LO8

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

LO8

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJD3_LEIBR

TriTrypDb:

LbrM.31.1730 , LBRM2903_310026700 , LBRM2903_310026800

Length:

960

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJD3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	411	415	PF00656	0.536
CLV_C14_Caspase3-7	542	546	PF00656	0.677
CLV_NRD_NRD_1	612	614	PF00675	0.447
CLV_NRD_NRD_1	634	636	PF00675	0.627
CLV_NRD_NRD_1	780	782	PF00675	0.656
CLV_PCSK_KEX2_1	612	614	PF00082	0.520
CLV_PCSK_KEX2_1	780	782	PF00082	0.611
CLV_PCSK_SKI1_1	115	119	PF00082	0.517
CLV_PCSK_SKI1_1	195	199	PF00082	0.348
CLV_PCSK_SKI1_1	294	298	PF00082	0.562
CLV_PCSK_SKI1_1	378	382	PF00082	0.472
CLV_PCSK_SKI1_1	582	586	PF00082	0.505
CLV_PCSK_SKI1_1	669	673	PF00082	0.560
CLV_PCSK_SKI1_1	85	89	PF00082	0.531
DEG_APCC_DBOX_1	114	122	PF00400	0.511
DOC_CDC14_PxL_1	214	222	PF14671	0.356
DOC_CKS1_1	35	40	PF01111	0.443
DOC_CKS1_1	486	491	PF01111	0.515
DOC_CYCLIN_RxL_1	82	91	PF00134	0.418
DOC_CYCLIN_yCln2_LP_2	726	729	PF00134	0.606
DOC_MAPK_DCC_7	228	236	PF00069	0.356
DOC_MAPK_JIP1_4	164	170	PF00069	0.351
DOC_MAPK_MEF2A_6	164	172	PF00069	0.502
DOC_MAPK_MEF2A_6	228	236	PF00069	0.356
DOC_PP2B_LxvP_1	168	171	PF13499	0.471
DOC_PP2B_LxvP_1	248	251	PF13499	0.533
DOC_PP2B_LxvP_1	715	718	PF13499	0.544
DOC_PP2B_LxvP_1	726	729	PF13499	0.527
DOC_PP2B_LxvP_1	752	755	PF13499	0.500
DOC_PP4_FxxP_1	15	18	PF00568	0.475
DOC_PP4_FxxP_1	35	38	PF00568	0.409
DOC_PP4_FxxP_1	455	458	PF00568	0.510
DOC_PP4_FxxP_1	506	509	PF00568	0.501
DOC_PP4_FxxP_1	626	629	PF00568	0.653
DOC_PP4_FxxP_1	711	714	PF00568	0.628
DOC_PP4_FxxP_1	808	811	PF00568	0.517
DOC_PP4_MxPP_1	844	847	PF00568	0.561
DOC_USP7_MATH_1	132	136	PF00917	0.428
DOC_USP7_MATH_1	251	255	PF00917	0.585
DOC_USP7_MATH_1	340	344	PF00917	0.597
DOC_USP7_MATH_1	534	538	PF00917	0.666
DOC_USP7_MATH_1	658	662	PF00917	0.609
DOC_USP7_MATH_1	682	686	PF00917	0.569
DOC_USP7_MATH_1	703	707	PF00917	0.655
DOC_USP7_MATH_1	748	752	PF00917	0.604
DOC_USP7_MATH_1	870	874	PF00917	0.657
DOC_WW_Pin1_4	137	142	PF00397	0.659
DOC_WW_Pin1_4	34	39	PF00397	0.412
DOC_WW_Pin1_4	416	421	PF00397	0.579
DOC_WW_Pin1_4	464	469	PF00397	0.592
DOC_WW_Pin1_4	485	490	PF00397	0.534
DOC_WW_Pin1_4	546	551	PF00397	0.544
DOC_WW_Pin1_4	678	683	PF00397	0.732
DOC_WW_Pin1_4	713	718	PF00397	0.542
DOC_WW_Pin1_4	732	737	PF00397	0.756
DOC_WW_Pin1_4	842	847	PF00397	0.716
DOC_WW_Pin1_4	911	916	PF00397	0.670
LIG_14-3-3_CanoR_1	179	184	PF00244	0.324
LIG_14-3-3_CanoR_1	317	326	PF00244	0.491
LIG_14-3-3_CanoR_1	378	386	PF00244	0.563
LIG_14-3-3_CanoR_1	407	411	PF00244	0.617
LIG_14-3-3_CanoR_1	709	714	PF00244	0.556
LIG_14-3-3_CanoR_1	89	97	PF00244	0.466
LIG_14-3-3_CanoR_1	903	909	PF00244	0.538
LIG_BIR_III_2	465	469	PF00653	0.502
LIG_BIR_III_2	695	699	PF00653	0.598
LIG_BRCT_BRCA1_1	252	256	PF00533	0.431
LIG_BRCT_BRCA1_1	466	470	PF00533	0.506
LIG_BRCT_BRCA1_1	502	506	PF00533	0.522
LIG_BRCT_BRCA1_1	513	517	PF00533	0.534
LIG_EVH1_1	752	756	PF00568	0.668
LIG_FHA_1	156	162	PF00498	0.465
LIG_FHA_1	367	373	PF00498	0.511
LIG_FHA_1	375	381	PF00498	0.383
LIG_FHA_1	399	405	PF00498	0.465
LIG_FHA_1	417	423	PF00498	0.418
LIG_FHA_1	436	442	PF00498	0.391
LIG_FHA_1	467	473	PF00498	0.540
LIG_FHA_1	486	492	PF00498	0.592
LIG_FHA_1	689	695	PF00498	0.545
LIG_FHA_1	722	728	PF00498	0.552
LIG_FHA_1	912	918	PF00498	0.575
LIG_FHA_2	406	412	PF00498	0.543
LIG_FHA_2	540	546	PF00498	0.641
LIG_FHA_2	547	553	PF00498	0.527
LIG_FHA_2	583	589	PF00498	0.513
LIG_GSK3_LRP6_1	847	852	PF00069	0.533
LIG_Integrin_RGD_1	449	451	PF01839	0.384
LIG_LIR_Apic_2	12	18	PF02991	0.471
LIG_LIR_Apic_2	32	38	PF02991	0.423
LIG_LIR_Apic_2	454	458	PF02991	0.495
LIG_LIR_Apic_2	48	53	PF02991	0.398
LIG_LIR_Apic_2	503	509	PF02991	0.501
LIG_LIR_Apic_2	807	811	PF02991	0.515
LIG_LIR_Apic_2	830	835	PF02991	0.534
LIG_LIR_Apic_2	905	909	PF02991	0.528
LIG_LIR_Gen_1	146	155	PF02991	0.436
LIG_LIR_Gen_1	223	232	PF02991	0.532
LIG_LIR_Gen_1	920	928	PF02991	0.602
LIG_LIR_Gen_1	950	958	PF02991	0.510
LIG_LIR_Nem_3	110	114	PF02991	0.360
LIG_LIR_Nem_3	146	151	PF02991	0.441
LIG_LIR_Nem_3	223	227	PF02991	0.394
LIG_LIR_Nem_3	617	623	PF02991	0.469
LIG_LIR_Nem_3	786	790	PF02991	0.692
LIG_LIR_Nem_3	920	924	PF02991	0.571
LIG_MLH1_MIPbox_1	253	257	PF16413	0.329
LIG_MYND_1	915	919	PF01753	0.526
LIG_PAM2_1	213	225	PF00658	0.272
LIG_PCNA_yPIPBox_3	99	113	PF02747	0.450
LIG_SH2_CRK	486	490	PF00017	0.517
LIG_SH2_CRK	58	62	PF00017	0.502
LIG_SH2_CRK	593	597	PF00017	0.359
LIG_SH2_CRK	620	624	PF00017	0.393
LIG_SH2_CRK	832	836	PF00017	0.526
LIG_SH2_CRK	906	910	PF00017	0.522
LIG_SH2_NCK_1	337	341	PF00017	0.627
LIG_SH2_NCK_1	50	54	PF00017	0.435
LIG_SH2_NCK_1	832	836	PF00017	0.526
LIG_SH2_NCK_1	906	910	PF00017	0.522
LIG_SH2_PTP2	921	924	PF00017	0.586
LIG_SH2_SRC	456	459	PF00017	0.550
LIG_SH2_STAP1	337	341	PF00017	0.602
LIG_SH2_STAP1	790	794	PF00017	0.619
LIG_SH2_STAT3	204	207	PF00017	0.532
LIG_SH2_STAT5	202	205	PF00017	0.384
LIG_SH2_STAT5	271	274	PF00017	0.335
LIG_SH2_STAT5	283	286	PF00017	0.323
LIG_SH2_STAT5	337	340	PF00017	0.636
LIG_SH2_STAT5	34	37	PF00017	0.565
LIG_SH2_STAT5	370	373	PF00017	0.486
LIG_SH2_STAT5	375	378	PF00017	0.564
LIG_SH2_STAT5	394	397	PF00017	0.245
LIG_SH2_STAT5	456	459	PF00017	0.550
LIG_SH2_STAT5	50	53	PF00017	0.301
LIG_SH2_STAT5	607	610	PF00017	0.469
LIG_SH2_STAT5	742	745	PF00017	0.595
LIG_SH2_STAT5	806	809	PF00017	0.680
LIG_SH2_STAT5	832	835	PF00017	0.536
LIG_SH2_STAT5	906	909	PF00017	0.689
LIG_SH2_STAT5	921	924	PF00017	0.586
LIG_SH2_STAT5	952	955	PF00017	0.624
LIG_SH3_3	159	165	PF00018	0.488
LIG_SH3_3	212	218	PF00018	0.360
LIG_SH3_3	35	41	PF00018	0.573
LIG_SH3_3	589	595	PF00018	0.346
LIG_SH3_3	696	702	PF00018	0.634
LIG_SH3_3	711	717	PF00018	0.693
LIG_SH3_3	750	756	PF00018	0.577
LIG_SH3_3	779	785	PF00018	0.541
LIG_SH3_3	843	849	PF00018	0.740
LIG_SH3_3	913	919	PF00018	0.536
LIG_SH3_3	940	946	PF00018	0.649
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.419
LIG_SxIP_EBH_1	224	238	PF03271	0.358
LIG_TRFH_1	832	836	PF08558	0.526
LIG_WRC_WIRS_1	283	288	PF05994	0.451
LIG_WRC_WIRS_1	452	457	PF05994	0.459
LIG_WRC_WIRS_1	805	810	PF05994	0.678
LIG_WW_1	755	758	PF00397	0.685
LIG_WW_1	915	918	PF00397	0.492
LIG_WW_2	702	705	PF00397	0.519
MOD_CK1_1	139	145	PF00069	0.496
MOD_CK1_1	335	341	PF00069	0.619
MOD_CK1_1	379	385	PF00069	0.373
MOD_CK1_1	502	508	PF00069	0.635
MOD_CK1_1	634	640	PF00069	0.626
MOD_CK1_1	661	667	PF00069	0.601
MOD_CK1_1	761	767	PF00069	0.800
MOD_CK1_1	872	878	PF00069	0.721
MOD_CK1_1	934	940	PF00069	0.578
MOD_CK2_1	405	411	PF00069	0.622
MOD_CK2_1	522	528	PF00069	0.541
MOD_CK2_1	546	552	PF00069	0.496
MOD_GlcNHglycan	141	144	PF01048	0.547
MOD_GlcNHglycan	145	148	PF01048	0.436
MOD_GlcNHglycan	186	189	PF01048	0.449
MOD_GlcNHglycan	458	461	PF01048	0.527
MOD_GlcNHglycan	5	8	PF01048	0.466
MOD_GlcNHglycan	513	516	PF01048	0.625
MOD_GlcNHglycan	636	639	PF01048	0.776
MOD_GlcNHglycan	640	643	PF01048	0.800
MOD_GlcNHglycan	656	659	PF01048	0.638
MOD_GlcNHglycan	66	69	PF01048	0.554
MOD_GlcNHglycan	665	668	PF01048	0.635
MOD_GlcNHglycan	684	687	PF01048	0.618
MOD_GlcNHglycan	748	751	PF01048	0.677
MOD_GlcNHglycan	763	766	PF01048	0.577
MOD_GlcNHglycan	790	793	PF01048	0.616
MOD_GlcNHglycan	933	936	PF01048	0.550
MOD_GSK3_1	132	139	PF00069	0.474
MOD_GSK3_1	328	335	PF00069	0.646
MOD_GSK3_1	374	381	PF00069	0.347
MOD_GSK3_1	414	421	PF00069	0.628
MOD_GSK3_1	456	463	PF00069	0.586
MOD_GSK3_1	466	473	PF00069	0.580
MOD_GSK3_1	490	497	PF00069	0.607
MOD_GSK3_1	498	505	PF00069	0.621
MOD_GSK3_1	507	514	PF00069	0.496
MOD_GSK3_1	530	537	PF00069	0.602
MOD_GSK3_1	634	641	PF00069	0.640
MOD_GSK3_1	64	71	PF00069	0.527
MOD_GSK3_1	654	661	PF00069	0.582
MOD_GSK3_1	665	672	PF00069	0.616
MOD_GSK3_1	678	685	PF00069	0.553
MOD_GSK3_1	709	716	PF00069	0.635
MOD_GSK3_1	742	749	PF00069	0.515
MOD_GSK3_1	809	816	PF00069	0.606
MOD_GSK3_1	838	845	PF00069	0.581
MOD_GSK3_1	866	873	PF00069	0.812
MOD_GSK3_1	930	937	PF00069	0.660
MOD_N-GLC_1	191	196	PF02516	0.450
MOD_N-GLC_1	384	389	PF02516	0.480
MOD_N-GLC_1	498	503	PF02516	0.655
MOD_N-GLC_1	529	534	PF02516	0.507
MOD_N-GLC_1	546	551	PF02516	0.464
MOD_N-GLC_1	669	674	PF02516	0.563
MOD_N-GLC_1	678	683	PF02516	0.525
MOD_N-GLC_1	687	692	PF02516	0.570
MOD_N-GLC_2	78	80	PF02516	0.294
MOD_NEK2_1	470	475	PF00069	0.675
MOD_NEK2_1	494	499	PF00069	0.569
MOD_NEK2_1	500	505	PF00069	0.522
MOD_NEK2_1	687	692	PF00069	0.654
MOD_NEK2_1	721	726	PF00069	0.614
MOD_NEK2_1	771	776	PF00069	0.783
MOD_NEK2_1	804	809	PF00069	0.623
MOD_NEK2_1	88	93	PF00069	0.396
MOD_NEK2_1	904	909	PF00069	0.567
MOD_NEK2_1	931	936	PF00069	0.631
MOD_NMyristoyl	1	7	PF02799	0.570
MOD_PIKK_1	340	346	PF00454	0.398
MOD_PIKK_1	703	709	PF00454	0.646
MOD_PIKK_1	809	815	PF00454	0.617
MOD_PIKK_1	904	910	PF00454	0.523
MOD_PKA_1	554	560	PF00069	0.508
MOD_PKA_2	406	412	PF00069	0.701
MOD_PKA_2	522	528	PF00069	0.497
MOD_PKA_2	634	640	PF00069	0.661
MOD_PKA_2	88	94	PF00069	0.466
MOD_PKA_2	902	908	PF00069	0.540
MOD_Plk_1	191	197	PF00069	0.444
MOD_Plk_1	398	404	PF00069	0.466
MOD_Plk_1	405	411	PF00069	0.511
MOD_Plk_1	436	442	PF00069	0.425
MOD_Plk_1	68	74	PF00069	0.617
MOD_Plk_1	758	764	PF00069	0.551
MOD_Plk_2-3	406	412	PF00069	0.601
MOD_Plk_4	126	132	PF00069	0.459
MOD_Plk_4	157	163	PF00069	0.462
MOD_Plk_4	207	213	PF00069	0.329
MOD_Plk_4	321	327	PF00069	0.615
MOD_Plk_4	332	338	PF00069	0.628
MOD_Plk_4	418	424	PF00069	0.467
MOD_Plk_4	451	457	PF00069	0.453
MOD_Plk_4	569	575	PF00069	0.357
MOD_Plk_4	602	608	PF00069	0.510
MOD_Plk_4	804	810	PF00069	0.677
MOD_Plk_4	917	923	PF00069	0.679
MOD_ProDKin_1	137	143	PF00069	0.665
MOD_ProDKin_1	34	40	PF00069	0.409
MOD_ProDKin_1	416	422	PF00069	0.584
MOD_ProDKin_1	464	470	PF00069	0.595
MOD_ProDKin_1	485	491	PF00069	0.532
MOD_ProDKin_1	546	552	PF00069	0.538
MOD_ProDKin_1	678	684	PF00069	0.728
MOD_ProDKin_1	713	719	PF00069	0.541
MOD_ProDKin_1	732	738	PF00069	0.749
MOD_ProDKin_1	842	848	PF00069	0.710
MOD_ProDKin_1	911	917	PF00069	0.670
MOD_SUMO_for_1	289	292	PF00179	0.479
MOD_SUMO_rev_2	572	581	PF00179	0.400
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.430
TRG_ENDOCYTIC_2	283	286	PF00928	0.443
TRG_ENDOCYTIC_2	593	596	PF00928	0.381
TRG_ENDOCYTIC_2	620	623	PF00928	0.395
TRG_ENDOCYTIC_2	806	809	PF00928	0.680
TRG_ENDOCYTIC_2	921	924	PF00928	0.586
TRG_ENDOCYTIC_2	952	955	PF00928	0.512
TRG_ER_diArg_1	112	115	PF00400	0.429
TRG_ER_diArg_1	178	181	PF00400	0.391
TRG_ER_diArg_1	611	613	PF00400	0.606
TRG_ER_diArg_1	780	782	PF00400	0.611
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4H0	Leishmania donovani	71%	100%
A4I6T0	Leishmania infantum	70%	100%
E9B1V2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q6B0	Leishmania major	71%	98%
V5DGF9	Trypanosoma cruzi	31%	100%