Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJF3_LEIBR

TriTrypDb:

LbrM.31.1940 , LBRM2903_310028600

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJF3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	605	609	PF00656	0.618
CLV_NRD_NRD_1	154	156	PF00675	0.659
CLV_NRD_NRD_1	19	21	PF00675	0.628
CLV_NRD_NRD_1	263	265	PF00675	0.627
CLV_NRD_NRD_1	388	390	PF00675	0.480
CLV_NRD_NRD_1	486	488	PF00675	0.571
CLV_NRD_NRD_1	49	51	PF00675	0.552
CLV_NRD_NRD_1	491	493	PF00675	0.565
CLV_NRD_NRD_1	555	557	PF00675	0.587
CLV_PCSK_KEX2_1	154	156	PF00082	0.609
CLV_PCSK_KEX2_1	19	21	PF00082	0.628
CLV_PCSK_KEX2_1	390	392	PF00082	0.526
CLV_PCSK_KEX2_1	486	488	PF00082	0.571
CLV_PCSK_KEX2_1	49	51	PF00082	0.552
CLV_PCSK_KEX2_1	554	556	PF00082	0.585
CLV_PCSK_KEX2_1	603	605	PF00082	0.566
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.502
CLV_PCSK_PC1ET2_1	603	605	PF00082	0.566
CLV_PCSK_PC7_1	386	392	PF00082	0.497
CLV_PCSK_SKI1_1	298	302	PF00082	0.527
CLV_PCSK_SKI1_1	399	403	PF00082	0.519
CLV_PCSK_SKI1_1	480	484	PF00082	0.652
CLV_PCSK_SKI1_1	548	552	PF00082	0.633
DEG_SCF_FBW7_1	280	286	PF00400	0.550
DEG_SCF_FBW7_1	8	13	PF00400	0.566
DEG_SPOP_SBC_1	10	14	PF00917	0.563
DEG_SPOP_SBC_1	445	449	PF00917	0.500
DEG_SPOP_SBC_1	67	71	PF00917	0.704
DOC_CKS1_1	280	285	PF01111	0.555
DOC_CKS1_1	316	321	PF01111	0.686
DOC_CKS1_1	88	93	PF01111	0.540
DOC_MAPK_gen_1	462	470	PF00069	0.473
DOC_MAPK_MEF2A_6	462	470	PF00069	0.582
DOC_SPAK_OSR1_1	340	344	PF12202	0.485
DOC_USP7_MATH_1	11	15	PF00917	0.768
DOC_USP7_MATH_1	157	161	PF00917	0.665
DOC_USP7_MATH_1	195	199	PF00917	0.644
DOC_USP7_MATH_1	2	6	PF00917	0.620
DOC_USP7_MATH_1	283	287	PF00917	0.672
DOC_USP7_MATH_1	57	61	PF00917	0.730
DOC_USP7_MATH_1	594	598	PF00917	0.404
DOC_USP7_MATH_2	2	8	PF00917	0.593
DOC_WW_Pin1_4	119	124	PF00397	0.570
DOC_WW_Pin1_4	168	173	PF00397	0.599
DOC_WW_Pin1_4	174	179	PF00397	0.661
DOC_WW_Pin1_4	190	195	PF00397	0.576
DOC_WW_Pin1_4	22	27	PF00397	0.657
DOC_WW_Pin1_4	279	284	PF00397	0.651
DOC_WW_Pin1_4	315	320	PF00397	0.621
DOC_WW_Pin1_4	372	377	PF00397	0.635
DOC_WW_Pin1_4	41	46	PF00397	0.589
DOC_WW_Pin1_4	438	443	PF00397	0.637
DOC_WW_Pin1_4	446	451	PF00397	0.599
DOC_WW_Pin1_4	480	485	PF00397	0.592
DOC_WW_Pin1_4	6	11	PF00397	0.664
DOC_WW_Pin1_4	608	613	PF00397	0.613
DOC_WW_Pin1_4	614	619	PF00397	0.670
DOC_WW_Pin1_4	638	643	PF00397	0.635
DOC_WW_Pin1_4	87	92	PF00397	0.736
LIG_14-3-3_CanoR_1	155	165	PF00244	0.575
LIG_14-3-3_CanoR_1	20	26	PF00244	0.663
LIG_14-3-3_CanoR_1	380	385	PF00244	0.495
LIG_14-3-3_CanoR_1	465	471	PF00244	0.493
LIG_14-3-3_CanoR_1	492	496	PF00244	0.481
LIG_14-3-3_CanoR_1	556	564	PF00244	0.557
LIG_14-3-3_CanoR_1	698	706	PF00244	0.568
LIG_Actin_WH2_2	34	51	PF00022	0.529
LIG_Actin_WH2_2	642	660	PF00022	0.460
LIG_BIR_III_4	326	330	PF00653	0.490
LIG_BRCT_BRCA1_1	117	121	PF00533	0.565
LIG_BRCT_BRCA1_1	501	505	PF00533	0.448
LIG_deltaCOP1_diTrp_1	221	229	PF00928	0.565
LIG_deltaCOP1_diTrp_1	420	426	PF00928	0.512
LIG_eIF4E_1	656	662	PF01652	0.535
LIG_EVH1_2	538	542	PF00568	0.417
LIG_FHA_1	280	286	PF00498	0.560
LIG_FHA_1	343	349	PF00498	0.509
LIG_FHA_1	35	41	PF00498	0.658
LIG_FHA_1	400	406	PF00498	0.438
LIG_FHA_1	426	432	PF00498	0.553
LIG_FHA_1	57	63	PF00498	0.614
LIG_FHA_1	609	615	PF00498	0.598
LIG_FHA_2	115	121	PF00498	0.615
LIG_FHA_2	231	237	PF00498	0.566
LIG_FHA_2	294	300	PF00498	0.536
LIG_GBD_Chelix_1	219	227	PF00786	0.511
LIG_Integrin_isoDGR_2	328	330	PF01839	0.492
LIG_LIR_Apic_2	168	172	PF02991	0.539
LIG_LIR_Apic_2	310	316	PF02991	0.528
LIG_LIR_Gen_1	420	429	PF02991	0.668
LIG_LIR_Gen_1	461	470	PF02991	0.473
LIG_LIR_Gen_1	654	663	PF02991	0.497
LIG_LIR_Gen_1	682	693	PF02991	0.572
LIG_LIR_Nem_3	222	228	PF02991	0.487
LIG_LIR_Nem_3	338	344	PF02991	0.549
LIG_LIR_Nem_3	409	415	PF02991	0.520
LIG_LIR_Nem_3	420	425	PF02991	0.613
LIG_LIR_Nem_3	461	466	PF02991	0.608
LIG_LIR_Nem_3	469	473	PF02991	0.567
LIG_LIR_Nem_3	541	545	PF02991	0.500
LIG_LIR_Nem_3	597	602	PF02991	0.436
LIG_LIR_Nem_3	654	659	PF02991	0.650
LIG_LIR_Nem_3	682	688	PF02991	0.576
LIG_Pex14_1	422	426	PF04695	0.509
LIG_Pex14_1	669	673	PF04695	0.416
LIG_PTB_Apo_2	245	252	PF02174	0.531
LIG_SH2_CRK	169	173	PF00017	0.540
LIG_SH2_GRB2like	77	80	PF00017	0.542
LIG_SH2_NCK_1	313	317	PF00017	0.522
LIG_SH2_NCK_1	509	513	PF00017	0.484
LIG_SH2_SRC	77	80	PF00017	0.542
LIG_SH2_STAT3	667	670	PF00017	0.419
LIG_SH2_STAT5	230	233	PF00017	0.630
LIG_SH2_STAT5	351	354	PF00017	0.452
LIG_SH2_STAT5	412	415	PF00017	0.517
LIG_SH2_STAT5	576	579	PF00017	0.438
LIG_SH2_STAT5	601	604	PF00017	0.455
LIG_SH2_STAT5	648	651	PF00017	0.475
LIG_SH2_STAT5	656	659	PF00017	0.511
LIG_SH3_1	313	319	PF00018	0.519
LIG_SH3_3	159	165	PF00018	0.597
LIG_SH3_3	191	197	PF00018	0.571
LIG_SH3_3	199	205	PF00018	0.518
LIG_SH3_3	23	29	PF00018	0.752
LIG_SH3_3	277	283	PF00018	0.570
LIG_SH3_3	313	319	PF00018	0.670
LIG_SH3_3	439	445	PF00018	0.667
LIG_SH3_3	447	453	PF00018	0.551
LIG_SH3_3	492	498	PF00018	0.651
LIG_SH3_3	612	618	PF00018	0.677
LIG_SUMO_SIM_par_1	39	44	PF11976	0.532
LIG_TRAF2_1	335	338	PF00917	0.501
LIG_TYR_ITIM	413	418	PF00017	0.439
LIG_WW_2	194	197	PF00397	0.548
MOD_CDC14_SPxK_1	127	130	PF00782	0.543
MOD_CDK_SPxK_1	124	130	PF00069	0.557
MOD_CDK_SPxK_1	480	486	PF00069	0.591
MOD_CDK_SPxK_1	87	93	PF00069	0.538
MOD_CDK_SPxxK_3	480	487	PF00069	0.586
MOD_CK1_1	122	128	PF00069	0.650
MOD_CK1_1	294	300	PF00069	0.595
MOD_CK1_1	304	310	PF00069	0.669
MOD_CK1_1	36	42	PF00069	0.774
MOD_CK1_1	362	368	PF00069	0.577
MOD_CK1_1	370	376	PF00069	0.605
MOD_CK1_1	403	409	PF00069	0.524
MOD_CK1_1	441	447	PF00069	0.653
MOD_CK1_1	557	563	PF00069	0.743
MOD_CK1_1	6	12	PF00069	0.735
MOD_CK1_1	613	619	PF00069	0.683
MOD_CK1_1	638	644	PF00069	0.608
MOD_CK1_1	66	72	PF00069	0.772
MOD_CK1_1	87	93	PF00069	0.734
MOD_CK2_1	114	120	PF00069	0.613
MOD_CK2_1	230	236	PF00069	0.553
MOD_CK2_1	247	253	PF00069	0.533
MOD_CK2_1	332	338	PF00069	0.499
MOD_CK2_1	372	378	PF00069	0.586
MOD_CK2_1	516	522	PF00069	0.644
MOD_CK2_1	563	569	PF00069	0.609
MOD_CK2_1	57	63	PF00069	0.608
MOD_CK2_1	648	654	PF00069	0.534
MOD_CK2_1	689	695	PF00069	0.562
MOD_CK2_1	9	15	PF00069	0.660
MOD_Cter_Amidation	552	555	PF01082	0.500
MOD_GlcNHglycan	110	113	PF01048	0.629
MOD_GlcNHglycan	277	280	PF01048	0.775
MOD_GlcNHglycan	306	309	PF01048	0.667
MOD_GlcNHglycan	355	359	PF01048	0.531
MOD_GlcNHglycan	361	364	PF01048	0.526
MOD_GlcNHglycan	394	397	PF01048	0.658
MOD_GlcNHglycan	513	516	PF01048	0.681
MOD_GlcNHglycan	518	521	PF01048	0.629
MOD_GlcNHglycan	637	640	PF01048	0.520
MOD_GlcNHglycan	642	645	PF01048	0.510
MOD_GlcNHglycan	65	68	PF01048	0.670
MOD_GlcNHglycan	691	694	PF01048	0.466
MOD_GlcNHglycan	74	77	PF01048	0.668
MOD_GSK3_1	115	122	PF00069	0.608
MOD_GSK3_1	196	203	PF00069	0.568
MOD_GSK3_1	2	9	PF00069	0.735
MOD_GSK3_1	243	250	PF00069	0.679
MOD_GSK3_1	275	282	PF00069	0.682
MOD_GSK3_1	303	310	PF00069	0.713
MOD_GSK3_1	311	318	PF00069	0.568
MOD_GSK3_1	332	339	PF00069	0.498
MOD_GSK3_1	399	406	PF00069	0.430
MOD_GSK3_1	421	428	PF00069	0.515
MOD_GSK3_1	433	440	PF00069	0.570
MOD_GSK3_1	441	448	PF00069	0.450
MOD_GSK3_1	454	461	PF00069	0.552
MOD_GSK3_1	499	506	PF00069	0.461
MOD_GSK3_1	507	514	PF00069	0.478
MOD_GSK3_1	555	562	PF00069	0.590
MOD_GSK3_1	563	570	PF00069	0.615
MOD_GSK3_1	57	64	PF00069	0.743
MOD_GSK3_1	578	585	PF00069	0.435
MOD_GSK3_1	606	613	PF00069	0.649
MOD_GSK3_1	626	633	PF00069	0.684
MOD_GSK3_1	634	641	PF00069	0.626
MOD_GSK3_1	68	75	PF00069	0.599
MOD_GSK3_1	698	705	PF00069	0.490
MOD_GSK3_1	83	90	PF00069	0.712
MOD_N-GLC_1	108	113	PF02516	0.703
MOD_N-GLC_1	189	194	PF02516	0.843
MOD_N-GLC_1	301	306	PF02516	0.654
MOD_N-GLC_1	689	694	PF02516	0.485
MOD_NEK2_1	108	113	PF00069	0.587
MOD_NEK2_1	21	26	PF00069	0.692
MOD_NEK2_1	223	228	PF00069	0.562
MOD_NEK2_1	301	306	PF00069	0.639
MOD_NEK2_1	33	38	PF00069	0.529
MOD_NEK2_1	367	372	PF00069	0.587
MOD_NEK2_1	400	405	PF00069	0.487
MOD_NEK2_1	425	430	PF00069	0.525
MOD_NEK2_1	48	53	PF00069	0.663
MOD_NEK2_1	491	496	PF00069	0.556
MOD_NEK2_1	533	538	PF00069	0.452
MOD_NEK2_1	567	572	PF00069	0.455
MOD_NEK2_1	671	676	PF00069	0.438
MOD_NEK2_1	68	73	PF00069	0.659
MOD_NEK2_1	688	693	PF00069	0.503
MOD_NEK2_1	95	100	PF00069	0.591
MOD_NEK2_2	149	154	PF00069	0.652
MOD_NEK2_2	421	426	PF00069	0.509
MOD_PIKK_1	122	128	PF00454	0.685
MOD_PIKK_1	362	368	PF00454	0.637
MOD_PIKK_1	406	412	PF00454	0.564
MOD_PIKK_1	503	509	PF00454	0.468
MOD_PIKK_1	559	565	PF00454	0.522
MOD_PK_1	49	55	PF00069	0.531
MOD_PK_1	555	561	PF00069	0.555
MOD_PKA_1	49	55	PF00069	0.531
MOD_PKA_1	554	560	PF00069	0.584
MOD_PKA_1	630	636	PF00069	0.577
MOD_PKA_2	114	120	PF00069	0.685
MOD_PKA_2	165	171	PF00069	0.630
MOD_PKA_2	182	188	PF00069	0.702
MOD_PKA_2	263	269	PF00069	0.557
MOD_PKA_2	48	54	PF00069	0.528
MOD_PKA_2	491	497	PF00069	0.710
MOD_PKA_2	554	560	PF00069	0.579
MOD_PKA_2	697	703	PF00069	0.445
MOD_Plk_1	3	9	PF00069	0.560
MOD_Plk_1	34	40	PF00069	0.630
MOD_Plk_1	689	695	PF00069	0.489
MOD_Plk_4	36	42	PF00069	0.646
MOD_Plk_4	421	427	PF00069	0.511
MOD_Plk_4	49	55	PF00069	0.541
MOD_Plk_4	491	497	PF00069	0.624
MOD_Plk_4	538	544	PF00069	0.535
MOD_Plk_4	594	600	PF00069	0.535
MOD_Plk_4	610	616	PF00069	0.599
MOD_Plk_4	679	685	PF00069	0.573
MOD_ProDKin_1	119	125	PF00069	0.571
MOD_ProDKin_1	168	174	PF00069	0.601
MOD_ProDKin_1	190	196	PF00069	0.584
MOD_ProDKin_1	22	28	PF00069	0.648
MOD_ProDKin_1	279	285	PF00069	0.649
MOD_ProDKin_1	315	321	PF00069	0.622
MOD_ProDKin_1	372	378	PF00069	0.630
MOD_ProDKin_1	41	47	PF00069	0.588
MOD_ProDKin_1	438	444	PF00069	0.637
MOD_ProDKin_1	446	452	PF00069	0.598
MOD_ProDKin_1	480	486	PF00069	0.591
MOD_ProDKin_1	6	12	PF00069	0.663
MOD_ProDKin_1	608	614	PF00069	0.616
MOD_ProDKin_1	638	644	PF00069	0.623
MOD_ProDKin_1	87	93	PF00069	0.738
MOD_SUMO_for_1	602	605	PF00179	0.548
MOD_SUMO_rev_2	232	240	PF00179	0.634
MOD_SUMO_rev_2	241	249	PF00179	0.585
TRG_ENDOCYTIC_2	228	231	PF00928	0.545
TRG_ENDOCYTIC_2	415	418	PF00928	0.513
TRG_ENDOCYTIC_2	656	659	PF00928	0.492
TRG_ER_diArg_1	153	155	PF00400	0.656
TRG_ER_diArg_1	19	21	PF00400	0.628
TRG_ER_diArg_1	388	391	PF00400	0.476
TRG_ER_diArg_1	48	50	PF00400	0.551
TRG_ER_diArg_1	485	487	PF00400	0.596
TRG_ER_diArg_1	554	556	PF00400	0.590
TRG_NLS_MonoExtC_3	388	394	PF00514	0.476
TRG_NLS_MonoExtN_4	386	393	PF00514	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P597	Leptomonas seymouri	44%	100%
A0A3S7X4L3	Leishmania donovani	63%	100%
A4I6U8	Leishmania infantum	64%	100%
E9B1X1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4Q691	Leishmania major	62%	100%