CRAL-TRIO domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HJI7_LEIBR

TriTrypDb:

LbrM.31.2310 , LBRM2903_310032200

Length:

506

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 36
NetGPI	no	yes: 0, no: 36

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJI7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	232	234	PF00675	0.374
CLV_NRD_NRD_1	341	343	PF00675	0.402
CLV_NRD_NRD_1	372	374	PF00675	0.391
CLV_NRD_NRD_1	482	484	PF00675	0.412
CLV_PCSK_FUR_1	480	484	PF00082	0.291
CLV_PCSK_KEX2_1	232	234	PF00082	0.318
CLV_PCSK_KEX2_1	372	374	PF00082	0.385
CLV_PCSK_KEX2_1	482	484	PF00082	0.485
CLV_PCSK_KEX2_1	489	491	PF00082	0.368
CLV_PCSK_PC1ET2_1	489	491	PF00082	0.536
CLV_PCSK_SKI1_1	272	276	PF00082	0.344
CLV_PCSK_SKI1_1	283	287	PF00082	0.330
CLV_PCSK_SKI1_1	306	310	PF00082	0.383
CLV_PCSK_SKI1_1	448	452	PF00082	0.527
CLV_Separin_Metazoa	188	192	PF03568	0.219
DEG_Nend_UBRbox_2	1	3	PF02207	0.553
DEG_SPOP_SBC_1	499	503	PF00917	0.506
DOC_CYCLIN_yCln2_LP_2	54	57	PF00134	0.320
DOC_MAPK_gen_1	171	181	PF00069	0.326
DOC_MAPK_HePTP_8	265	277	PF00069	0.263
DOC_MAPK_MEF2A_6	268	277	PF00069	0.459
DOC_PP1_RVXF_1	321	327	PF00149	0.315
DOC_PP2B_LxvP_1	54	57	PF13499	0.319
DOC_PP2B_PxIxI_1	123	129	PF00149	0.203
DOC_PP4_FxxP_1	121	124	PF00568	0.198
DOC_PP4_FxxP_1	430	433	PF00568	0.368
DOC_USP7_MATH_1	231	235	PF00917	0.361
DOC_USP7_MATH_1	454	458	PF00917	0.489
DOC_USP7_MATH_1	461	465	PF00917	0.490
DOC_USP7_UBL2_3	268	272	PF12436	0.478
DOC_USP7_UBL2_3	283	287	PF12436	0.392
DOC_WW_Pin1_4	140	145	PF00397	0.342
DOC_WW_Pin1_4	199	204	PF00397	0.340
DOC_WW_Pin1_4	244	249	PF00397	0.438
DOC_WW_Pin1_4	298	303	PF00397	0.260
DOC_WW_Pin1_4	448	453	PF00397	0.541
DOC_WW_Pin1_4	84	89	PF00397	0.488
LIG_14-3-3_CanoR_1	194	200	PF00244	0.382
LIG_14-3-3_CanoR_1	233	242	PF00244	0.160
LIG_14-3-3_CanoR_1	441	447	PF00244	0.484
LIG_14-3-3_CanoR_1	480	486	PF00244	0.385
LIG_APCC_ABBA_1	275	280	PF00400	0.382
LIG_BRCT_BRCA1_1	463	467	PF00533	0.584
LIG_deltaCOP1_diTrp_1	94	101	PF00928	0.477
LIG_EH1_1	75	83	PF00400	0.279
LIG_eIF4E_1	85	91	PF01652	0.437
LIG_FHA_1	131	137	PF00498	0.359
LIG_FHA_1	157	163	PF00498	0.265
LIG_FHA_1	17	23	PF00498	0.571
LIG_FHA_1	387	393	PF00498	0.394
LIG_FHA_1	424	430	PF00498	0.333
LIG_FHA_2	245	251	PF00498	0.194
LIG_LIR_Apic_2	118	124	PF02991	0.260
LIG_LIR_Apic_2	428	433	PF02991	0.398
LIG_LIR_Apic_2	84	88	PF02991	0.227
LIG_LIR_Gen_1	205	215	PF02991	0.407
LIG_LIR_Gen_1	424	433	PF02991	0.413
LIG_LIR_Gen_1	49	59	PF02991	0.325
LIG_LIR_Nem_3	276	281	PF02991	0.348
LIG_LIR_Nem_3	284	289	PF02991	0.392
LIG_LIR_Nem_3	364	369	PF02991	0.260
LIG_LIR_Nem_3	39	44	PF02991	0.472
LIG_LIR_Nem_3	424	430	PF02991	0.365
LIG_LIR_Nem_3	49	54	PF02991	0.297
LIG_Pex14_2	427	431	PF04695	0.315
LIG_REV1ctd_RIR_1	283	289	PF16727	0.483
LIG_SH2_CRK	224	228	PF00017	0.357
LIG_SH2_CRK	366	370	PF00017	0.281
LIG_SH2_CRK	41	45	PF00017	0.458
LIG_SH2_CRK	85	89	PF00017	0.332
LIG_SH2_PTP2	178	181	PF00017	0.223
LIG_SH2_SRC	344	347	PF00017	0.387
LIG_SH2_STAP1	307	311	PF00017	0.478
LIG_SH2_STAT5	178	181	PF00017	0.318
LIG_SH2_STAT5	344	347	PF00017	0.365
LIG_SH2_STAT5	51	54	PF00017	0.449
LIG_SH2_STAT5	85	88	PF00017	0.343
LIG_SH3_2	368	373	PF14604	0.513
LIG_SH3_3	296	302	PF00018	0.343
LIG_SH3_3	365	371	PF00018	0.472
LIG_SUMO_SIM_anti_2	182	188	PF11976	0.157
LIG_SUMO_SIM_anti_2	471	478	PF11976	0.385
LIG_TRAF2_1	63	66	PF00917	0.729
LIG_TYR_ITIM	176	181	PF00017	0.364
LIG_UBA3_1	258	263	PF00899	0.438
LIG_UBA3_1	277	283	PF00899	0.206
LIG_UBA3_1	33	38	PF00899	0.483
MOD_CDK_SPK_2	140	145	PF00069	0.299
MOD_CK1_1	234	240	PF00069	0.178
MOD_CK1_1	325	331	PF00069	0.381
MOD_CK1_1	435	441	PF00069	0.399
MOD_CK1_1	60	66	PF00069	0.629
MOD_CK1_1	84	90	PF00069	0.324
MOD_CK2_1	129	135	PF00069	0.322
MOD_CK2_1	140	146	PF00069	0.268
MOD_CK2_1	244	250	PF00069	0.194
MOD_CK2_1	440	446	PF00069	0.540
MOD_CK2_1	60	66	PF00069	0.615
MOD_GlcNHglycan	16	19	PF01048	0.694
MOD_GlcNHglycan	233	236	PF01048	0.409
MOD_GlcNHglycan	363	366	PF01048	0.445
MOD_GlcNHglycan	434	437	PF01048	0.366
MOD_GlcNHglycan	6	11	PF01048	0.724
MOD_GlcNHglycan	62	65	PF01048	0.684
MOD_GlcNHglycan	66	70	PF01048	0.652
MOD_GSK3_1	14	21	PF00069	0.459
MOD_GSK3_1	140	147	PF00069	0.429
MOD_GSK3_1	156	163	PF00069	0.235
MOD_GSK3_1	195	202	PF00069	0.402
MOD_GSK3_1	231	238	PF00069	0.314
MOD_GSK3_1	240	247	PF00069	0.419
MOD_GSK3_1	322	329	PF00069	0.321
MOD_GSK3_1	386	393	PF00069	0.457
MOD_GSK3_1	394	401	PF00069	0.458
MOD_NEK2_1	394	399	PF00069	0.391
MOD_NEK2_1	500	505	PF00069	0.540
MOD_NEK2_1	81	86	PF00069	0.506
MOD_NEK2_2	124	129	PF00069	0.338
MOD_PIKK_1	156	162	PF00454	0.320
MOD_PIKK_1	249	255	PF00454	0.157
MOD_PIKK_1	394	400	PF00454	0.377
MOD_PK_1	263	269	PF00069	0.438
MOD_PKA_2	144	150	PF00069	0.482
MOD_PKA_2	231	237	PF00069	0.305
MOD_PKA_2	440	446	PF00069	0.325
MOD_PKA_2	481	487	PF00069	0.374
MOD_Plk_1	390	396	PF00069	0.445
MOD_Plk_1	423	429	PF00069	0.276
MOD_Plk_2-3	386	392	PF00069	0.342
MOD_Plk_4	217	223	PF00069	0.392
MOD_Plk_4	254	260	PF00069	0.327
MOD_Plk_4	300	306	PF00069	0.283
MOD_ProDKin_1	140	146	PF00069	0.348
MOD_ProDKin_1	199	205	PF00069	0.340
MOD_ProDKin_1	244	250	PF00069	0.438
MOD_ProDKin_1	298	304	PF00069	0.260
MOD_ProDKin_1	448	454	PF00069	0.540
MOD_ProDKin_1	84	90	PF00069	0.486
MOD_SUMO_rev_2	337	345	PF00179	0.259
MOD_SUMO_rev_2	443	450	PF00179	0.347
TRG_ENDOCYTIC_2	178	181	PF00928	0.331
TRG_ENDOCYTIC_2	224	227	PF00928	0.363
TRG_ENDOCYTIC_2	366	369	PF00928	0.261
TRG_ENDOCYTIC_2	41	44	PF00928	0.469
TRG_ENDOCYTIC_2	51	54	PF00928	0.491
TRG_ER_diArg_1	371	373	PF00400	0.357
TRG_ER_diArg_1	479	482	PF00400	0.524
TRG_NES_CRM1_1	205	219	PF08389	0.205
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	279	284	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D4	Leptomonas seymouri	43%	96%
A0A0N0P991	Leptomonas seymouri	27%	100%
A0A0N0P992	Leptomonas seymouri	22%	66%
A0A0N0P9K9	Leptomonas seymouri	27%	100%
A0A0N1I2J8	Leptomonas seymouri	36%	100%
A0A0N1PCS4	Leptomonas seymouri	38%	100%
A0A0S4J7N0	Bodo saltans	25%	100%
A0A0S4KJL3	Bodo saltans	28%	100%
A0A1X0NUH5	Trypanosomatidae	23%	87%
A0A1X0NUJ5	Trypanosomatidae	26%	100%
A0A3Q8ICN0	Leishmania donovani	40%	100%
A0A3Q8IGQ2	Leishmania donovani	29%	100%
A0A3R7MUL5	Trypanosoma rangeli	24%	92%
A0A3S5H7R8	Leishmania donovani	24%	66%
A0A3S7X4P4	Leishmania donovani	67%	97%
A0A3S7X4R1	Leishmania donovani	41%	100%
A0A422P1E3	Trypanosoma rangeli	27%	100%
A4HJI8	Leishmania braziliensis	41%	100%
A4HJI9	Leishmania braziliensis	40%	100%
A4HKB3	Leishmania braziliensis	29%	100%
A4HKB4	Leishmania braziliensis	27%	100%
A4HKB5	Leishmania braziliensis	22%	67%
A4I6Y2	Leishmania infantum	67%	97%
A4I6Y3	Leishmania infantum	40%	100%
A4I6Y4	Leishmania infantum	38%	100%
A4I7U3	Leishmania infantum	29%	100%
A4I7U4	Leishmania infantum	24%	66%
E9B204	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	97%
E9B205	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B206	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B2Q1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
O43304	Homo sapiens	20%	73%
O76054	Homo sapiens	22%	100%
P58875	Bos taurus	22%	100%
Q03606	Caenorhabditis elegans	23%	70%
Q0V9N0	Xenopus tropicalis	20%	72%
Q16KN5	Aedes aegypti	22%	78%
Q4Q5F6	Leishmania major	30%	100%
Q4Q655	Leishmania major	38%	100%
Q4Q656	Leishmania major	40%	99%
Q4Q657	Leishmania major	66%	100%
Q92503	Homo sapiens	21%	71%
Q99J08	Mus musculus	23%	100%
Q99MS0	Rattus norvegicus	23%	100%
Q9Z1J8	Rattus norvegicus	21%	100%
V5BL84	Trypanosoma cruzi	26%	100%
V5BQT0	Trypanosoma cruzi	27%	91%