Sld5 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GINS complex subunit Psf3, putative

Species:

Leishmania braziliensis

UniProt:

A4HJE8_LEIBR

TriTrypDb:

LbrM.31.1890 , LBRM2903_310028100

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0000811	GINS complex	4	1
GO:0031261	DNA replication preinitiation complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HJE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJE8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	11
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006270	DNA replication initiation	5	1
GO:0022402	cell cycle process	2	1
GO:1902292	cell cycle DNA replication initiation	3	1
GO:1902315	nuclear cell cycle DNA replication initiation	4	1
GO:1902975	mitotic DNA replication initiation	4	1
GO:1903047	mitotic cell cycle process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	94	96	PF00675	0.310
CLV_PCSK_SKI1_1	141	145	PF00082	0.225
CLV_PCSK_SKI1_1	165	169	PF00082	0.319
CLV_PCSK_SKI1_1	31	35	PF00082	0.518
CLV_PCSK_SKI1_1	82	86	PF00082	0.207
DEG_Nend_Nbox_1	1	3	PF02207	0.494
DOC_PP1_RVXF_1	139	145	PF00149	0.510
DOC_PP4_FxxP_1	22	25	PF00568	0.319
DOC_USP7_MATH_1	23	27	PF00917	0.443
DOC_WW_Pin1_4	94	99	PF00397	0.407
LIG_Actin_WH2_2	127	143	PF00022	0.417
LIG_BRCT_BRCA1_1	96	100	PF00533	0.449
LIG_deltaCOP1_diTrp_1	177	185	PF00928	0.416
LIG_FHA_1	19	25	PF00498	0.335
LIG_FHA_1	51	57	PF00498	0.349
LIG_FHA_1	84	90	PF00498	0.411
LIG_FHA_2	40	46	PF00498	0.486
LIG_FHA_2	78	84	PF00498	0.474
LIG_LIR_Apic_2	21	25	PF02991	0.319
LIG_LIR_Gen_1	64	73	PF02991	0.534
LIG_LIR_Nem_3	4	8	PF02991	0.397
LIG_LIR_Nem_3	64	70	PF02991	0.534
LIG_LIR_Nem_3	80	84	PF02991	0.413
LIG_MLH1_MIPbox_1	96	100	PF16413	0.449
LIG_NRBOX	106	112	PF00104	0.510
LIG_PCNA_TLS_4	165	172	PF02747	0.465
LIG_Pex14_1	181	185	PF04695	0.486
LIG_SH2_GRB2like	5	8	PF00017	0.274
LIG_SH2_PTP2	67	70	PF00017	0.474
LIG_SH2_SRC	14	17	PF00017	0.227
LIG_SH2_STAT3	99	102	PF00017	0.453
LIG_SH2_STAT5	139	142	PF00017	0.417
LIG_SH2_STAT5	171	174	PF00017	0.451
LIG_SH2_STAT5	5	8	PF00017	0.352
LIG_SH2_STAT5	67	70	PF00017	0.434
LIG_SH2_STAT5	99	102	PF00017	0.502
LIG_SH3_1	85	91	PF00018	0.510
LIG_SH3_3	67	73	PF00018	0.417
LIG_SH3_3	85	91	PF00018	0.510
LIG_SUMO_SIM_par_1	15	21	PF11976	0.339
LIG_TRAF2_1	13	16	PF00917	0.320
LIG_TYR_ITIM	137	142	PF00017	0.417
LIG_WRC_WIRS_1	19	24	PF05994	0.344
LIG_WRC_WIRS_1	78	83	PF05994	0.510
MOD_CK1_1	112	118	PF00069	0.512
MOD_CK1_1	77	83	PF00069	0.510
MOD_CK2_1	39	45	PF00069	0.473
MOD_CK2_1	77	83	PF00069	0.474
MOD_GlcNHglycan	115	118	PF01048	0.311
MOD_GlcNHglycan	120	123	PF01048	0.309
MOD_GSK3_1	109	116	PF00069	0.519
MOD_GSK3_1	57	64	PF00069	0.457
MOD_NEK2_1	1	6	PF00069	0.411
MOD_NEK2_1	167	172	PF00069	0.429
MOD_NEK2_2	66	71	PF00069	0.510
MOD_Plk_1	31	37	PF00069	0.493
MOD_Plk_2-3	39	45	PF00069	0.440
MOD_Plk_4	167	173	PF00069	0.442
MOD_ProDKin_1	94	100	PF00069	0.407
MOD_SUMO_rev_2	77	86	PF00179	0.422
TRG_DiLeu_BaLyEn_6	106	111	PF01217	0.529
TRG_ENDOCYTIC_2	139	142	PF00928	0.428
TRG_ENDOCYTIC_2	182	185	PF00928	0.489
TRG_ENDOCYTIC_2	5	8	PF00928	0.352
TRG_ENDOCYTIC_2	67	70	PF00928	0.484
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVI8	Leptomonas seymouri	85%	100%
A0A0S4JLR8	Bodo saltans	47%	100%
A0A1X0NPW8	Trypanosomatidae	61%	100%
A0A3Q8IEW7	Leishmania donovani	94%	100%
A0A422MYQ9	Trypanosoma rangeli	60%	100%
A4I6U3	Leishmania infantum	94%	100%
C9ZMB4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	85%
E9B1W6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q696	Leishmania major	94%	100%
Q54EH6	Dictyostelium discoideum	25%	70%
V5CZR6	Trypanosoma cruzi	60%	78%