SH2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJH7_LEIBR

TriTrypDb:

LbrM.31.2180 , LBRM2903_310031900

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HJH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJH7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	449	453	PF00656	0.627
CLV_NRD_NRD_1	131	133	PF00675	0.458
CLV_NRD_NRD_1	253	255	PF00675	0.459
CLV_NRD_NRD_1	282	284	PF00675	0.534
CLV_NRD_NRD_1	36	38	PF00675	0.477
CLV_PCSK_FUR_1	129	133	PF00082	0.464
CLV_PCSK_FUR_1	34	38	PF00082	0.382
CLV_PCSK_KEX2_1	131	133	PF00082	0.459
CLV_PCSK_KEX2_1	253	255	PF00082	0.459
CLV_PCSK_KEX2_1	281	283	PF00082	0.654
CLV_PCSK_KEX2_1	36	38	PF00082	0.482
CLV_PCSK_PC7_1	127	133	PF00082	0.465
CLV_PCSK_PC7_1	32	38	PF00082	0.429
CLV_PCSK_SKI1_1	344	348	PF00082	0.444
DOC_CKS1_1	200	205	PF01111	0.610
DOC_CYCLIN_yCln2_LP_2	493	499	PF00134	0.635
DOC_CYCLIN_yCln2_LP_2	545	551	PF00134	0.767
DOC_MAPK_gen_1	36	47	PF00069	0.604
DOC_PP4_FxxP_1	309	312	PF00568	0.651
DOC_PP4_FxxP_1	534	537	PF00568	0.689
DOC_PP4_FxxP_1	549	552	PF00568	0.780
DOC_USP7_MATH_1	233	237	PF00917	0.729
DOC_USP7_MATH_1	248	252	PF00917	0.660
DOC_USP7_MATH_1	305	309	PF00917	0.691
DOC_USP7_MATH_1	389	393	PF00917	0.639
DOC_USP7_MATH_1	394	398	PF00917	0.647
DOC_USP7_MATH_1	415	419	PF00917	0.645
DOC_USP7_MATH_1	472	476	PF00917	0.651
DOC_USP7_MATH_1	503	507	PF00917	0.663
DOC_USP7_MATH_1	517	521	PF00917	0.689
DOC_WW_Pin1_4	110	115	PF00397	0.686
DOC_WW_Pin1_4	180	185	PF00397	0.659
DOC_WW_Pin1_4	199	204	PF00397	0.763
DOC_WW_Pin1_4	220	225	PF00397	0.629
DOC_WW_Pin1_4	244	249	PF00397	0.698
DOC_WW_Pin1_4	260	265	PF00397	0.711
DOC_WW_Pin1_4	283	288	PF00397	0.781
DOC_WW_Pin1_4	294	299	PF00397	0.686
DOC_WW_Pin1_4	356	361	PF00397	0.789
DOC_WW_Pin1_4	430	435	PF00397	0.698
DOC_WW_Pin1_4	468	473	PF00397	0.694
DOC_WW_Pin1_4	520	525	PF00397	0.650
DOC_WW_Pin1_4	53	58	PF00397	0.671
DOC_WW_Pin1_4	544	549	PF00397	0.717
DOC_WW_Pin1_4	559	564	PF00397	0.762
LIG_14-3-3_CanoR_1	259	267	PF00244	0.644
LIG_14-3-3_CanoR_1	405	413	PF00244	0.661
LIG_14-3-3_CanoR_1	540	548	PF00244	0.780
LIG_APCC_ABBA_1	329	334	PF00400	0.621
LIG_BRCT_BRCA1_1	239	243	PF00533	0.697
LIG_BRCT_BRCA1_1	322	326	PF00533	0.703
LIG_BRCT_BRCA1_1	43	47	PF00533	0.608
LIG_FHA_1	200	206	PF00498	0.652
LIG_FHA_1	272	278	PF00498	0.642
LIG_FHA_1	3	9	PF00498	0.220
LIG_FHA_1	376	382	PF00498	0.656
LIG_FHA_1	431	437	PF00498	0.699
LIG_FHA_1	446	452	PF00498	0.593
LIG_FHA_1	531	537	PF00498	0.635
LIG_FHA_1	54	60	PF00498	0.663
LIG_FHA_2	165	171	PF00498	0.643
LIG_FHA_2	320	326	PF00498	0.721
LIG_FHA_2	447	453	PF00498	0.627
LIG_LIR_Apic_2	307	312	PF02991	0.649
LIG_LIR_Apic_2	532	537	PF02991	0.761
LIG_LIR_Apic_2	547	552	PF02991	0.776
LIG_LIR_Gen_1	100	110	PF02991	0.631
LIG_LIR_Gen_1	323	331	PF02991	0.692
LIG_LIR_Nem_3	100	105	PF02991	0.639
LIG_LIR_Nem_3	151	155	PF02991	0.624
LIG_LIR_Nem_3	323	329	PF02991	0.694
LIG_LIR_Nem_3	378	382	PF02991	0.621
LIG_PTB_Apo_2	330	337	PF02174	0.606
LIG_SH2_CRK	219	223	PF00017	0.604
LIG_SH2_GRB2like	72	75	PF00017	0.652
LIG_SH2_STAT3	143	146	PF00017	0.551
LIG_SH2_STAT5	94	97	PF00017	0.626
LIG_SH3_3	108	114	PF00018	0.688
LIG_SH3_3	197	203	PF00018	0.752
LIG_SH3_3	408	414	PF00018	0.674
LIG_SH3_3	459	465	PF00018	0.724
LIG_SH3_3	488	494	PF00018	0.710
LIG_SH3_3	554	560	PF00018	0.697
LIG_SUMO_SIM_par_1	164	170	PF11976	0.719
LIG_SUMO_SIM_par_1	202	210	PF11976	0.609
LIG_SUMO_SIM_par_1	378	384	PF11976	0.625
LIG_SUMO_SIM_par_1	495	502	PF11976	0.635
LIG_TRAF2_1	167	170	PF00917	0.634
LIG_TRFH_1	534	538	PF08558	0.626
LIG_WRC_WIRS_1	531	536	PF05994	0.783
MOD_CDC14_SPxK_1	286	289	PF00782	0.778
MOD_CDK_SPK_2	53	58	PF00069	0.671
MOD_CDK_SPxK_1	283	289	PF00069	0.784
MOD_CDK_SPxxK_3	220	227	PF00069	0.633
MOD_CDK_SPxxK_3	520	527	PF00069	0.651
MOD_CDK_SPxxK_3	53	60	PF00069	0.633
MOD_CK1_1	234	240	PF00069	0.679
MOD_CK1_1	307	313	PF00069	0.806
MOD_CK1_1	359	365	PF00069	0.821
MOD_CK1_1	392	398	PF00069	0.814
MOD_CK1_1	450	456	PF00069	0.691
MOD_CK1_1	471	477	PF00069	0.719
MOD_CK1_1	501	507	PF00069	0.802
MOD_CK1_1	520	526	PF00069	0.650
MOD_CK1_1	547	553	PF00069	0.697
MOD_CK1_1	564	570	PF00069	0.775
MOD_CK1_1	66	72	PF00069	0.701
MOD_CK2_1	164	170	PF00069	0.647
MOD_CK2_1	520	526	PF00069	0.650
MOD_GlcNHglycan	224	227	PF01048	0.470
MOD_GlcNHglycan	250	253	PF01048	0.519
MOD_GlcNHglycan	260	263	PF01048	0.522
MOD_GlcNHglycan	309	312	PF01048	0.561
MOD_GlcNHglycan	406	409	PF01048	0.456
MOD_GlcNHglycan	452	455	PF01048	0.490
MOD_GlcNHglycan	503	506	PF01048	0.471
MOD_GlcNHglycan	513	516	PF01048	0.580
MOD_GlcNHglycan	519	522	PF01048	0.518
MOD_GlcNHglycan	542	545	PF01048	0.566
MOD_GlcNHglycan	563	566	PF01048	0.499
MOD_GlcNHglycan	65	68	PF01048	0.468
MOD_GSK3_1	195	202	PF00069	0.661
MOD_GSK3_1	227	234	PF00069	0.815
MOD_GSK3_1	244	251	PF00069	0.661
MOD_GSK3_1	371	378	PF00069	0.761
MOD_GSK3_1	388	395	PF00069	0.618
MOD_GSK3_1	446	453	PF00069	0.738
MOD_GSK3_1	467	474	PF00069	0.728
MOD_GSK3_1	497	504	PF00069	0.815
MOD_GSK3_1	513	520	PF00069	0.651
MOD_GSK3_1	540	547	PF00069	0.704
MOD_GSK3_1	555	562	PF00069	0.740
MOD_GSK3_1	63	70	PF00069	0.640
MOD_N-GLC_1	207	212	PF02516	0.399
MOD_N-GLC_1	305	310	PF02516	0.460
MOD_N-GLC_1	336	341	PF02516	0.386
MOD_N-GLC_1	67	72	PF02516	0.459
MOD_N-GLC_1	75	80	PF02516	0.405
MOD_NEK2_1	206	211	PF00069	0.664
MOD_NEK2_1	375	380	PF00069	0.732
MOD_NEK2_1	436	441	PF00069	0.713
MOD_NEK2_1	445	450	PF00069	0.661
MOD_NEK2_1	467	472	PF00069	0.740
MOD_NEK2_1	498	503	PF00069	0.682
MOD_NEK2_2	239	244	PF00069	0.778
MOD_PIKK_1	76	82	PF00454	0.784
MOD_PKA_2	258	264	PF00069	0.644
MOD_PKA_2	404	410	PF00069	0.664
MOD_PKA_2	539	545	PF00069	0.822
MOD_Plk_1	207	213	PF00069	0.596
MOD_Plk_1	234	240	PF00069	0.773
MOD_Plk_1	305	311	PF00069	0.649
MOD_Plk_1	327	333	PF00069	0.685
MOD_Plk_1	436	442	PF00069	0.770
MOD_Plk_1	67	73	PF00069	0.644
MOD_Plk_2-3	320	326	PF00069	0.705
MOD_Plk_4	201	207	PF00069	0.690
MOD_ProDKin_1	110	116	PF00069	0.682
MOD_ProDKin_1	180	186	PF00069	0.661
MOD_ProDKin_1	199	205	PF00069	0.764
MOD_ProDKin_1	220	226	PF00069	0.630
MOD_ProDKin_1	244	250	PF00069	0.699
MOD_ProDKin_1	260	266	PF00069	0.711
MOD_ProDKin_1	283	289	PF00069	0.784
MOD_ProDKin_1	294	300	PF00069	0.684
MOD_ProDKin_1	356	362	PF00069	0.788
MOD_ProDKin_1	430	436	PF00069	0.698
MOD_ProDKin_1	468	474	PF00069	0.695
MOD_ProDKin_1	520	526	PF00069	0.650
MOD_ProDKin_1	53	59	PF00069	0.671
MOD_ProDKin_1	544	550	PF00069	0.717
MOD_ProDKin_1	559	565	PF00069	0.762
MOD_SUMO_for_1	348	351	PF00179	0.751
TRG_DiLeu_BaEn_4	169	175	PF01217	0.707
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.698
TRG_ENDOCYTIC_2	102	105	PF00928	0.776
TRG_ENDOCYTIC_2	219	222	PF00928	0.602
TRG_ER_diArg_1	127	130	PF00400	0.670
TRG_ER_diArg_1	135	138	PF00400	0.631
TRG_ER_diArg_1	178	181	PF00400	0.575
TRG_ER_diArg_1	253	256	PF00400	0.653
TRG_ER_diArg_1	280	283	PF00400	0.727
TRG_ER_diArg_1	31	34	PF00400	0.614
TRG_ER_diArg_1	312	315	PF00400	0.808
TRG_ER_diArg_1	35	37	PF00400	0.669
TRG_ER_diArg_1	57	60	PF00400	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYM8	Leptomonas seymouri	46%	77%
A0A3S7X4M7	Leishmania donovani	65%	100%
A4I6X0	Leishmania infantum	65%	100%
E9B1Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	99%
Q4Q667	Leishmania major	63%	100%