L51_S25_CI-B8 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HJD6_LEIBR

TriTrypDb:

LbrM.31.1760 , LBRM2903_310027100

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	10
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:1990904	ribonucleoprotein complex	2	11
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1

Expansion

Sequence features

A4HJD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJD6

PDB structure(s): 7aih_Ab , 7am2_Ab , 7ane_Ab

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0032543	mitochondrial translation	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.451
CLV_NRD_NRD_1	134	136	PF00675	0.501
CLV_NRD_NRD_1	165	167	PF00675	0.571
CLV_NRD_NRD_1	210	212	PF00675	0.424
CLV_NRD_NRD_1	241	243	PF00675	0.456
CLV_NRD_NRD_1	253	255	PF00675	0.478
CLV_PCSK_FUR_1	163	167	PF00082	0.617
CLV_PCSK_KEX2_1	106	108	PF00082	0.466
CLV_PCSK_KEX2_1	165	167	PF00082	0.571
CLV_PCSK_KEX2_1	210	212	PF00082	0.466
CLV_PCSK_KEX2_1	240	242	PF00082	0.456
CLV_PCSK_SKI1_1	135	139	PF00082	0.546
DEG_APCC_DBOX_1	210	218	PF00400	0.397
DOC_MAPK_MEF2A_6	38	47	PF00069	0.350
DOC_PP2B_LxvP_1	258	261	PF13499	0.514
DOC_PP4_FxxP_1	223	226	PF00568	0.469
DOC_USP7_MATH_1	171	175	PF00917	0.554
DOC_USP7_MATH_1	226	230	PF00917	0.579
DOC_USP7_MATH_1	53	57	PF00917	0.377
DOC_USP7_UBL2_3	128	132	PF12436	0.605
DOC_USP7_UBL2_3	255	259	PF12436	0.488
DOC_WW_Pin1_4	14	19	PF00397	0.453
LIG_14-3-3_CanoR_1	106	110	PF00244	0.455
LIG_14-3-3_CanoR_1	135	144	PF00244	0.476
LIG_14-3-3_CanoR_1	189	198	PF00244	0.480
LIG_BIR_II_1	1	5	PF00653	0.472
LIG_BRCT_BRCA1_1	69	73	PF00533	0.449
LIG_FHA_1	173	179	PF00498	0.490
LIG_FHA_2	136	142	PF00498	0.556
LIG_FHA_2	157	163	PF00498	0.582
LIG_FHA_2	190	196	PF00498	0.464
LIG_FHA_2	214	220	PF00498	0.486
LIG_IBAR_NPY_1	114	116	PF08397	0.551
LIG_LIR_Apic_2	221	226	PF02991	0.581
LIG_LIR_Gen_1	219	226	PF02991	0.586
LIG_LIR_Nem_3	139	145	PF02991	0.432
LIG_LIR_Nem_3	219	223	PF02991	0.465
LIG_LIR_Nem_3	35	40	PF02991	0.386
LIG_LYPXL_yS_3	40	43	PF13949	0.344
LIG_PCNA_yPIPBox_3	20	29	PF02747	0.538
LIG_SH2_NCK_1	167	171	PF00017	0.643
LIG_SH2_STAP1	69	73	PF00017	0.475
LIG_SH2_STAT3	144	147	PF00017	0.442
LIG_SH2_STAT3	149	152	PF00017	0.430
LIG_SH2_STAT5	116	119	PF00017	0.559
LIG_SH2_STAT5	145	148	PF00017	0.438
LIG_SH2_STAT5	167	170	PF00017	0.649
LIG_SH2_STAT5	32	35	PF00017	0.433
LIG_SH3_3	109	115	PF00018	0.333
LIG_SH3_3	209	215	PF00018	0.617
LIG_SH3_4	128	135	PF00018	0.566
LIG_TRAF2_1	174	177	PF00917	0.591
MOD_CDC14_SPxK_1	17	20	PF00782	0.524
MOD_CDK_SPxK_1	14	20	PF00069	0.501
MOD_CK1_1	213	219	PF00069	0.564
MOD_CK1_1	221	227	PF00069	0.556
MOD_CK1_1	55	61	PF00069	0.410
MOD_CK2_1	135	141	PF00069	0.436
MOD_CK2_1	171	177	PF00069	0.522
MOD_CK2_1	189	195	PF00069	0.360
MOD_CK2_1	213	219	PF00069	0.488
MOD_GlcNHglycan	206	209	PF01048	0.530
MOD_GlcNHglycan	97	100	PF01048	0.477
MOD_GSK3_1	93	100	PF00069	0.584
MOD_N-GLC_1	196	201	PF02516	0.469
MOD_N-GLC_1	93	98	PF02516	0.591
MOD_NEK2_1	28	33	PF00069	0.359
MOD_NEK2_1	73	78	PF00069	0.473
MOD_NEK2_1	97	102	PF00069	0.507
MOD_PK_1	67	73	PF00069	0.449
MOD_PKA_1	135	141	PF00069	0.467
MOD_PKA_1	165	171	PF00069	0.608
MOD_PKA_1	210	216	PF00069	0.399
MOD_PKA_2	105	111	PF00069	0.451
MOD_PKA_2	165	171	PF00069	0.583
MOD_PKA_2	210	216	PF00069	0.399
MOD_PKB_1	163	171	PF00069	0.630
MOD_Plk_1	156	162	PF00069	0.556
MOD_Plk_1	196	202	PF00069	0.492
MOD_Plk_1	218	224	PF00069	0.591
MOD_Plk_1	226	232	PF00069	0.591
MOD_Plk_1	53	59	PF00069	0.376
MOD_Plk_1	93	99	PF00069	0.607
MOD_Plk_2-3	156	162	PF00069	0.576
MOD_Plk_2-3	172	178	PF00069	0.602
MOD_Plk_4	218	224	PF00069	0.591
MOD_Plk_4	28	34	PF00069	0.433
MOD_ProDKin_1	14	20	PF00069	0.461
MOD_SUMO_for_1	153	156	PF00179	0.448
TRG_ENDOCYTIC_2	167	170	PF00928	0.649
TRG_ENDOCYTIC_2	220	223	PF00928	0.461
TRG_ENDOCYTIC_2	40	43	PF00928	0.344
TRG_ER_diArg_1	163	166	PF00400	0.577
TRG_ER_diArg_1	210	212	PF00400	0.424
TRG_ER_diArg_1	239	242	PF00400	0.472
TRG_ER_diArg_1	47	50	PF00400	0.344
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZE9	Leptomonas seymouri	87%	100%
A0A0S4IRQ7	Bodo saltans	51%	94%
A0A1X0NRH7	Trypanosomatidae	63%	100%
A0A3Q8ISM3	Leishmania donovani	93%	100%
A0A3R7MT16	Trypanosoma rangeli	65%	100%
A4I6T3	Leishmania infantum	93%	100%
C9ZMA5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9B1V5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q6A7	Leishmania major	92%	100%
V5BPL4	Trypanosoma cruzi	64%	100%