Enkurin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJE9_LEIBR

TriTrypDb:

LbrM.31.1900 , LBRM2903_310028200

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJE9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.562
CLV_NRD_NRD_1	225	227	PF00675	0.450
CLV_NRD_NRD_1	260	262	PF00675	0.456
CLV_PCSK_KEX2_1	128	130	PF00082	0.710
CLV_PCSK_KEX2_1	17	19	PF00082	0.516
CLV_PCSK_KEX2_1	22	24	PF00082	0.684
CLV_PCSK_KEX2_1	224	226	PF00082	0.495
CLV_PCSK_KEX2_1	260	262	PF00082	0.482
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.516
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.766
CLV_PCSK_PC7_1	18	24	PF00082	0.512
CLV_PCSK_SKI1_1	225	229	PF00082	0.518
CLV_PCSK_SKI1_1	241	245	PF00082	0.514
CLV_PCSK_SKI1_1	260	264	PF00082	0.296
CLV_Separin_Metazoa	238	242	PF03568	0.367
DEG_APCC_DBOX_1	224	232	PF00400	0.485
DOC_CYCLIN_RxL_1	219	232	PF00134	0.359
DOC_PP2B_LxvP_1	60	63	PF13499	0.615
DOC_USP7_MATH_1	152	156	PF00917	0.578
DOC_USP7_MATH_1	16	20	PF00917	0.664
DOC_WW_Pin1_4	172	177	PF00397	0.524
LIG_14-3-3_CanoR_1	96	101	PF00244	0.527
LIG_Actin_WH2_2	227	243	PF00022	0.466
LIG_BIR_II_1	1	5	PF00653	0.604
LIG_BIR_III_4	27	31	PF00653	0.508
LIG_FHA_1	154	160	PF00498	0.437
LIG_FHA_2	252	258	PF00498	0.457
LIG_LIR_Nem_3	146	151	PF02991	0.633
LIG_LIR_Nem_3	157	163	PF02991	0.658
LIG_NRBOX	235	241	PF00104	0.423
LIG_PTB_Apo_2	147	154	PF02174	0.501
LIG_SH2_CRK	57	61	PF00017	0.542
LIG_SH2_STAP1	276	280	PF00017	0.374
LIG_SH2_STAT3	276	279	PF00017	0.615
LIG_SH2_STAT5	160	163	PF00017	0.664
LIG_SH3_3	244	250	PF00018	0.468
LIG_SH3_3	73	79	PF00018	0.502
MOD_CDC14_SPxK_1	175	178	PF00782	0.494
MOD_CDK_SPxK_1	172	178	PF00069	0.517
MOD_CK1_1	169	175	PF00069	0.498
MOD_CK2_1	229	235	PF00069	0.523
MOD_GlcNHglycan	109	112	PF01048	0.594
MOD_GlcNHglycan	120	123	PF01048	0.590
MOD_GlcNHglycan	14	17	PF01048	0.614
MOD_GlcNHglycan	156	159	PF01048	0.654
MOD_GlcNHglycan	172	175	PF01048	0.610
MOD_GlcNHglycan	33	36	PF01048	0.433
MOD_GSK3_1	107	114	PF00069	0.683
MOD_GSK3_1	12	19	PF00069	0.658
MOD_GSK3_1	166	173	PF00069	0.529
MOD_N-GLC_1	118	123	PF02516	0.587
MOD_N-GLC_1	208	213	PF02516	0.493
MOD_N-GLC_1	251	256	PF02516	0.449
MOD_N-GLC_1	30	35	PF02516	0.626
MOD_NEK2_1	1	6	PF00069	0.622
MOD_NEK2_1	153	158	PF00069	0.602
MOD_NEK2_1	251	256	PF00069	0.449
MOD_NEK2_1	95	100	PF00069	0.582
MOD_PIKK_1	275	281	PF00454	0.379
MOD_PKA_2	95	101	PF00069	0.604
MOD_Plk_1	50	56	PF00069	0.624
MOD_ProDKin_1	172	178	PF00069	0.517
MOD_SUMO_rev_2	238	246	PF00179	0.547
TRG_DiLeu_BaEn_1	235	240	PF01217	0.532
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.366
TRG_ENDOCYTIC_2	160	163	PF00928	0.664
TRG_ENDOCYTIC_2	57	60	PF00928	0.570
TRG_ER_diArg_1	127	129	PF00400	0.562
TRG_ER_diArg_1	193	196	PF00400	0.504
TRG_ER_diArg_1	224	226	PF00400	0.585
TRG_ER_diArg_1	259	261	PF00400	0.469
TRG_NES_CRM1_1	177	189	PF08389	0.430
TRG_NLS_MonoExtC_3	215	221	PF00514	0.536
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2I0	Leptomonas seymouri	24%	100%
A0A0N1PBJ9	Leptomonas seymouri	74%	99%
A0A1X0NQE4	Trypanosomatidae	59%	100%
A0A3Q8IK28	Leishmania donovani	89%	100%
A0A3R7JXC5	Trypanosoma rangeli	60%	100%
A4I6U4	Leishmania infantum	89%	100%
C9ZMB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B1W7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q695	Leishmania major	90%	100%
V5AJB0	Trypanosoma cruzi	57%	100%