00397	0.806
DOC_WW_Pin1_4	402	407	PF00397	0.687
DOC_WW_Pin1_4	498	503	PF00397	0.625
DOC_WW_Pin1_4	507	512	PF00397	0.656
DOC_WW_Pin1_4	537	542	PF00397	0.601
DOC_WW_Pin1_4	544	549	PF00397	0.570
DOC_WW_Pin1_4	605	610	PF00397	0.632
DOC_WW_Pin1_4	796	801	PF00397	0.713
DOC_WW_Pin1_4	854	859	PF00397	0.592
DOC_WW_Pin1_4	870	875	PF00397	0.600
DOC_WW_Pin1_4	876	881	PF00397	0.666
DOC_WW_Pin1_4	89	94	PF00397	0.699
DOC_WW_Pin1_4	907	912	PF00397	0.777
LIG_14-3-3_CanoR_1	133	139	PF00244	0.657
LIG_14-3-3_CanoR_1	206	216	PF00244	0.625
LIG_14-3-3_CanoR_1	241	248	PF00244	0.828
LIG_14-3-3_CanoR_1	276	282	PF00244	0.603
LIG_14-3-3_CanoR_1	442	452	PF00244	0.701
LIG_14-3-3_CanoR_1	500	506	PF00244	0.586
LIG_14-3-3_CanoR_1	534	538	PF00244	0.598
LIG_14-3-3_CanoR_1	6	13	PF00244	0.586
LIG_14-3-3_CanoR_1	676	685	PF00244	0.617
LIG_14-3-3_CanoR_1	728	735	PF00244	0.758
LIG_14-3-3_CanoR_1	73	83	PF00244	0.619
LIG_14-3-3_CanoR_1	87	93	PF00244	0.599
LIG_14-3-3_CanoR_1	885	893	PF00244	0.784
LIG_Actin_WH2_2	394	410	PF00022	0.674
LIG_BIR_III_2	371	375	PF00653	0.587
LIG_BRCT_BRCA1_1	254	258	PF00533	0.674
LIG_BRCT_BRCA1_1	578	582	PF00533	0.575
LIG_BRCT_BRCA1_1	585	589	PF00533	0.537
LIG_Clathr_ClatBox_1	896	900	PF01394	0.769
LIG_deltaCOP1_diTrp_1	842	853	PF00928	0.738
LIG_EVH1_2	880	884	PF00568	0.546
LIG_FHA_1	123	129	PF00498	0.744
LIG_FHA_1	159	165	PF00498	0.572
LIG_FHA_1	25	31	PF00498	0.617
LIG_FHA_1	544	550	PF00498	0.600
LIG_FHA_1	62	68	PF00498	0.698
LIG_FHA_1	849	855	PF00498	0.599
LIG_FHA_1	870	876	PF00498	0.795
LIG_FHA_2	425	431	PF00498	0.730
LIG_FHA_2	436	442	PF00498	0.637
LIG_FHA_2	468	474	PF00498	0.649
LIG_FHA_2	591	597	PF00498	0.588
LIG_FHA_2	644	650	PF00498	0.607
LIG_FHA_2	728	734	PF00498	0.607
LIG_Integrin_RGD_1	335	337	PF01839	0.782
LIG_Integrin_RGD_1	647	649	PF01839	0.610
LIG_LIR_Apic_2	147	153	PF02991	0.784
LIG_LIR_Apic_2	255	261	PF02991	0.678
LIG_LIR_Apic_2	298	303	PF02991	0.722
LIG_LIR_Apic_2	876	880	PF02991	0.554
LIG_LIR_Gen_1	14	24	PF02991	0.577
LIG_LIR_Gen_1	154	163	PF02991	0.573
LIG_LIR_Gen_1	289	299	PF02991	0.590
LIG_LIR_Gen_1	319	329	PF02991	0.574
LIG_LIR_Gen_1	342	350	PF02991	0.754
LIG_LIR_Gen_1	393	401	PF02991	0.588
LIG_LIR_Gen_1	418	425	PF02991	0.580
LIG_LIR_Nem_3	14	19	PF02991	0.581
LIG_LIR_Nem_3	154	158	PF02991	0.577
LIG_LIR_Nem_3	319	324	PF02991	0.593
LIG_LIR_Nem_3	342	347	PF02991	0.753
LIG_LIR_Nem_3	393	397	PF02991	0.610
LIG_LIR_Nem_3	626	631	PF02991	0.561
LIG_LIR_Nem_3	775	781	PF02991	0.609
LIG_LIR_Nem_3	910	916	PF02991	0.768
LIG_MYND_1	284	288	PF01753	0.585
LIG_MYND_1	765	769	PF01753	0.613
LIG_Pex14_1	421	425	PF04695	0.824
LIG_Pex14_2	151	155	PF04695	0.815
LIG_Pex14_2	291	295	PF04695	0.633
LIG_SH2_CRK	344	348	PF00017	0.579
LIG_SH2_CRK	778	782	PF00017	0.609
LIG_SH2_CRK	831	835	PF00017	0.814
LIG_SH2_NCK_1	344	348	PF00017	0.579
LIG_SH2_NCK_1	877	881	PF00017	0.648
LIG_SH2_PTP2	797	800	PF00017	0.583
LIG_SH2_STAT3	262	265	PF00017	0.818
LIG_SH2_STAT5	150	153	PF00017	0.812
LIG_SH2_STAT5	797	800	PF00017	0.583
LIG_SH2_STAT5	824	827	PF00017	0.768
LIG_SH2_STAT5	865	868	PF00017	0.742
LIG_SH2_STAT6	456	460	PF00017	0.575
LIG_SH3_1	173	179	PF00018	0.571
LIG_SH3_1	293	299	PF00018	0.599
LIG_SH3_2	296	301	PF14604	0.602
LIG_SH3_3	136	142	PF00018	0.582
LIG_SH3_3	173	179	PF00018	0.571
LIG_SH3_3	234	240	PF00018	0.638
LIG_SH3_3	293	299	PF00018	0.599
LIG_SH3_3	37	43	PF00018	0.822
LIG_SH3_3	386	392	PF00018	0.579
LIG_SH3_3	505	511	PF00018	0.606
LIG_SH3_3	762	768	PF00018	0.858
LIG_SH3_3	801	807	PF00018	0.577
LIG_SH3_3	905	911	PF00018	0.769
LIG_SUMO_SIM_anti_2	504	510	PF11976	0.604
LIG_SUMO_SIM_par_1	135	143	PF11976	0.661
LIG_SUMO_SIM_par_1	306	312	PF11976	0.576
LIG_SUMO_SIM_par_1	552	558	PF11976	0.574
LIG_SxIP_EBH_1	229	241	PF03271	0.574
LIG_TRAF2_1	104	107	PF00917	0.598
LIG_TRAF2_1	109	112	PF00917	0.580
LIG_TRAF2_1	225	228	PF00917	0.579
LIG_TRAF2_1	8	11	PF00917	0.822
LIG_ULM_U2AF65_1	32	37	PF00076	0.598
LIG_WRC_WIRS_1	457	462	PF05994	0.574
LIG_WRC_WIRS_1	556	561	PF05994	0.570
LIG_WW_3	238	242	PF00397	0.560
MOD_CDC14_SPxK_1	238	241	PF00782	0.554
MOD_CDC14_SPxK_1	359	362	PF00782	0.601
MOD_CDK_SPK_2	537	542	PF00069	0.601
MOD_CDK_SPK_2	796	801	PF00069	0.781
MOD_CDK_SPxK_1	235	241	PF00069	0.561
MOD_CDK_SPxK_1	356	362	PF00069	0.594
MOD_CDK_SPxK_1	402	408	PF00069	0.584
MOD_CDK_SPxxK_3	39	46	PF00069	0.827
MOD_CDK_SPxxK_3	89	96	PF00069	0.616
MOD_CK1_1	132	138	PF00069	0.694
MOD_CK1_1	143	149	PF00069	0.720
MOD_CK1_1	156	162	PF00069	0.597
MOD_CK1_1	183	189	PF00069	0.590
MOD_CK1_1	207	213	PF00069	0.703
MOD_CK1_1	222	228	PF00069	0.574
MOD_CK1_1	250	256	PF00069	0.638
MOD_CK1_1	339	345	PF00069	0.570
MOD_CK1_1	409	415	PF00069	0.583
MOD_CK1_1	41	47	PF00069	0.729
MOD_CK1_1	474	480	PF00069	0.616
MOD_CK1_1	510	516	PF00069	0.846
MOD_CK1_1	555	561	PF00069	0.570
MOD_CK1_1	575	581	PF00069	0.572
MOD_CK1_1	608	614	PF00069	0.819
MOD_CK1_1	680	686	PF00069	0.808
MOD_CK1_1	727	733	PF00069	0.734
MOD_CK1_1	743	749	PF00069	0.582
MOD_CK1_1	77	83	PF00069	0.668
MOD_CK1_1	856	862	PF00069	0.740
MOD_CK1_1	869	875	PF00069	0.583
MOD_CK1_1	89	95	PF00069	0.718
MOD_CK2_1	222	228	PF00069	0.573
MOD_CK2_1	409	415	PF00069	0.583
MOD_CK2_1	433	439	PF00069	0.616
MOD_CK2_1	467	473	PF00069	0.595
MOD_CK2_1	5	11	PF00069	0.828
MOD_CK2_1	510	516	PF00069	0.611
MOD_CK2_1	560	566	PF00069	0.567
MOD_CK2_1	595	601	PF00069	0.587
MOD_CK2_1	727	733	PF00069	0.637
MOD_CK2_1	734	740	PF00069	0.618
MOD_CK2_1	858	864	PF00069	0.598
MOD_DYRK1A_RPxSP_1	907	911	PF00069	0.536
MOD_GlcNHglycan	142	145	PF01048	0.654
MOD_GlcNHglycan	185	188	PF01048	0.595
MOD_GlcNHglycan	194	197	PF01048	0.584
MOD_GlcNHglycan	224	227	PF01048	0.690
MOD_GlcNHglycan	233	236	PF01048	0.778
MOD_GlcNHglycan	356	359	PF01048	0.616
MOD_GlcNHglycan	378	381	PF01048	0.818
MOD_GlcNHglycan	408	411	PF01048	0.653
MOD_GlcNHglycan	415	418	PF01048	0.581
MOD_GlcNHglycan	47	50	PF01048	0.752
MOD_GlcNHglycan	475	479	PF01048	0.670
MOD_GlcNHglycan	512	515	PF01048	0.611
MOD_GlcNHglycan	562	565	PF01048	0.566
MOD_GlcNHglycan	578	581	PF01048	0.504
MOD_GlcNHglycan	585	588	PF01048	0.533
MOD_GlcNHglycan	861	864	PF01048	0.604
MOD_GlcNHglycan	868	871	PF01048	0.569
MOD_GlcNHglycan	89	92	PF01048	0.694
MOD_GSK3_1	11	18	PF00069	0.749
MOD_GSK3_1	128	135	PF00069	0.779
MOD_GSK3_1	218	225	PF00069	0.673
MOD_GSK3_1	231	238	PF00069	0.744
MOD_GSK3_1	246	253	PF00069	0.557
MOD_GSK3_1	335	342	PF00069	0.688
MOD_GSK3_1	352	359	PF00069	0.547
MOD_GSK3_1	402	409	PF00069	0.598
MOD_GSK3_1	41	48	PF00069	0.727
MOD_GSK3_1	420	427	PF00069	0.811
MOD_GSK3_1	444	451	PF00069	0.681
MOD_GSK3_1	456	463	PF00069	0.728
MOD_GSK3_1	467	474	PF00069	0.537
MOD_GSK3_1	506	513	PF00069	0.806
MOD_GSK3_1	533	540	PF00069	0.596
MOD_GSK3_1	560	567	PF00069	0.563
MOD_GSK3_1	572	579	PF00069	0.496
MOD_GSK3_1	607	614	PF00069	0.692
MOD_GSK3_1	62	69	PF00069	0.628
MOD_GSK3_1	676	683	PF00069	0.655
MOD_GSK3_1	687	694	PF00069	0.728
MOD_GSK3_1	702	709	PF00069	0.579
MOD_GSK3_1	73	80	PF00069	0.617
MOD_GSK3_1	848	855	PF00069	0.646
MOD_GSK3_1	859	866	PF00069	0.632
MOD_GSK3_1	869	876	PF00069	0.562
MOD_GSK3_1	87	94	PF00069	0.708
MOD_GSK3_1	884	891	PF00069	0.488
MOD_N-GLC_1	251	256	PF02516	0.565
MOD_N-GLC_1	342	347	PF02516	0.667
MOD_N-GLC_1	859	864	PF02516	0.606
MOD_N-GLC_1	87	92	PF02516	0.581
MOD_NEK2_1	128	133	PF00069	0.781
MOD_NEK2_1	248	253	PF00069	0.799
MOD_NEK2_1	424	429	PF00069	0.790
MOD_NEK2_1	45	50	PF00069	0.799
MOD_NEK2_1	460	465	PF00069	0.580
MOD_NEK2_1	560	565	PF00069	0.567
MOD_NEK2_1	583	588	PF00069	0.566
MOD_NEK2_1	589	594	PF00069	0.563
MOD_NEK2_1	66	71	PF00069	0.610
MOD_NEK2_1	678	683	PF00069	0.578
MOD_NEK2_1	702	707	PF00069	0.611
MOD_NEK2_1	836	841	PF00069	0.601
MOD_NEK2_1	853	858	PF00069	0.558
MOD_NEK2_1	884	889	PF00069	0.786
MOD_NEK2_2	456	461	PF00069	0.658
MOD_NEK2_2	564	569	PF00069	0.556
MOD_NEK2_2	590	595	PF00069	0.589
MOD_PIKK_1	207	213	PF00454	0.798
MOD_PIKK_1	241	247	PF00454	0.828
MOD_PIKK_1	611	617	PF00454	0.581
MOD_PIKK_1	722	728	PF00454	0.692
MOD_PIKK_1	74	80	PF00454	0.582
MOD_PKA_1	205	211	PF00069	0.596
MOD_PKA_1	533	539	PF00069	0.596
MOD_PKA_1	621	627	PF00069	0.691
MOD_PKA_1	676	682	PF00069	0.615
MOD_PKA_2	132	138	PF00069	0.581
MOD_PKA_2	204	210	PF00069	0.629
MOD_PKA_2	218	224	PF00069	0.522
MOD_PKA_2	5	11	PF00069	0.587
MOD_PKA_2	50	56	PF00069	0.708
MOD_PKA_2	533	539	PF00069	0.596
MOD_PKA_2	583	589	PF00069	0.569
MOD_PKA_2	676	682	PF00069	0.615
MOD_PKA_2	727	733	PF00069	0.801
MOD_PKA_2	788	794	PF00069	0.613
MOD_PKA_2	86	92	PF00069	0.645
MOD_PKA_2	884	890	PF00069	0.798
MOD_Plk_1	153	159	PF00069	0.814
MOD_Plk_1	251	257	PF00069	0.609
MOD_Plk_1	289	295	PF00069	0.584
MOD_Plk_1	342	348	PF00069	0.575
MOD_Plk_1	492	498	PF00069	0.808
MOD_Plk_2-3	649	655	PF00069	0.724
MOD_Plk_4	134	140	PF00069	0.672
MOD_Plk_4	15	21	PF00069	0.579
MOD_Plk_4	328	334	PF00069	0.577
MOD_Plk_4	415	421	PF00069	0.761
MOD_Plk_4	456	462	PF00069	0.575
MOD_Plk_4	493	499	PF00069	0.828
MOD_Plk_4	62	68	PF00069	0.599
MOD_Plk_4	888	894	PF00069	0.516
MOD_ProDKin_1	105	111	PF00069	0.549
MOD_ProDKin_1	11	17	PF00069	0.778
MOD_ProDKin_1	219	225	PF00069	0.755
MOD_ProDKin_1	235	241	PF00069	0.539
MOD_ProDKin_1	257	263	PF00069	0.576
MOD_ProDKin_1	356	362	PF00069	0.835
MOD_ProDKin_1	39	45	PF00069	0.808
MOD_ProDKin_1	402	408	PF00069	0.689
MOD_ProDKin_1	498	504	PF00069	0.626
MOD_ProDKin_1	507	513	PF00069	0.654
MOD_ProDKin_1	537	543	PF00069	0.596
MOD_ProDKin_1	544	550	PF00069	0.569
MOD_ProDKin_1	605	611	PF00069	0.630
MOD_ProDKin_1	796	802	PF00069	0.712
MOD_ProDKin_1	854	860	PF00069	0.593
MOD_ProDKin_1	870	876	PF00069	0.600
MOD_ProDKin_1	89	95	PF00069	0.700
MOD_ProDKin_1	907	913	PF00069	0.776
MOD_SUMO_rev_2	614	624	PF00179	0.570
MOD_SUMO_rev_2	743	752	PF00179	0.800
TRG_DiLeu_BaEn_1	415	420	PF01217	0.576
TRG_ENDOCYTIC_2	16	19	PF00928	0.613
TRG_ENDOCYTIC_2	344	347	PF00928	0.579
TRG_ENDOCYTIC_2	457	460	PF00928	0.574
TRG_ENDOCYTIC_2	778	781	PF00928	0.611
TRG_ENDOCYTIC_2	831	834	PF00928	0.812
TRG_ER_diArg_1	276	278	PF00400	0.623
TRG_ER_diArg_1	317	320	PF00400	0.803
TRG_ER_diArg_1	34	36	PF00400	0.599
TRG_ER_diArg_1	676	678	PF00400	0.611
TRG_ER_diArg_1	778	780	PF00400	0.671
TRG_ER_diArg_1	788	790	PF00400	0.661
TRG_ER_diArg_1	884	886	PF00400	0.586
TRG_ER_diArg_1	906	909	PF00400	0.540
TRG_NLS_MonoCore_2	31	36	PF00514	0.662
TRG_NLS_MonoExtN_4	32	37	PF00514	0.826
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9B216	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
Q4Q645	Leishmania major	42%	89%