Leucine rich repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJE4_LEIBR

TriTrypDb:

LbrM.31.1850 , LBRM2903_310027600

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8
GO:0000151	ubiquitin ligase complex	3	1
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HJE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJE4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.278
CLV_NRD_NRD_1	277	279	PF00675	0.458
CLV_PCSK_KEX2_1	171	173	PF00082	0.278
CLV_PCSK_KEX2_1	277	279	PF00082	0.458
CLV_PCSK_KEX2_1	68	70	PF00082	0.307
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.307
CLV_PCSK_PC7_1	64	70	PF00082	0.305
CLV_PCSK_SKI1_1	217	221	PF00082	0.236
CLV_PCSK_SKI1_1	277	281	PF00082	0.489
CLV_PCSK_SKI1_1	319	323	PF00082	0.343
CLV_PCSK_SKI1_1	34	38	PF00082	0.466
CLV_PCSK_SKI1_1	47	51	PF00082	0.313
CLV_PCSK_SKI1_1	68	72	PF00082	0.298
DEG_Nend_UBRbox_1	1	3	PF02207	0.418
DEG_SCF_FBW7_1	175	182	PF00400	0.255
DOC_CDC14_PxL_1	27	35	PF14671	0.317
DOC_CYCLIN_RxL_1	29	42	PF00134	0.308
DOC_MAPK_MEF2A_6	258	267	PF00069	0.245
DOC_MAPK_MEF2A_6	284	292	PF00069	0.325
DOC_MAPK_MEF2A_6	29	37	PF00069	0.266
DOC_MAPK_RevD_3	53	69	PF00069	0.282
DOC_USP7_MATH_1	132	136	PF00917	0.254
DOC_USP7_MATH_1	179	183	PF00917	0.259
DOC_USP7_MATH_1	247	251	PF00917	0.269
DOC_WW_Pin1_4	137	142	PF00397	0.254
DOC_WW_Pin1_4	175	180	PF00397	0.245
LIG_Actin_WH2_2	31	49	PF00022	0.260
LIG_Clathr_ClatBox_1	253	257	PF01394	0.242
LIG_FHA_1	30	36	PF00498	0.472
LIG_FHA_1	315	321	PF00498	0.308
LIG_FHA_2	198	204	PF00498	0.310
LIG_FHA_2	247	253	PF00498	0.381
LIG_FHA_2	84	90	PF00498	0.511
LIG_LIR_Gen_1	222	229	PF02991	0.297
LIG_LIR_Gen_1	257	267	PF02991	0.245
LIG_LIR_Gen_1	268	276	PF02991	0.233
LIG_LIR_Gen_1	294	303	PF02991	0.365
LIG_LIR_Gen_1	59	70	PF02991	0.290
LIG_LIR_Nem_3	204	210	PF02991	0.545
LIG_LIR_Nem_3	222	226	PF02991	0.298
LIG_LIR_Nem_3	257	263	PF02991	0.254
LIG_LIR_Nem_3	268	272	PF02991	0.284
LIG_LIR_Nem_3	294	300	PF02991	0.368
LIG_LIR_Nem_3	59	65	PF02991	0.275
LIG_NRBOX	32	38	PF00104	0.471
LIG_SH2_CRK	269	273	PF00017	0.265
LIG_SH2_NCK_1	269	273	PF00017	0.265
LIG_SH2_NCK_1	297	301	PF00017	0.272
LIG_SH2_SRC	297	300	PF00017	0.272
LIG_SH2_STAP1	297	301	PF00017	0.272
LIG_SH2_STAT5	269	272	PF00017	0.385
LIG_SH2_STAT5	302	305	PF00017	0.280
LIG_SH3_3	1	7	PF00018	0.376
LIG_SUMO_SIM_anti_2	191	197	PF11976	0.242
LIG_SUMO_SIM_par_1	34	39	PF11976	0.266
LIG_TRAF2_1	125	128	PF00917	0.252
LIG_TYR_ITIM	267	272	PF00017	0.243
LIG_UBA3_1	104	111	PF00899	0.253
LIG_UBA3_1	285	291	PF00899	0.244
LIG_WRC_WIRS_1	195	200	PF05994	0.243
LIG_WRC_WIRS_1	220	225	PF05994	0.246
MOD_CK1_1	110	116	PF00069	0.439
MOD_CK1_1	157	163	PF00069	0.275
MOD_CK1_1	78	84	PF00069	0.293
MOD_CK2_1	122	128	PF00069	0.481
MOD_CK2_1	233	239	PF00069	0.374
MOD_GlcNHglycan	51	54	PF01048	0.279
MOD_GlcNHglycan	77	80	PF01048	0.344
MOD_GSK3_1	106	113	PF00069	0.533
MOD_GSK3_1	137	144	PF00069	0.418
MOD_GSK3_1	153	160	PF00069	0.350
MOD_GSK3_1	175	182	PF00069	0.255
MOD_GSK3_1	184	191	PF00069	0.370
MOD_GSK3_1	38	45	PF00069	0.501
MOD_N-GLC_1	265	270	PF02516	0.437
MOD_N-GLC_1	314	319	PF02516	0.287
MOD_N-GLC_1	75	80	PF02516	0.313
MOD_NEK2_1	107	112	PF00069	0.468
MOD_NEK2_1	131	136	PF00069	0.317
MOD_NEK2_1	14	19	PF00069	0.549
MOD_NEK2_1	143	148	PF00069	0.267
MOD_NEK2_1	153	158	PF00069	0.387
MOD_NEK2_1	219	224	PF00069	0.456
MOD_NEK2_1	265	270	PF00069	0.525
MOD_NEK2_1	36	41	PF00069	0.273
MOD_NEK2_1	72	77	PF00069	0.512
MOD_NEK2_2	154	159	PF00069	0.259
MOD_PIKK_1	314	320	PF00454	0.294
MOD_PKA_1	277	283	PF00069	0.262
MOD_PKA_2	277	283	PF00069	0.309
MOD_Plk_1	265	271	PF00069	0.241
MOD_Plk_1	41	47	PF00069	0.259
MOD_Plk_1	75	81	PF00069	0.348
MOD_Plk_2-3	122	128	PF00069	0.310
MOD_Plk_2-3	188	194	PF00069	0.260
MOD_Plk_4	14	20	PF00069	0.537
MOD_Plk_4	322	328	PF00069	0.403
MOD_ProDKin_1	137	143	PF00069	0.251
MOD_ProDKin_1	175	181	PF00069	0.251
MOD_SUMO_rev_2	182	192	PF00179	0.257
MOD_SUMO_rev_2	54	63	PF00179	0.260
TRG_AP2beta_CARGO_1	59	69	PF09066	0.292
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.264
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.248
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.322
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.265
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.243
TRG_ENDOCYTIC_2	269	272	PF00928	0.256
TRG_ENDOCYTIC_2	297	300	PF00928	0.272
TRG_ER_diArg_1	170	172	PF00400	0.277
TRG_ER_diArg_1	276	278	PF00400	0.335
TRG_NES_CRM1_1	28	42	PF08389	0.440
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.261

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZS0	Leptomonas seymouri	25%	100%
A0A3S5H7C2	Leishmania donovani	24%	67%
A4I0G3	Leishmania infantum	24%	67%
E9AWC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	67%
Q4QB46	Leishmania major	25%	67%
V5BND5	Trypanosoma cruzi	26%	93%