Leishmanolysin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Leishmanolysin

Gene product:

metallo-peptidase, Clan MA(M), Family M8

Species:

Leishmania braziliensis

UniProt:

A4HJI0_LEIBR

TriTrypDb:

LbrM.31.2260 , LBRM2903_310032100

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 1
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HJI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJI0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0007155	cell adhesion	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0019538	protein metabolic process	3	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004175	endopeptidase activity	4	6
GO:0004222	metalloendopeptidase activity	5	6
GO:0005488	binding	1	6
GO:0008233	peptidase activity	3	6
GO:0008237	metallopeptidase activity	4	6
GO:0016787	hydrolase activity	2	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0140096	catalytic activity, acting on a protein	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.310
CLV_NRD_NRD_1	68	70	PF00675	0.590
CLV_PCSK_KEX2_1	161	163	PF00082	0.386
CLV_PCSK_KEX2_1	68	70	PF00082	0.590
CLV_PCSK_KEX2_1	83	85	PF00082	0.486
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.386
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.446
DEG_SCF_FBW7_2	120	126	PF00400	0.186
DOC_CKS1_1	120	125	PF01111	0.186
DOC_MAPK_MEF2A_6	10	19	PF00069	0.417
DOC_MAPK_MEF2A_6	75	82	PF00069	0.444
DOC_MAPK_NFAT4_5	10	18	PF00069	0.354
DOC_PP4_FxxP_1	204	207	PF00568	0.189
DOC_USP7_MATH_1	140	144	PF00917	0.186
DOC_USP7_MATH_1	28	32	PF00917	0.624
DOC_USP7_MATH_1	5	9	PF00917	0.428
DOC_WW_Pin1_4	119	124	PF00397	0.186
DOC_WW_Pin1_4	228	233	PF00397	0.186
DOC_WW_Pin1_4	43	48	PF00397	0.448
LIG_14-3-3_CanoR_1	148	153	PF00244	0.186
LIG_14-3-3_CanoR_1	162	170	PF00244	0.221
LIG_14-3-3_CanoR_1	99	105	PF00244	0.186
LIG_BIR_II_1	1	5	PF00653	0.410
LIG_FHA_1	120	126	PF00498	0.198
LIG_FHA_1	187	193	PF00498	0.210
LIG_FHA_1	210	216	PF00498	0.190
LIG_FHA_1	24	30	PF00498	0.577
LIG_FHA_1	246	252	PF00498	0.201
LIG_LIR_Apic_2	203	207	PF02991	0.198
LIG_LIR_Nem_3	110	116	PF02991	0.186
LIG_LIR_Nem_3	217	223	PF02991	0.190
LIG_LIR_Nem_3	63	67	PF02991	0.463
LIG_PTB_Apo_2	260	267	PF02174	0.221
LIG_PTB_Phospho_1	260	266	PF10480	0.221
LIG_SH2_GRB2like	261	264	PF00017	0.186
LIG_SH2_PTP2	64	67	PF00017	0.461
LIG_SH2_STAT5	131	134	PF00017	0.221
LIG_SH2_STAT5	21	24	PF00017	0.377
LIG_SH2_STAT5	223	226	PF00017	0.189
LIG_SH2_STAT5	261	264	PF00017	0.199
LIG_SH2_STAT5	266	269	PF00017	0.245
LIG_SH2_STAT5	64	67	PF00017	0.461
LIG_SH3_3	117	123	PF00018	0.186
LIG_SH3_3	179	185	PF00018	0.248
LIG_SH3_3	210	216	PF00018	0.186
LIG_SUMO_SIM_par_1	188	195	PF11976	0.186
LIG_TYR_ITIM	62	67	PF00017	0.455
MOD_CDK_SPK_2	228	233	PF00069	0.192
MOD_CK1_1	105	111	PF00069	0.182
MOD_CK1_1	142	148	PF00069	0.192
MOD_CK1_1	55	61	PF00069	0.409
MOD_CK1_1	88	94	PF00069	0.654
MOD_GlcNHglycan	110	113	PF01048	0.241
MOD_GlcNHglycan	141	145	PF01048	0.192
MOD_GlcNHglycan	31	34	PF01048	0.418
MOD_GlcNHglycan	87	90	PF01048	0.520
MOD_GSK3_1	126	133	PF00069	0.192
MOD_GSK3_1	160	167	PF00069	0.289
MOD_GSK3_1	192	199	PF00069	0.318
MOD_GSK3_1	227	234	PF00069	0.247
MOD_GSK3_1	245	252	PF00069	0.172
MOD_N-GLC_1	85	90	PF02516	0.447
MOD_NEK2_1	164	169	PF00069	0.281
MOD_NEK2_1	85	90	PF00069	0.447
MOD_PK_1	148	154	PF00069	0.192
MOD_PKA_1	160	166	PF00069	0.192
MOD_PKA_1	68	74	PF00069	0.445
MOD_PKA_2	147	153	PF00069	0.192
MOD_PKA_2	68	74	PF00069	0.445
MOD_Plk_1	187	193	PF00069	0.192
MOD_Plk_4	142	148	PF00069	0.255
MOD_Plk_4	164	170	PF00069	0.488
MOD_Plk_4	187	193	PF00069	0.215
MOD_Plk_4	60	66	PF00069	0.449
MOD_ProDKin_1	119	125	PF00069	0.192
MOD_ProDKin_1	228	234	PF00069	0.192
MOD_ProDKin_1	43	49	PF00069	0.442
TRG_ENDOCYTIC_2	21	24	PF00928	0.358
TRG_ENDOCYTIC_2	64	67	PF00928	0.461
TRG_ER_diArg_1	67	69	PF00400	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NDC6	Trypanosomatidae	25%	72%
A0A1X0NFI2	Trypanosomatidae	27%	78%
A0A1X0P868	Trypanosomatidae	26%	86%
A0A422MNW0	Trypanosoma rangeli	34%	67%