Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJD7_LEIBR

TriTrypDb:

LbrM.31.1770 , LBRM2903_310027200

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJD7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.486
CLV_NRD_NRD_1	226	228	PF00675	0.526
CLV_NRD_NRD_1	319	321	PF00675	0.551
CLV_PCSK_KEX2_1	226	228	PF00082	0.474
CLV_PCSK_SKI1_1	260	264	PF00082	0.365
DEG_Nend_Nbox_1	1	3	PF02207	0.341
DOC_MAPK_gen_1	41	48	PF00069	0.538
DOC_MAPK_MEF2A_6	41	48	PF00069	0.553
DOC_PP2B_LxvP_1	44	47	PF13499	0.536
DOC_USP7_MATH_1	206	210	PF00917	0.402
DOC_USP7_MATH_1	291	295	PF00917	0.507
DOC_USP7_MATH_1	71	75	PF00917	0.640
DOC_USP7_MATH_1	94	98	PF00917	0.634
DOC_WW_Pin1_4	102	107	PF00397	0.617
DOC_WW_Pin1_4	66	71	PF00397	0.734
LIG_14-3-3_CanoR_1	148	155	PF00244	0.401
LIG_14-3-3_CanoR_1	214	222	PF00244	0.522
LIG_14-3-3_CanoR_1	268	274	PF00244	0.481
LIG_14-3-3_CanoR_1	309	315	PF00244	0.439
LIG_14-3-3_CanoR_1	41	47	PF00244	0.626
LIG_14-3-3_CanoR_1	5	11	PF00244	0.459
LIG_Actin_WH2_2	307	322	PF00022	0.534
LIG_CSL_BTD_1	11	14	PF09270	0.333
LIG_eIF4E_1	82	88	PF01652	0.448
LIG_FHA_1	127	133	PF00498	0.477
LIG_FHA_1	177	183	PF00498	0.412
LIG_FHA_1	29	35	PF00498	0.374
LIG_LIR_Nem_3	183	188	PF02991	0.336
LIG_LIR_Nem_3	209	215	PF02991	0.344
LIG_PCNA_yPIPBox_3	226	237	PF02747	0.484
LIG_PCNA_yPIPBox_3	252	263	PF02747	0.325
LIG_SH2_CRK	212	216	PF00017	0.401
LIG_SH2_SRC	118	121	PF00017	0.377
LIG_SH2_STAT5	118	121	PF00017	0.376
LIG_SH3_3	64	70	PF00018	0.470
LIG_SH3_3	88	94	PF00018	0.434
LIG_SH3_4	220	227	PF00018	0.308
LIG_SUMO_SIM_anti_2	19	24	PF11976	0.323
LIG_SUMO_SIM_par_1	135	141	PF11976	0.392
LIG_SUMO_SIM_par_1	30	35	PF11976	0.389
LIG_TRAF2_1	276	279	PF00917	0.584
MOD_CK1_1	122	128	PF00069	0.497
MOD_CK1_1	138	144	PF00069	0.547
MOD_CK1_1	294	300	PF00069	0.572
MOD_CK2_1	111	117	PF00069	0.553
MOD_CK2_1	166	172	PF00069	0.613
MOD_CK2_1	273	279	PF00069	0.570
MOD_GlcNHglycan	129	132	PF01048	0.516
MOD_GlcNHglycan	202	205	PF01048	0.525
MOD_GlcNHglycan	285	288	PF01048	0.502
MOD_GlcNHglycan	296	299	PF01048	0.448
MOD_GlcNHglycan	96	99	PF01048	0.669
MOD_GSK3_1	119	126	PF00069	0.513
MOD_GSK3_1	12	19	PF00069	0.395
MOD_GSK3_1	143	150	PF00069	0.489
MOD_GSK3_1	176	183	PF00069	0.439
MOD_GSK3_1	238	245	PF00069	0.543
MOD_GSK3_1	269	276	PF00069	0.553
MOD_GSK3_1	290	297	PF00069	0.635
MOD_GSK3_1	71	78	PF00069	0.665
MOD_N-GLC_1	273	278	PF02516	0.521
MOD_NEK2_1	119	124	PF00069	0.544
MOD_NEK2_1	135	140	PF00069	0.366
MOD_NEK2_1	147	152	PF00069	0.363
MOD_NEK2_1	161	166	PF00069	0.372
MOD_NEK2_1	187	192	PF00069	0.354
MOD_NEK2_1	200	205	PF00069	0.365
MOD_NEK2_1	215	220	PF00069	0.321
MOD_NEK2_2	36	41	PF00069	0.412
MOD_PIKK_1	104	110	PF00454	0.559
MOD_PKA_2	147	153	PF00069	0.403
MOD_PKA_2	206	212	PF00069	0.334
MOD_PKA_2	294	300	PF00069	0.404
MOD_PKA_2	42	48	PF00069	0.616
MOD_Plk_1	119	125	PF00069	0.490
MOD_Plk_1	161	167	PF00069	0.438
MOD_Plk_1	273	279	PF00069	0.519
MOD_Plk_1	75	81	PF00069	0.622
MOD_Plk_2-3	278	284	PF00069	0.369
MOD_Plk_4	111	117	PF00069	0.475
MOD_Plk_4	16	22	PF00069	0.266
MOD_Plk_4	28	34	PF00069	0.429
MOD_Plk_4	6	12	PF00069	0.363
MOD_ProDKin_1	102	108	PF00069	0.613
MOD_ProDKin_1	66	72	PF00069	0.732
TRG_DiLeu_BaEn_4	196	202	PF01217	0.483
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.530
TRG_ENDOCYTIC_2	212	215	PF00928	0.383
TRG_ER_diArg_1	226	228	PF00400	0.526
TRG_ER_diArg_1	40	43	PF00400	0.596
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A2	Leptomonas seymouri	61%	99%
A0A1X0NQ31	Trypanosomatidae	41%	97%
A0A3R7KN88	Trypanosoma rangeli	43%	100%
A0A3S7X4K4	Leishmania donovani	88%	100%
A4I6T4	Leishmania infantum	88%	100%
C9ZMA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B1V6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q6A6	Leishmania major	87%	100%
V5BFH9	Trypanosoma cruzi	42%	100%