LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein, unknown function (fragment)
Species:
Leishmania braziliensis
UniProt:
A4HJG6_LEIBR
TriTrypDb:
LbrM.31.2070 *
Length:
793

Annotations

LeishMANIAdb annotations

A typical Kinetoplastid receptor kinase, belonging to the STE11 kinase family (MAP3K). Very tentatively required for stress response and / or developmental stage regulation. Expanded in many kinetoplastid groups, but especially in Leishmaniids.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 2
NetGPI no yes: 0, no: 2
Cellular components
Term Name Level Count
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

A4HJG6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJG6

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016310 phosphorylation 5 1
GO:0044237 cellular metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0016740 transferase activity 2 3
GO:0004672 protein kinase activity 3 1
GO:0004674 protein serine/threonine kinase activity 4 1
GO:0016301 kinase activity 4 1
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 1
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 713 717 PF00656 0.352
CLV_NRD_NRD_1 19 21 PF00675 0.461
CLV_NRD_NRD_1 375 377 PF00675 0.482
CLV_NRD_NRD_1 421 423 PF00675 0.226
CLV_NRD_NRD_1 444 446 PF00675 0.509
CLV_NRD_NRD_1 452 454 PF00675 0.483
CLV_NRD_NRD_1 466 468 PF00675 0.516
CLV_NRD_NRD_1 515 517 PF00675 0.667
CLV_NRD_NRD_1 533 535 PF00675 0.634
CLV_NRD_NRD_1 702 704 PF00675 0.538
CLV_PCSK_FUR_1 17 21 PF00082 0.455
CLV_PCSK_FUR_1 419 423 PF00082 0.301
CLV_PCSK_KEX2_1 16 18 PF00082 0.446
CLV_PCSK_KEX2_1 19 21 PF00082 0.459
CLV_PCSK_KEX2_1 375 377 PF00082 0.482
CLV_PCSK_KEX2_1 421 423 PF00082 0.226
CLV_PCSK_KEX2_1 444 446 PF00082 0.509
CLV_PCSK_KEX2_1 452 454 PF00082 0.483
CLV_PCSK_KEX2_1 466 468 PF00082 0.516
CLV_PCSK_KEX2_1 515 517 PF00082 0.667
CLV_PCSK_KEX2_1 702 704 PF00082 0.538
CLV_PCSK_PC1ET2_1 16 18 PF00082 0.446
CLV_PCSK_SKI1_1 224 228 PF00082 0.513
CLV_PCSK_SKI1_1 358 362 PF00082 0.503
CLV_PCSK_SKI1_1 41 45 PF00082 0.373
CLV_PCSK_SKI1_1 421 425 PF00082 0.226
CLV_PCSK_SKI1_1 452 456 PF00082 0.555
CLV_PCSK_SKI1_1 467 471 PF00082 0.503
CLV_PCSK_SKI1_1 534 538 PF00082 0.673
CLV_PCSK_SKI1_1 76 80 PF00082 0.498
DEG_APCC_DBOX_1 33 41 PF00400 0.573
DEG_APCC_DBOX_1 357 365 PF00400 0.302
DEG_APCC_DBOX_1 420 428 PF00400 0.426
DEG_Nend_UBRbox_2 1 3 PF02207 0.659
DOC_CKS1_1 612 617 PF01111 0.380
DOC_CYCLIN_RxL_1 140 153 PF00134 0.272
DOC_CYCLIN_RxL_1 36 48 PF00134 0.546
DOC_CYCLIN_RxL_1 73 81 PF00134 0.298
DOC_CYCLIN_yCln2_LP_2 400 406 PF00134 0.292
DOC_MAPK_gen_1 140 149 PF00069 0.272
DOC_MAPK_MEF2A_6 41 49 PF00069 0.527
DOC_MAPK_MEF2A_6 773 782 PF00069 0.387
DOC_PP1_RVXF_1 374 381 PF00149 0.275
DOC_PP2B_LxvP_1 114 117 PF13499 0.468
DOC_PP2B_LxvP_1 400 403 PF13499 0.292
DOC_PP2B_LxvP_1 574 577 PF13499 0.448
DOC_PP2B_LxvP_1 6 9 PF13499 0.630
DOC_PP2B_LxvP_1 687 690 PF13499 0.462
DOC_PP4_FxxP_1 196 199 PF00568 0.335
DOC_PP4_FxxP_1 612 615 PF00568 0.382
DOC_USP7_MATH_1 328 332 PF00917 0.299
DOC_USP7_MATH_1 752 756 PF00917 0.427
DOC_USP7_UBL2_3 491 495 PF12436 0.317
DOC_WW_Pin1_4 250 255 PF00397 0.277
DOC_WW_Pin1_4 555 560 PF00397 0.380
DOC_WW_Pin1_4 611 616 PF00397 0.383
DOC_WW_Pin1_4 661 666 PF00397 0.500
DOC_WW_Pin1_4 728 733 PF00397 0.438
LIG_14-3-3_CanoR_1 10 18 PF00244 0.647
LIG_14-3-3_CanoR_1 130 136 PF00244 0.265
LIG_14-3-3_CanoR_1 145 150 PF00244 0.230
LIG_14-3-3_CanoR_1 375 379 PF00244 0.278
LIG_14-3-3_CanoR_1 444 450 PF00244 0.298
LIG_14-3-3_CanoR_1 452 459 PF00244 0.290
LIG_14-3-3_CanoR_1 474 478 PF00244 0.365
LIG_14-3-3_CanoR_1 516 522 PF00244 0.439
LIG_14-3-3_CanoR_1 542 552 PF00244 0.323
LIG_14-3-3_CanoR_1 588 594 PF00244 0.442
LIG_14-3-3_CanoR_1 76 85 PF00244 0.291
LIG_14-3-3_CanoR_1 781 791 PF00244 0.359
LIG_14-3-3_CanoR_1 96 104 PF00244 0.243
LIG_Actin_WH2_2 447 465 PF00022 0.314
LIG_Actin_WH2_2 493 511 PF00022 0.355
LIG_BIR_III_4 716 720 PF00653 0.393
LIG_BRCT_BRCA1_1 608 612 PF00533 0.395
LIG_Clathr_ClatBox_1 44 48 PF01394 0.525
LIG_DLG_GKlike_1 145 152 PF00625 0.254
LIG_eIF4E_1 73 79 PF01652 0.297
LIG_EVH1_1 574 578 PF00568 0.449
LIG_FHA_1 156 162 PF00498 0.273
LIG_FHA_1 251 257 PF00498 0.269
LIG_FHA_1 339 345 PF00498 0.362
LIG_FHA_1 453 459 PF00498 0.323
LIG_FHA_1 512 518 PF00498 0.430
LIG_FHA_1 617 623 PF00498 0.355
LIG_FHA_1 73 79 PF00498 0.318
LIG_FHA_1 756 762 PF00498 0.409
LIG_FHA_1 786 792 PF00498 0.362
LIG_FHA_1 92 98 PF00498 0.245
LIG_FHA_1 99 105 PF00498 0.264
LIG_FHA_2 593 599 PF00498 0.425
LIG_LIR_Apic_2 193 199 PF02991 0.328
LIG_LIR_Apic_2 322 328 PF02991 0.290
LIG_LIR_Apic_2 609 615 PF02991 0.385
LIG_LIR_Gen_1 136 146 PF02991 0.318
LIG_LIR_Gen_1 192 202 PF02991 0.346
LIG_LIR_Gen_1 275 286 PF02991 0.338
LIG_LIR_Gen_1 294 303 PF02991 0.384
LIG_LIR_Gen_1 333 344 PF02991 0.320
LIG_LIR_Gen_1 345 352 PF02991 0.290
LIG_LIR_Gen_1 414 424 PF02991 0.594
LIG_LIR_Gen_1 472 483 PF02991 0.482
LIG_LIR_Gen_1 499 508 PF02991 0.371
LIG_LIR_Gen_1 52 63 PF02991 0.280
LIG_LIR_Gen_1 550 561 PF02991 0.323
LIG_LIR_Gen_1 80 90 PF02991 0.317
LIG_LIR_Nem_3 192 197 PF02991 0.331
LIG_LIR_Nem_3 275 281 PF02991 0.356
LIG_LIR_Nem_3 294 298 PF02991 0.395
LIG_LIR_Nem_3 333 339 PF02991 0.480
LIG_LIR_Nem_3 345 349 PF02991 0.289
LIG_LIR_Nem_3 414 420 PF02991 0.503
LIG_LIR_Nem_3 436 442 PF02991 0.292
LIG_LIR_Nem_3 472 478 PF02991 0.483
LIG_LIR_Nem_3 499 504 PF02991 0.360
LIG_LIR_Nem_3 52 58 PF02991 0.280
LIG_LIR_Nem_3 550 556 PF02991 0.285
LIG_LIR_Nem_3 80 85 PF02991 0.325
LIG_NRBOX 55 61 PF00104 0.236
LIG_Pex14_1 51 55 PF04695 0.292
LIG_PTB_Apo_2 181 188 PF02174 0.272
LIG_PTB_Phospho_1 181 187 PF10480 0.272
LIG_PTB_Phospho_1 188 194 PF10480 0.273
LIG_RPA_C_Fungi 697 709 PF08784 0.393
LIG_SH2_CRK 194 198 PF00017 0.314
LIG_SH2_CRK 475 479 PF00017 0.412
LIG_SH2_CRK 501 505 PF00017 0.426
LIG_SH2_GRB2like 233 236 PF00017 0.328
LIG_SH2_GRB2like 471 474 PF00017 0.420
LIG_SH2_PTP2 259 262 PF00017 0.258
LIG_SH2_PTP2 363 366 PF00017 0.359
LIG_SH2_SRC 233 236 PF00017 0.328
LIG_SH2_STAP1 138 142 PF00017 0.339
LIG_SH2_STAP1 471 475 PF00017 0.425
LIG_SH2_STAT5 176 179 PF00017 0.355
LIG_SH2_STAT5 187 190 PF00017 0.299
LIG_SH2_STAT5 233 236 PF00017 0.352
LIG_SH2_STAT5 259 262 PF00017 0.258
LIG_SH2_STAT5 265 268 PF00017 0.356
LIG_SH2_STAT5 278 281 PF00017 0.526
LIG_SH2_STAT5 346 349 PF00017 0.370
LIG_SH2_STAT5 363 366 PF00017 0.359
LIG_SH2_STAT5 394 397 PF00017 0.293
LIG_SH2_STAT5 417 420 PF00017 0.345
LIG_SH2_STAT5 471 474 PF00017 0.420
LIG_SH2_STAT5 475 478 PF00017 0.416
LIG_SH2_STAT5 55 58 PF00017 0.250
LIG_SH2_STAT5 73 76 PF00017 0.308
LIG_SH2_STAT5 750 753 PF00017 0.494
LIG_SH2_STAT5 92 95 PF00017 0.266
LIG_SH3_2 25 30 PF14604 0.521
LIG_SH3_3 22 28 PF00018 0.546
LIG_SH3_3 295 301 PF00018 0.387
LIG_SH3_3 564 570 PF00018 0.575
LIG_SH3_3 572 578 PF00018 0.561
LIG_SH3_3 59 65 PF00018 0.236
LIG_SUMO_SIM_par_1 148 155 PF11976 0.549
LIG_SUMO_SIM_par_1 315 322 PF11976 0.305
LIG_SUMO_SIM_par_1 402 409 PF11976 0.236
LIG_SUMO_SIM_par_1 430 436 PF11976 0.292
LIG_SUMO_SIM_par_1 64 70 PF11976 0.258
LIG_SxIP_EBH_1 523 535 PF03271 0.547
LIG_TRAF2_1 624 627 PF00917 0.406
LIG_TRAF2_1 689 692 PF00917 0.548
LIG_TRFH_1 227 231 PF08558 0.310
LIG_TYR_ITIM 344 349 PF00017 0.396
LIG_TYR_ITIM 361 366 PF00017 0.353
LIG_TYR_ITIM 53 58 PF00017 0.236
LIG_WRC_WIRS_1 305 310 PF05994 0.304
LIG_WW_3 23 27 PF00397 0.542
LIG_WW_3 7 11 PF00397 0.531
MOD_CDK_SPxxK_3 555 562 PF00069 0.428
MOD_CK1_1 148 154 PF00069 0.337
MOD_CK1_1 169 175 PF00069 0.366
MOD_CK1_1 331 337 PF00069 0.362
MOD_CK1_1 350 356 PF00069 0.258
MOD_CK1_1 393 399 PF00069 0.367
MOD_CK1_1 519 525 PF00069 0.583
MOD_CK1_1 543 549 PF00069 0.392
MOD_CK1_1 592 598 PF00069 0.513
MOD_CK1_1 721 727 PF00069 0.580
MOD_CK1_1 743 749 PF00069 0.416
MOD_CK1_1 755 761 PF00069 0.445
MOD_CK1_1 98 104 PF00069 0.523
MOD_CK2_1 592 598 PF00069 0.519
MOD_Cter_Amidation 464 467 PF01082 0.397
MOD_GlcNHglycan 12 15 PF01048 0.563
MOD_GlcNHglycan 208 211 PF01048 0.362
MOD_GlcNHglycan 213 216 PF01048 0.324
MOD_GlcNHglycan 250 253 PF01048 0.363
MOD_GlcNHglycan 381 385 PF01048 0.339
MOD_GlcNHglycan 578 581 PF01048 0.565
MOD_GlcNHglycan 608 611 PF01048 0.489
MOD_GlcNHglycan 649 652 PF01048 0.426
MOD_GlcNHglycan 720 723 PF01048 0.553
MOD_GSK3_1 216 223 PF00069 0.347
MOD_GSK3_1 272 279 PF00069 0.427
MOD_GSK3_1 334 341 PF00069 0.436
MOD_GSK3_1 469 476 PF00069 0.412
MOD_GSK3_1 517 524 PF00069 0.569
MOD_GSK3_1 525 532 PF00069 0.583
MOD_GSK3_1 534 541 PF00069 0.529
MOD_GSK3_1 543 550 PF00069 0.347
MOD_GSK3_1 616 623 PF00069 0.425
MOD_GSK3_1 628 635 PF00069 0.355
MOD_GSK3_1 739 746 PF00069 0.393
MOD_GSK3_1 91 98 PF00069 0.425
MOD_N-GLC_1 155 160 PF02516 0.285
MOD_N-GLC_1 183 188 PF02516 0.336
MOD_N-GLC_1 190 195 PF02516 0.338
MOD_N-GLC_1 211 216 PF02516 0.393
MOD_N-GLC_1 234 239 PF02516 0.341
MOD_N-GLC_1 271 276 PF02516 0.392
MOD_N-GLC_1 331 336 PF02516 0.418
MOD_N-GLC_1 517 522 PF02516 0.535
MOD_N-GLC_1 583 588 PF02516 0.572
MOD_NEK2_1 216 221 PF00069 0.346
MOD_NEK2_1 286 291 PF00069 0.471
MOD_NEK2_1 319 324 PF00069 0.320
MOD_NEK2_1 347 352 PF00069 0.437
MOD_NEK2_1 380 385 PF00069 0.316
MOD_NEK2_1 39 44 PF00069 0.416
MOD_NEK2_1 406 411 PF00069 0.451
MOD_NEK2_1 433 438 PF00069 0.315
MOD_NEK2_1 457 462 PF00069 0.516
MOD_NEK2_1 628 633 PF00069 0.416
MOD_NEK2_1 67 72 PF00069 0.366
MOD_NEK2_1 739 744 PF00069 0.387
MOD_NEK2_1 77 82 PF00069 0.334
MOD_PIKK_1 279 285 PF00454 0.282
MOD_PIKK_1 445 451 PF00454 0.337
MOD_PIKK_1 562 568 PF00454 0.536
MOD_PIKK_1 67 73 PF00454 0.392
MOD_PK_1 348 354 PF00069 0.297
MOD_PKA_1 19 25 PF00069 0.559
MOD_PKA_1 452 458 PF00069 0.355
MOD_PKA_1 534 540 PF00069 0.535
MOD_PKA_2 19 25 PF00069 0.559
MOD_PKA_2 374 380 PF00069 0.300
MOD_PKA_2 452 458 PF00069 0.355
MOD_PKA_2 473 479 PF00069 0.419
MOD_PKA_2 95 101 PF00069 0.301
MOD_PKB_1 143 151 PF00069 0.279
MOD_PKB_1 17 25 PF00069 0.555
MOD_Plk_1 190 196 PF00069 0.420
MOD_Plk_1 211 217 PF00069 0.453
MOD_Plk_1 271 277 PF00069 0.386
MOD_Plk_1 279 285 PF00069 0.275
MOD_Plk_1 331 337 PF00069 0.414
MOD_Plk_1 47 53 PF00069 0.236
MOD_Plk_1 517 523 PF00069 0.537
MOD_Plk_1 690 696 PF00069 0.521
MOD_Plk_1 740 746 PF00069 0.395
MOD_Plk_1 755 761 PF00069 0.431
MOD_Plk_2-3 190 196 PF00069 0.321
MOD_Plk_2-3 710 716 PF00069 0.390
MOD_Plk_4 145 151 PF00069 0.474
MOD_Plk_4 183 189 PF00069 0.344
MOD_Plk_4 304 310 PF00069 0.507
MOD_Plk_4 331 337 PF00069 0.552
MOD_Plk_4 342 348 PF00069 0.342
MOD_Plk_4 39 45 PF00069 0.414
MOD_Plk_4 473 479 PF00069 0.575
MOD_Plk_4 589 595 PF00069 0.528
MOD_Plk_4 710 716 PF00069 0.390
MOD_Plk_4 740 746 PF00069 0.395
MOD_Plk_4 787 793 PF00069 0.413
MOD_ProDKin_1 250 256 PF00069 0.302
MOD_ProDKin_1 555 561 PF00069 0.467
MOD_ProDKin_1 611 617 PF00069 0.450
MOD_ProDKin_1 661 667 PF00069 0.621
MOD_ProDKin_1 728 734 PF00069 0.516
TRG_DiLeu_BaEn_1 482 487 PF01217 0.419
TRG_DiLeu_BaEn_1 787 792 PF01217 0.419
TRG_DiLeu_BaEn_2 191 197 PF01217 0.319
TRG_DiLeu_BaEn_2 298 304 PF01217 0.352
TRG_DiLeu_BaEn_2 498 504 PF01217 0.414
TRG_DiLeu_BaLyEn_6 123 128 PF01217 0.356
TRG_DiLeu_BaLyEn_6 442 447 PF01217 0.335
TRG_ENDOCYTIC_2 138 141 PF00928 0.346
TRG_ENDOCYTIC_2 194 197 PF00928 0.301
TRG_ENDOCYTIC_2 278 281 PF00928 0.561
TRG_ENDOCYTIC_2 295 298 PF00928 0.554
TRG_ENDOCYTIC_2 336 339 PF00928 0.629
TRG_ENDOCYTIC_2 346 349 PF00928 0.397
TRG_ENDOCYTIC_2 363 366 PF00928 0.467
TRG_ENDOCYTIC_2 417 420 PF00928 0.370
TRG_ENDOCYTIC_2 475 478 PF00928 0.424
TRG_ENDOCYTIC_2 501 504 PF00928 0.423
TRG_ENDOCYTIC_2 55 58 PF00928 0.250
TRG_ER_diArg_1 17 20 PF00400 0.558
TRG_ER_diArg_1 374 376 PF00400 0.308
TRG_ER_diArg_1 418 421 PF00400 0.334
TRG_ER_diArg_1 444 446 PF00400 0.353
TRG_ER_diArg_1 451 453 PF00400 0.329
TRG_ER_diArg_1 515 517 PF00400 0.566
TRG_NLS_MonoCore_2 15 20 PF00514 0.553
TRG_NLS_MonoExtC_3 15 20 PF00514 0.553
TRG_Pf-PMV_PEXEL_1 290 294 PF00026 0.381
TRG_Pf-PMV_PEXEL_1 444 449 PF00026 0.337
TRG_Pf-PMV_PEXEL_1 495 499 PF00026 0.392

Homologs

Protein Taxonomy Sequence identity Coverage
A4HJG2 Leishmania braziliensis 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS