HMG box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJJ2_LEIBR

TriTrypDb:

LbrM.31.2360 , LBRM2903_310033100

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJJ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.565
CLV_NRD_NRD_1	11	13	PF00675	0.497
CLV_NRD_NRD_1	272	274	PF00675	0.660
CLV_NRD_NRD_1	387	389	PF00675	0.577
CLV_PCSK_KEX2_1	11	13	PF00082	0.497
CLV_PCSK_KEX2_1	314	316	PF00082	0.593
CLV_PCSK_KEX2_1	348	350	PF00082	0.625
CLV_PCSK_KEX2_1	387	389	PF00082	0.686
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.593
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.619
CLV_PCSK_SKI1_1	111	115	PF00082	0.574
CLV_PCSK_SKI1_1	237	241	PF00082	0.612
CLV_PCSK_SKI1_1	252	256	PF00082	0.820
DEG_Nend_Nbox_1	1	3	PF02207	0.618
DEG_SPOP_SBC_1	127	131	PF00917	0.586
DOC_CKS1_1	139	144	PF01111	0.541
DOC_PP4_FxxP_1	330	333	PF00568	0.576
DOC_USP7_MATH_1	116	120	PF00917	0.583
DOC_USP7_MATH_1	172	176	PF00917	0.572
DOC_USP7_MATH_1	214	218	PF00917	0.719
DOC_USP7_MATH_1	224	228	PF00917	0.671
DOC_USP7_MATH_1	230	234	PF00917	0.610
DOC_USP7_MATH_1	263	267	PF00917	0.578
DOC_USP7_MATH_1	340	344	PF00917	0.583
DOC_USP7_MATH_1	79	83	PF00917	0.693
DOC_WW_Pin1_4	138	143	PF00397	0.686
DOC_WW_Pin1_4	149	154	PF00397	0.623
DOC_WW_Pin1_4	252	257	PF00397	0.718
DOC_WW_Pin1_4	259	264	PF00397	0.763
DOC_WW_Pin1_4	265	270	PF00397	0.607
DOC_WW_Pin1_4	338	343	PF00397	0.609
DOC_WW_Pin1_4	360	365	PF00397	0.765
DOC_WW_Pin1_4	62	67	PF00397	0.717
DOC_WW_Pin1_4	88	93	PF00397	0.761
DOC_WW_Pin1_4	95	100	PF00397	0.656
LIG_14-3-3_CanoR_1	273	278	PF00244	0.688
LIG_14-3-3_CanoR_1	349	354	PF00244	0.792
LIG_14-3-3_CanoR_1	86	92	PF00244	0.567
LIG_BRCT_BRCA1_1	317	321	PF00533	0.505
LIG_EH1_1	22	30	PF00400	0.529
LIG_FHA_1	164	170	PF00498	0.569
LIG_FHA_1	253	259	PF00498	0.796
LIG_FHA_1	73	79	PF00498	0.689
LIG_FHA_1	89	95	PF00498	0.609
LIG_FHA_2	238	244	PF00498	0.566
LIG_LIR_Apic_2	218	224	PF02991	0.779
LIG_LIR_Apic_2	329	333	PF02991	0.570
LIG_LIR_Apic_2	350	356	PF02991	0.558
LIG_LIR_Apic_2	60	66	PF02991	0.725
LIG_LIR_Gen_1	155	161	PF02991	0.528
LIG_SH2_CRK	353	357	PF00017	0.558
LIG_SH2_NCK_1	190	194	PF00017	0.752
LIG_SH2_NCK_1	221	225	PF00017	0.555
LIG_SH2_SRC	190	193	PF00017	0.755
LIG_SH2_STAT3	15	18	PF00017	0.722
LIG_SH2_STAT5	148	151	PF00017	0.543
LIG_SH3_3	136	142	PF00018	0.737
LIG_SH3_3	358	364	PF00018	0.766
LIG_SH3_3	53	59	PF00018	0.603
LIG_TRAF2_1	171	174	PF00917	0.577
LIG_TRAF2_1	334	337	PF00917	0.571
MOD_CDK_SPxxK_3	95	102	PF00069	0.564
MOD_CK1_1	107	113	PF00069	0.619
MOD_CK1_1	247	253	PF00069	0.626
MOD_CK1_1	262	268	PF00069	0.749
MOD_CK1_1	276	282	PF00069	0.576
MOD_CK1_1	295	301	PF00069	0.552
MOD_CK1_1	326	332	PF00069	0.593
MOD_CK1_1	351	357	PF00069	0.769
MOD_CK1_1	375	381	PF00069	0.572
MOD_CK2_1	216	222	PF00069	0.567
MOD_CK2_1	375	381	PF00069	0.631
MOD_CK2_1	79	85	PF00069	0.580
MOD_Cter_Amidation	385	388	PF01082	0.784
MOD_GlcNHglycan	111	114	PF01048	0.586
MOD_GlcNHglycan	118	121	PF01048	0.634
MOD_GlcNHglycan	132	135	PF01048	0.622
MOD_GlcNHglycan	187	190	PF01048	0.725
MOD_GlcNHglycan	204	207	PF01048	0.727
MOD_GlcNHglycan	246	249	PF01048	0.728
MOD_GlcNHglycan	318	321	PF01048	0.627
MOD_GlcNHglycan	337	341	PF01048	0.790
MOD_GlcNHglycan	353	356	PF01048	0.544
MOD_GSK3_1	107	114	PF00069	0.601
MOD_GSK3_1	126	133	PF00069	0.689
MOD_GSK3_1	152	159	PF00069	0.682
MOD_GSK3_1	173	180	PF00069	0.597
MOD_GSK3_1	212	219	PF00069	0.657
MOD_GSK3_1	224	231	PF00069	0.763
MOD_GSK3_1	244	251	PF00069	0.658
MOD_GSK3_1	259	266	PF00069	0.754
MOD_GSK3_1	289	296	PF00069	0.633
MOD_GSK3_1	336	343	PF00069	0.716
MOD_GSK3_1	347	354	PF00069	0.712
MOD_GSK3_1	368	375	PF00069	0.670
MOD_N-GLC_1	163	168	PF02516	0.626
MOD_N-GLC_1	177	182	PF02516	0.712
MOD_N-GLC_1	212	217	PF02516	0.629
MOD_N-GLC_1	248	253	PF02516	0.759
MOD_N-GLC_1	289	294	PF02516	0.638
MOD_N-GLC_1	316	321	PF02516	0.712
MOD_NEK2_1	156	161	PF00069	0.661
MOD_NEK2_1	372	377	PF00069	0.746
MOD_PIKK_1	140	146	PF00454	0.538
MOD_PK_1	273	279	PF00069	0.566
MOD_PKA_1	273	279	PF00069	0.649
MOD_PKA_1	282	288	PF00069	0.630
MOD_PKA_1	348	354	PF00069	0.794
MOD_PKA_2	326	332	PF00069	0.653
MOD_PKA_2	348	354	PF00069	0.625
MOD_PKA_2	373	379	PF00069	0.565
MOD_Plk_1	173	179	PF00069	0.765
MOD_Plk_1	215	221	PF00069	0.767
MOD_Plk_1	231	237	PF00069	0.553
MOD_Plk_1	368	374	PF00069	0.568
MOD_Plk_4	152	158	PF00069	0.518
MOD_Plk_4	178	184	PF00069	0.631
MOD_Plk_4	207	213	PF00069	0.620
MOD_Plk_4	216	222	PF00069	0.651
MOD_ProDKin_1	138	144	PF00069	0.683
MOD_ProDKin_1	149	155	PF00069	0.625
MOD_ProDKin_1	252	258	PF00069	0.719
MOD_ProDKin_1	259	265	PF00069	0.766
MOD_ProDKin_1	338	344	PF00069	0.607
MOD_ProDKin_1	360	366	PF00069	0.766
MOD_ProDKin_1	62	68	PF00069	0.718
MOD_ProDKin_1	88	94	PF00069	0.763
MOD_ProDKin_1	95	101	PF00069	0.655
MOD_SUMO_for_1	313	316	PF00179	0.500
MOD_SUMO_rev_2	276	285	PF00179	0.586
TRG_DiLeu_BaEn_4	32	38	PF01217	0.427
TRG_ENDOCYTIC_2	157	160	PF00928	0.534
TRG_ER_diArg_1	387	389	PF00400	0.572
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILC0	Leptomonas seymouri	35%	94%
A0A3S5H7Q3	Leishmania donovani	57%	100%
A4I6Z0	Leishmania infantum	54%	100%
E9AEF6	Leishmania major	58%	97%
E9B211	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%