LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HJF5_LEIBR
TriTrypDb:
LbrM.31.1960 , LBRM2903_310028900 *
Length:
384

Annotations

LeishMANIAdb annotations

A membrane-associated protein in Kinetoplastids with quite unique helical folds.. Only expanded in the Strigomonas lineage

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A4HJF5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJF5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 105 107 PF00675 0.492
CLV_NRD_NRD_1 283 285 PF00675 0.543
CLV_NRD_NRD_1 286 288 PF00675 0.462
CLV_NRD_NRD_1 342 344 PF00675 0.461
CLV_NRD_NRD_1 371 373 PF00675 0.439
CLV_NRD_NRD_1 53 55 PF00675 0.422
CLV_NRD_NRD_1 65 67 PF00675 0.515
CLV_NRD_NRD_1 99 101 PF00675 0.518
CLV_PCSK_FUR_1 103 107 PF00082 0.450
CLV_PCSK_FUR_1 280 284 PF00082 0.434
CLV_PCSK_FUR_1 63 67 PF00082 0.523
CLV_PCSK_KEX2_1 105 107 PF00082 0.492
CLV_PCSK_KEX2_1 282 284 PF00082 0.547
CLV_PCSK_KEX2_1 307 309 PF00082 0.384
CLV_PCSK_KEX2_1 52 54 PF00082 0.417
CLV_PCSK_KEX2_1 65 67 PF00082 0.514
CLV_PCSK_KEX2_1 99 101 PF00082 0.518
CLV_PCSK_PC1ET2_1 282 284 PF00082 0.468
CLV_PCSK_PC1ET2_1 307 309 PF00082 0.381
CLV_PCSK_SKI1_1 272 276 PF00082 0.388
CLV_PCSK_SKI1_1 307 311 PF00082 0.386
CLV_PCSK_SKI1_1 344 348 PF00082 0.413
DEG_SCF_TRCP1_1 215 220 PF00400 0.664
DOC_CKS1_1 320 325 PF01111 0.583
DOC_CYCLIN_RxL_1 267 277 PF00134 0.534
DOC_CYCLIN_yClb5_NLxxxL_5 112 119 PF00134 0.672
DOC_MAPK_gen_1 267 276 PF00069 0.612
DOC_MAPK_gen_1 63 73 PF00069 0.611
DOC_MAPK_HePTP_8 102 119 PF00069 0.636
DOC_MAPK_MEF2A_6 112 119 PF00069 0.618
DOC_MAPK_MEF2A_6 270 278 PF00069 0.540
DOC_MAPK_MEF2A_6 65 74 PF00069 0.587
DOC_PP4_FxxP_1 320 323 PF00568 0.586
DOC_PP4_FxxP_1 327 330 PF00568 0.636
DOC_PP4_FxxP_1 379 382 PF00568 0.614
DOC_PP4_FxxP_1 88 91 PF00568 0.657
DOC_USP7_MATH_1 2 6 PF00917 0.356
DOC_USP7_MATH_1 213 217 PF00917 0.653
DOC_USP7_MATH_1 240 244 PF00917 0.725
DOC_USP7_MATH_1 330 334 PF00917 0.755
DOC_USP7_MATH_1 352 356 PF00917 0.751
DOC_USP7_MATH_1 94 98 PF00917 0.724
DOC_WW_Pin1_4 190 195 PF00397 0.676
DOC_WW_Pin1_4 217 222 PF00397 0.714
DOC_WW_Pin1_4 319 324 PF00397 0.637
DOC_WW_Pin1_4 326 331 PF00397 0.639
DOC_WW_Pin1_4 348 353 PF00397 0.675
LIG_14-3-3_CanoR_1 106 112 PF00244 0.668
LIG_14-3-3_CanoR_1 188 194 PF00244 0.640
LIG_14-3-3_CanoR_1 343 350 PF00244 0.609
LIG_BIR_II_1 1 5 PF00653 0.414
LIG_BIR_III_2 151 155 PF00653 0.674
LIG_BRCT_BRCA1_1 314 318 PF00533 0.658
LIG_BRCT_BRCA1_1 84 88 PF00533 0.707
LIG_Clathr_ClatBox_1 72 76 PF01394 0.598
LIG_FHA_1 12 18 PF00498 0.320
LIG_FHA_1 191 197 PF00498 0.768
LIG_FHA_1 254 260 PF00498 0.647
LIG_FHA_2 170 176 PF00498 0.686
LIG_FHA_2 246 252 PF00498 0.665
LIG_Integrin_isoDGR_2 146 148 PF01839 0.445
LIG_LIR_Apic_2 319 323 PF02991 0.587
LIG_LIR_Apic_2 378 382 PF02991 0.613
LIG_LIR_Apic_2 85 91 PF02991 0.711
LIG_LIR_Nem_3 345 350 PF02991 0.705
LIG_MYND_1 225 229 PF01753 0.657
LIG_SH2_STAT3 356 359 PF00017 0.625
LIG_SH2_STAT5 356 359 PF00017 0.625
LIG_SH3_3 88 94 PF00018 0.658
LIG_SUMO_SIM_anti_2 69 76 PF11976 0.592
LIG_SUMO_SIM_par_1 69 76 PF11976 0.592
LIG_TRAF2_1 139 142 PF00917 0.558
LIG_TRAF2_1 351 354 PF00917 0.727
LIG_UBA3_1 274 282 PF00899 0.664
LIG_UBA3_1 324 332 PF00899 0.582
LIG_WRC_WIRS_1 331 336 PF05994 0.602
MOD_CDC14_SPxK_1 329 332 PF00782 0.590
MOD_CDK_SPxK_1 326 332 PF00069 0.596
MOD_CDK_SPxxK_3 319 326 PF00069 0.641
MOD_CK1_1 3 9 PF00069 0.414
MOD_CK1_1 319 325 PF00069 0.668
MOD_CK1_1 368 374 PF00069 0.651
MOD_CK2_1 169 175 PF00069 0.737
MOD_CK2_1 348 354 PF00069 0.769
MOD_CK2_1 375 381 PF00069 0.616
MOD_Cter_Amidation 341 344 PF01082 0.404
MOD_GlcNHglycan 215 218 PF01048 0.513
MOD_GlcNHglycan 34 38 PF01048 0.365
MOD_GlcNHglycan 344 347 PF01048 0.474
MOD_GlcNHglycan 95 99 PF01048 0.532
MOD_GSK3_1 171 178 PF00069 0.693
MOD_GSK3_1 190 197 PF00069 0.608
MOD_GSK3_1 213 220 PF00069 0.804
MOD_GSK3_1 29 36 PF00069 0.482
MOD_GSK3_1 312 319 PF00069 0.617
MOD_GSK3_1 326 333 PF00069 0.730
MOD_GSK3_1 334 341 PF00069 0.715
MOD_GSK3_1 348 355 PF00069 0.713
MOD_N-GLC_1 316 321 PF02516 0.444
MOD_N-GLC_1 375 380 PF02516 0.530
MOD_NEK2_1 187 192 PF00069 0.717
MOD_NEK2_1 334 339 PF00069 0.619
MOD_NEK2_1 365 370 PF00069 0.661
MOD_NEK2_2 330 335 PF00069 0.695
MOD_PIKK_1 194 200 PF00454 0.679
MOD_PKA_2 187 193 PF00069 0.639
MOD_PKA_2 211 217 PF00069 0.655
MOD_PKA_2 334 340 PF00069 0.651
MOD_PKA_2 342 348 PF00069 0.623
MOD_Plk_1 123 129 PF00069 0.594
MOD_Plk_1 3 9 PF00069 0.445
MOD_Plk_1 316 322 PF00069 0.591
MOD_Plk_1 360 366 PF00069 0.704
MOD_Plk_1 375 381 PF00069 0.728
MOD_Plk_4 352 358 PF00069 0.712
MOD_ProDKin_1 190 196 PF00069 0.676
MOD_ProDKin_1 217 223 PF00069 0.710
MOD_ProDKin_1 319 325 PF00069 0.635
MOD_ProDKin_1 326 332 PF00069 0.642
MOD_ProDKin_1 348 354 PF00069 0.678
TRG_DiLeu_BaEn_1 271 276 PF01217 0.536
TRG_ER_diArg_1 102 105 PF00400 0.699
TRG_ER_diArg_1 52 54 PF00400 0.634
TRG_ER_diArg_1 65 68 PF00400 0.700
TRG_ER_diArg_1 99 101 PF00400 0.727
TRG_NLS_MonoCore_2 371 376 PF00514 0.610
TRG_NLS_MonoExtC_3 283 288 PF00514 0.641
TRG_NLS_MonoExtN_4 282 288 PF00514 0.634
TRG_Pf-PMV_PEXEL_1 138 142 PF00026 0.351
TRG_Pf-PMV_PEXEL_1 308 313 PF00026 0.391
TRG_Pf-PMV_PEXEL_1 65 69 PF00026 0.388
TRG_PTS1 381 384 PF00515 0.611

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HX69 Leptomonas seymouri 54% 98%
A0A3Q8IFM0 Leishmania donovani 65% 100%
A4I6V0 Leishmania infantum 65% 100%
E9B1X3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 66% 100%
Q4Q689 Leishmania major 64% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS