DUF1992 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJF0_LEIBR

TriTrypDb:

LbrM.31.1910 , LBRM2903_310028300

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HJF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.552
CLV_NRD_NRD_1	149	151	PF00675	0.387
CLV_NRD_NRD_1	264	266	PF00675	0.505
CLV_NRD_NRD_1	28	30	PF00675	0.501
CLV_PCSK_KEX2_1	142	144	PF00082	0.514
CLV_PCSK_KEX2_1	171	173	PF00082	0.565
CLV_PCSK_KEX2_1	28	30	PF00082	0.551
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.602
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.484
CLV_PCSK_PC7_1	138	144	PF00082	0.520
CLV_PCSK_SKI1_1	104	108	PF00082	0.565
CLV_PCSK_SKI1_1	151	155	PF00082	0.461
CLV_PCSK_SKI1_1	172	176	PF00082	0.593
DOC_ANK_TNKS_1	164	171	PF00023	0.565
DOC_PP1_RVXF_1	255	261	PF00149	0.337
DOC_PP1_RVXF_1	72	78	PF00149	0.707
DOC_USP7_MATH_1	235	239	PF00917	0.454
DOC_USP7_MATH_1	270	274	PF00917	0.583
DOC_USP7_MATH_1	67	71	PF00917	0.592
LIG_14-3-3_CanoR_1	120	126	PF00244	0.688
LIG_BIR_III_4	167	171	PF00653	0.567
LIG_FHA_2	205	211	PF00498	0.602
LIG_FHA_2	214	220	PF00498	0.436
LIG_GBD_Chelix_1	196	204	PF00786	0.462
LIG_LIR_Gen_1	238	248	PF02991	0.579
LIG_LIR_Nem_3	219	224	PF02991	0.446
LIG_LIR_Nem_3	238	243	PF02991	0.476
LIG_LIR_Nem_3	6	12	PF02991	0.425
LIG_SH2_CRK	240	244	PF00017	0.583
LIG_SH2_STAT5	230	233	PF00017	0.533
LIG_SH2_STAT5	247	250	PF00017	0.350
LIG_SH2_STAT5	61	64	PF00017	0.566
LIG_UBA3_1	162	171	PF00899	0.494
MOD_CK1_1	3	9	PF00069	0.584
MOD_CK2_1	213	219	PF00069	0.515
MOD_Cter_Amidation	169	172	PF01082	0.563
MOD_GlcNHglycan	62	65	PF01048	0.687
MOD_GlcNHglycan	68	72	PF01048	0.687
MOD_GlcNHglycan	88	91	PF01048	0.699
MOD_GSK3_1	120	127	PF00069	0.663
MOD_GSK3_1	29	36	PF00069	0.659
MOD_GSK3_1	82	89	PF00069	0.615
MOD_GSK3_1	96	103	PF00069	0.708
MOD_NEK2_1	131	136	PF00069	0.638
MOD_NEK2_1	153	158	PF00069	0.335
MOD_NEK2_1	181	186	PF00069	0.504
MOD_NEK2_1	204	209	PF00069	0.611
MOD_NEK2_1	60	65	PF00069	0.635
MOD_NEK2_2	270	275	PF00069	0.388
MOD_NEK2_2	73	78	PF00069	0.619
MOD_PIKK_1	190	196	PF00454	0.548
MOD_PKA_2	210	216	PF00069	0.429
MOD_PKA_2	96	102	PF00069	0.455
MOD_SUMO_for_1	141	144	PF00179	0.605
MOD_SUMO_rev_2	144	153	PF00179	0.448
MOD_SUMO_rev_2	167	173	PF00179	0.580
TRG_DiLeu_BaEn_2	148	154	PF01217	0.357
TRG_DiLeu_BaEn_4	250	256	PF01217	0.437
TRG_ENDOCYTIC_2	221	224	PF00928	0.441
TRG_ENDOCYTIC_2	240	243	PF00928	0.457
TRG_ER_diArg_1	257	260	PF00400	0.561
TRG_ER_diArg_1	27	29	PF00400	0.549
TRG_NLS_MonoExtC_3	134	140	PF00514	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2I0	Leptomonas seymouri	61%	100%
A0A1X0NRC6	Trypanosomatidae	44%	99%
A0A3Q8IFD5	Leishmania donovani	84%	100%
A0A422MYM9	Trypanosoma rangeli	45%	99%
A4I6U5	Leishmania infantum	84%	100%
C9ZMB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B1W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q694	Leishmania major	85%	100%
V5AZM2	Trypanosoma cruzi	43%	100%