Peptidase m20/m25/m40 family-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidase m20/m25/m40 family-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJG9_LEIBR

TriTrypDb:

LbrM.31.2100 , LBRM2903_310031100

Length:

471

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 33

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJG9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0019538	protein metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	24
GO:0016787	hydrolase activity	2	24
GO:0005488	binding	1	1
GO:0005506	iron ion binding	6	1
GO:0016491	oxidoreductase activity	2	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0008233	peptidase activity	3	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	8	10	PF00675	0.363
CLV_PCSK_KEX2_1	354	356	PF00082	0.438
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.438
CLV_PCSK_SKI1_1	242	246	PF00082	0.367
CLV_PCSK_SKI1_1	354	358	PF00082	0.345
CLV_PCSK_SKI1_1	452	456	PF00082	0.355
DEG_APCC_DBOX_1	241	249	PF00400	0.365
DOC_ANK_TNKS_1	106	113	PF00023	0.452
DOC_ANK_TNKS_1	208	215	PF00023	0.365
DOC_CYCLIN_RxL_1	239	249	PF00134	0.354
DOC_MAPK_gen_1	180	188	PF00069	0.427
DOC_MAPK_MEF2A_6	182	190	PF00069	0.381
DOC_MAPK_MEF2A_6	329	338	PF00069	0.372
DOC_MAPK_MEF2A_6	76	84	PF00069	0.446
DOC_PP1_RVXF_1	364	370	PF00149	0.390
DOC_PP2B_LxvP_1	446	449	PF13499	0.347
DOC_PP4_FxxP_1	306	309	PF00568	0.427
DOC_USP7_MATH_1	143	147	PF00917	0.478
DOC_USP7_MATH_1	289	293	PF00917	0.301
DOC_USP7_UBL2_3	366	370	PF12436	0.485
DOC_WW_Pin1_4	166	171	PF00397	0.443
DOC_WW_Pin1_4	31	36	PF00397	0.457
DOC_WW_Pin1_4	466	471	PF00397	0.456
DOC_WW_Pin1_4	74	79	PF00397	0.437
LIG_14-3-3_CanoR_1	329	335	PF00244	0.381
LIG_14-3-3_CanoR_1	9	13	PF00244	0.584
LIG_APCC_ABBA_1	419	424	PF00400	0.365
LIG_BIR_II_1	1	5	PF00653	0.551
LIG_BRCT_BRCA1_1	33	37	PF00533	0.547
LIG_EH1_1	426	434	PF00400	0.379
LIG_FHA_1	203	209	PF00498	0.369
LIG_FHA_1	235	241	PF00498	0.416
LIG_FHA_1	251	257	PF00498	0.297
LIG_FHA_1	331	337	PF00498	0.382
LIG_FHA_1	41	47	PF00498	0.522
LIG_FHA_1	428	434	PF00498	0.357
LIG_FHA_1	453	459	PF00498	0.362
LIG_FHA_1	75	81	PF00498	0.426
LIG_FHA_2	218	224	PF00498	0.381
LIG_FHA_2	255	261	PF00498	0.484
LIG_LIR_Gen_1	132	143	PF02991	0.409
LIG_LIR_Gen_1	196	204	PF02991	0.366
LIG_LIR_Gen_1	2	12	PF02991	0.477
LIG_LIR_Gen_1	25	35	PF02991	0.430
LIG_LIR_Gen_1	444	451	PF02991	0.377
LIG_LIR_Gen_1	48	58	PF02991	0.425
LIG_LIR_Gen_1	67	73	PF02991	0.486
LIG_LIR_Gen_1	77	85	PF02991	0.378
LIG_LIR_Nem_3	132	138	PF02991	0.380
LIG_LIR_Nem_3	196	202	PF02991	0.366
LIG_LIR_Nem_3	2	8	PF02991	0.476
LIG_LIR_Nem_3	25	30	PF02991	0.429
LIG_LIR_Nem_3	368	372	PF02991	0.321
LIG_LIR_Nem_3	444	448	PF02991	0.377
LIG_LIR_Nem_3	48	54	PF02991	0.474
LIG_LIR_Nem_3	67	71	PF02991	0.391
LIG_LIR_Nem_3	77	82	PF02991	0.370
LIG_LRP6_Inhibitor_1	323	329	PF00058	0.448
LIG_MYND_1	104	108	PF01753	0.369
LIG_MYND_1	381	385	PF01753	0.377
LIG_Pex14_2	281	285	PF04695	0.394
LIG_Pex14_2	37	41	PF04695	0.576
LIG_SH2_CRK	68	72	PF00017	0.476
LIG_SH2_PTP2	27	30	PF00017	0.446
LIG_SH2_SRC	27	30	PF00017	0.459
LIG_SH2_SRC	68	71	PF00017	0.368
LIG_SH2_STAP1	199	203	PF00017	0.370
LIG_SH2_STAP1	268	272	PF00017	0.336
LIG_SH2_STAT3	403	406	PF00017	0.480
LIG_SH2_STAT5	199	202	PF00017	0.234
LIG_SH2_STAT5	27	30	PF00017	0.446
LIG_SH2_STAT5	70	73	PF00017	0.390
LIG_SH3_1	102	108	PF00018	0.369
LIG_SH3_3	102	108	PF00018	0.368
LIG_SH3_3	253	259	PF00018	0.409
LIG_SUMO_SIM_par_1	157	162	PF11976	0.361
LIG_TRAF2_1	163	166	PF00917	0.361
LIG_TYR_ITIM	66	71	PF00017	0.490
LIG_UBA3_1	244	252	PF00899	0.443
MOD_CDK_SPK_2	466	471	PF00069	0.456
MOD_CK1_1	224	230	PF00069	0.404
MOD_CK2_1	11	17	PF00069	0.447
MOD_CK2_1	217	223	PF00069	0.381
MOD_CK2_1	254	260	PF00069	0.434
MOD_GlcNHglycan	1	4	PF01048	0.605
MOD_GlcNHglycan	165	169	PF01048	0.381
MOD_GlcNHglycan	193	196	PF01048	0.371
MOD_GlcNHglycan	226	229	PF01048	0.361
MOD_GlcNHglycan	24	27	PF01048	0.481
MOD_GlcNHglycan	393	397	PF01048	0.448
MOD_GSK3_1	139	146	PF00069	0.506
MOD_GSK3_1	193	200	PF00069	0.421
MOD_GSK3_1	217	224	PF00069	0.494
MOD_GSK3_1	234	241	PF00069	0.349
MOD_GSK3_1	250	257	PF00069	0.347
MOD_GSK3_1	307	314	PF00069	0.503
MOD_GSK3_1	330	337	PF00069	0.381
MOD_N-GLC_1	197	202	PF02516	0.489
MOD_N-GLC_1	31	36	PF02516	0.468
MOD_N-GLC_2	376	378	PF02516	0.443
MOD_NEK2_1	197	202	PF00069	0.395
MOD_NEK2_1	204	209	PF00069	0.335
MOD_NEK2_1	221	226	PF00069	0.347
MOD_NEK2_1	311	316	PF00069	0.448
MOD_NEK2_1	399	404	PF00069	0.406
MOD_NEK2_1	427	432	PF00069	0.399
MOD_NEK2_1	454	459	PF00069	0.461
MOD_NEK2_2	365	370	PF00069	0.525
MOD_PIKK_1	197	203	PF00454	0.489
MOD_PIKK_1	3	9	PF00454	0.431
MOD_PKA_2	238	244	PF00069	0.477
MOD_PKA_2	8	14	PF00069	0.579
MOD_Plk_1	16	22	PF00069	0.443
MOD_Plk_1	197	203	PF00069	0.531
MOD_Plk_1	214	220	PF00069	0.424
MOD_Plk_1	254	260	PF00069	0.365
MOD_Plk_1	3	9	PF00069	0.451
MOD_Plk_4	16	22	PF00069	0.447
MOD_Plk_4	90	96	PF00069	0.447
MOD_ProDKin_1	166	172	PF00069	0.443
MOD_ProDKin_1	31	37	PF00069	0.461
MOD_ProDKin_1	74	80	PF00069	0.433
MOD_SUMO_for_1	344	347	PF00179	0.365
TRG_ENDOCYTIC_2	135	138	PF00928	0.442
TRG_ENDOCYTIC_2	199	202	PF00928	0.381
TRG_ENDOCYTIC_2	27	30	PF00928	0.444
TRG_ENDOCYTIC_2	68	71	PF00928	0.458
TRG_ENDOCYTIC_2	97	100	PF00928	0.369
TRG_NES_CRM1_1	181	193	PF08389	0.499
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	355	360	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.254

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q9	Leptomonas seymouri	74%	100%
A0A0N1PBD8	Leptomonas seymouri	79%	100%
A0A0S4JJE7	Bodo saltans	60%	100%
A0A1X0P1Q0	Trypanosomatidae	65%	99%
A0A381MQ29	Leishmania infantum	92%	100%
A0A3Q8IFP2	Leishmania donovani	92%	83%
A0A3R7KSZ4	Trypanosoma rangeli	63%	100%
A0A3S7X4P6	Leishmania donovani	92%	100%
A0A3S7X6U2	Leishmania donovani	74%	100%
A4HJH1	Leishmania braziliensis	100%	100%
A4HJI4	Leishmania braziliensis	99%	100%
A4HLM2	Leishmania braziliensis	72%	100%
A4I933	Leishmania infantum	74%	100%
B2KZE7	Corynebacterium striatum	26%	100%
C9ZQ48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	99%
D0A536	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	99%
E9B1Y8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B201	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B3Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q3ZC84	Bos taurus	27%	99%
Q4Q426	Leishmania major	74%	100%
Q4Q660	Leishmania major	92%	100%
Q4Q673	Leishmania major	92%	100%
Q5R432	Pongo abelii	27%	99%
Q66HG3	Rattus norvegicus	25%	96%
Q6Q0N1	Rattus norvegicus	26%	99%
Q96KP4	Homo sapiens	27%	99%
Q9D1A2	Mus musculus	26%	99%
Q9P6I2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	99%
V5BHA2	Trypanosoma cruzi	63%	99%