Nucleosome assembly protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleosome assembly protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJF7_LEIBR

TriTrypDb:

LbrM.31.1980 , LBRM2903_310029100

Length:

407

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0000785	chromatin	2	1

Expansion

Sequence features

A4HJF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJF7

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	12
GO:0006334	nucleosome assembly	7	12
GO:0006338	chromatin remodeling	5	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0034728	nucleosome organization	6	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0065004	protein-DNA complex assembly	6	12
GO:0071824	protein-DNA complex subunit organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	387	389	PF00675	0.679
CLV_NRD_NRD_1	40	42	PF00675	0.289
CLV_NRD_NRD_1	55	57	PF00675	0.306
CLV_NRD_NRD_1	80	82	PF00675	0.348
CLV_PCSK_KEX2_1	387	389	PF00082	0.784
CLV_PCSK_KEX2_1	39	41	PF00082	0.327
CLV_PCSK_KEX2_1	57	59	PF00082	0.306
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.216
CLV_PCSK_SKI1_1	117	121	PF00082	0.320
CLV_PCSK_SKI1_1	167	171	PF00082	0.283
CLV_PCSK_SKI1_1	190	194	PF00082	0.380
CLV_PCSK_SKI1_1	238	242	PF00082	0.288
CLV_PCSK_SKI1_1	313	317	PF00082	0.323
CLV_PCSK_SKI1_1	89	93	PF00082	0.300
DEG_APCC_DBOX_1	166	174	PF00400	0.492
DOC_MAPK_gen_1	165	173	PF00069	0.502
DOC_MAPK_gen_1	234	244	PF00069	0.519
DOC_MAPK_gen_1	250	259	PF00069	0.409
DOC_MAPK_MEF2A_6	237	244	PF00069	0.547
DOC_PP1_RVXF_1	188	194	PF00149	0.523
DOC_PP1_RVXF_1	96	102	PF00149	0.416
DOC_PP4_FxxP_1	272	275	PF00568	0.484
DOC_USP7_MATH_1	138	142	PF00917	0.552
DOC_USP7_MATH_1	265	269	PF00917	0.576
DOC_USP7_MATH_1	367	371	PF00917	0.738
DOC_USP7_UBL2_3	116	120	PF12436	0.542
DOC_USP7_UBL2_3	234	238	PF12436	0.499
DOC_USP7_UBL2_3	248	252	PF12436	0.441
DOC_WW_Pin1_4	101	106	PF00397	0.425
DOC_WW_Pin1_4	136	141	PF00397	0.557
DOC_WW_Pin1_4	193	198	PF00397	0.549
DOC_WW_Pin1_4	271	276	PF00397	0.575
LIG_14-3-3_CanoR_1	222	227	PF00244	0.533
LIG_14-3-3_CanoR_1	58	66	PF00244	0.416
LIG_14-3-3_CanoR_1	98	108	PF00244	0.603
LIG_BIR_III_2	111	115	PF00653	0.579
LIG_CaM_IQ_9	42	58	PF13499	0.575
LIG_eIF4E_1	43	49	PF01652	0.492
LIG_FHA_1	222	228	PF00498	0.567
LIG_FHA_1	239	245	PF00498	0.396
LIG_FHA_1	305	311	PF00498	0.567
LIG_FHA_2	161	167	PF00498	0.482
LIG_FHA_2	210	216	PF00498	0.529
LIG_FHA_2	285	291	PF00498	0.524
LIG_FHA_2	324	330	PF00498	0.598
LIG_FHA_2	33	39	PF00498	0.502
LIG_FHA_2	342	348	PF00498	0.775
LIG_FHA_2	90	96	PF00498	0.491
LIG_LIR_Gen_1	267	278	PF02991	0.484
LIG_LIR_Nem_3	267	273	PF02991	0.484
LIG_LIR_Nem_3	370	375	PF02991	0.715
LIG_LIR_Nem_3	51	55	PF02991	0.506
LIG_NRBOX	44	50	PF00104	0.492
LIG_PCNA_PIPBox_1	46	55	PF02747	0.579
LIG_PCNA_yPIPBox_3	39	53	PF02747	0.464
LIG_Pex14_2	269	273	PF04695	0.481
LIG_SH2_STAT3	43	46	PF00017	0.575
LIG_SH2_STAT5	200	203	PF00017	0.484
LIG_SH2_STAT5	318	321	PF00017	0.492
LIG_SH3_2	105	110	PF14604	0.579
LIG_SH3_3	102	108	PF00018	0.595
LIG_SH3_3	272	278	PF00018	0.577
LIG_SH3_4	398	405	PF00018	0.560
LIG_SUMO_SIM_anti_2	26	33	PF11976	0.588
LIG_TRAF2_1	400	403	PF00917	0.784
LIG_TRAF2_1	92	95	PF00917	0.506
MOD_CK1_1	15	21	PF00069	0.732
MOD_CK2_1	150	156	PF00069	0.556
MOD_CK2_1	18	24	PF00069	0.681
MOD_CK2_1	193	199	PF00069	0.555
MOD_CK2_1	32	38	PF00069	0.384
MOD_CK2_1	323	329	PF00069	0.559
MOD_CK2_1	89	95	PF00069	0.491
MOD_Cter_Amidation	385	388	PF01082	0.689
MOD_GlcNHglycan	140	143	PF01048	0.370
MOD_GSK3_1	15	22	PF00069	0.722
MOD_GSK3_1	152	159	PF00069	0.606
MOD_N-GLC_1	202	207	PF02516	0.346
MOD_N-GLC_1	238	243	PF02516	0.292
MOD_N-GLC_2	68	70	PF02516	0.379
MOD_NEK2_1	147	152	PF00069	0.481
MOD_NEK2_1	240	245	PF00069	0.579
MOD_NEK2_1	32	37	PF00069	0.366
MOD_NEK2_2	265	270	PF00069	0.575
MOD_PIKK_1	304	310	PF00454	0.579
MOD_PKA_2	221	227	PF00069	0.590
MOD_PKB_1	56	64	PF00069	0.416
MOD_Plk_1	202	208	PF00069	0.546
MOD_Plk_1	238	244	PF00069	0.492
MOD_Plk_1	32	38	PF00069	0.484
MOD_Plk_2-3	209	215	PF00069	0.534
MOD_Plk_2-3	284	290	PF00069	0.416
MOD_Plk_2-3	341	347	PF00069	0.753
MOD_Plk_4	222	228	PF00069	0.479
MOD_Plk_4	265	271	PF00069	0.481
MOD_ProDKin_1	101	107	PF00069	0.425
MOD_ProDKin_1	136	142	PF00069	0.557
MOD_ProDKin_1	193	199	PF00069	0.549
MOD_ProDKin_1	271	277	PF00069	0.575
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.479
TRG_ENDOCYTIC_2	52	55	PF00928	0.492
TRG_ER_diArg_1	376	379	PF00400	0.714
TRG_ER_diArg_1	39	41	PF00400	0.417
TRG_ER_diArg_1	55	58	PF00400	0.575
TRG_ER_FFAT_2	267	277	PF00635	0.461
TRG_NES_CRM1_1	26	38	PF08389	0.478
TRG_NLS_Bipartite_1	237	251	PF00514	0.575
TRG_NLS_Bipartite_1	39	61	PF00514	0.357
TRG_NLS_MonoExtC_3	55	60	PF00514	0.416
TRG_NLS_MonoExtN_4	245	251	PF00514	0.481
TRG_NLS_MonoExtN_4	56	61	PF00514	0.416
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J2	Leptomonas seymouri	31%	100%
A0A0N1IJI7	Leptomonas seymouri	68%	100%
A0A0S4J1L1	Bodo saltans	41%	99%
A0A1X0NTY9	Trypanosomatidae	42%	94%
A0A1X0P6J1	Trypanosomatidae	29%	97%
A0A3Q8IA70	Leishmania donovani	32%	100%
A0A3R7KHX6	Trypanosoma rangeli	41%	94%
A0A3R7KRI5	Trypanosoma rangeli	29%	100%
A0A3S7X4M4	Leishmania donovani	84%	100%
A4HA02	Leishmania braziliensis	32%	100%
A4HY66	Leishmania infantum	31%	100%
A4I6V2	Leishmania infantum	84%	100%
A6H767	Bos taurus	34%	100%
B8AW64	Oryza sativa subsp. indica	33%	100%
B8B2R4	Oryza sativa subsp. indica	33%	100%
B9FU45	Oryza sativa subsp. japonica	29%	100%
C9ZXT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	97%
D0A0I6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ARZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B1X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
O59797	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
P25293	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	98%
P28656	Mus musculus	33%	100%
P55209	Homo sapiens	34%	100%
P78920	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q28EB4	Xenopus tropicalis	34%	100%
Q2TA40	Bos taurus	32%	100%
Q4Q687	Leishmania major	83%	100%
Q4QDH7	Leishmania major	33%	100%
Q4U0Y4	Xenopus laevis	32%	100%
Q53WK4	Oryza sativa subsp. japonica	33%	100%
Q55ED1	Dictyostelium discoideum	30%	100%
Q5AAI8	Candida albicans (strain SC5314 / ATCC MYA-2876)	31%	94%
Q5R4D4	Pongo abelii	34%	100%
Q5U2Z3	Rattus norvegicus	32%	100%
Q5VND6	Oryza sativa subsp. japonica	33%	100%
Q70Z17	Nicotiana tabacum	33%	100%
Q70Z18	Nicotiana tabacum	34%	100%
Q70Z19	Nicotiana tabacum	31%	100%
Q78ZA7	Mus musculus	33%	100%
Q7ZY81	Xenopus laevis	34%	100%
Q94K07	Arabidopsis thaliana	35%	100%
Q99733	Homo sapiens	33%	100%
Q9SZI2	Arabidopsis thaliana	34%	100%
Q9Z2G8	Rattus norvegicus	33%	100%
Q9ZUP3	Arabidopsis thaliana	34%	100%
V5BUC1	Trypanosoma cruzi	42%	90%
V5BX23	Trypanosoma cruzi	26%	100%