Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJF6_LEIBR

TriTrypDb:

LbrM.31.1970 , LBRM2903_310029000

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.315
CLV_NRD_NRD_1	108	110	PF00675	0.491
CLV_NRD_NRD_1	357	359	PF00675	0.438
CLV_PCSK_KEX2_1	357	359	PF00082	0.490
CLV_PCSK_SKI1_1	109	113	PF00082	0.422
CLV_PCSK_SKI1_1	130	134	PF00082	0.424
CLV_PCSK_SKI1_1	19	23	PF00082	0.547
CLV_PCSK_SKI1_1	206	210	PF00082	0.471
CLV_PCSK_SKI1_1	369	373	PF00082	0.538
DEG_APCC_DBOX_1	18	26	PF00400	0.585
DEG_MDM2_SWIB_1	290	297	PF02201	0.488
DEG_Nend_UBRbox_1	1	4	PF02207	0.792
DEG_SCF_FBW7_1	1	8	PF00400	0.510
DEG_SPOP_SBC_1	193	197	PF00917	0.532
DEG_SPOP_SBC_1	280	284	PF00917	0.651
DOC_CKS1_1	72	77	PF01111	0.606
DOC_MAPK_DCC_7	19	27	PF00069	0.454
DOC_MAPK_gen_1	109	119	PF00069	0.477
DOC_MAPK_gen_1	201	211	PF00069	0.391
DOC_MAPK_MEF2A_6	110	119	PF00069	0.484
DOC_MAPK_MEF2A_6	19	27	PF00069	0.665
DOC_MAPK_MEF2A_6	50	57	PF00069	0.369
DOC_PP2B_LxvP_1	121	124	PF13499	0.472
DOC_PP4_FxxP_1	20	23	PF00568	0.458
DOC_PP4_FxxP_1	346	349	PF00568	0.439
DOC_USP7_MATH_1	193	197	PF00917	0.544
DOC_USP7_MATH_1	220	224	PF00917	0.672
DOC_USP7_MATH_1	235	239	PF00917	0.601
DOC_USP7_MATH_1	286	290	PF00917	0.593
DOC_USP7_MATH_1	353	357	PF00917	0.544
DOC_USP7_MATH_1	386	390	PF00917	0.715
DOC_USP7_MATH_1	42	46	PF00917	0.570
DOC_USP7_MATH_1	51	55	PF00917	0.423
DOC_WW_Pin1_4	1	6	PF00397	0.508
DOC_WW_Pin1_4	100	105	PF00397	0.550
DOC_WW_Pin1_4	194	199	PF00397	0.460
DOC_WW_Pin1_4	272	277	PF00397	0.626
DOC_WW_Pin1_4	345	350	PF00397	0.561
DOC_WW_Pin1_4	71	76	PF00397	0.659
DOC_WW_Pin1_4	80	85	PF00397	0.669
LIG_14-3-3_CanoR_1	109	119	PF00244	0.420
LIG_14-3-3_CanoR_1	269	277	PF00244	0.628
LIG_14-3-3_CanoR_1	387	393	PF00244	0.664
LIG_14-3-3_CanoR_1	50	56	PF00244	0.589
LIG_Actin_RPEL_3	102	121	PF02755	0.444
LIG_BRCT_BRCA1_1	171	175	PF00533	0.322
LIG_BRCT_BRCA1_1	245	249	PF00533	0.600
LIG_BRCT_BRCA1_1	342	346	PF00533	0.451
LIG_CaM_NSCaTE_8	129	136	PF13499	0.357
LIG_deltaCOP1_diTrp_1	292	299	PF00928	0.425
LIG_FHA_1	2	8	PF00498	0.543
LIG_FHA_1	272	278	PF00498	0.624
LIG_FHA_1	282	288	PF00498	0.645
LIG_FHA_1	388	394	PF00498	0.628
LIG_FHA_1	402	408	PF00498	0.486
LIG_FHA_1	72	78	PF00498	0.551
LIG_FHA_2	83	89	PF00498	0.546
LIG_LIR_Apic_2	343	349	PF02991	0.441
LIG_LIR_Gen_1	113	124	PF02991	0.395
LIG_LIR_Gen_1	289	298	PF02991	0.439
LIG_LIR_Gen_1	304	313	PF02991	0.371
LIG_LIR_Nem_3	113	119	PF02991	0.472
LIG_LIR_Nem_3	225	231	PF02991	0.445
LIG_LIR_Nem_3	289	293	PF02991	0.473
LIG_LIR_Nem_3	304	308	PF02991	0.466
LIG_MYND_1	100	104	PF01753	0.514
LIG_NRBOX	258	264	PF00104	0.357
LIG_Pex14_2	290	294	PF04695	0.499
LIG_PTB_Apo_2	14	21	PF02174	0.462
LIG_Rb_LxCxE_1	207	225	PF01857	0.312
LIG_SH2_CRK	305	309	PF00017	0.508
LIG_SH2_CRK	352	356	PF00017	0.631
LIG_SH2_NCK_1	159	163	PF00017	0.495
LIG_SH2_NCK_1	352	356	PF00017	0.631
LIG_SH2_STAT3	98	101	PF00017	0.634
LIG_SH2_STAT5	364	367	PF00017	0.422
LIG_SH3_3	69	75	PF00018	0.669
LIG_SUMO_SIM_anti_2	54	59	PF11976	0.394
LIG_TRAF2_1	238	241	PF00917	0.759
LIG_TRAF2_1	85	88	PF00917	0.498
LIG_TYR_ITIM	350	355	PF00017	0.559
LIG_WRC_WIRS_1	287	292	PF05994	0.454
LIG_WRC_WIRS_1	293	298	PF05994	0.339
MOD_CDC14_SPxK_1	348	351	PF00782	0.424
MOD_CDK_SPK_2	1	6	PF00069	0.508
MOD_CDK_SPxK_1	345	351	PF00069	0.433
MOD_CDK_SPxxK_3	194	201	PF00069	0.395
MOD_CK1_1	176	182	PF00069	0.554
MOD_CK1_1	196	202	PF00069	0.472
MOD_CK1_1	243	249	PF00069	0.616
MOD_CK1_1	272	278	PF00069	0.706
MOD_CK1_1	375	381	PF00069	0.607
MOD_CK1_1	45	51	PF00069	0.647
MOD_CK1_1	8	14	PF00069	0.500
MOD_CK2_1	234	240	PF00069	0.579
MOD_CK2_1	82	88	PF00069	0.601
MOD_GlcNHglycan	178	181	PF01048	0.343
MOD_GlcNHglycan	222	225	PF01048	0.630
MOD_GlcNHglycan	237	240	PF01048	0.600
MOD_GlcNHglycan	251	254	PF01048	0.324
MOD_GlcNHglycan	271	274	PF01048	0.440
MOD_GlcNHglycan	32	35	PF01048	0.596
MOD_GlcNHglycan	336	339	PF01048	0.580
MOD_GlcNHglycan	342	345	PF01048	0.665
MOD_GlcNHglycan	377	380	PF01048	0.505
MOD_GSK3_1	1	8	PF00069	0.584
MOD_GSK3_1	165	172	PF00069	0.462
MOD_GSK3_1	188	195	PF00069	0.561
MOD_GSK3_1	271	278	PF00069	0.572
MOD_GSK3_1	38	45	PF00069	0.453
MOD_N-GLC_1	280	285	PF02516	0.467
MOD_NEK2_1	119	124	PF00069	0.391
MOD_NEK2_1	175	180	PF00069	0.545
MOD_NEK2_1	181	186	PF00069	0.500
MOD_NEK2_1	372	377	PF00069	0.451
MOD_NEK2_2	23	28	PF00069	0.563
MOD_NEK2_2	286	291	PF00069	0.490
MOD_PIKK_1	281	287	PF00454	0.594
MOD_PIKK_1	322	328	PF00454	0.606
MOD_PIKK_1	45	51	PF00454	0.532
MOD_PKA_2	181	187	PF00069	0.342
MOD_PKA_2	243	249	PF00069	0.677
MOD_PKA_2	30	36	PF00069	0.701
MOD_PKA_2	372	378	PF00069	0.485
MOD_PKA_2	386	392	PF00069	0.515
MOD_PKA_2	393	399	PF00069	0.591
MOD_PKA_2	5	11	PF00069	0.791
MOD_Plk_4	181	187	PF00069	0.361
MOD_Plk_4	23	29	PF00069	0.562
MOD_Plk_4	51	57	PF00069	0.393
MOD_ProDKin_1	1	7	PF00069	0.509
MOD_ProDKin_1	100	106	PF00069	0.541
MOD_ProDKin_1	194	200	PF00069	0.459
MOD_ProDKin_1	272	278	PF00069	0.628
MOD_ProDKin_1	345	351	PF00069	0.561
MOD_ProDKin_1	71	77	PF00069	0.659
MOD_ProDKin_1	80	86	PF00069	0.667
MOD_SUMO_for_1	93	96	PF00179	0.482
MOD_SUMO_rev_2	103	111	PF00179	0.432
MOD_SUMO_rev_2	126	132	PF00179	0.388
MOD_SUMO_rev_2	87	95	PF00179	0.763
TRG_ENDOCYTIC_2	305	308	PF00928	0.376
TRG_ENDOCYTIC_2	352	355	PF00928	0.632
TRG_ER_diArg_1	357	359	PF00400	0.483
TRG_Pf-PMV_PEXEL_1	369	374	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	60	65	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3T2	Leptomonas seymouri	49%	98%
A0A0S4IUI6	Bodo saltans	26%	100%
A0A1X0NVH2	Trypanosomatidae	31%	100%
A0A3R7MTX4	Trypanosoma rangeli	29%	100%
A0A3S7X4N0	Leishmania donovani	71%	99%
A4I6V1	Leishmania infantum	71%	99%
D0A7B7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B1X4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	98%
Q4Q688	Leishmania major	72%	100%
V5C1D3	Trypanosoma cruzi	29%	100%