tRNA_lig_CPD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJJ5_LEIBR

TriTrypDb:

LbrM.31.2390 , LBRM2903_310033400

Length:

913

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJJ5

Function

Biological processes
Term	Name	Level	Count
GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	8	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	9	10
GO:0006396	RNA processing	6	10
GO:0006399	tRNA metabolic process	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008033	tRNA processing	8	10
GO:0008152	metabolic process	1	10
GO:0008380	RNA splicing	7	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0034470	ncRNA processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034660	ncRNA metabolic process	6	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0016310	phosphorylation	5	1
GO:0033554	cellular response to stress	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046939	obsolete nucleotide phosphorylation	6	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0003972	RNA ligase (ATP) activity	5	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0008452	RNA ligase activity	4	10
GO:0016874	ligase activity	2	10
GO:0016886	ligase activity, forming phosphoric ester bonds	3	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140098	catalytic activity, acting on RNA	3	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0019205	nucleobase-containing compound kinase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0046403	polynucleotide 3'-phosphatase activity	6	1
GO:0046404	polydeoxyribonucleotide 5'-hydroxyl-kinase activity	7	1
GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	5	1
GO:0051733	polydeoxyribonucleotide kinase activity	6	1
GO:0051734	polynucleotide kinase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.466
CLV_C14_Caspase3-7	302	306	PF00656	0.328
CLV_C14_Caspase3-7	356	360	PF00656	0.680
CLV_C14_Caspase3-7	368	372	PF00656	0.376
CLV_C14_Caspase3-7	531	535	PF00656	0.475
CLV_NRD_NRD_1	147	149	PF00675	0.355
CLV_NRD_NRD_1	413	415	PF00675	0.468
CLV_NRD_NRD_1	49	51	PF00675	0.470
CLV_NRD_NRD_1	504	506	PF00675	0.450
CLV_NRD_NRD_1	52	54	PF00675	0.395
CLV_NRD_NRD_1	601	603	PF00675	0.417
CLV_NRD_NRD_1	694	696	PF00675	0.475
CLV_NRD_NRD_1	728	730	PF00675	0.358
CLV_NRD_NRD_1	73	75	PF00675	0.300
CLV_NRD_NRD_1	870	872	PF00675	0.292
CLV_NRD_NRD_1	894	896	PF00675	0.404
CLV_NRD_NRD_1	91	93	PF00675	0.284
CLV_PCSK_FUR_1	50	54	PF00082	0.420
CLV_PCSK_KEX2_1	188	190	PF00082	0.573
CLV_PCSK_KEX2_1	327	329	PF00082	0.482
CLV_PCSK_KEX2_1	413	415	PF00082	0.466
CLV_PCSK_KEX2_1	49	51	PF00082	0.499
CLV_PCSK_KEX2_1	504	506	PF00082	0.405
CLV_PCSK_KEX2_1	52	54	PF00082	0.688
CLV_PCSK_KEX2_1	694	696	PF00082	0.343
CLV_PCSK_KEX2_1	728	730	PF00082	0.358
CLV_PCSK_KEX2_1	894	896	PF00082	0.358
CLV_PCSK_KEX2_1	91	93	PF00082	0.284
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.573
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.460
CLV_PCSK_PC1ET2_1	894	896	PF00082	0.420
CLV_PCSK_SKI1_1	254	258	PF00082	0.446
CLV_PCSK_SKI1_1	327	331	PF00082	0.510
CLV_PCSK_SKI1_1	504	508	PF00082	0.486
CLV_PCSK_SKI1_1	603	607	PF00082	0.387
CLV_PCSK_SKI1_1	699	703	PF00082	0.370
CLV_PCSK_SKI1_1	91	95	PF00082	0.274
DOC_ANK_TNKS_1	210	217	PF00023	0.402
DOC_CKS1_1	719	724	PF01111	0.288
DOC_CYCLIN_yClb1_LxF_4	315	320	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	82	88	PF00134	0.503
DOC_MAPK_DCC_7	76	86	PF00069	0.281
DOC_MAPK_gen_1	317	325	PF00069	0.266
DOC_MAPK_gen_1	49	59	PF00069	0.399
DOC_MAPK_gen_1	74	81	PF00069	0.527
DOC_MAPK_gen_1	894	900	PF00069	0.358
DOC_MAPK_MEF2A_6	369	377	PF00069	0.465
DOC_MAPK_MEF2A_6	708	717	PF00069	0.446
DOC_PP1_RVXF_1	315	321	PF00149	0.364
DOC_PP2B_LxvP_1	373	376	PF13499	0.418
DOC_PP2B_LxvP_1	82	85	PF13499	0.460
DOC_PP2B_PxIxI_1	863	869	PF00149	0.308
DOC_PP4_FxxP_1	182	185	PF00568	0.451
DOC_PP4_FxxP_1	80	83	PF00568	0.454
DOC_SPAK_OSR1_1	211	215	PF12202	0.331
DOC_SPAK_OSR1_1	92	96	PF12202	0.260
DOC_USP7_MATH_1	196	200	PF00917	0.649
DOC_USP7_MATH_1	532	536	PF00917	0.537
DOC_USP7_MATH_2	550	556	PF00917	0.390
DOC_USP7_UBL2_3	149	153	PF12436	0.466
DOC_USP7_UBL2_3	327	331	PF12436	0.310
DOC_USP7_UBL2_3	614	618	PF12436	0.362
DOC_WW_Pin1_4	128	133	PF00397	0.492
DOC_WW_Pin1_4	22	27	PF00397	0.751
DOC_WW_Pin1_4	272	277	PF00397	0.554
DOC_WW_Pin1_4	304	309	PF00397	0.365
DOC_WW_Pin1_4	399	404	PF00397	0.547
DOC_WW_Pin1_4	5	10	PF00397	0.527
DOC_WW_Pin1_4	504	509	PF00397	0.560
DOC_WW_Pin1_4	718	723	PF00397	0.529
DOC_WW_Pin1_4	881	886	PF00397	0.360
LIG_14-3-3_CanoR_1	242	249	PF00244	0.440
LIG_14-3-3_CanoR_1	413	417	PF00244	0.354
LIG_14-3-3_CanoR_1	434	443	PF00244	0.361
LIG_14-3-3_CanoR_1	52	58	PF00244	0.526
LIG_14-3-3_CanoR_1	521	526	PF00244	0.330
LIG_14-3-3_CanoR_1	786	791	PF00244	0.324
LIG_APCC_ABBA_1	848	853	PF00400	0.203
LIG_BIR_III_4	427	431	PF00653	0.512
LIG_BRCT_BRCA1_1	208	212	PF00533	0.450
LIG_BRCT_BRCA1_1	906	910	PF00533	0.317
LIG_CtBP_PxDLS_1	475	479	PF00389	0.331
LIG_CtBP_PxDLS_1	641	645	PF00389	0.457
LIG_CtBP_PxDLS_1	710	714	PF00389	0.415
LIG_deltaCOP1_diTrp_1	293	299	PF00928	0.254
LIG_deltaCOP1_diTrp_1	484	492	PF00928	0.377
LIG_FHA_1	501	507	PF00498	0.443
LIG_FHA_1	555	561	PF00498	0.546
LIG_FHA_1	618	624	PF00498	0.417
LIG_FHA_1	718	724	PF00498	0.421
LIG_FHA_1	831	837	PF00498	0.465
LIG_FHA_2	190	196	PF00498	0.484
LIG_FHA_2	300	306	PF00498	0.538
LIG_FHA_2	457	463	PF00498	0.307
LIG_FHA_2	529	535	PF00498	0.466
LIG_FHA_2	744	750	PF00498	0.463
LIG_LIR_Apic_2	154	160	PF02991	0.476
LIG_LIR_Apic_2	180	185	PF02991	0.423
LIG_LIR_Apic_2	397	403	PF02991	0.465
LIG_LIR_Apic_2	645	651	PF02991	0.375
LIG_LIR_Apic_2	78	83	PF02991	0.273
LIG_LIR_Gen_1	113	123	PF02991	0.442
LIG_LIR_Gen_1	135	144	PF02991	0.438
LIG_LIR_Gen_1	381	391	PF02991	0.271
LIG_LIR_Gen_1	402	412	PF02991	0.301
LIG_LIR_Gen_1	520	529	PF02991	0.459
LIG_LIR_Gen_1	636	644	PF02991	0.405
LIG_LIR_Gen_1	757	768	PF02991	0.325
LIG_LIR_Nem_3	113	118	PF02991	0.456
LIG_LIR_Nem_3	135	141	PF02991	0.462
LIG_LIR_Nem_3	209	215	PF02991	0.366
LIG_LIR_Nem_3	381	387	PF02991	0.284
LIG_LIR_Nem_3	402	408	PF02991	0.366
LIG_LIR_Nem_3	520	525	PF02991	0.497
LIG_LIR_Nem_3	636	640	PF02991	0.401
LIG_LIR_Nem_3	757	763	PF02991	0.313
LIG_LIR_Nem_3	809	815	PF02991	0.295
LIG_MYND_1	276	280	PF01753	0.351
LIG_MYND_1	679	683	PF01753	0.448
LIG_NRBOX	462	468	PF00104	0.309
LIG_NRBOX	579	585	PF00104	0.347
LIG_NRBOX	823	829	PF00104	0.470
LIG_Pex14_1	295	299	PF04695	0.437
LIG_Pex14_1	492	496	PF04695	0.429
LIG_Pex14_2	299	303	PF04695	0.467
LIG_SH2_CRK	138	142	PF00017	0.584
LIG_SH2_CRK	236	240	PF00017	0.465
LIG_SH2_CRK	384	388	PF00017	0.418
LIG_SH2_CRK	581	585	PF00017	0.270
LIG_SH2_CRK	637	641	PF00017	0.516
LIG_SH2_CRK	773	777	PF00017	0.328
LIG_SH2_GRB2like	637	640	PF00017	0.520
LIG_SH2_GRB2like	878	881	PF00017	0.284
LIG_SH2_NCK_1	138	142	PF00017	0.582
LIG_SH2_NCK_1	384	388	PF00017	0.384
LIG_SH2_NCK_1	400	404	PF00017	0.575
LIG_SH2_NCK_1	773	777	PF00017	0.352
LIG_SH2_PTP2	405	408	PF00017	0.298
LIG_SH2_STAP1	243	247	PF00017	0.421
LIG_SH2_STAP1	321	325	PF00017	0.526
LIG_SH2_STAP1	760	764	PF00017	0.356
LIG_SH2_STAP1	878	882	PF00017	0.284
LIG_SH2_STAT3	367	370	PF00017	0.426
LIG_SH2_STAT5	126	129	PF00017	0.530
LIG_SH2_STAT5	138	141	PF00017	0.328
LIG_SH2_STAT5	405	408	PF00017	0.537
LIG_SH2_STAT5	443	446	PF00017	0.315
LIG_SH2_STAT5	481	484	PF00017	0.341
LIG_SH2_STAT5	811	814	PF00017	0.466
LIG_SH3_2	889	894	PF14604	0.360
LIG_SH3_3	384	390	PF00018	0.327
LIG_SH3_3	704	710	PF00018	0.553
LIG_SH3_3	765	771	PF00018	0.519
LIG_SH3_3	812	818	PF00018	0.280
LIG_SH3_3	837	843	PF00018	0.330
LIG_SH3_3	886	892	PF00018	0.358
LIG_SH3_3	895	901	PF00018	0.272
LIG_SUFU_1	175	182	PF12470	0.245
LIG_SUMO_SIM_anti_2	559	564	PF11976	0.439
LIG_SUMO_SIM_par_1	640	645	PF11976	0.468
LIG_SUMO_SIM_par_1	712	718	PF11976	0.455
LIG_SUMO_SIM_par_1	831	838	PF11976	0.416
LIG_TRAF2_1	353	356	PF00917	0.532
LIG_TRAF2_1	682	685	PF00917	0.578
LIG_TYR_ITIM	136	141	PF00017	0.301
LIG_WRC_WIRS_1	2	7	PF05994	0.517
LIG_WRC_WIRS_1	760	765	PF05994	0.392
LIG_WW_1	875	878	PF00397	0.400
MOD_CK1_1	25	31	PF00069	0.743
MOD_CK1_1	265	271	PF00069	0.532
MOD_CK1_1	304	310	PF00069	0.396
MOD_CK1_1	415	421	PF00069	0.398
MOD_CK1_1	617	623	PF00069	0.502
MOD_CK2_1	294	300	PF00069	0.404
MOD_CK2_1	350	356	PF00069	0.724
MOD_CK2_1	398	404	PF00069	0.492
MOD_CK2_1	456	462	PF00069	0.321
MOD_CK2_1	538	544	PF00069	0.456
MOD_GlcNHglycan	100	103	PF01048	0.491
MOD_GlcNHglycan	179	182	PF01048	0.394
MOD_GlcNHglycan	264	267	PF01048	0.558
MOD_GlcNHglycan	27	30	PF01048	0.587
MOD_GlcNHglycan	311	315	PF01048	0.535
MOD_GlcNHglycan	340	343	PF01048	0.628
MOD_GlcNHglycan	37	40	PF01048	0.585
MOD_GlcNHglycan	554	557	PF01048	0.621
MOD_GlcNHglycan	906	909	PF01048	0.273
MOD_GSK3_1	1	8	PF00069	0.675
MOD_GSK3_1	128	135	PF00069	0.501
MOD_GSK3_1	25	32	PF00069	0.758
MOD_GSK3_1	261	268	PF00069	0.554
MOD_GSK3_1	272	279	PF00069	0.646
MOD_GSK3_1	299	306	PF00069	0.411
MOD_GSK3_1	350	357	PF00069	0.567
MOD_GSK3_1	389	396	PF00069	0.354
MOD_GSK3_1	408	415	PF00069	0.541
MOD_GSK3_1	500	507	PF00069	0.399
MOD_GSK3_1	517	524	PF00069	0.407
MOD_GSK3_1	528	535	PF00069	0.523
MOD_GSK3_1	640	647	PF00069	0.500
MOD_GSK3_1	667	674	PF00069	0.360
MOD_GSK3_1	828	835	PF00069	0.312
MOD_GSK3_1	96	103	PF00069	0.300
MOD_N-GLC_1	132	137	PF02516	0.536
MOD_N-GLC_1	902	907	PF02516	0.446
MOD_NEK2_1	1	6	PF00069	0.733
MOD_NEK2_1	294	299	PF00069	0.344
MOD_NEK2_1	303	308	PF00069	0.356
MOD_NEK2_1	310	315	PF00069	0.424
MOD_NEK2_1	383	388	PF00069	0.371
MOD_NEK2_1	408	413	PF00069	0.324
MOD_NEK2_1	500	505	PF00069	0.397
MOD_NEK2_1	565	570	PF00069	0.474
MOD_NEK2_1	605	610	PF00069	0.492
MOD_NEK2_1	63	68	PF00069	0.546
MOD_NEK2_1	642	647	PF00069	0.450
MOD_NEK2_1	717	722	PF00069	0.477
MOD_NEK2_1	805	810	PF00069	0.331
MOD_NEK2_1	828	833	PF00069	0.404
MOD_NEK2_2	667	672	PF00069	0.469
MOD_PIKK_1	106	112	PF00454	0.354
MOD_PIKK_1	554	560	PF00454	0.528
MOD_PIKK_1	565	571	PF00454	0.237
MOD_PIKK_1	68	74	PF00454	0.316
MOD_PK_1	786	792	PF00069	0.359
MOD_PKA_1	75	81	PF00069	0.263
MOD_PKA_2	241	247	PF00069	0.407
MOD_PKA_2	35	41	PF00069	0.737
MOD_PKA_2	412	418	PF00069	0.347
MOD_PKA_2	446	452	PF00069	0.437
MOD_PKA_2	667	673	PF00069	0.390
MOD_PKB_1	519	527	PF00069	0.382
MOD_Plk_1	153	159	PF00069	0.485
MOD_Plk_1	190	196	PF00069	0.460
MOD_Plk_1	299	305	PF00069	0.298
MOD_Plk_1	902	908	PF00069	0.477
MOD_Plk_1	96	102	PF00069	0.381
MOD_Plk_4	136	142	PF00069	0.449
MOD_Plk_4	162	168	PF00069	0.412
MOD_Plk_4	394	400	PF00069	0.390
MOD_Plk_4	644	650	PF00069	0.412
MOD_Plk_4	75	81	PF00069	0.283
MOD_Plk_4	759	765	PF00069	0.310
MOD_Plk_4	786	792	PF00069	0.310
MOD_Plk_4	835	841	PF00069	0.350
MOD_Plk_4	846	852	PF00069	0.359
MOD_ProDKin_1	128	134	PF00069	0.497
MOD_ProDKin_1	22	28	PF00069	0.751
MOD_ProDKin_1	272	278	PF00069	0.537
MOD_ProDKin_1	304	310	PF00069	0.363
MOD_ProDKin_1	399	405	PF00069	0.541
MOD_ProDKin_1	5	11	PF00069	0.529
MOD_ProDKin_1	504	510	PF00069	0.557
MOD_ProDKin_1	718	724	PF00069	0.528
MOD_ProDKin_1	881	887	PF00069	0.360
MOD_SUMO_rev_2	534	539	PF00179	0.541
MOD_SUMO_rev_2	597	605	PF00179	0.398
TRG_DiLeu_BaEn_1	404	409	PF01217	0.322
TRG_DiLeu_BaEn_1	462	467	PF01217	0.306
TRG_DiLeu_BaLyEn_6	783	788	PF01217	0.273
TRG_ENDOCYTIC_2	138	141	PF00928	0.434
TRG_ENDOCYTIC_2	236	239	PF00928	0.464
TRG_ENDOCYTIC_2	384	387	PF00928	0.347
TRG_ENDOCYTIC_2	405	408	PF00928	0.305
TRG_ENDOCYTIC_2	581	584	PF00928	0.375
TRG_ENDOCYTIC_2	637	640	PF00928	0.455
TRG_ENDOCYTIC_2	760	763	PF00928	0.315
TRG_ENDOCYTIC_2	773	776	PF00928	0.408
TRG_ER_diArg_1	412	414	PF00400	0.491
TRG_ER_diArg_1	48	50	PF00400	0.499
TRG_ER_diArg_1	504	506	PF00400	0.428
TRG_ER_diArg_1	519	522	PF00400	0.313
TRG_ER_diArg_1	52	55	PF00400	0.396
TRG_ER_diArg_1	693	695	PF00400	0.353
TRG_ER_diArg_1	727	729	PF00400	0.355
TRG_ER_diArg_1	91	93	PF00400	0.530
TRG_NES_CRM1_1	823	837	PF08389	0.293
TRG_NLS_MonoExtN_4	892	898	PF00514	0.360
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.286
TRG_Pf-PMV_PEXEL_1	673	678	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	728	732	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	92	97	PF00026	0.259

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S2	Leptomonas seymouri	60%	100%
A0A0S4J4W5	Bodo saltans	33%	100%
A0A1X0NHZ8	Trypanosomatidae	34%	100%
A0A3R7M5Z2	Trypanosoma rangeli	36%	100%
A0A3S7X4Q3	Leishmania donovani	70%	98%
A4I6Z2	Leishmania infantum	70%	98%
E9B213	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	98%
Q4Q648	Leishmania major	70%	100%