Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJI6_LEIBR

TriTrypDb:

LbrM.31.2300 , LBRM2903_310031300

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.572
CLV_NRD_NRD_1	300	302	PF00675	0.662
CLV_NRD_NRD_1	41	43	PF00675	0.545
CLV_NRD_NRD_1	471	473	PF00675	0.582
CLV_NRD_NRD_1	94	96	PF00675	0.508
CLV_PCSK_KEX2_1	300	302	PF00082	0.662
CLV_PCSK_KEX2_1	41	43	PF00082	0.545
CLV_PCSK_KEX2_1	471	473	PF00082	0.582
CLV_PCSK_KEX2_1	94	96	PF00082	0.508
CLV_PCSK_PC7_1	296	302	PF00082	0.535
CLV_PCSK_PC7_1	467	473	PF00082	0.564
CLV_PCSK_SKI1_1	334	338	PF00082	0.786
CLV_PCSK_SKI1_1	368	372	PF00082	0.603
CLV_PCSK_SKI1_1	374	378	PF00082	0.551
CLV_PCSK_SKI1_1	42	46	PF00082	0.552
DEG_SCF_FBW7_1	244	249	PF00400	0.547
DEG_SPOP_SBC_1	203	207	PF00917	0.647
DOC_CKS1_1	108	113	PF01111	0.522
DOC_CYCLIN_RxL_1	42	55	PF00134	0.599
DOC_CYCLIN_yCln2_LP_2	3	9	PF00134	0.579
DOC_MAPK_gen_1	334	344	PF00069	0.670
DOC_PP1_RVXF_1	366	372	PF00149	0.604
DOC_PP2B_LxvP_1	284	287	PF13499	0.498
DOC_PP2B_LxvP_1	3	6	PF13499	0.575
DOC_PP2B_LxvP_1	342	345	PF13499	0.669
DOC_PP2B_LxvP_1	50	53	PF13499	0.616
DOC_PP2B_LxvP_1	67	70	PF13499	0.505
DOC_USP7_MATH_1	109	113	PF00917	0.566
DOC_USP7_MATH_1	198	202	PF00917	0.545
DOC_USP7_MATH_1	246	250	PF00917	0.559
DOC_USP7_MATH_1	345	349	PF00917	0.582
DOC_USP7_MATH_1	445	449	PF00917	0.604
DOC_USP7_MATH_1	73	77	PF00917	0.616
DOC_WW_Pin1_4	107	112	PF00397	0.692
DOC_WW_Pin1_4	169	174	PF00397	0.578
DOC_WW_Pin1_4	231	236	PF00397	0.577
DOC_WW_Pin1_4	242	247	PF00397	0.595
DOC_WW_Pin1_4	288	293	PF00397	0.549
DOC_WW_Pin1_4	299	304	PF00397	0.637
DOC_WW_Pin1_4	402	407	PF00397	0.635
LIG_14-3-3_CanoR_1	148	156	PF00244	0.560
LIG_14-3-3_CanoR_1	294	300	PF00244	0.653
LIG_14-3-3_CanoR_1	301	307	PF00244	0.610
LIG_14-3-3_CanoR_1	368	376	PF00244	0.602
LIG_14-3-3_CanoR_1	396	406	PF00244	0.504
LIG_14-3-3_CanoR_1	422	426	PF00244	0.541
LIG_Actin_WH2_2	322	339	PF00022	0.656
LIG_AP2alpha_1	371	375	PF02296	0.606
LIG_BRCT_BRCA1_1	277	281	PF00533	0.491
LIG_FHA_1	231	237	PF00498	0.663
LIG_FHA_1	261	267	PF00498	0.574
LIG_FHA_1	28	34	PF00498	0.501
LIG_FHA_1	62	68	PF00498	0.657
LIG_FHA_1	81	87	PF00498	0.465
LIG_FHA_2	115	121	PF00498	0.495
LIG_FHA_2	218	224	PF00498	0.567
LIG_FHA_2	415	421	PF00498	0.666
LIG_FHA_2	449	455	PF00498	0.576
LIG_KLC1_Yacidic_2	218	223	PF13176	0.572
LIG_LIR_Gen_1	112	122	PF02991	0.615
LIG_LIR_Gen_1	162	171	PF02991	0.655
LIG_LIR_Gen_1	186	197	PF02991	0.506
LIG_LIR_Nem_3	112	118	PF02991	0.625
LIG_LIR_Nem_3	162	167	PF02991	0.662
LIG_LIR_Nem_3	186	192	PF02991	0.505
LIG_LIR_Nem_3	278	284	PF02991	0.545
LIG_LIR_Nem_3	389	394	PF02991	0.546
LIG_LIR_Nem_3	469	473	PF02991	0.475
LIG_LIR_Nem_3	93	99	PF02991	0.557
LIG_MYND_1	169	173	PF01753	0.512
LIG_Pex14_2	371	375	PF04695	0.606
LIG_SH2_CRK	189	193	PF00017	0.506
LIG_SH2_CRK	96	100	PF00017	0.507
LIG_SH2_PTP2	4	7	PF00017	0.519
LIG_SH2_SRC	221	224	PF00017	0.653
LIG_SH2_STAP1	115	119	PF00017	0.635
LIG_SH2_STAT5	221	224	PF00017	0.653
LIG_SH2_STAT5	4	7	PF00017	0.519
LIG_SH2_STAT5	484	487	PF00017	0.658
LIG_SH3_1	141	147	PF00018	0.565
LIG_SH3_1	436	442	PF00018	0.541
LIG_SH3_2	442	447	PF14604	0.470
LIG_SH3_3	105	111	PF00018	0.582
LIG_SH3_3	118	124	PF00018	0.578
LIG_SH3_3	131	137	PF00018	0.524
LIG_SH3_3	141	147	PF00018	0.610
LIG_SH3_3	219	225	PF00018	0.650
LIG_SH3_3	436	442	PF00018	0.541
LIG_SH3_3	50	56	PF00018	0.719
LIG_SH3_3	82	88	PF00018	0.623
LIG_SH3_5	111	115	PF00018	0.560
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.469
LIG_SUMO_SIM_anti_2	199	208	PF11976	0.532
LIG_SUMO_SIM_anti_2	355	361	PF11976	0.510
LIG_SUMO_SIM_par_1	384	389	PF11976	0.406
LIG_SUMO_SIM_par_1	87	93	PF11976	0.483
LIG_TYR_ITIM	187	192	PF00017	0.506
LIG_Vh1_VBS_1	444	462	PF01044	0.553
LIG_WRC_WIRS_1	115	120	PF05994	0.501
LIG_WW_3	291	295	PF00397	0.524
MOD_CDC14_SPxK_1	291	294	PF00782	0.524
MOD_CDK_SPxK_1	288	294	PF00069	0.522
MOD_CK1_1	13	19	PF00069	0.420
MOD_CK1_1	208	214	PF00069	0.779
MOD_CK1_1	230	236	PF00069	0.590
MOD_CK1_1	295	301	PF00069	0.556
MOD_CK1_1	302	308	PF00069	0.540
MOD_CK1_1	321	327	PF00069	0.519
MOD_CK1_1	340	346	PF00069	0.653
MOD_CK1_1	347	353	PF00069	0.592
MOD_CK1_1	397	403	PF00069	0.618
MOD_CK1_1	405	411	PF00069	0.609
MOD_CK1_1	448	454	PF00069	0.589
MOD_CK2_1	114	120	PF00069	0.561
MOD_CK2_1	125	131	PF00069	0.559
MOD_CK2_1	13	19	PF00069	0.420
MOD_CK2_1	414	420	PF00069	0.666
MOD_CK2_1	448	454	PF00069	0.589
MOD_GlcNHglycan	211	214	PF01048	0.716
MOD_GlcNHglycan	277	280	PF01048	0.619
MOD_GlcNHglycan	347	350	PF01048	0.645
MOD_GlcNHglycan	388	391	PF01048	0.537
MOD_GSK3_1	109	116	PF00069	0.554
MOD_GSK3_1	155	162	PF00069	0.708
MOD_GSK3_1	198	205	PF00069	0.692
MOD_GSK3_1	227	234	PF00069	0.780
MOD_GSK3_1	242	249	PF00069	0.649
MOD_GSK3_1	288	295	PF00069	0.720
MOD_GSK3_1	321	328	PF00069	0.712
MOD_GSK3_1	336	343	PF00069	0.658
MOD_GSK3_1	344	351	PF00069	0.578
MOD_GSK3_1	394	401	PF00069	0.493
MOD_GSK3_1	405	412	PF00069	0.596
MOD_GSK3_1	416	423	PF00069	0.551
MOD_N-GLC_1	203	208	PF02516	0.666
MOD_N-GLC_1	409	414	PF02516	0.552
MOD_N-GLC_1	80	85	PF02516	0.625
MOD_NEK2_1	156	161	PF00069	0.635
MOD_NEK2_1	202	207	PF00069	0.756
MOD_NEK2_1	217	222	PF00069	0.618
MOD_NEK2_1	304	309	PF00069	0.629
MOD_NEK2_1	325	330	PF00069	0.669
MOD_NEK2_1	395	400	PF00069	0.635
MOD_NEK2_1	478	483	PF00069	0.635
MOD_PIKK_1	159	165	PF00454	0.708
MOD_PKA_2	137	143	PF00069	0.549
MOD_PKA_2	295	301	PF00069	0.608
MOD_PKA_2	395	401	PF00069	0.467
MOD_PKA_2	421	427	PF00069	0.544
MOD_PKA_2	466	472	PF00069	0.584
MOD_Plk_1	113	119	PF00069	0.635
MOD_Plk_1	13	19	PF00069	0.420
MOD_Plk_1	156	162	PF00069	0.610
MOD_Plk_1	217	223	PF00069	0.560
MOD_Plk_1	340	346	PF00069	0.669
MOD_Plk_1	409	415	PF00069	0.538
MOD_Plk_1	73	79	PF00069	0.610
MOD_Plk_2-3	114	120	PF00069	0.503
MOD_Plk_2-3	414	420	PF00069	0.536
MOD_Plk_4	114	120	PF00069	0.627
MOD_Plk_4	125	131	PF00069	0.482
MOD_Plk_4	198	204	PF00069	0.657
MOD_Plk_4	217	223	PF00069	0.490
MOD_Plk_4	224	230	PF00069	0.554
MOD_ProDKin_1	107	113	PF00069	0.687
MOD_ProDKin_1	169	175	PF00069	0.577
MOD_ProDKin_1	231	237	PF00069	0.578
MOD_ProDKin_1	242	248	PF00069	0.596
MOD_ProDKin_1	288	294	PF00069	0.552
MOD_ProDKin_1	299	305	PF00069	0.634
MOD_ProDKin_1	402	408	PF00069	0.636
MOD_SUMO_rev_2	102	108	PF00179	0.537
TRG_ENDOCYTIC_2	115	118	PF00928	0.634
TRG_ENDOCYTIC_2	189	192	PF00928	0.506
TRG_ENDOCYTIC_2	4	7	PF00928	0.629
TRG_ENDOCYTIC_2	96	99	PF00928	0.559
TRG_ER_diArg_1	23	26	PF00400	0.515
TRG_ER_diArg_1	293	296	PF00400	0.611
TRG_ER_diArg_1	299	301	PF00400	0.638
TRG_ER_diArg_1	470	472	PF00400	0.577
TRG_ER_diArg_1	94	96	PF00400	0.502
TRG_Pf-PMV_PEXEL_1	308	313	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	368	373	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4R8	Leishmania donovani	63%	99%
A4I6Y1	Leishmania infantum	64%	99%
E9B203	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	99%
Q4Q658	Leishmania major	63%	100%