CRAL-TRIO domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HJI8_LEIBR

TriTrypDb:

LbrM.31.2320 , LBRM2903_310032300

Length:

348

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 30
NetGPI	no	yes: 0, no: 30

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	313	317	PF00656	0.351
CLV_NRD_NRD_1	245	247	PF00675	0.268
CLV_NRD_NRD_1	78	80	PF00675	0.254
CLV_PCSK_KEX2_1	78	80	PF00082	0.323
CLV_PCSK_SKI1_1	122	126	PF00082	0.318
CLV_PCSK_SKI1_1	20	24	PF00082	0.444
CLV_PCSK_SKI1_1	247	251	PF00082	0.333
CLV_PCSK_SKI1_1	258	262	PF00082	0.315
CLV_PCSK_SKI1_1	27	31	PF00082	0.466
CLV_PCSK_SKI1_1	288	292	PF00082	0.372
CLV_PCSK_SKI1_1	73	77	PF00082	0.268
DEG_COP1_1	313	323	PF00400	0.256
DOC_CDC14_PxL_1	33	41	PF14671	0.330
DOC_MAPK_DCC_7	32	41	PF00069	0.345
DOC_MAPK_gen_1	20	28	PF00069	0.457
DOC_MAPK_gen_1	246	252	PF00069	0.278
DOC_MAPK_gen_1	78	86	PF00069	0.538
DOC_MAPK_MEF2A_6	156	164	PF00069	0.314
DOC_MAPK_MEF2A_6	229	237	PF00069	0.371
DOC_MAPK_MEF2A_6	32	41	PF00069	0.381
DOC_PP1_RVXF_1	133	139	PF00149	0.249
DOC_PP1_RVXF_1	286	292	PF00149	0.283
DOC_PP4_FxxP_1	63	66	PF00568	0.281
DOC_USP7_MATH_1	100	104	PF00917	0.448
DOC_WW_Pin1_4	184	189	PF00397	0.305
DOC_WW_Pin1_4	273	278	PF00397	0.306
DOC_WW_Pin1_4	289	294	PF00397	0.423
DOC_WW_Pin1_4	304	309	PF00397	0.436
DOC_WW_Pin1_4	44	49	PF00397	0.520
DOC_WW_Pin1_4	62	67	PF00397	0.520
LIG_14-3-3_CanoR_1	229	237	PF00244	0.376
LIG_14-3-3_CanoR_1	3	7	PF00244	0.694
LIG_14-3-3_CanoR_1	300	308	PF00244	0.305
LIG_14-3-3_CanoR_1	73	82	PF00244	0.388
LIG_Actin_WH2_2	230	248	PF00022	0.159
LIG_BIR_III_2	57	61	PF00653	0.355
LIG_FHA_1	146	152	PF00498	0.487
LIG_FHA_1	185	191	PF00498	0.467
LIG_FHA_1	2	8	PF00498	0.633
LIG_FHA_1	21	27	PF00498	0.434
LIG_FHA_1	230	236	PF00498	0.315
LIG_FHA_1	45	51	PF00498	0.502
LIG_FHA_2	308	314	PF00498	0.226
LIG_LIR_Apic_2	155	160	PF02991	0.241
LIG_LIR_Apic_2	62	66	PF02991	0.290
LIG_LIR_Gen_1	241	250	PF02991	0.172
LIG_LIR_Nem_3	241	245	PF02991	0.360
LIG_LIR_Nem_3	259	264	PF02991	0.393
LIG_LIR_Nem_3	31	36	PF02991	0.478
LIG_LIR_Nem_3	62	67	PF02991	0.491
LIG_LIR_Nem_3	8	14	PF02991	0.597
LIG_LYPXL_yS_3	11	14	PF13949	0.349
LIG_PCNA_PIPBox_1	192	201	PF02747	0.281
LIG_PTB_Apo_2	66	73	PF02174	0.251
LIG_PTB_Phospho_1	66	72	PF10480	0.249
LIG_SH2_CRK	157	161	PF00017	0.416
LIG_SH2_CRK	284	288	PF00017	0.351
LIG_SH2_CRK	33	37	PF00017	0.445
LIG_SH2_CRK	72	76	PF00017	0.334
LIG_SH2_GRB2like	163	166	PF00017	0.465
LIG_SH2_STAP1	338	342	PF00017	0.295
LIG_SH2_STAT3	263	266	PF00017	0.159
LIG_SH2_STAT5	146	149	PF00017	0.328
LIG_SH2_STAT5	163	166	PF00017	0.285
LIG_SH2_STAT5	214	217	PF00017	0.207
LIG_SH2_STAT5	323	326	PF00017	0.396
LIG_SH2_STAT5	46	49	PF00017	0.558
LIG_SH2_STAT5	70	73	PF00017	0.374
LIG_SH3_1	32	38	PF00018	0.312
LIG_SH3_3	125	131	PF00018	0.505
LIG_SH3_3	271	277	PF00018	0.383
LIG_SH3_3	32	38	PF00018	0.410
LIG_SUMO_SIM_par_1	230	236	PF11976	0.368
LIG_SUMO_SIM_par_1	270	276	PF11976	0.220
LIG_TRAF2_1	16	19	PF00917	0.358
LIG_TYR_ITIM	161	166	PF00017	0.410
LIG_UBA3_1	25	32	PF00899	0.508
MOD_CDC14_SPxK_1	65	68	PF00782	0.257
MOD_CDK_SPxK_1	62	68	PF00069	0.272
MOD_CK1_1	109	115	PF00069	0.482
MOD_CK2_1	100	106	PF00069	0.285
MOD_CK2_1	91	97	PF00069	0.292
MOD_GlcNHglycan	108	111	PF01048	0.458
MOD_GlcNHglycan	170	174	PF01048	0.227
MOD_GlcNHglycan	302	305	PF01048	0.431
MOD_GlcNHglycan	335	338	PF01048	0.444
MOD_GSK3_1	1	8	PF00069	0.599
MOD_GSK3_1	165	172	PF00069	0.416
MOD_GSK3_1	300	307	PF00069	0.359
MOD_N-GLC_1	52	57	PF02516	0.687
MOD_N-GLC_2	69	71	PF02516	0.243
MOD_NEK2_1	1	6	PF00069	0.498
MOD_NEK2_1	138	143	PF00069	0.347
MOD_NEK2_1	212	217	PF00069	0.338
MOD_NEK2_1	227	232	PF00069	0.323
MOD_NEK2_1	240	245	PF00069	0.341
MOD_NEK2_1	253	258	PF00069	0.346
MOD_NEK2_1	74	79	PF00069	0.454
MOD_NEK2_1	89	94	PF00069	0.334
MOD_PKA_1	20	26	PF00069	0.262
MOD_PKA_2	129	135	PF00069	0.472
MOD_PKA_2	2	8	PF00069	0.689
MOD_PKA_2	228	234	PF00069	0.409
MOD_Plk_4	2	8	PF00069	0.654
MOD_Plk_4	229	235	PF00069	0.357
MOD_Plk_4	59	65	PF00069	0.592
MOD_ProDKin_1	184	190	PF00069	0.305
MOD_ProDKin_1	273	279	PF00069	0.306
MOD_ProDKin_1	289	295	PF00069	0.423
MOD_ProDKin_1	304	310	PF00069	0.436
MOD_ProDKin_1	44	50	PF00069	0.529
MOD_ProDKin_1	62	68	PF00069	0.515
MOD_SUMO_rev_2	17	23	PF00179	0.383
TRG_DiLeu_BaEn_1	297	302	PF01217	0.367
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.490
TRG_DiLeu_LyEn_5	297	302	PF01217	0.338
TRG_ENDOCYTIC_2	11	14	PF00928	0.559
TRG_ENDOCYTIC_2	146	149	PF00928	0.376
TRG_ENDOCYTIC_2	163	166	PF00928	0.380
TRG_ENDOCYTIC_2	209	212	PF00928	0.402
TRG_ENDOCYTIC_2	284	287	PF00928	0.366
TRG_ENDOCYTIC_2	33	36	PF00928	0.453
TRG_ENDOCYTIC_2	72	75	PF00928	0.334
TRG_ER_diArg_1	78	80	PF00400	0.295
TRG_NES_CRM1_1	83	97	PF08389	0.216
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D4	Leptomonas seymouri	39%	66%
A0A0N0P991	Leptomonas seymouri	30%	73%
A0A0N0P9K9	Leptomonas seymouri	26%	72%
A0A0N1I2J8	Leptomonas seymouri	41%	75%
A0A0N1PCS4	Leptomonas seymouri	49%	75%
A0A0S4INM2	Bodo saltans	22%	85%
A0A0S4J7N0	Bodo saltans	26%	93%
A0A0S4KJL3	Bodo saltans	29%	76%
A0A1X0NUJ5	Trypanosomatidae	30%	74%
A0A3Q8ICN0	Leishmania donovani	51%	70%
A0A3Q8IGQ2	Leishmania donovani	31%	73%
A0A3S7X4P4	Leishmania donovani	41%	67%
A0A3S7X4R1	Leishmania donovani	76%	71%
A0A422P1E3	Trypanosoma rangeli	31%	75%
A4HJI7	Leishmania braziliensis	41%	100%
A4HJI9	Leishmania braziliensis	50%	98%
A4HKB3	Leishmania braziliensis	29%	73%
A4HKB4	Leishmania braziliensis	24%	71%
A4I6Y2	Leishmania infantum	40%	67%
A4I6Y3	Leishmania infantum	76%	71%
A4I6Y4	Leishmania infantum	51%	98%
A4I7U3	Leishmania infantum	31%	73%
E9B204	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	67%
E9B205	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	71%
E9B206	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	98%
E9B2Q1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	73%
O76054	Homo sapiens	22%	86%
P58875	Bos taurus	22%	86%
Q10137	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q4Q5F6	Leishmania major	32%	73%
Q4Q655	Leishmania major	49%	100%
Q4Q656	Leishmania major	76%	100%
Q4Q657	Leishmania major	40%	100%
Q99J08	Mus musculus	22%	86%
Q99MS0	Rattus norvegicus	22%	86%
Q9UDX3	Homo sapiens	24%	86%
V5BL84	Trypanosoma cruzi	27%	75%