MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MYND finger, putative

Species:

Leishmania braziliensis

UniProt:

A4HJE7_LEIBR

TriTrypDb:

LbrM.31.1880 , LBRM2903_310028000

Length:

475

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJE7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003676	nucleic acid binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.381
CLV_C14_Caspase3-7	39	43	PF00656	0.509
CLV_NRD_NRD_1	163	165	PF00675	0.490
CLV_NRD_NRD_1	174	176	PF00675	0.482
CLV_NRD_NRD_1	453	455	PF00675	0.475
CLV_PCSK_KEX2_1	174	176	PF00082	0.503
CLV_PCSK_KEX2_1	453	455	PF00082	0.553
CLV_PCSK_KEX2_1	48	50	PF00082	0.500
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.500
CLV_PCSK_SKI1_1	120	124	PF00082	0.445
CLV_PCSK_SKI1_1	165	169	PF00082	0.500
CLV_PCSK_SKI1_1	181	185	PF00082	0.320
CLV_PCSK_SKI1_1	201	205	PF00082	0.524
CLV_PCSK_SKI1_1	288	292	PF00082	0.303
CLV_PCSK_SKI1_1	315	319	PF00082	0.487
CLV_PCSK_SKI1_1	321	325	PF00082	0.432
CLV_PCSK_SKI1_1	395	399	PF00082	0.542
CLV_PCSK_SKI1_1	417	421	PF00082	0.299
CLV_PCSK_SKI1_1	74	78	PF00082	0.440
CLV_PCSK_SKI1_1	82	86	PF00082	0.447
CLV_PCSK_SKI1_1	90	94	PF00082	0.567
DEG_APCC_DBOX_1	320	328	PF00400	0.469
DOC_MAPK_gen_1	174	182	PF00069	0.389
DOC_MAPK_gen_1	218	227	PF00069	0.397
DOC_MAPK_gen_1	232	241	PF00069	0.385
DOC_MAPK_MEF2A_6	218	227	PF00069	0.541
DOC_MAPK_MEF2A_6	373	381	PF00069	0.375
DOC_PP1_RVXF_1	179	186	PF00149	0.320
DOC_PP1_RVXF_1	199	205	PF00149	0.461
DOC_PP1_RVXF_1	72	79	PF00149	0.392
DOC_PP2B_LxvP_1	383	386	PF13499	0.389
DOC_USP7_MATH_1	195	199	PF00917	0.535
DOC_USP7_MATH_1	2	6	PF00917	0.590
DOC_USP7_MATH_1	349	353	PF00917	0.447
DOC_USP7_MATH_1	391	395	PF00917	0.331
DOC_USP7_MATH_1	408	412	PF00917	0.455
DOC_USP7_UBL2_3	330	334	PF12436	0.463
DOC_USP7_UBL2_3	417	421	PF12436	0.303
DOC_WW_Pin1_4	191	196	PF00397	0.474
DOC_WW_Pin1_4	300	305	PF00397	0.493
DOC_WW_Pin1_4	42	47	PF00397	0.447
DOC_WW_Pin1_4	456	461	PF00397	0.615
DOC_WW_Pin1_4	6	11	PF00397	0.696
LIG_14-3-3_CanoR_1	164	173	PF00244	0.474
LIG_14-3-3_CanoR_1	453	457	PF00244	0.631
LIG_14-3-3_CanoR_1	82	89	PF00244	0.434
LIG_AP2alpha_2	69	71	PF02296	0.359
LIG_BIR_II_1	1	5	PF00653	0.570
LIG_BRCT_BRCA1_1	178	182	PF00533	0.435
LIG_deltaCOP1_diTrp_1	439	446	PF00928	0.367
LIG_eIF4E_1	286	292	PF01652	0.433
LIG_FHA_1	119	125	PF00498	0.479
LIG_FHA_1	155	161	PF00498	0.430
LIG_FHA_1	222	228	PF00498	0.456
LIG_FHA_1	314	320	PF00498	0.505
LIG_FHA_1	376	382	PF00498	0.396
LIG_FHA_1	414	420	PF00498	0.369
LIG_FHA_2	10	16	PF00498	0.638
LIG_FHA_2	166	172	PF00498	0.319
LIG_FHA_2	369	375	PF00498	0.346
LIG_FHA_2	413	419	PF00498	0.413
LIG_GBD_Chelix_1	52	60	PF00786	0.452
LIG_Integrin_isoDGR_2	281	283	PF01839	0.459
LIG_LIR_Gen_1	179	187	PF02991	0.375
LIG_LIR_Gen_1	289	298	PF02991	0.452
LIG_LIR_Gen_1	378	388	PF02991	0.360
LIG_LIR_Gen_1	77	84	PF02991	0.444
LIG_LIR_Nem_3	101	106	PF02991	0.347
LIG_LIR_Nem_3	171	176	PF02991	0.341
LIG_LIR_Nem_3	179	185	PF02991	0.297
LIG_LIR_Nem_3	289	295	PF02991	0.377
LIG_LIR_Nem_3	35	40	PF02991	0.556
LIG_LIR_Nem_3	354	360	PF02991	0.340
LIG_LIR_Nem_3	378	383	PF02991	0.395
LIG_LIR_Nem_3	77	83	PF02991	0.454
LIG_NRBOX	122	128	PF00104	0.481
LIG_Pex14_1	36	40	PF04695	0.338
LIG_Pex14_2	258	262	PF04695	0.508
LIG_SH2_CRK	216	220	PF00017	0.511
LIG_SH2_CRK	80	84	PF00017	0.459
LIG_SH2_NCK_1	80	84	PF00017	0.459
LIG_SH2_STAT5	216	219	PF00017	0.331
LIG_SH2_STAT5	286	289	PF00017	0.396
LIG_SH2_STAT5	370	373	PF00017	0.369
LIG_SH2_STAT5	430	433	PF00017	0.272
LIG_SH3_1	454	460	PF00018	0.564
LIG_SH3_3	407	413	PF00018	0.400
LIG_SH3_3	454	460	PF00018	0.664
LIG_SH3_3	466	472	PF00018	0.605
LIG_SUMO_SIM_par_1	315	320	PF11976	0.463
LIG_UBA3_1	176	181	PF00899	0.324
LIG_WRC_WIRS_1	204	209	PF05994	0.464
MOD_CDC14_SPxK_1	45	48	PF00782	0.456
MOD_CDK_SPxK_1	42	48	PF00069	0.448
MOD_CDK_SPxxK_3	42	49	PF00069	0.445
MOD_CK1_1	143	149	PF00069	0.548
MOD_CK1_1	194	200	PF00069	0.522
MOD_CK1_1	300	306	PF00069	0.499
MOD_CK1_1	313	319	PF00069	0.280
MOD_CK1_1	452	458	PF00069	0.616
MOD_CK1_1	5	11	PF00069	0.683
MOD_CK2_1	165	171	PF00069	0.295
MOD_CK2_1	348	354	PF00069	0.497
MOD_CK2_1	368	374	PF00069	0.368
MOD_CK2_1	381	387	PF00069	0.323
MOD_GlcNHglycan	168	171	PF01048	0.479
MOD_GlcNHglycan	312	315	PF01048	0.497
MOD_GlcNHglycan	351	354	PF01048	0.473
MOD_GlcNHglycan	383	386	PF01048	0.389
MOD_GlcNHglycan	422	425	PF01048	0.284
MOD_GSK3_1	106	113	PF00069	0.487
MOD_GSK3_1	191	198	PF00069	0.495
MOD_GSK3_1	2	9	PF00069	0.629
MOD_GSK3_1	214	221	PF00069	0.412
MOD_GSK3_1	299	306	PF00069	0.468
MOD_GSK3_1	408	415	PF00069	0.446
MOD_GSK3_1	425	432	PF00069	0.239
MOD_GSK3_1	452	459	PF00069	0.616
MOD_N-GLC_1	154	159	PF02516	0.427
MOD_N-GLC_1	165	170	PF02516	0.329
MOD_N-GLC_1	42	47	PF02516	0.447
MOD_N-GLC_1	90	95	PF02516	0.639
MOD_N-GLC_2	261	263	PF02516	0.523
MOD_N-GLC_2	445	447	PF02516	0.337
MOD_NEK2_1	112	117	PF00069	0.510
MOD_NEK2_1	176	181	PF00069	0.309
MOD_NEK2_1	183	188	PF00069	0.287
MOD_NEK2_1	203	208	PF00069	0.474
MOD_NEK2_1	251	256	PF00069	0.393
MOD_NEK2_1	381	386	PF00069	0.421
MOD_NEK2_1	420	425	PF00069	0.284
MOD_NEK2_1	61	66	PF00069	0.427
MOD_NEK2_2	425	430	PF00069	0.303
MOD_OFUCOSY	407	412	PF10250	0.448
MOD_PIKK_1	452	458	PF00454	0.539
MOD_PKA_2	452	458	PF00069	0.616
MOD_PKA_2	5	11	PF00069	0.734
MOD_Plk_1	118	124	PF00069	0.564
MOD_Plk_1	425	431	PF00069	0.427
MOD_Plk_4	20	26	PF00069	0.455
MOD_Plk_4	203	209	PF00069	0.385
MOD_Plk_4	221	227	PF00069	0.421
MOD_Plk_4	375	381	PF00069	0.460
MOD_Plk_4	425	431	PF00069	0.284
MOD_Plk_4	61	67	PF00069	0.420
MOD_Plk_4	74	80	PF00069	0.309
MOD_ProDKin_1	191	197	PF00069	0.475
MOD_ProDKin_1	300	306	PF00069	0.496
MOD_ProDKin_1	42	48	PF00069	0.448
MOD_ProDKin_1	456	462	PF00069	0.616
MOD_ProDKin_1	6	12	PF00069	0.696
MOD_SUMO_for_1	329	332	PF00179	0.454
MOD_SUMO_rev_2	331	336	PF00179	0.519
TRG_DiLeu_BaEn_1	119	124	PF01217	0.482
TRG_DiLeu_BaEn_2	157	163	PF01217	0.248
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.409
TRG_ENDOCYTIC_2	216	219	PF00928	0.437
TRG_ENDOCYTIC_2	357	360	PF00928	0.355
TRG_ENDOCYTIC_2	80	83	PF00928	0.424
TRG_ER_diArg_1	173	175	PF00400	0.492
TRG_NES_CRM1_1	335	348	PF08389	0.251
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJJ2	Leptomonas seymouri	81%	100%
A0A0S4JQ55	Bodo saltans	31%	71%
A0A1X0NPU0	Trypanosomatidae	35%	98%
A0A3R7M2S8	Trypanosoma rangeli	36%	98%
A0A3S7X4J0	Leishmania donovani	93%	99%
A4I6U2	Leishmania infantum	93%	99%
C9ZMB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	93%
E9B1W5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q697	Leishmania major	93%	100%
V5B432	Trypanosoma cruzi	36%	98%