Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJD5_LEIBR

TriTrypDb:

LbrM.31.1750 , LBRM2903_310027000

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJD5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.497
CLV_C14_Caspase3-7	7	11	PF00656	0.577
CLV_NRD_NRD_1	162	164	PF00675	0.525
CLV_PCSK_KEX2_1	203	205	PF00082	0.567
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.567
CLV_Separin_Metazoa	160	164	PF03568	0.506
DEG_COP1_1	165	174	PF00400	0.531
DEG_SCF_FBW7_1	115	120	PF00400	0.537
DEG_SCF_FBW7_1	162	169	PF00400	0.690
DEG_SPOP_SBC_1	221	225	PF00917	0.574
DEG_SPOP_SBC_1	269	273	PF00917	0.527
DOC_CKS1_1	230	235	PF01111	0.648
DOC_CKS1_1	236	241	PF01111	0.702
DOC_CKS1_1	365	370	PF01111	0.664
DOC_MAPK_DCC_7	68	76	PF00069	0.522
DOC_MAPK_gen_1	68	76	PF00069	0.522
DOC_MAPK_MEF2A_6	400	409	PF00069	0.541
DOC_MAPK_MEF2A_6	68	76	PF00069	0.660
DOC_PP4_MxPP_1	231	234	PF00568	0.520
DOC_USP7_MATH_1	110	114	PF00917	0.560
DOC_USP7_MATH_1	170	174	PF00917	0.680
DOC_USP7_MATH_1	189	193	PF00917	0.526
DOC_USP7_MATH_1	226	230	PF00917	0.663
DOC_USP7_MATH_1	269	273	PF00917	0.684
DOC_USP7_MATH_1	378	382	PF00917	0.594
DOC_USP7_MATH_1	390	394	PF00917	0.525
DOC_WW_Pin1_4	101	106	PF00397	0.643
DOC_WW_Pin1_4	111	116	PF00397	0.683
DOC_WW_Pin1_4	118	123	PF00397	0.744
DOC_WW_Pin1_4	162	167	PF00397	0.655
DOC_WW_Pin1_4	184	189	PF00397	0.637
DOC_WW_Pin1_4	197	202	PF00397	0.718
DOC_WW_Pin1_4	222	227	PF00397	0.578
DOC_WW_Pin1_4	229	234	PF00397	0.609
DOC_WW_Pin1_4	235	240	PF00397	0.677
DOC_WW_Pin1_4	260	265	PF00397	0.728
DOC_WW_Pin1_4	296	301	PF00397	0.692
DOC_WW_Pin1_4	312	317	PF00397	0.461
DOC_WW_Pin1_4	355	360	PF00397	0.612
DOC_WW_Pin1_4	364	369	PF00397	0.659
LIG_14-3-3_CanoR_1	377	383	PF00244	0.503
LIG_14-3-3_CanoR_1	80	85	PF00244	0.652
LIG_Actin_WH2_2	148	165	PF00022	0.507
LIG_APCC_ABBAyCdc20_2	395	401	PF00400	0.462
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_DLG_GKlike_1	80	88	PF00625	0.519
LIG_FHA_1	122	128	PF00498	0.584
LIG_FHA_1	222	228	PF00498	0.536
LIG_FHA_1	230	236	PF00498	0.538
LIG_FHA_1	277	283	PF00498	0.614
LIG_FHA_1	377	383	PF00498	0.504
LIG_FHA_1	86	92	PF00498	0.532
LIG_FHA_2	39	45	PF00498	0.718
LIG_LIR_Apic_2	116	122	PF02991	0.734
LIG_LIR_Apic_2	229	233	PF02991	0.516
LIG_LIR_Gen_1	165	174	PF02991	0.694
LIG_LIR_Gen_1	401	409	PF02991	0.540
LIG_LIR_Nem_3	165	171	PF02991	0.694
LIG_LIR_Nem_3	263	268	PF02991	0.554
LIG_LIR_Nem_3	401	407	PF02991	0.461
LIG_PDZ_Class_2	404	409	PF00595	0.459
LIG_PTB_Apo_2	28	35	PF02174	0.469
LIG_SH2_CRK	119	123	PF00017	0.809
LIG_SH2_CRK	236	240	PF00017	0.791
LIG_SH2_NCK_1	119	123	PF00017	0.702
LIG_SH2_NCK_1	236	240	PF00017	0.598
LIG_SH2_STAT5	366	369	PF00017	0.601
LIG_SH3_3	263	269	PF00018	0.525
LIG_SH3_3	356	362	PF00018	0.576
LIG_SUMO_SIM_par_1	87	94	PF11976	0.529
LIG_TRAF2_1	97	100	PF00917	0.538
LIG_TRFH_1	329	333	PF08558	0.419
LIG_UBA3_1	28	37	PF00899	0.476
LIG_WW_1	233	236	PF00397	0.524
MOD_CDK_SPxK_1	197	203	PF00069	0.585
MOD_CDK_SPxxK_3	197	204	PF00069	0.548
MOD_CK1_1	111	117	PF00069	0.711
MOD_CK1_1	120	126	PF00069	0.613
MOD_CK1_1	138	144	PF00069	0.630
MOD_CK1_1	173	179	PF00069	0.578
MOD_CK1_1	184	190	PF00069	0.644
MOD_CK1_1	209	215	PF00069	0.801
MOD_CK1_1	229	235	PF00069	0.596
MOD_CK1_1	251	257	PF00069	0.739
MOD_CK1_1	301	307	PF00069	0.625
MOD_CK1_1	341	347	PF00069	0.706
MOD_CK1_1	38	44	PF00069	0.614
MOD_CK1_1	403	409	PF00069	0.406
MOD_CK1_1	60	66	PF00069	0.600
MOD_CK2_1	27	33	PF00069	0.563
MOD_CK2_1	39	45	PF00069	0.559
MOD_CK2_1	94	100	PF00069	0.599
MOD_GlcNHglycan	110	113	PF01048	0.715
MOD_GlcNHglycan	175	178	PF01048	0.733
MOD_GlcNHglycan	191	194	PF01048	0.546
MOD_GlcNHglycan	288	291	PF01048	0.690
MOD_GlcNHglycan	307	310	PF01048	0.653
MOD_GlcNHglycan	340	343	PF01048	0.626
MOD_GlcNHglycan	351	354	PF01048	0.627
MOD_GlcNHglycan	387	390	PF01048	0.510
MOD_GlcNHglycan	65	68	PF01048	0.738
MOD_GSK3_1	113	120	PF00069	0.715
MOD_GSK3_1	121	128	PF00069	0.720
MOD_GSK3_1	135	142	PF00069	0.561
MOD_GSK3_1	162	169	PF00069	0.699
MOD_GSK3_1	175	182	PF00069	0.633
MOD_GSK3_1	208	215	PF00069	0.623
MOD_GSK3_1	217	224	PF00069	0.608
MOD_GSK3_1	248	255	PF00069	0.667
MOD_GSK3_1	298	305	PF00069	0.694
MOD_GSK3_1	33	40	PF00069	0.519
MOD_GSK3_1	349	356	PF00069	0.657
MOD_GSK3_1	372	379	PF00069	0.552
MOD_GSK3_1	45	52	PF00069	0.673
MOD_GSK3_1	80	87	PF00069	0.614
MOD_N-GLC_1	305	310	PF02516	0.663
MOD_N-GLC_1	63	68	PF02516	0.592
MOD_NEK2_1	276	281	PF00069	0.649
MOD_NEK2_1	302	307	PF00069	0.552
MOD_NEK2_1	349	354	PF00069	0.514
MOD_NEK2_1	84	89	PF00069	0.636
MOD_PIKK_1	175	181	PF00454	0.537
MOD_PKA_2	155	161	PF00069	0.617
MOD_PKA_2	376	382	PF00069	0.645
MOD_PKA_2	79	85	PF00069	0.651
MOD_Plk_1	143	149	PF00069	0.527
MOD_Plk_1	166	172	PF00069	0.693
MOD_Plk_1	38	44	PF00069	0.527
MOD_Plk_2-3	39	45	PF00069	0.533
MOD_Plk_4	226	232	PF00069	0.518
MOD_Plk_4	278	284	PF00069	0.683
MOD_Plk_4	298	304	PF00069	0.615
MOD_Plk_4	400	406	PF00069	0.364
MOD_ProDKin_1	101	107	PF00069	0.643
MOD_ProDKin_1	111	117	PF00069	0.678
MOD_ProDKin_1	118	124	PF00069	0.744
MOD_ProDKin_1	162	168	PF00069	0.657
MOD_ProDKin_1	184	190	PF00069	0.641
MOD_ProDKin_1	197	203	PF00069	0.721
MOD_ProDKin_1	222	228	PF00069	0.579
MOD_ProDKin_1	229	235	PF00069	0.611
MOD_ProDKin_1	260	266	PF00069	0.724
MOD_ProDKin_1	296	302	PF00069	0.691
MOD_ProDKin_1	312	318	PF00069	0.457
MOD_ProDKin_1	355	361	PF00069	0.613
MOD_ProDKin_1	364	370	PF00069	0.657
MOD_SUMO_rev_2	30	38	PF00179	0.486
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.462
TRG_ENDOCYTIC_2	20	23	PF00928	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC35	Leptomonas seymouri	27%	95%
A0A3S7X4K9	Leishmania donovani	62%	93%
A4I6T2	Leishmania infantum	62%	92%
E9B1V4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	98%
Q4Q6A8	Leishmania major	64%	100%