Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJJ4_LEIBR

TriTrypDb:

LbrM.31.2380 , LBRM2903_310033300

Length:

774

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJJ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	390	394	PF00656	0.540
CLV_C14_Caspase3-7	522	526	PF00656	0.553
CLV_C14_Caspase3-7	90	94	PF00656	0.705
CLV_NRD_NRD_1	357	359	PF00675	0.593
CLV_NRD_NRD_1	398	400	PF00675	0.633
CLV_NRD_NRD_1	413	415	PF00675	0.559
CLV_NRD_NRD_1	571	573	PF00675	0.532
CLV_NRD_NRD_1	582	584	PF00675	0.524
CLV_NRD_NRD_1	727	729	PF00675	0.492
CLV_NRD_NRD_1	751	753	PF00675	0.571
CLV_NRD_NRD_1	767	769	PF00675	0.564
CLV_PCSK_FUR_1	29	33	PF00082	0.701
CLV_PCSK_FUR_1	355	359	PF00082	0.588
CLV_PCSK_KEX2_1	31	33	PF00082	0.687
CLV_PCSK_KEX2_1	357	359	PF00082	0.586
CLV_PCSK_KEX2_1	413	415	PF00082	0.596
CLV_PCSK_KEX2_1	582	584	PF00082	0.554
CLV_PCSK_KEX2_1	687	689	PF00082	0.650
CLV_PCSK_KEX2_1	727	729	PF00082	0.492
CLV_PCSK_KEX2_1	751	753	PF00082	0.565
CLV_PCSK_KEX2_1	767	769	PF00082	0.507
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.703
CLV_PCSK_PC1ET2_1	687	689	PF00082	0.650
CLV_PCSK_SKI1_1	210	214	PF00082	0.507
CLV_PCSK_SKI1_1	236	240	PF00082	0.559
CLV_PCSK_SKI1_1	251	255	PF00082	0.530
CLV_PCSK_SKI1_1	60	64	PF00082	0.568
DEG_SCF_FBW7_1	137	143	PF00400	0.720
DEG_SCF_FBW7_2	307	312	PF00400	0.537
DEG_SPOP_SBC_1	10	14	PF00917	0.473
DEG_SPOP_SBC_1	456	460	PF00917	0.573
DOC_CDC14_PxL_1	123	131	PF14671	0.670
DOC_CKS1_1	137	142	PF01111	0.720
DOC_CKS1_1	533	538	PF01111	0.709
DOC_CKS1_1	85	90	PF01111	0.550
DOC_MAPK_gen_1	582	589	PF00069	0.562
DOC_MAPK_gen_1	75	84	PF00069	0.725
DOC_MAPK_MEF2A_6	600	607	PF00069	0.554
DOC_MAPK_MEF2A_6	75	84	PF00069	0.564
DOC_PP1_RVXF_1	729	736	PF00149	0.470
DOC_PP1_SILK_1	113	118	PF00149	0.692
DOC_PP2B_LxvP_1	190	193	PF13499	0.541
DOC_PP2B_LxvP_1	230	233	PF13499	0.605
DOC_PP2B_LxvP_1	254	257	PF13499	0.558
DOC_PP2B_LxvP_1	273	276	PF13499	0.511
DOC_PP2B_LxvP_1	682	685	PF13499	0.574
DOC_PP4_FxxP_1	24	27	PF00568	0.526
DOC_PP4_MxPP_1	714	717	PF00568	0.545
DOC_USP7_MATH_1	125	129	PF00917	0.554
DOC_USP7_MATH_1	154	158	PF00917	0.714
DOC_USP7_MATH_1	200	204	PF00917	0.523
DOC_USP7_MATH_1	43	47	PF00917	0.632
DOC_USP7_MATH_1	507	511	PF00917	0.555
DOC_USP7_MATH_1	51	55	PF00917	0.631
DOC_USP7_MATH_1	574	578	PF00917	0.654
DOC_USP7_MATH_1	64	68	PF00917	0.562
DOC_USP7_MATH_1	753	757	PF00917	0.652
DOC_WW_Pin1_4	133	138	PF00397	0.694
DOC_WW_Pin1_4	140	145	PF00397	0.657
DOC_WW_Pin1_4	242	247	PF00397	0.625
DOC_WW_Pin1_4	257	262	PF00397	0.642
DOC_WW_Pin1_4	305	310	PF00397	0.601
DOC_WW_Pin1_4	41	46	PF00397	0.639
DOC_WW_Pin1_4	448	453	PF00397	0.695
DOC_WW_Pin1_4	457	462	PF00397	0.736
DOC_WW_Pin1_4	470	475	PF00397	0.584
DOC_WW_Pin1_4	496	501	PF00397	0.763
DOC_WW_Pin1_4	509	514	PF00397	0.621
DOC_WW_Pin1_4	532	537	PF00397	0.698
DOC_WW_Pin1_4	626	631	PF00397	0.643
DOC_WW_Pin1_4	634	639	PF00397	0.573
DOC_WW_Pin1_4	640	645	PF00397	0.528
DOC_WW_Pin1_4	687	692	PF00397	0.798
DOC_WW_Pin1_4	84	89	PF00397	0.556
LIG_14-3-3_CanoR_1	117	123	PF00244	0.618
LIG_14-3-3_CanoR_1	210	217	PF00244	0.496
LIG_14-3-3_CanoR_1	320	328	PF00244	0.542
LIG_14-3-3_CanoR_1	413	417	PF00244	0.571
LIG_14-3-3_CanoR_1	447	452	PF00244	0.542
LIG_14-3-3_CanoR_1	490	494	PF00244	0.551
LIG_14-3-3_CanoR_1	537	542	PF00244	0.566
LIG_14-3-3_CanoR_1	555	559	PF00244	0.628
LIG_14-3-3_CanoR_1	656	660	PF00244	0.697
LIG_14-3-3_CanoR_1	705	713	PF00244	0.669
LIG_14-3-3_CanoR_1	737	741	PF00244	0.493
LIG_Actin_WH2_2	102	119	PF00022	0.692
LIG_BRCT_BRCA1_1	617	621	PF00533	0.639
LIG_BRCT_BRCA1_1	80	84	PF00533	0.723
LIG_Clathr_ClatBox_1	129	133	PF01394	0.672
LIG_EVH1_2	20	24	PF00568	0.492
LIG_FHA_1	100	106	PF00498	0.555
LIG_FHA_1	306	312	PF00498	0.538
LIG_FHA_1	313	319	PF00498	0.532
LIG_FHA_1	374	380	PF00498	0.541
LIG_FHA_1	387	393	PF00498	0.506
LIG_FHA_1	457	463	PF00498	0.601
LIG_FHA_1	536	542	PF00498	0.714
LIG_FHA_1	635	641	PF00498	0.686
LIG_FHA_1	739	745	PF00498	0.478
LIG_FHA_1	760	766	PF00498	0.545
LIG_FHA_2	211	217	PF00498	0.492
LIG_FHA_2	346	352	PF00498	0.588
LIG_FHA_2	592	598	PF00498	0.517
LIG_FHA_2	604	610	PF00498	0.578
LIG_FHA_2	85	91	PF00498	0.550
LIG_LIR_Apic_2	131	137	PF02991	0.685
LIG_LIR_Apic_2	529	533	PF02991	0.703
LIG_LIR_Gen_1	294	301	PF02991	0.520
LIG_LIR_Gen_1	525	536	PF02991	0.697
LIG_LIR_Nem_3	294	300	PF02991	0.611
LIG_LIR_Nem_3	440	445	PF02991	0.521
LIG_LIR_Nem_3	525	531	PF02991	0.677
LIG_NRBOX	728	734	PF00104	0.475
LIG_PCNA_PIPBox_1	435	444	PF02747	0.511
LIG_Pex14_2	589	593	PF04695	0.531
LIG_Rb_pABgroove_1	124	132	PF01858	0.669
LIG_REV1ctd_RIR_1	441	451	PF16727	0.533
LIG_SH2_CRK	297	301	PF00017	0.637
LIG_SH2_CRK	7	11	PF00017	0.634
LIG_SH2_GRB2like	530	533	PF00017	0.692
LIG_SH2_PTP2	530	533	PF00017	0.717
LIG_SH2_SRC	465	468	PF00017	0.620
LIG_SH2_SRC	528	531	PF00017	0.724
LIG_SH2_SRC	7	10	PF00017	0.634
LIG_SH2_STAP1	297	301	PF00017	0.531
LIG_SH2_STAP1	504	508	PF00017	0.569
LIG_SH2_STAT3	445	448	PF00017	0.703
LIG_SH2_STAT5	301	304	PF00017	0.544
LIG_SH2_STAT5	384	387	PF00017	0.657
LIG_SH2_STAT5	442	445	PF00017	0.689
LIG_SH2_STAT5	530	533	PF00017	0.717
LIG_SH2_STAT5	764	767	PF00017	0.645
LIG_SH3_1	134	140	PF00018	0.701
LIG_SH3_1	141	147	PF00018	0.658
LIG_SH3_1	530	536	PF00018	0.710
LIG_SH3_1	686	692	PF00018	0.583
LIG_SH3_3	134	140	PF00018	0.701
LIG_SH3_3	141	147	PF00018	0.658
LIG_SH3_3	175	181	PF00018	0.553
LIG_SH3_3	269	275	PF00018	0.586
LIG_SH3_3	290	296	PF00018	0.510
LIG_SH3_3	42	48	PF00018	0.658
LIG_SH3_3	530	536	PF00018	0.699
LIG_SH3_3	673	679	PF00018	0.568
LIG_SH3_3	686	692	PF00018	0.858
LIG_SH3_3	713	719	PF00018	0.708
LIG_SH3_3	95	101	PF00018	0.572
LIG_SUMO_SIM_anti_2	538	547	PF11976	0.609
LIG_TRAF2_1	348	351	PF00917	0.592
LIG_TRAF2_1	366	369	PF00917	0.512
LIG_WW_2	48	51	PF00397	0.580
LIG_WW_3	344	348	PF00397	0.715
MOD_CDK_SPK_2	136	141	PF00069	0.712
MOD_CDK_SPK_2	532	537	PF00069	0.548
MOD_CDK_SPK_2	640	645	PF00069	0.544
MOD_CK1_1	136	142	PF00069	0.716
MOD_CK1_1	157	163	PF00069	0.705
MOD_CK1_1	191	197	PF00069	0.600
MOD_CK1_1	353	359	PF00069	0.606
MOD_CK1_1	373	379	PF00069	0.625
MOD_CK1_1	387	393	PF00069	0.585
MOD_CK1_1	412	418	PF00069	0.569
MOD_CK1_1	489	495	PF00069	0.645
MOD_CK1_1	520	526	PF00069	0.576
MOD_CK1_1	54	60	PF00069	0.661
MOD_CK1_1	554	560	PF00069	0.634
MOD_CK1_1	577	583	PF00069	0.502
MOD_CK1_1	610	616	PF00069	0.734
MOD_CK1_1	624	630	PF00069	0.661
MOD_CK1_1	65	71	PF00069	0.608
MOD_CK1_1	658	664	PF00069	0.575
MOD_CK1_1	73	79	PF00069	0.584
MOD_CK2_1	140	146	PF00069	0.731
MOD_CK2_1	155	161	PF00069	0.568
MOD_CK2_1	278	284	PF00069	0.542
MOD_CK2_1	345	351	PF00069	0.582
MOD_CK2_1	554	560	PF00069	0.536
MOD_CK2_1	591	597	PF00069	0.531
MOD_CK2_1	603	609	PF00069	0.578
MOD_CK2_1	647	653	PF00069	0.558
MOD_CK2_1	705	711	PF00069	0.723
MOD_GlcNHglycan	13	16	PF01048	0.486
MOD_GlcNHglycan	161	166	PF01048	0.679
MOD_GlcNHglycan	254	257	PF01048	0.594
MOD_GlcNHglycan	280	283	PF01048	0.672
MOD_GlcNHglycan	288	291	PF01048	0.569
MOD_GlcNHglycan	297	300	PF01048	0.498
MOD_GlcNHglycan	482	486	PF01048	0.726
MOD_GlcNHglycan	504	507	PF01048	0.569
MOD_GlcNHglycan	509	512	PF01048	0.534
MOD_GlcNHglycan	682	685	PF01048	0.640
MOD_GlcNHglycan	755	759	PF01048	0.666
MOD_GSK3_1	111	118	PF00069	0.531
MOD_GSK3_1	136	143	PF00069	0.717
MOD_GSK3_1	157	164	PF00069	0.677
MOD_GSK3_1	295	302	PF00069	0.597
MOD_GSK3_1	312	319	PF00069	0.524
MOD_GSK3_1	331	338	PF00069	0.527
MOD_GSK3_1	370	377	PF00069	0.685
MOD_GSK3_1	380	387	PF00069	0.580
MOD_GSK3_1	405	412	PF00069	0.727
MOD_GSK3_1	49	56	PF00069	0.640
MOD_GSK3_1	494	501	PF00069	0.763
MOD_GSK3_1	517	524	PF00069	0.678
MOD_GSK3_1	531	538	PF00069	0.688
MOD_GSK3_1	603	610	PF00069	0.600
MOD_GSK3_1	62	69	PF00069	0.617
MOD_GSK3_1	624	631	PF00069	0.725
MOD_GSK3_1	636	643	PF00069	0.585
MOD_GSK3_1	654	661	PF00069	0.526
MOD_GSK3_1	71	78	PF00069	0.629
MOD_GSK3_1	9	16	PF00069	0.474
MOD_N-GLC_1	351	356	PF02516	0.583
MOD_N-GLC_1	456	461	PF02516	0.565
MOD_N-GLC_1	470	475	PF02516	0.618
MOD_NEK2_1	116	121	PF00069	0.620
MOD_NEK2_1	286	291	PF00069	0.543
MOD_NEK2_1	300	305	PF00069	0.532
MOD_NEK2_1	481	486	PF00069	0.710
MOD_NEK2_1	494	499	PF00069	0.565
MOD_NEK2_1	607	612	PF00069	0.549
MOD_NEK2_1	621	626	PF00069	0.506
MOD_NEK2_1	655	660	PF00069	0.714
MOD_NEK2_2	759	764	PF00069	0.618
MOD_PIKK_1	13	19	PF00454	0.472
MOD_PIKK_1	155	161	PF00454	0.728
MOD_PIKK_1	320	326	PF00454	0.679
MOD_PIKK_1	332	338	PF00454	0.585
MOD_PIKK_1	377	383	PF00454	0.605
MOD_PIKK_1	43	49	PF00454	0.579
MOD_PK_1	179	185	PF00069	0.545
MOD_PK_1	705	711	PF00069	0.673
MOD_PKA_2	116	122	PF00069	0.619
MOD_PKA_2	373	379	PF00069	0.545
MOD_PKA_2	412	418	PF00069	0.569
MOD_PKA_2	446	452	PF00069	0.540
MOD_PKA_2	489	495	PF00069	0.549
MOD_PKA_2	520	526	PF00069	0.548
MOD_PKA_2	554	560	PF00069	0.674
MOD_PKA_2	574	580	PF00069	0.455
MOD_PKA_2	644	650	PF00069	0.583
MOD_PKA_2	655	661	PF00069	0.624
MOD_PKA_2	704	710	PF00069	0.678
MOD_PKA_2	71	77	PF00069	0.635
MOD_PKA_2	736	742	PF00069	0.497
MOD_PKA_2	753	759	PF00069	0.657
MOD_PKB_1	177	185	PF00069	0.546
MOD_PKB_1	752	760	PF00069	0.557
MOD_Plk_1	481	487	PF00069	0.755
MOD_Plk_1	494	500	PF00069	0.575
MOD_Plk_1	543	549	PF00069	0.597
MOD_Plk_1	608	614	PF00069	0.701
MOD_Plk_1	621	627	PF00069	0.549
MOD_Plk_2-3	434	440	PF00069	0.507
MOD_Plk_4	111	117	PF00069	0.696
MOD_Plk_4	118	124	PF00069	0.604
MOD_Plk_4	125	131	PF00069	0.520
MOD_Plk_4	268	274	PF00069	0.627
MOD_Plk_4	434	440	PF00069	0.527
MOD_Plk_4	489	495	PF00069	0.590
MOD_Plk_4	537	543	PF00069	0.763
MOD_Plk_4	554	560	PF00069	0.597
MOD_Plk_4	603	609	PF00069	0.553
MOD_Plk_4	621	627	PF00069	0.496
MOD_Plk_4	655	661	PF00069	0.551
MOD_Plk_4	759	765	PF00069	0.546
MOD_ProDKin_1	133	139	PF00069	0.697
MOD_ProDKin_1	140	146	PF00069	0.657
MOD_ProDKin_1	242	248	PF00069	0.625
MOD_ProDKin_1	257	263	PF00069	0.643
MOD_ProDKin_1	305	311	PF00069	0.601
MOD_ProDKin_1	41	47	PF00069	0.640
MOD_ProDKin_1	448	454	PF00069	0.699
MOD_ProDKin_1	457	463	PF00069	0.735
MOD_ProDKin_1	470	476	PF00069	0.581
MOD_ProDKin_1	496	502	PF00069	0.765
MOD_ProDKin_1	509	515	PF00069	0.625
MOD_ProDKin_1	532	538	PF00069	0.698
MOD_ProDKin_1	626	632	PF00069	0.642
MOD_ProDKin_1	634	640	PF00069	0.574
MOD_ProDKin_1	687	693	PF00069	0.797
MOD_ProDKin_1	84	90	PF00069	0.553
MOD_SUMO_rev_2	157	165	PF00179	0.634
MOD_SUMO_rev_2	368	373	PF00179	0.714
TRG_DiLeu_BaLyEn_6	728	733	PF01217	0.518
TRG_ENDOCYTIC_2	297	300	PF00928	0.642
TRG_ENDOCYTIC_2	528	531	PF00928	0.724
TRG_ER_diArg_1	177	180	PF00400	0.551
TRG_ER_diArg_1	355	358	PF00400	0.592
TRG_ER_diArg_1	581	583	PF00400	0.596
TRG_ER_diArg_1	727	729	PF00400	0.492
TRG_ER_diArg_1	751	754	PF00400	0.564
TRG_ER_diArg_1	767	769	PF00400	0.507
TRG_ER_diLys_1	770	774	PF00400	0.641
TRG_NLS_MonoExtN_4	569	576	PF00514	0.527
TRG_NLS_MonoExtN_4	685	690	PF00514	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEZ8	Leishmania donovani	53%	100%
A4I6Z1	Leishmania infantum	53%	100%
E9B212	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
Q4Q649	Leishmania major	49%	99%