Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJF2_LEIBR

TriTrypDb:

LbrM.31.1930 , LBRM2903_310028500

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJF2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	192	194	PF00675	0.599
CLV_NRD_NRD_1	53	55	PF00675	0.566
CLV_PCSK_KEX2_1	166	168	PF00082	0.547
CLV_PCSK_KEX2_1	192	194	PF00082	0.649
CLV_PCSK_KEX2_1	300	302	PF00082	0.635
CLV_PCSK_KEX2_1	53	55	PF00082	0.565
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.547
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.518
CLV_PCSK_SKI1_1	151	155	PF00082	0.597
CLV_PCSK_SKI1_1	491	495	PF00082	0.339
CLV_PCSK_SKI1_1	543	547	PF00082	0.503
CLV_PCSK_SKI1_1	581	585	PF00082	0.579
CLV_PCSK_SKI1_1	630	634	PF00082	0.479
DEG_SCF_TRCP1_1	375	381	PF00400	0.368
DEG_SPOP_SBC_1	112	116	PF00917	0.537
DOC_CKS1_1	347	352	PF01111	0.530
DOC_CKS1_1	87	92	PF01111	0.506
DOC_CYCLIN_RxL_1	272	286	PF00134	0.453
DOC_CYCLIN_RxL_1	540	551	PF00134	0.539
DOC_MAPK_gen_1	421	430	PF00069	0.556
DOC_MAPK_gen_1	66	76	PF00069	0.827
DOC_PP1_RVXF_1	231	238	PF00149	0.446
DOC_PP1_RVXF_1	541	548	PF00149	0.455
DOC_PP4_FxxP_1	546	549	PF00568	0.547
DOC_SPAK_OSR1_1	5	9	PF12202	0.535
DOC_USP7_MATH_1	112	116	PF00917	0.775
DOC_USP7_MATH_1	122	126	PF00917	0.694
DOC_USP7_MATH_1	142	146	PF00917	0.525
DOC_USP7_MATH_1	159	163	PF00917	0.666
DOC_USP7_MATH_1	185	189	PF00917	0.720
DOC_USP7_MATH_1	348	352	PF00917	0.481
DOC_USP7_MATH_1	395	399	PF00917	0.524
DOC_USP7_MATH_1	407	411	PF00917	0.631
DOC_USP7_MATH_1	422	426	PF00917	0.643
DOC_USP7_MATH_1	529	533	PF00917	0.402
DOC_USP7_MATH_1	561	565	PF00917	0.508
DOC_USP7_MATH_1	647	651	PF00917	0.556
DOC_USP7_MATH_1	668	672	PF00917	0.572
DOC_USP7_UBL2_3	99	103	PF12436	0.487
DOC_WW_Pin1_4	120	125	PF00397	0.700
DOC_WW_Pin1_4	134	139	PF00397	0.647
DOC_WW_Pin1_4	155	160	PF00397	0.576
DOC_WW_Pin1_4	257	262	PF00397	0.438
DOC_WW_Pin1_4	346	351	PF00397	0.548
DOC_WW_Pin1_4	378	383	PF00397	0.497
DOC_WW_Pin1_4	403	408	PF00397	0.642
DOC_WW_Pin1_4	410	415	PF00397	0.754
DOC_WW_Pin1_4	444	449	PF00397	0.401
DOC_WW_Pin1_4	48	53	PF00397	0.815
DOC_WW_Pin1_4	482	487	PF00397	0.494
DOC_WW_Pin1_4	548	553	PF00397	0.568
DOC_WW_Pin1_4	557	562	PF00397	0.751
DOC_WW_Pin1_4	565	570	PF00397	0.752
DOC_WW_Pin1_4	574	579	PF00397	0.595
DOC_WW_Pin1_4	67	72	PF00397	0.509
DOC_WW_Pin1_4	86	91	PF00397	0.720
DOC_WW_Pin1_4	92	97	PF00397	0.734
LIG_14-3-3_CanoR_1	10	17	PF00244	0.593
LIG_14-3-3_CanoR_1	111	121	PF00244	0.687
LIG_14-3-3_CanoR_1	240	248	PF00244	0.389
LIG_14-3-3_CanoR_1	421	430	PF00244	0.339
LIG_14-3-3_CanoR_1	498	506	PF00244	0.326
LIG_14-3-3_CanoR_1	530	538	PF00244	0.388
LIG_14-3-3_CanoR_1	554	561	PF00244	0.554
LIG_14-3-3_CanoR_1	640	648	PF00244	0.540
LIG_Actin_WH2_2	538	556	PF00022	0.494
LIG_APCC_ABBA_1	215	220	PF00400	0.569
LIG_APCC_ABBA_1	657	662	PF00400	0.459
LIG_BRCT_BRCA1_1	543	547	PF00533	0.550
LIG_Clathr_ClatBox_1	427	431	PF01394	0.500
LIG_deltaCOP1_diTrp_1	327	331	PF00928	0.473
LIG_FHA_1	201	207	PF00498	0.633
LIG_FHA_1	379	385	PF00498	0.454
LIG_FHA_1	492	498	PF00498	0.474
LIG_FHA_1	516	522	PF00498	0.381
LIG_FHA_1	590	596	PF00498	0.327
LIG_FHA_1	608	614	PF00498	0.470
LIG_FHA_2	112	118	PF00498	0.505
LIG_FHA_2	176	182	PF00498	0.513
LIG_FHA_2	284	290	PF00498	0.347
LIG_FHA_2	404	410	PF00498	0.582
LIG_FHA_2	445	451	PF00498	0.396
LIG_FHA_2	476	482	PF00498	0.441
LIG_LIR_Apic_2	544	550	PF02991	0.546
LIG_LIR_Gen_1	20	31	PF02991	0.439
LIG_LIR_Gen_1	242	252	PF02991	0.400
LIG_LIR_Gen_1	285	295	PF02991	0.380
LIG_LIR_Gen_1	455	462	PF02991	0.401
LIG_LIR_Gen_1	592	601	PF02991	0.420
LIG_LIR_Gen_1	603	613	PF02991	0.424
LIG_LIR_LC3C_4	212	217	PF02991	0.617
LIG_LIR_Nem_3	20	26	PF02991	0.530
LIG_LIR_Nem_3	242	247	PF02991	0.387
LIG_LIR_Nem_3	285	290	PF02991	0.382
LIG_LIR_Nem_3	364	370	PF02991	0.342
LIG_LIR_Nem_3	455	459	PF02991	0.367
LIG_LIR_Nem_3	537	542	PF02991	0.354
LIG_LIR_Nem_3	603	609	PF02991	0.431
LIG_MLH1_MIPbox_1	543	547	PF16413	0.453
LIG_MYND_3	669	673	PF01753	0.641
LIG_NRBOX	21	27	PF00104	0.432
LIG_NRBOX	627	633	PF00104	0.399
LIG_SH2_CRK	23	27	PF00017	0.439
LIG_SH2_CRK	244	248	PF00017	0.277
LIG_SH2_CRK	370	374	PF00017	0.421
LIG_SH2_CRK	489	493	PF00017	0.359
LIG_SH2_CRK	542	546	PF00017	0.382
LIG_SH2_GRB2like	244	247	PF00017	0.276
LIG_SH2_GRB2like	328	331	PF00017	0.448
LIG_SH2_NCK_1	287	291	PF00017	0.361
LIG_SH2_PTP2	456	459	PF00017	0.313
LIG_SH2_SRC	211	214	PF00017	0.613
LIG_SH2_SRC	287	290	PF00017	0.356
LIG_SH2_STAP1	23	27	PF00017	0.583
LIG_SH2_STAP1	287	291	PF00017	0.333
LIG_SH2_STAP1	489	493	PF00017	0.359
LIG_SH2_STAP1	502	506	PF00017	0.394
LIG_SH2_STAT5	160	163	PF00017	0.551
LIG_SH2_STAT5	372	375	PF00017	0.557
LIG_SH2_STAT5	387	390	PF00017	0.247
LIG_SH2_STAT5	451	454	PF00017	0.340
LIG_SH2_STAT5	456	459	PF00017	0.313
LIG_SH2_STAT5	502	505	PF00017	0.459
LIG_SH2_STAT5	520	523	PF00017	0.437
LIG_SH2_STAT5	606	609	PF00017	0.535
LIG_SH3_2	549	554	PF14604	0.655
LIG_SH3_3	118	124	PF00018	0.771
LIG_SH3_3	546	552	PF00018	0.600
LIG_SUMO_SIM_anti_2	333	339	PF11976	0.456
LIG_SUMO_SIM_anti_2	424	431	PF11976	0.533
LIG_SUMO_SIM_par_1	424	431	PF11976	0.533
LIG_TRAF2_1	478	481	PF00917	0.543
LIG_TRFH_1	444	448	PF08558	0.385
LIG_UBA3_1	149	154	PF00899	0.495
LIG_UBA3_1	627	633	PF00899	0.472
LIG_WRC_WIRS_1	538	543	PF05994	0.272
LIG_WRC_WIRS_1	590	595	PF05994	0.485
MOD_CDC14_SPxK_1	137	140	PF00782	0.722
MOD_CDC14_SPxK_1	51	54	PF00782	0.557
MOD_CDC14_SPxK_1	551	554	PF00782	0.554
MOD_CDC14_SPxK_1	560	563	PF00782	0.603
MOD_CDC14_SPxK_1	70	73	PF00782	0.488
MOD_CDK_SPK_2	124	129	PF00069	0.722
MOD_CDK_SPK_2	378	383	PF00069	0.497
MOD_CDK_SPK_2	48	53	PF00069	0.524
MOD_CDK_SPK_2	67	72	PF00069	0.490
MOD_CDK_SPxK_1	134	140	PF00069	0.767
MOD_CDK_SPxK_1	48	54	PF00069	0.555
MOD_CDK_SPxK_1	548	554	PF00069	0.525
MOD_CDK_SPxK_1	557	563	PF00069	0.611
MOD_CDK_SPxK_1	67	73	PF00069	0.490
MOD_CDK_SPxxK_3	257	264	PF00069	0.435
MOD_CDK_SPxxK_3	574	581	PF00069	0.466
MOD_CDK_SPxxK_3	86	93	PF00069	0.506
MOD_CK1_1	123	129	PF00069	0.788
MOD_CK1_1	145	151	PF00069	0.604
MOD_CK1_1	200	206	PF00069	0.592
MOD_CK1_1	257	263	PF00069	0.438
MOD_CK1_1	312	318	PF00069	0.731
MOD_CK1_1	339	345	PF00069	0.507
MOD_CK1_1	351	357	PF00069	0.448
MOD_CK1_1	410	416	PF00069	0.715
MOD_CK1_1	500	506	PF00069	0.349
MOD_CK1_1	537	543	PF00069	0.277
MOD_CK1_1	564	570	PF00069	0.540
MOD_CK1_1	577	583	PF00069	0.632
MOD_CK1_1	589	595	PF00069	0.388
MOD_CK1_1	65	71	PF00069	0.802
MOD_CK1_1	75	81	PF00069	0.738
MOD_CK1_1	92	98	PF00069	0.585
MOD_CK2_1	111	117	PF00069	0.592
MOD_CK2_1	257	263	PF00069	0.425
MOD_CK2_1	444	450	PF00069	0.402
MOD_CK2_1	475	481	PF00069	0.434
MOD_CK2_1	647	653	PF00069	0.351
MOD_DYRK1A_RPxSP_1	403	407	PF00069	0.414
MOD_GlcNHglycan	145	148	PF01048	0.638
MOD_GlcNHglycan	183	186	PF01048	0.680
MOD_GlcNHglycan	315	318	PF01048	0.653
MOD_GlcNHglycan	320	323	PF01048	0.704
MOD_GlcNHglycan	338	341	PF01048	0.672
MOD_GlcNHglycan	350	353	PF01048	0.550
MOD_GlcNHglycan	375	378	PF01048	0.428
MOD_GlcNHglycan	409	412	PF01048	0.715
MOD_GlcNHglycan	424	427	PF01048	0.610
MOD_GlcNHglycan	562	566	PF01048	0.648
MOD_GlcNHglycan	581	584	PF01048	0.609
MOD_GlcNHglycan	649	652	PF01048	0.567
MOD_GSK3_1	112	119	PF00069	0.809
MOD_GSK3_1	120	127	PF00069	0.687
MOD_GSK3_1	145	152	PF00069	0.582
MOD_GSK3_1	155	162	PF00069	0.631
MOD_GSK3_1	181	188	PF00069	0.653
MOD_GSK3_1	309	316	PF00069	0.619
MOD_GSK3_1	332	339	PF00069	0.615
MOD_GSK3_1	348	355	PF00069	0.481
MOD_GSK3_1	403	410	PF00069	0.676
MOD_GSK3_1	471	478	PF00069	0.394
MOD_GSK3_1	537	544	PF00069	0.313
MOD_GSK3_1	553	560	PF00069	0.685
MOD_GSK3_1	561	568	PF00069	0.565
MOD_GSK3_1	577	584	PF00069	0.641
MOD_GSK3_1	600	607	PF00069	0.529
MOD_NEK2_1	1	6	PF00069	0.711
MOD_NEK2_1	149	154	PF00069	0.587
MOD_NEK2_1	17	22	PF00069	0.503
MOD_NEK2_1	26	31	PF00069	0.477
MOD_NEK2_1	313	318	PF00069	0.652
MOD_NEK2_1	336	341	PF00069	0.628
MOD_NEK2_1	373	378	PF00069	0.482
MOD_NEK2_1	39	44	PF00069	0.483
MOD_NEK2_1	541	546	PF00069	0.379
MOD_NEK2_1	555	560	PF00069	0.658
MOD_NEK2_1	634	639	PF00069	0.411
MOD_NEK2_2	18	23	PF00069	0.385
MOD_PIKK_1	116	122	PF00454	0.711
MOD_PIKK_1	239	245	PF00454	0.593
MOD_PIKK_1	600	606	PF00454	0.435
MOD_PK_1	72	78	PF00069	0.735
MOD_PKA_1	72	78	PF00069	0.775
MOD_PKA_2	112	118	PF00069	0.686
MOD_PKA_2	170	176	PF00069	0.703
MOD_PKA_2	239	245	PF00069	0.309
MOD_PKA_2	34	40	PF00069	0.761
MOD_PKA_2	422	428	PF00069	0.566
MOD_PKA_2	471	477	PF00069	0.385
MOD_PKA_2	497	503	PF00069	0.291
MOD_PKA_2	529	535	PF00069	0.401
MOD_PKA_2	553	559	PF00069	0.701
MOD_PKA_2	62	68	PF00069	0.701
MOD_PKA_2	9	15	PF00069	0.537
MOD_PKB_1	111	119	PF00069	0.555
MOD_PKB_1	281	289	PF00069	0.364
MOD_PKB_1	419	427	PF00069	0.384
MOD_Plk_1	116	122	PF00069	0.614
MOD_Plk_1	332	338	PF00069	0.480
MOD_Plk_1	449	455	PF00069	0.341
MOD_Plk_1	607	613	PF00069	0.427
MOD_Plk_2-3	197	203	PF00069	0.533
MOD_Plk_4	145	151	PF00069	0.651
MOD_Plk_4	18	24	PF00069	0.570
MOD_Plk_4	264	270	PF00069	0.519
MOD_Plk_4	290	296	PF00069	0.494
MOD_Plk_4	352	358	PF00069	0.468
MOD_Plk_4	433	439	PF00069	0.341
MOD_Plk_4	452	458	PF00069	0.319
MOD_Plk_4	516	522	PF00069	0.470
MOD_Plk_4	534	540	PF00069	0.466
MOD_Plk_4	586	592	PF00069	0.461
MOD_Plk_4	607	613	PF00069	0.472
MOD_ProDKin_1	120	126	PF00069	0.700
MOD_ProDKin_1	134	140	PF00069	0.645
MOD_ProDKin_1	155	161	PF00069	0.570
MOD_ProDKin_1	257	263	PF00069	0.438
MOD_ProDKin_1	346	352	PF00069	0.538
MOD_ProDKin_1	378	384	PF00069	0.492
MOD_ProDKin_1	403	409	PF00069	0.649
MOD_ProDKin_1	410	416	PF00069	0.752
MOD_ProDKin_1	444	450	PF00069	0.402
MOD_ProDKin_1	48	54	PF00069	0.816
MOD_ProDKin_1	482	488	PF00069	0.485
MOD_ProDKin_1	548	554	PF00069	0.577
MOD_ProDKin_1	557	563	PF00069	0.750
MOD_ProDKin_1	565	571	PF00069	0.752
MOD_ProDKin_1	574	580	PF00069	0.588
MOD_ProDKin_1	67	73	PF00069	0.509
MOD_ProDKin_1	86	92	PF00069	0.718
MOD_SUMO_rev_2	425	434	PF00179	0.495
MOD_SUMO_rev_2	650	657	PF00179	0.510
MOD_SUMO_rev_2	661	665	PF00179	0.403
TRG_DiLeu_BaLyEn_6	488	493	PF01217	0.342
TRG_ENDOCYTIC_2	23	26	PF00928	0.450
TRG_ENDOCYTIC_2	244	247	PF00928	0.358
TRG_ENDOCYTIC_2	287	290	PF00928	0.370
TRG_ENDOCYTIC_2	370	373	PF00928	0.371
TRG_ENDOCYTIC_2	456	459	PF00928	0.313
TRG_ENDOCYTIC_2	489	492	PF00928	0.362
TRG_ENDOCYTIC_2	542	545	PF00928	0.387
TRG_ENDOCYTIC_2	606	609	PF00928	0.391
TRG_ER_diArg_1	280	283	PF00400	0.375
TRG_ER_diArg_1	52	54	PF00400	0.558
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ1	Leptomonas seymouri	65%	100%
A0A1X0NQ51	Trypanosomatidae	43%	100%
A0A3R7LJ81	Trypanosoma rangeli	43%	100%
A0A3S7X4H9	Leishmania donovani	80%	99%
A4I6U7	Leishmania infantum	80%	99%
C9ZMB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B1X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
Q4Q692	Leishmania major	79%	100%
V5B8N6	Trypanosoma cruzi	41%	100%