LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania braziliensis
UniProt:
A4HJG7_LEIBR
TriTrypDb:
LbrM.31.2080 , LBRM2903_310030000 *
Length:
1343

Annotations

LeishMANIAdb annotations

A typical Kinetoplastid receptor kinase, belonging to the STE11 kinase family (MAP3K). Very tentatively required for stress response and / or developmental stage regulation. Expanded in many kinetoplastid groups, but especially in Leishmaniids.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 13
NetGPI no yes: 0, no: 14
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
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Expansion

Sequence features

A4HJG7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
TermNameLevelCount
GO:0006468 protein phosphorylation 5 14
GO:0006793 phosphorus metabolic process 3 15
GO:0006796 phosphate-containing compound metabolic process 4 15
GO:0006807 nitrogen compound metabolic process 2 14
GO:0008152 metabolic process 1 15
GO:0009987 cellular process 1 15
GO:0016310 phosphorylation 5 15
GO:0019538 protein metabolic process 3 14
GO:0036211 protein modification process 4 14
GO:0043170 macromolecule metabolic process 3 14
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 14
GO:0003824 catalytic activity 1 15
GO:0004672 protein kinase activity 3 15
GO:0004674 protein serine/threonine kinase activity 4 2
GO:0005488 binding 1 14
GO:0005524 ATP binding 5 14
GO:0016301 kinase activity 4 15
GO:0016740 transferase activity 2 15
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 15
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 15
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 1068 1072 PF00656 0.537
CLV_C14_Caspase3-7 173 177 PF00656 0.272
CLV_C14_Caspase3-7 707 711 PF00656 0.521
CLV_NRD_NRD_1 1026 1028 PF00675 0.388
CLV_NRD_NRD_1 517 519 PF00675 0.467
CLV_NRD_NRD_1 535 537 PF00675 0.426
CLV_NRD_NRD_1 696 698 PF00675 0.355
CLV_NRD_NRD_1 792 794 PF00675 0.312
CLV_NRD_NRD_1 885 887 PF00675 0.560
CLV_PCSK_FUR_1 533 537 PF00082 0.381
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Homologs

ProteinTaxonomySequence identityCoverage
A0A3Q8IG80 Leishmania donovani 61% 98%
A0A3S7WQ86 Leishmania donovani 44% 99%
A0A3S7X4L0 Leishmania donovani 59% 99%
A4HJG2 Leishmania braziliensis 88% 100%
A4HTL4 Leishmania infantum 44% 99%
A4I6V7 Leishmania infantum 61% 98%
A4I6V8 Leishmania infantum 58% 99%
E9AME5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9B1Y1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 60% 98%
E9B1Y2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 99%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS