Protein kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJG4_LEIBR

TriTrypDb:

LbrM.31.2050 , LBRM2903_310029800

Length:

475

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJG4

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0004672	protein kinase activity	3	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	414	418	PF00656	0.549
CLV_NRD_NRD_1	143	145	PF00675	0.779
CLV_NRD_NRD_1	2	4	PF00675	0.826
CLV_NRD_NRD_1	217	219	PF00675	0.549
CLV_NRD_NRD_1	317	319	PF00675	0.549
CLV_PCSK_KEX2_1	142	144	PF00082	0.772
CLV_PCSK_KEX2_1	157	159	PF00082	0.406
CLV_PCSK_KEX2_1	2	4	PF00082	0.826
CLV_PCSK_KEX2_1	217	219	PF00082	0.549
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.669
CLV_PCSK_SKI1_1	107	111	PF00082	0.757
CLV_PCSK_SKI1_1	157	161	PF00082	0.653
CLV_PCSK_SKI1_1	200	204	PF00082	0.712
CLV_PCSK_SKI1_1	217	221	PF00082	0.252
CLV_PCSK_SKI1_1	268	272	PF00082	0.549
CLV_PCSK_SKI1_1	336	340	PF00082	0.549
CLV_PCSK_SKI1_1	367	371	PF00082	0.549
CLV_PCSK_SKI1_1	449	453	PF00082	0.673
DEG_APCC_DBOX_1	273	281	PF00400	0.549
DEG_Nend_UBRbox_1	1	4	PF02207	0.819
DEG_SPOP_SBC_1	465	469	PF00917	0.808
DOC_CKS1_1	342	347	PF01111	0.549
DOC_CYCLIN_RxL_1	155	164	PF00134	0.660
DOC_CYCLIN_RxL_1	214	221	PF00134	0.549
DOC_CYCLIN_RxL_1	426	437	PF00134	0.549
DOC_CYCLIN_yClb5_NLxxxL_5	226	235	PF00134	0.549
DOC_MAPK_DCC_7	40	48	PF00069	0.784
DOC_MAPK_FxFP_2	262	265	PF00069	0.549
DOC_MAPK_gen_1	263	272	PF00069	0.549
DOC_MAPK_gen_1	40	48	PF00069	0.784
DOC_MAPK_MEF2A_6	227	235	PF00069	0.549
DOC_MAPK_MEF2A_6	402	409	PF00069	0.549
DOC_PP1_RVXF_1	256	263	PF00149	0.549
DOC_PP1_RVXF_1	27	33	PF00149	0.710
DOC_PP2B_LxvP_1	110	113	PF13499	0.762
DOC_PP4_FxxP_1	262	265	PF00568	0.549
DOC_USP7_MATH_1	161	165	PF00917	0.645
DOC_USP7_MATH_1	167	171	PF00917	0.509
DOC_USP7_MATH_1	5	9	PF00917	0.793
DOC_USP7_UBL2_3	388	392	PF12436	0.549
DOC_WW_Pin1_4	147	152	PF00397	0.751
DOC_WW_Pin1_4	200	205	PF00397	0.710
DOC_WW_Pin1_4	249	254	PF00397	0.549
DOC_WW_Pin1_4	331	336	PF00397	0.549
DOC_WW_Pin1_4	341	346	PF00397	0.375
LIG_14-3-3_CanoR_1	31	37	PF00244	0.732
LIG_14-3-3_CanoR_1	429	434	PF00244	0.549
LIG_Actin_WH2_2	396	413	PF00022	0.549
LIG_APCC_ABBAyCdc20_2	68	74	PF00400	0.859
LIG_CtBP_PxDLS_1	92	98	PF00389	0.851
LIG_deltaCOP1_diTrp_1	363	368	PF00928	0.549
LIG_EH1_1	421	429	PF00400	0.549
LIG_FHA_1	328	334	PF00498	0.549
LIG_FHA_1	33	39	PF00498	0.742
LIG_FHA_1	337	343	PF00498	0.392
LIG_FHA_2	254	260	PF00498	0.549
LIG_FHA_2	368	374	PF00498	0.549
LIG_FHA_2	377	383	PF00498	0.392
LIG_FHA_2	438	444	PF00498	0.549
LIG_FHA_2	445	451	PF00498	0.546
LIG_FHA_2	456	462	PF00498	0.429
LIG_FHA_2	466	472	PF00498	0.650
LIG_GBD_Chelix_1	423	431	PF00786	0.549
LIG_Integrin_RGD_1	144	146	PF01839	0.763
LIG_LIR_Apic_2	259	265	PF02991	0.549
LIG_LIR_Apic_2	330	335	PF02991	0.549
LIG_LIR_Nem_3	116	122	PF02991	0.789
LIG_LIR_Nem_3	170	176	PF02991	0.616
LIG_LYPXL_yS_3	264	267	PF13949	0.549
LIG_SH2_PTP2	332	335	PF00017	0.549
LIG_SH2_STAP1	419	423	PF00017	0.549
LIG_SH2_STAT3	326	329	PF00017	0.549
LIG_SH2_STAT5	108	111	PF00017	0.758
LIG_SH2_STAT5	173	176	PF00017	0.630
LIG_SH2_STAT5	285	288	PF00017	0.549
LIG_SH2_STAT5	326	329	PF00017	0.549
LIG_SH2_STAT5	332	335	PF00017	0.444
LIG_SH3_1	188	194	PF00018	0.759
LIG_SH3_3	121	127	PF00018	0.734
LIG_SH3_3	188	194	PF00018	0.759
LIG_SUMO_SIM_par_1	158	164	PF11976	0.642
LIG_TRAF2_1	210	213	PF00917	0.671
LIG_TRAF2_1	458	461	PF00917	0.746
LIG_TRAF2_1	85	88	PF00917	0.863
LIG_TYR_ITIM	174	179	PF00017	0.672
MOD_CDK_SPK_2	331	336	PF00069	0.549
MOD_CK1_1	376	382	PF00069	0.549
MOD_CK1_1	8	14	PF00069	0.810
MOD_CK1_1	94	100	PF00069	0.844
MOD_CK2_1	207	213	PF00069	0.675
MOD_CK2_1	244	250	PF00069	0.549
MOD_CK2_1	253	259	PF00069	0.392
MOD_CK2_1	352	358	PF00069	0.549
MOD_CK2_1	376	382	PF00069	0.549
MOD_CK2_1	437	443	PF00069	0.549
MOD_CK2_1	444	450	PF00069	0.543
MOD_CK2_1	455	461	PF00069	0.420
MOD_DYRK1A_RPxSP_1	200	204	PF00069	0.712
MOD_GlcNHglycan	163	166	PF01048	0.661
MOD_GlcNHglycan	200	203	PF01048	0.712
MOD_GlcNHglycan	303	306	PF01048	0.549
MOD_GlcNHglycan	314	317	PF01048	0.357
MOD_GlcNHglycan	379	382	PF01048	0.549
MOD_GlcNHglycan	7	10	PF01048	0.803
MOD_GSK3_1	114	121	PF00069	0.789
MOD_GSK3_1	146	153	PF00069	0.743
MOD_GSK3_1	249	256	PF00069	0.549
MOD_GSK3_1	327	334	PF00069	0.549
MOD_GSK3_1	373	380	PF00069	0.549
MOD_GSK3_1	429	436	PF00069	0.549
MOD_GSK3_1	466	473	PF00069	0.827
MOD_N-GLC_1	417	422	PF02516	0.549
MOD_NEK2_1	195	200	PF00069	0.746
MOD_NEK2_1	352	357	PF00069	0.549
MOD_NEK2_1	464	469	PF00069	0.802
MOD_NEK2_1	52	57	PF00069	0.824
MOD_NEK2_2	115	120	PF00069	0.792
MOD_NEK2_2	253	258	PF00069	0.549
MOD_OFUCOSY	365	371	PF10250	0.549
MOD_PKA_2	309	315	PF00069	0.549
MOD_PKA_2	32	38	PF00069	0.734
MOD_PKA_2	410	416	PF00069	0.549
MOD_PKA_2	437	443	PF00069	0.549
MOD_PKA_2	444	450	PF00069	0.543
MOD_PKA_2	52	58	PF00069	0.478
MOD_Plk_4	150	156	PF00069	0.711
MOD_Plk_4	169	175	PF00069	0.277
MOD_Plk_4	244	250	PF00069	0.549
MOD_Plk_4	281	287	PF00069	0.549
MOD_Plk_4	423	429	PF00069	0.549
MOD_ProDKin_1	147	153	PF00069	0.746
MOD_ProDKin_1	200	206	PF00069	0.708
MOD_ProDKin_1	249	255	PF00069	0.549
MOD_ProDKin_1	331	337	PF00069	0.549
MOD_ProDKin_1	341	347	PF00069	0.375
MOD_SUMO_rev_2	315	321	PF00179	0.549
MOD_SUMO_rev_2	49	58	PF00179	0.812
TRG_DiLeu_BaEn_1	382	387	PF01217	0.549
TRG_ENDOCYTIC_2	176	179	PF00928	0.689
TRG_ENDOCYTIC_2	264	267	PF00928	0.549
TRG_ER_diArg_1	1	3	PF00400	0.823
TRG_ER_diArg_1	142	144	PF00400	0.772
TRG_ER_diArg_1	217	219	PF00400	0.549
TRG_ER_diArg_1	29	32	PF00400	0.707
TRG_ER_diArg_1	83	86	PF00400	0.866
TRG_ER_diArg_1	98	101	PF00400	0.567
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	429	434	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A2XW02	ORYSI	22%	100%
G4N7X0	MAGO7	26%	52%
O14019	SCHPO	25%	75%
O59790	SCHPO	28%	100%
O88866	MOUSE	24%	67%
P28829	SCHPO	23%	72%
P32577	RAT	26%	100%
P41239	CHICK	26%	100%
P41240	HUMAN	26%	100%
P41241	MOUSE	27%	100%
P57058	HUMAN	24%	67%
Q54QI2	DICDI	31%	50%
Q55CE0	DICDI	31%	70%
Q68UT7	PANTR	24%	67%
Q7XR88	ORYSJ	22%	100%
Q86ME2	CAEEL	24%	81%
Q9STF0	ARATH	28%	100%