Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJH3_LEIBR

TriTrypDb:

LbrM.31.2140 , LBRM2903_310031400

Length:

812

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJH3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.510
CLV_C14_Caspase3-7	96	100	PF00656	0.546
CLV_NRD_NRD_1	227	229	PF00675	0.545
CLV_NRD_NRD_1	269	271	PF00675	0.702
CLV_NRD_NRD_1	366	368	PF00675	0.523
CLV_NRD_NRD_1	454	456	PF00675	0.552
CLV_NRD_NRD_1	575	577	PF00675	0.610
CLV_NRD_NRD_1	635	637	PF00675	0.539
CLV_NRD_NRD_1	723	725	PF00675	0.516
CLV_NRD_NRD_1	83	85	PF00675	0.564
CLV_PCSK_FUR_1	633	637	PF00082	0.546
CLV_PCSK_FUR_1	729	733	PF00082	0.425
CLV_PCSK_KEX2_1	269	271	PF00082	0.702
CLV_PCSK_KEX2_1	337	339	PF00082	0.606
CLV_PCSK_KEX2_1	366	368	PF00082	0.523
CLV_PCSK_KEX2_1	453	455	PF00082	0.638
CLV_PCSK_KEX2_1	53	55	PF00082	0.596
CLV_PCSK_KEX2_1	575	577	PF00082	0.614
CLV_PCSK_KEX2_1	610	612	PF00082	0.693
CLV_PCSK_KEX2_1	633	635	PF00082	0.554
CLV_PCSK_KEX2_1	718	720	PF00082	0.578
CLV_PCSK_KEX2_1	731	733	PF00082	0.424
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.606
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.596
CLV_PCSK_PC1ET2_1	610	612	PF00082	0.586
CLV_PCSK_PC1ET2_1	718	720	PF00082	0.578
CLV_PCSK_PC1ET2_1	731	733	PF00082	0.424
CLV_PCSK_PC7_1	629	635	PF00082	0.559
CLV_PCSK_SKI1_1	297	301	PF00082	0.579
CLV_PCSK_SKI1_1	366	370	PF00082	0.656
CLV_PCSK_SKI1_1	53	57	PF00082	0.532
CLV_PCSK_SKI1_1	586	590	PF00082	0.755
CLV_PCSK_SKI1_1	664	668	PF00082	0.570
CLV_PCSK_SKI1_1	72	76	PF00082	0.516
DEG_APCC_DBOX_1	791	799	PF00400	0.447
DEG_Nend_UBRbox_1	1	4	PF02207	0.503
DEG_SPOP_SBC_1	329	333	PF00917	0.689
DOC_CKS1_1	323	328	PF01111	0.590
DOC_CKS1_1	431	436	PF01111	0.573
DOC_MAPK_MEF2A_6	618	627	PF00069	0.577
DOC_MAPK_RevD_3	438	454	PF00069	0.522
DOC_PP2B_LxvP_1	181	184	PF13499	0.546
DOC_PP4_FxxP_1	308	311	PF00568	0.574
DOC_PP4_FxxP_1	491	494	PF00568	0.546
DOC_USP7_MATH_1	116	120	PF00917	0.568
DOC_USP7_MATH_1	241	245	PF00917	0.617
DOC_USP7_MATH_1	248	252	PF00917	0.606
DOC_USP7_MATH_1	344	348	PF00917	0.664
DOC_USP7_MATH_1	494	498	PF00917	0.563
DOC_USP7_MATH_1	561	565	PF00917	0.694
DOC_USP7_MATH_1	791	795	PF00917	0.445
DOC_USP7_UBL2_3	214	218	PF12436	0.678
DOC_WW_Pin1_4	141	146	PF00397	0.631
DOC_WW_Pin1_4	312	317	PF00397	0.694
DOC_WW_Pin1_4	322	327	PF00397	0.561
DOC_WW_Pin1_4	331	336	PF00397	0.645
DOC_WW_Pin1_4	430	435	PF00397	0.660
DOC_WW_Pin1_4	469	474	PF00397	0.689
DOC_WW_Pin1_4	599	604	PF00397	0.674
DOC_WW_Pin1_4	648	653	PF00397	0.622
DOC_WW_Pin1_4	654	659	PF00397	0.591
LIG_14-3-3_CanoR_1	101	107	PF00244	0.508
LIG_14-3-3_CanoR_1	192	199	PF00244	0.682
LIG_14-3-3_CanoR_1	209	216	PF00244	0.550
LIG_14-3-3_CanoR_1	228	234	PF00244	0.513
LIG_14-3-3_CanoR_1	240	248	PF00244	0.551
LIG_14-3-3_CanoR_1	269	279	PF00244	0.677
LIG_14-3-3_CanoR_1	304	309	PF00244	0.630
LIG_14-3-3_CanoR_1	328	335	PF00244	0.565
LIG_14-3-3_CanoR_1	377	386	PF00244	0.555
LIG_14-3-3_CanoR_1	54	60	PF00244	0.482
LIG_14-3-3_CanoR_1	6	11	PF00244	0.600
LIG_14-3-3_CanoR_1	72	78	PF00244	0.511
LIG_14-3-3_CanoR_1	732	738	PF00244	0.414
LIG_14-3-3_CanoR_1	87	97	PF00244	0.516
LIG_BRCT_BRCA1_1	351	355	PF00533	0.617
LIG_CtBP_PxDLS_1	675	679	PF00389	0.555
LIG_deltaCOP1_diTrp_1	482	491	PF00928	0.528
LIG_FHA_1	29	35	PF00498	0.524
LIG_FHA_1	417	423	PF00498	0.633
LIG_FHA_1	521	527	PF00498	0.702
LIG_FHA_1	622	628	PF00498	0.652
LIG_FHA_2	103	109	PF00498	0.627
LIG_FHA_2	22	28	PF00498	0.512
LIG_FHA_2	360	366	PF00498	0.518
LIG_FHA_2	444	450	PF00498	0.624
LIG_FHA_2	94	100	PF00498	0.599
LIG_LIR_Apic_2	280	284	PF02991	0.667
LIG_LIR_Apic_2	307	311	PF02991	0.571
LIG_LIR_Apic_2	562	568	PF02991	0.584
LIG_LIR_Gen_1	637	646	PF02991	0.546
LIG_LIR_Gen_1	784	791	PF02991	0.542
LIG_LIR_Nem_3	27	33	PF02991	0.652
LIG_LIR_Nem_3	49	55	PF02991	0.471
LIG_LIR_Nem_3	591	596	PF02991	0.626
LIG_LIR_Nem_3	637	641	PF02991	0.546
LIG_LIR_Nem_3	692	698	PF02991	0.548
LIG_LIR_Nem_3	736	740	PF02991	0.421
LIG_LIR_Nem_3	784	788	PF02991	0.560
LIG_LYPXL_yS_3	695	698	PF13949	0.666
LIG_NRBOX	794	800	PF00104	0.416
LIG_PCNA_yPIPBox_3	2	11	PF02747	0.501
LIG_PDZ_Class_1	807	812	PF00595	0.612
LIG_Pex14_2	589	593	PF04695	0.532
LIG_SH2_CRK	30	34	PF00017	0.594
LIG_SH2_CRK	52	56	PF00017	0.476
LIG_SH2_CRK	565	569	PF00017	0.570
LIG_SH2_CRK	785	789	PF00017	0.569
LIG_SH2_GRB2like	59	62	PF00017	0.510
LIG_SH2_STAP1	785	789	PF00017	0.569
LIG_SH2_STAT5	254	257	PF00017	0.561
LIG_SH2_STAT5	30	33	PF00017	0.530
LIG_SH2_STAT5	500	503	PF00017	0.546
LIG_SH2_STAT5	508	511	PF00017	0.572
LIG_SH2_STAT5	59	62	PF00017	0.510
LIG_SH2_STAT5	93	96	PF00017	0.543
LIG_SH3_1	459	465	PF00018	0.633
LIG_SH3_1	642	648	PF00018	0.543
LIG_SH3_2	323	328	PF14604	0.650
LIG_SH3_2	606	611	PF14604	0.642
LIG_SH3_3	174	180	PF00018	0.553
LIG_SH3_3	320	326	PF00018	0.783
LIG_SH3_3	383	389	PF00018	0.569
LIG_SH3_3	420	426	PF00018	0.581
LIG_SH3_3	428	434	PF00018	0.561
LIG_SH3_3	459	465	PF00018	0.683
LIG_SH3_3	467	473	PF00018	0.650
LIG_SH3_3	577	583	PF00018	0.686
LIG_SH3_3	600	606	PF00018	0.646
LIG_SH3_3	617	623	PF00018	0.623
LIG_SH3_3	642	648	PF00018	0.588
LIG_SH3_3	695	701	PF00018	0.664
LIG_SH3_4	214	221	PF00018	0.680
LIG_TYR_ITIM	783	788	PF00017	0.512
LIG_WRC_WIRS_1	140	145	PF05994	0.541
LIG_WRC_WIRS_1	734	739	PF05994	0.419
LIG_WW_3	699	703	PF00397	0.665
MOD_CDK_SPK_2	141	146	PF00069	0.542
MOD_CDK_SPxK_1	141	147	PF00069	0.546
MOD_CDK_SPxK_1	322	328	PF00069	0.602
MOD_CDK_SPxK_1	331	337	PF00069	0.647
MOD_CDK_SPxxK_3	331	338	PF00069	0.702
MOD_CK1_1	119	125	PF00069	0.538
MOD_CK1_1	156	162	PF00069	0.608
MOD_CK1_1	167	173	PF00069	0.560
MOD_CK1_1	201	207	PF00069	0.655
MOD_CK1_1	239	245	PF00069	0.631
MOD_CK1_1	28	34	PF00069	0.603
MOD_CK1_1	330	336	PF00069	0.646
MOD_CK1_1	36	42	PF00069	0.607
MOD_CK1_1	376	382	PF00069	0.552
MOD_CK1_1	415	421	PF00069	0.598
MOD_CK1_1	432	438	PF00069	0.667
MOD_CK1_1	64	70	PF00069	0.632
MOD_CK1_1	73	79	PF00069	0.559
MOD_CK1_1	743	749	PF00069	0.483
MOD_CK1_1	775	781	PF00069	0.540
MOD_CK1_1	83	89	PF00069	0.597
MOD_CK2_1	239	245	PF00069	0.578
MOD_CK2_1	344	350	PF00069	0.668
MOD_CK2_1	359	365	PF00069	0.518
MOD_CK2_1	443	449	PF00069	0.563
MOD_CK2_1	670	676	PF00069	0.656
MOD_GlcNHglycan	128	132	PF01048	0.560
MOD_GlcNHglycan	194	197	PF01048	0.579
MOD_GlcNHglycan	200	203	PF01048	0.551
MOD_GlcNHglycan	292	295	PF01048	0.662
MOD_GlcNHglycan	297	300	PF01048	0.699
MOD_GlcNHglycan	396	399	PF01048	0.628
MOD_GlcNHglycan	440	443	PF01048	0.594
MOD_GlcNHglycan	464	468	PF01048	0.640
MOD_GlcNHglycan	479	482	PF01048	0.580
MOD_GlcNHglycan	484	487	PF01048	0.531
MOD_GlcNHglycan	494	497	PF01048	0.595
MOD_GlcNHglycan	501	504	PF01048	0.618
MOD_GlcNHglycan	547	550	PF01048	0.647
MOD_GlcNHglycan	66	69	PF01048	0.633
MOD_GlcNHglycan	72	75	PF01048	0.657
MOD_GlcNHglycan	78	81	PF01048	0.606
MOD_GlcNHglycan	87	90	PF01048	0.553
MOD_GSK3_1	163	170	PF00069	0.628
MOD_GSK3_1	188	195	PF00069	0.705
MOD_GSK3_1	197	204	PF00069	0.620
MOD_GSK3_1	21	28	PF00069	0.563
MOD_GSK3_1	235	242	PF00069	0.643
MOD_GSK3_1	243	250	PF00069	0.597
MOD_GSK3_1	300	307	PF00069	0.748
MOD_GSK3_1	327	334	PF00069	0.622
MOD_GSK3_1	33	40	PF00069	0.607
MOD_GSK3_1	412	419	PF00069	0.706
MOD_GSK3_1	494	501	PF00069	0.547
MOD_GSK3_1	53	60	PF00069	0.440
MOD_GSK3_1	597	604	PF00069	0.609
MOD_GSK3_1	72	79	PF00069	0.526
MOD_GSK3_1	758	765	PF00069	0.565
MOD_GSK3_1	85	92	PF00069	0.575
MOD_LATS_1	336	342	PF00433	0.715
MOD_N-GLC_1	545	550	PF02516	0.561
MOD_N-GLC_1	61	66	PF02516	0.644
MOD_N-GLC_1	648	653	PF02516	0.545
MOD_N-GLC_1	772	777	PF02516	0.571
MOD_N-GLC_1	89	94	PF02516	0.676
MOD_NEK2_1	126	131	PF00069	0.664
MOD_NEK2_1	271	276	PF00069	0.723
MOD_NEK2_1	373	378	PF00069	0.787
MOD_NEK2_1	499	504	PF00069	0.645
MOD_NEK2_1	55	60	PF00069	0.611
MOD_NEK2_1	627	632	PF00069	0.672
MOD_NEK2_1	733	738	PF00069	0.413
MOD_NEK2_2	740	745	PF00069	0.555
MOD_NEK2_2	772	777	PF00069	0.561
MOD_PIKK_1	156	162	PF00454	0.571
MOD_PIKK_1	271	277	PF00454	0.670
MOD_PIKK_1	424	430	PF00454	0.641
MOD_PIKK_1	432	438	PF00454	0.593
MOD_PIKK_1	613	619	PF00454	0.640
MOD_PKA_1	228	234	PF00069	0.551
MOD_PKA_1	269	275	PF00069	0.683
MOD_PKA_1	53	59	PF00069	0.478
MOD_PKA_1	762	768	PF00069	0.571
MOD_PKA_2	102	108	PF00069	0.574
MOD_PKA_2	126	132	PF00069	0.564
MOD_PKA_2	208	214	PF00069	0.598
MOD_PKA_2	236	242	PF00069	0.578
MOD_PKA_2	269	275	PF00069	0.683
MOD_PKA_2	327	333	PF00069	0.573
MOD_PKA_2	344	350	PF00069	0.688
MOD_PKA_2	37	43	PF00069	0.575
MOD_PKA_2	376	382	PF00069	0.552
MOD_PKA_2	53	59	PF00069	0.472
MOD_PKA_2	628	634	PF00069	0.626
MOD_PKA_2	701	707	PF00069	0.549
MOD_PKA_2	791	797	PF00069	0.442
MOD_PKA_2	83	89	PF00069	0.545
MOD_Plk_1	127	133	PF00069	0.660
MOD_Plk_1	164	170	PF00069	0.606
MOD_Plk_1	349	355	PF00069	0.623
MOD_Plk_1	89	95	PF00069	0.656
MOD_Plk_4	248	254	PF00069	0.559
MOD_Plk_4	25	31	PF00069	0.613
MOD_Plk_4	277	283	PF00069	0.661
MOD_Plk_4	561	567	PF00069	0.577
MOD_Plk_4	6	12	PF00069	0.501
MOD_Plk_4	89	95	PF00069	0.658
MOD_ProDKin_1	141	147	PF00069	0.635
MOD_ProDKin_1	312	318	PF00069	0.693
MOD_ProDKin_1	322	328	PF00069	0.565
MOD_ProDKin_1	331	337	PF00069	0.647
MOD_ProDKin_1	430	436	PF00069	0.659
MOD_ProDKin_1	469	475	PF00069	0.684
MOD_ProDKin_1	599	605	PF00069	0.571
MOD_ProDKin_1	648	654	PF00069	0.620
MOD_SUMO_rev_2	637	644	PF00179	0.548
TRG_DiLeu_BaEn_2	584	590	PF01217	0.537
TRG_ENDOCYTIC_2	18	21	PF00928	0.627
TRG_ENDOCYTIC_2	30	33	PF00928	0.570
TRG_ENDOCYTIC_2	52	55	PF00928	0.478
TRG_ENDOCYTIC_2	695	698	PF00928	0.666
TRG_ENDOCYTIC_2	734	737	PF00928	0.498
TRG_ENDOCYTIC_2	785	788	PF00928	0.590
TRG_ER_diArg_1	264	267	PF00400	0.686
TRG_ER_diArg_1	268	270	PF00400	0.679
TRG_ER_diArg_1	453	455	PF00400	0.534
TRG_ER_diArg_1	575	577	PF00400	0.610
TRG_ER_diArg_1	633	636	PF00400	0.549
TRG_NLS_MonoExtN_4	715	722	PF00514	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFN0	Leishmania donovani	49%	96%
A4I6W6	Leishmania infantum	49%	96%
E9B1Z0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	98%
Q4Q671	Leishmania major	47%	100%