LeishMANIAdb
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CRAL-TRIO domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CRAL-TRIO domain-containing protein
Gene product:
CRAL/TRIO domain containing protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HJI9_LEIBR
TriTrypDb:
LbrM.31.2330 , LBRM2903_310032400
Length:
355

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 31
NetGPI no yes: 0, no: 31
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HJI9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJI9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 11 13 PF00675 0.534
CLV_NRD_NRD_1 282 284 PF00675 0.364
CLV_PCSK_FUR_1 9 13 PF00082 0.386
CLV_PCSK_KEX2_1 11 13 PF00082 0.542
CLV_PCSK_KEX2_1 85 87 PF00082 0.332
CLV_PCSK_PC1ET2_1 85 87 PF00082 0.239
CLV_PCSK_SKI1_1 167 171 PF00082 0.298
CLV_PCSK_SKI1_1 233 237 PF00082 0.349
CLV_PCSK_SKI1_1 253 257 PF00082 0.321
CLV_PCSK_SKI1_1 283 287 PF00082 0.372
DEG_SCF_FBW7_1 56 61 PF00400 0.492
DEG_SCF_FBW7_2 14 21 PF00400 0.424
DOC_CYCLIN_RxL_1 250 257 PF00134 0.165
DOC_CYCLIN_yClb5_NLxxxL_5 164 173 PF00134 0.213
DOC_MAPK_gen_1 20 30 PF00069 0.456
DOC_MAPK_gen_1 295 305 PF00069 0.468
DOC_MAPK_HePTP_8 235 247 PF00069 0.304
DOC_MAPK_MEF2A_6 224 232 PF00069 0.368
DOC_MAPK_MEF2A_6 238 247 PF00069 0.435
DOC_USP7_MATH_1 297 301 PF00917 0.347
DOC_USP7_UBL2_3 167 171 PF12436 0.185
DOC_USP7_UBL2_3 238 242 PF12436 0.352
DOC_USP7_UBL2_3 336 340 PF12436 0.389
DOC_WW_Pin1_4 14 19 PF00397 0.448
DOC_WW_Pin1_4 334 339 PF00397 0.324
DOC_WW_Pin1_4 46 51 PF00397 0.501
DOC_WW_Pin1_4 54 59 PF00397 0.486
LIG_14-3-3_CanoR_1 224 232 PF00244 0.373
LIG_14-3-3_CanoR_1 59 67 PF00244 0.432
LIG_Actin_WH2_2 110 127 PF00022 0.237
LIG_BIR_II_1 1 5 PF00653 0.624
LIG_deltaCOP1_diTrp_1 74 81 PF00928 0.475
LIG_eIF4E_1 65 71 PF01652 0.443
LIG_FHA_1 181 187 PF00498 0.464
LIG_FHA_1 224 230 PF00498 0.319
LIG_FHA_1 23 29 PF00498 0.436
LIG_FHA_1 305 311 PF00498 0.377
LIG_FHA_1 340 346 PF00498 0.639
LIG_FHA_2 49 55 PF00498 0.553
LIG_GBD_Chelix_1 116 124 PF00786 0.240
LIG_LIR_Apic_2 150 155 PF02991 0.237
LIG_LIR_Gen_1 276 287 PF02991 0.165
LIG_LIR_Nem_3 139 144 PF02991 0.424
LIG_LIR_Nem_3 197 203 PF02991 0.351
LIG_LIR_Nem_3 236 240 PF02991 0.364
LIG_LIR_Nem_3 276 282 PF02991 0.336
LIG_LIR_Nem_3 311 317 PF02991 0.165
LIG_LIR_Nem_3 34 38 PF02991 0.474
LIG_LIR_Nem_3 62 68 PF02991 0.462
LIG_NRBOX 251 257 PF00104 0.272
LIG_NRBOX 41 47 PF00104 0.476
LIG_Pex14_1 200 204 PF04695 0.386
LIG_SH2_CRK 152 156 PF00017 0.416
LIG_SH2_CRK 279 283 PF00017 0.353
LIG_SH2_CRK 35 39 PF00017 0.445
LIG_SH2_CRK 68 72 PF00017 0.353
LIG_SH2_NCK_1 68 72 PF00017 0.211
LIG_SH2_STAT3 203 206 PF00017 0.331
LIG_SH2_STAT3 90 93 PF00017 0.458
LIG_SH2_STAT5 13 16 PF00017 0.536
LIG_SH2_STAT5 141 144 PF00017 0.335
LIG_SH2_STAT5 158 161 PF00017 0.288
LIG_SH2_STAT5 309 312 PF00017 0.379
LIG_SH2_STAT5 314 317 PF00017 0.390
LIG_SH2_STAT5 65 68 PF00017 0.374
LIG_SH3_2 335 340 PF14604 0.554
LIG_SH3_3 332 338 PF00018 0.503
LIG_SUMO_SIM_anti_2 112 118 PF11976 0.226
LIG_SUMO_SIM_anti_2 272 280 PF11976 0.165
LIG_SUMO_SIM_anti_2 300 308 PF11976 0.258
LIG_SUMO_SIM_par_1 226 231 PF11976 0.369
LIG_SUMO_SIM_par_1 341 346 PF11976 0.437
LIG_TYR_ITIM 156 161 PF00017 0.407
LIG_TYR_ITIM 235 240 PF00017 0.388
LIG_TYR_ITIM 277 282 PF00017 0.410
LIG_UBA3_1 169 174 PF00899 0.393
LIG_UBA3_1 277 284 PF00899 0.165
MOD_CDC14_SPxK_1 337 340 PF00782 0.361
MOD_CDK_SPK_2 54 59 PF00069 0.300
MOD_CDK_SPxK_1 14 20 PF00069 0.423
MOD_CDK_SPxK_1 334 340 PF00069 0.336
MOD_CK1_1 104 110 PF00069 0.460
MOD_CK1_1 273 279 PF00069 0.429
MOD_CK2_1 160 166 PF00069 0.428
MOD_CK2_1 349 355 PF00069 0.710
MOD_GlcNHglycan 103 106 PF01048 0.444
MOD_GlcNHglycan 196 199 PF01048 0.235
MOD_GlcNHglycan 272 275 PF01048 0.375
MOD_GlcNHglycan 351 354 PF01048 0.691
MOD_GlcNHglycan 5 8 PF01048 0.481
MOD_GSK3_1 269 276 PF00069 0.277
MOD_GSK3_1 293 300 PF00069 0.352
MOD_GSK3_1 54 61 PF00069 0.496
MOD_GSK3_1 97 104 PF00069 0.457
MOD_N-GLC_1 269 274 PF02516 0.165
MOD_N-GLC_1 59 64 PF02516 0.459
MOD_NEK2_1 247 252 PF00069 0.340
MOD_NEK2_1 277 282 PF00069 0.316
MOD_OFUCOSY 66 73 PF10250 0.228
MOD_PIKK_1 22 28 PF00454 0.452
MOD_PKA_2 223 229 PF00069 0.407
MOD_PKA_2 297 303 PF00069 0.359
MOD_PKA_2 58 64 PF00069 0.263
MOD_Plk_4 224 230 PF00069 0.353
MOD_Plk_4 273 279 PF00069 0.300
MOD_ProDKin_1 14 20 PF00069 0.441
MOD_ProDKin_1 334 340 PF00069 0.336
MOD_ProDKin_1 46 52 PF00069 0.507
MOD_ProDKin_1 54 60 PF00069 0.477
MOD_SUMO_rev_2 15 25 PF00179 0.426
MOD_SUMO_rev_2 163 169 PF00179 0.326
TRG_DiLeu_BaEn_1 301 306 PF01217 0.321
TRG_ENDOCYTIC_2 13 16 PF00928 0.579
TRG_ENDOCYTIC_2 141 144 PF00928 0.380
TRG_ENDOCYTIC_2 158 161 PF00928 0.378
TRG_ENDOCYTIC_2 204 207 PF00928 0.403
TRG_ENDOCYTIC_2 237 240 PF00928 0.358
TRG_ENDOCYTIC_2 279 282 PF00928 0.363
TRG_ENDOCYTIC_2 35 38 PF00928 0.455
TRG_ENDOCYTIC_2 67 70 PF00928 0.340
TRG_ER_diArg_1 8 11 PF00400 0.604
TRG_Pf-PMV_PEXEL_1 171 175 PF00026 0.481
TRG_Pf-PMV_PEXEL_1 253 257 PF00026 0.404

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6D4 Leptomonas seymouri 36% 68%
A0A0N0P991 Leptomonas seymouri 29% 74%
A0A0N0P9K9 Leptomonas seymouri 25% 74%
A0A0N1I2J8 Leptomonas seymouri 46% 76%
A0A0N1PCS4 Leptomonas seymouri 65% 76%
A0A0S4J7N0 Bodo saltans 25% 94%
A0A0S4KJL3 Bodo saltans 26% 78%
A0A1X0NUJ5 Trypanosomatidae 26% 75%
A0A3Q8ICN0 Leishmania donovani 77% 71%
A0A3Q8IGQ2 Leishmania donovani 31% 74%
A0A3S7X4P4 Leishmania donovani 38% 68%
A0A3S7X4R1 Leishmania donovani 51% 72%
A0A422P1E3 Trypanosoma rangeli 26% 76%
A4HJI7 Leishmania braziliensis 40% 100%
A4HJI8 Leishmania braziliensis 50% 100%
A4HKB3 Leishmania braziliensis 31% 74%
A4HKB4 Leishmania braziliensis 26% 72%
A4I6Y2 Leishmania infantum 38% 68%
A4I6Y3 Leishmania infantum 51% 72%
A4I6Y4 Leishmania infantum 77% 100%
A4I7U3 Leishmania infantum 31% 74%
B5MCN3 Homo sapiens 22% 89%
E9B204 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 68%
E9B205 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 72%
E9B206 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%
E9B2Q1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 74%
O76054 Homo sapiens 24% 88%
P58875 Bos taurus 23% 88%
Q4Q5F6 Leishmania major 30% 100%
Q4Q655 Leishmania major 77% 100%
Q4Q656 Leishmania major 51% 100%
Q4Q657 Leishmania major 39% 100%
Q8R0F9 Mus musculus 21% 88%
Q99J08 Mus musculus 24% 88%
Q99MS0 Rattus norvegicus 24% 88%
Q9UDX3 Homo sapiens 23% 87%
Q9UDX4 Homo sapiens 22% 89%
Q9Z1J8 Rattus norvegicus 22% 89%
V5BL84 Trypanosoma cruzi 28% 77%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2026 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS