DAGKc domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJC9_LEIBR

TriTrypDb:

LbrM.31.1690 , LBRM2903_310026300

Length:

1043

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJC9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	281	287	PF00089	0.473
CLV_NRD_NRD_1	1041	1043	PF00675	0.553
CLV_NRD_NRD_1	147	149	PF00675	0.580
CLV_NRD_NRD_1	598	600	PF00675	0.597
CLV_NRD_NRD_1	801	803	PF00675	0.819
CLV_NRD_NRD_1	986	988	PF00675	0.499
CLV_PCSK_KEX2_1	149	151	PF00082	0.576
CLV_PCSK_KEX2_1	433	435	PF00082	0.693
CLV_PCSK_KEX2_1	598	600	PF00082	0.597
CLV_PCSK_KEX2_1	801	803	PF00082	0.819
CLV_PCSK_KEX2_1	986	988	PF00082	0.499
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.576
CLV_PCSK_PC1ET2_1	433	435	PF00082	0.601
CLV_PCSK_SKI1_1	101	105	PF00082	0.765
CLV_PCSK_SKI1_1	149	153	PF00082	0.594
CLV_PCSK_SKI1_1	167	171	PF00082	0.649
CLV_PCSK_SKI1_1	279	283	PF00082	0.652
CLV_PCSK_SKI1_1	326	330	PF00082	0.680
CLV_PCSK_SKI1_1	593	597	PF00082	0.810
CLV_PCSK_SKI1_1	699	703	PF00082	0.531
CLV_PCSK_SKI1_1	819	823	PF00082	0.746
DEG_APCC_DBOX_1	334	342	PF00400	0.679
DEG_COP1_1	81	91	PF00400	0.806
DEG_MDM2_SWIB_1	394	402	PF02201	0.455
DEG_MDM2_SWIB_1	759	766	PF02201	0.504
DEG_Nend_Nbox_1	1	3	PF02207	0.815
DEG_SPOP_SBC_1	105	109	PF00917	0.651
DEG_SPOP_SBC_1	341	345	PF00917	0.499
DEG_SPOP_SBC_1	662	666	PF00917	0.654
DEG_SPOP_SBC_1	855	859	PF00917	0.555
DOC_CKS1_1	501	506	PF01111	0.576
DOC_CYCLIN_RxL_1	97	108	PF00134	0.761
DOC_CYCLIN_yCln2_LP_2	385	391	PF00134	0.727
DOC_CYCLIN_yCln2_LP_2	716	722	PF00134	0.805
DOC_CYCLIN_yCln2_LP_2	942	948	PF00134	0.579
DOC_MAPK_gen_1	279	289	PF00069	0.469
DOC_MAPK_MEF2A_6	282	289	PF00069	0.459
DOC_MAPK_MEF2A_6	675	683	PF00069	0.554
DOC_PP1_RVXF_1	938	945	PF00149	0.580
DOC_PP2B_LxvP_1	681	684	PF13499	0.714
DOC_PP4_FxxP_1	328	331	PF00568	0.604
DOC_PP4_FxxP_1	488	491	PF00568	0.745
DOC_PP4_FxxP_1	786	789	PF00568	0.776
DOC_PP4_FxxP_1	892	895	PF00568	0.772
DOC_SPAK_OSR1_1	474	478	PF12202	0.474
DOC_USP7_MATH_1	105	109	PF00917	0.651
DOC_USP7_MATH_1	155	159	PF00917	0.513
DOC_USP7_MATH_1	245	249	PF00917	0.652
DOC_USP7_MATH_1	267	271	PF00917	0.586
DOC_USP7_MATH_1	412	416	PF00917	0.724
DOC_USP7_MATH_1	427	431	PF00917	0.690
DOC_USP7_MATH_1	463	467	PF00917	0.659
DOC_USP7_MATH_1	5	9	PF00917	0.533
DOC_USP7_MATH_1	508	512	PF00917	0.837
DOC_USP7_MATH_1	537	541	PF00917	0.830
DOC_USP7_MATH_1	542	546	PF00917	0.761
DOC_USP7_MATH_1	584	588	PF00917	0.640
DOC_USP7_MATH_1	589	593	PF00917	0.631
DOC_USP7_MATH_1	59	63	PF00917	0.705
DOC_USP7_MATH_1	642	646	PF00917	0.804
DOC_USP7_MATH_1	651	655	PF00917	0.682
DOC_USP7_MATH_1	658	662	PF00917	0.562
DOC_USP7_MATH_1	792	796	PF00917	0.749
DOC_USP7_MATH_1	806	810	PF00917	0.510
DOC_USP7_MATH_1	851	855	PF00917	0.563
DOC_USP7_MATH_1	961	965	PF00917	0.607
DOC_WW_Pin1_4	142	147	PF00397	0.686
DOC_WW_Pin1_4	22	27	PF00397	0.804
DOC_WW_Pin1_4	419	424	PF00397	0.703
DOC_WW_Pin1_4	45	50	PF00397	0.822
DOC_WW_Pin1_4	464	469	PF00397	0.786
DOC_WW_Pin1_4	500	505	PF00397	0.571
DOC_WW_Pin1_4	611	616	PF00397	0.597
DOC_WW_Pin1_4	68	73	PF00397	0.805
DOC_WW_Pin1_4	734	739	PF00397	0.683
DOC_WW_Pin1_4	804	809	PF00397	0.780
DOC_WW_Pin1_4	844	849	PF00397	0.653
DOC_WW_Pin1_4	89	94	PF00397	0.776
DOC_WW_Pin1_4	901	906	PF00397	0.773
DOC_WW_Pin1_4	966	971	PF00397	0.800
LIG_14-3-3_CanoR_1	148	157	PF00244	0.541
LIG_14-3-3_CanoR_1	368	375	PF00244	0.591
LIG_14-3-3_CanoR_1	538	546	PF00244	0.644
LIG_14-3-3_CanoR_1	598	605	PF00244	0.602
LIG_14-3-3_CanoR_1	699	704	PF00244	0.530
LIG_14-3-3_CanoR_1	761	767	PF00244	0.529
LIG_14-3-3_CanoR_1	791	797	PF00244	0.777
LIG_14-3-3_CanoR_1	823	832	PF00244	0.582
LIG_Actin_WH2_2	153	169	PF00022	0.727
LIG_Actin_WH2_2	708	723	PF00022	0.781
LIG_Actin_WH2_2	989	1006	PF00022	0.485
LIG_APCC_ABBAyCdc20_2	376	382	PF00400	0.490
LIG_BRCT_BRCA1_1	764	768	PF00533	0.703
LIG_BRCT_BRCA1_1	920	924	PF00533	0.508
LIG_BRCT_BRCA1_2	920	926	PF00533	0.697
LIG_deltaCOP1_diTrp_1	882	892	PF00928	0.754
LIG_eIF4E_1	906	912	PF01652	0.728
LIG_FHA_1	1035	1041	PF00498	0.508
LIG_FHA_1	108	114	PF00498	0.639
LIG_FHA_1	125	131	PF00498	0.601
LIG_FHA_1	202	208	PF00498	0.535
LIG_FHA_1	214	220	PF00498	0.650
LIG_FHA_1	395	401	PF00498	0.642
LIG_FHA_1	4	10	PF00498	0.789
LIG_FHA_1	553	559	PF00498	0.624
LIG_FHA_1	630	636	PF00498	0.643
LIG_FHA_1	912	918	PF00498	0.444
LIG_FHA_1	98	104	PF00498	0.762
LIG_FHA_2	305	311	PF00498	0.555
LIG_FHA_2	478	484	PF00498	0.712
LIG_FHA_2	604	610	PF00498	0.606
LIG_FHA_2	69	75	PF00498	0.808
LIG_FHA_2	700	706	PF00498	0.769
LIG_FHA_2	947	953	PF00498	0.581
LIG_Integrin_RGD_1	533	535	PF01839	0.578
LIG_LIR_Apic_2	486	491	PF02991	0.755
LIG_LIR_Apic_2	784	789	PF02991	0.737
LIG_LIR_Apic_2	83	89	PF02991	0.555
LIG_LIR_Apic_2	903	909	PF02991	0.757
LIG_LIR_Gen_1	397	406	PF02991	0.674
LIG_LIR_Gen_1	472	479	PF02991	0.691
LIG_LIR_Gen_1	81	89	PF02991	0.810
LIG_LIR_Nem_3	397	402	PF02991	0.708
LIG_LIR_Nem_3	472	478	PF02991	0.697
LIG_LIR_Nem_3	81	85	PF02991	0.812
LIG_LIR_Nem_3	882	888	PF02991	0.746
LIG_LYPXL_SIV_4	59	67	PF13949	0.567
LIG_MYND_1	327	331	PF01753	0.574
LIG_Pex14_2	394	398	PF04695	0.459
LIG_Pex14_2	759	763	PF04695	0.520
LIG_RPA_C_Fungi	452	464	PF08784	0.674
LIG_RPA_C_Fungi	931	943	PF08784	0.567
LIG_SH2_CRK	1014	1018	PF00017	0.718
LIG_SH2_CRK	560	564	PF00017	0.754
LIG_SH2_CRK	86	90	PF00017	0.555
LIG_SH2_NCK_1	86	90	PF00017	0.555
LIG_SH2_PTP2	20	23	PF00017	0.805
LIG_SH2_SRC	20	23	PF00017	0.805
LIG_SH2_STAP1	380	384	PF00017	0.726
LIG_SH2_STAT3	742	745	PF00017	0.595
LIG_SH2_STAT5	102	105	PF00017	0.760
LIG_SH2_STAT5	1022	1025	PF00017	0.680
LIG_SH2_STAT5	20	23	PF00017	0.805
LIG_SH2_STAT5	202	205	PF00017	0.684
LIG_SH2_STAT5	60	63	PF00017	0.567
LIG_SH2_STAT5	673	676	PF00017	0.568
LIG_SH2_STAT5	906	909	PF00017	0.744
LIG_SH3_1	20	26	PF00018	0.805
LIG_SH3_1	548	554	PF00018	0.565
LIG_SH3_3	112	118	PF00018	0.580
LIG_SH3_3	20	26	PF00018	0.805
LIG_SH3_3	324	330	PF00018	0.723
LIG_SH3_3	331	337	PF00018	0.731
LIG_SH3_3	498	504	PF00018	0.562
LIG_SH3_3	548	554	PF00018	0.637
LIG_SH3_3	681	687	PF00018	0.560
LIG_SH3_3	735	741	PF00018	0.758
LIG_SH3_3	942	948	PF00018	0.793
LIG_SH3_CIN85_PxpxPR_1	330	335	PF14604	0.679
LIG_SUMO_SIM_anti_2	849	854	PF11976	0.565
LIG_SUMO_SIM_par_1	337	345	PF11976	0.761
LIG_SUMO_SIM_par_1	632	640	PF11976	0.788
LIG_SUMO_SIM_par_1	851	859	PF11976	0.559
LIG_SUMO_SIM_par_1	914	922	PF11976	0.452
LIG_TRAF2_1	969	972	PF00917	0.607
LIG_TRAF2_1	978	981	PF00917	0.629
LIG_TRAF2_2	49	54	PF00917	0.701
LIG_WW_3	436	440	PF00397	0.593
MOD_CDC14_SPxK_1	145	148	PF00782	0.585
MOD_CDK_SPxK_1	142	148	PF00069	0.593
MOD_CDK_SPxxK_3	142	149	PF00069	0.684
MOD_CDK_SPxxK_3	45	52	PF00069	0.823
MOD_CK1_1	107	113	PF00069	0.795
MOD_CK1_1	158	164	PF00069	0.637
MOD_CK1_1	206	212	PF00069	0.745
MOD_CK1_1	270	276	PF00069	0.762
MOD_CK1_1	344	350	PF00069	0.726
MOD_CK1_1	419	425	PF00069	0.704
MOD_CK1_1	444	450	PF00069	0.811
MOD_CK1_1	458	464	PF00069	0.614
MOD_CK1_1	466	472	PF00069	0.734
MOD_CK1_1	500	506	PF00069	0.572
MOD_CK1_1	654	660	PF00069	0.751
MOD_CK1_1	661	667	PF00069	0.599
MOD_CK1_1	682	688	PF00069	0.606
MOD_CK1_1	692	698	PF00069	0.595
MOD_CK1_1	737	743	PF00069	0.841
MOD_CK1_1	846	852	PF00069	0.782
MOD_CK1_1	854	860	PF00069	0.716
MOD_CK1_1	922	928	PF00069	0.502
MOD_CK2_1	137	143	PF00069	0.851
MOD_CK2_1	304	310	PF00069	0.591
MOD_CK2_1	50	56	PF00069	0.782
MOD_CK2_1	59	65	PF00069	0.670
MOD_CK2_1	603	609	PF00069	0.856
MOD_CK2_1	68	74	PF00069	0.545
MOD_CK2_1	699	705	PF00069	0.721
MOD_CK2_1	711	717	PF00069	0.632
MOD_CK2_1	737	743	PF00069	0.841
MOD_CK2_1	966	972	PF00069	0.694
MOD_CK2_1	996	1002	PF00069	0.726
MOD_Cter_Amidation	146	149	PF01082	0.583
MOD_GlcNHglycan	152	155	PF01048	0.669
MOD_GlcNHglycan	238	241	PF01048	0.633
MOD_GlcNHglycan	26	29	PF01048	0.809
MOD_GlcNHglycan	260	263	PF01048	0.773
MOD_GlcNHglycan	370	373	PF01048	0.773
MOD_GlcNHglycan	40	43	PF01048	0.582
MOD_GlcNHglycan	414	417	PF01048	0.814
MOD_GlcNHglycan	429	432	PF01048	0.600
MOD_GlcNHglycan	445	449	PF01048	0.662
MOD_GlcNHglycan	453	456	PF01048	0.754
MOD_GlcNHglycan	461	464	PF01048	0.682
MOD_GlcNHglycan	510	513	PF01048	0.672
MOD_GlcNHglycan	539	542	PF01048	0.625
MOD_GlcNHglycan	61	64	PF01048	0.601
MOD_GlcNHglycan	654	657	PF01048	0.833
MOD_GlcNHglycan	665	668	PF01048	0.623
MOD_GlcNHglycan	696	699	PF01048	0.568
MOD_GlcNHglycan	749	752	PF01048	0.566
MOD_GlcNHglycan	858	861	PF01048	0.548
MOD_GlcNHglycan	963	966	PF01048	0.648
MOD_GSK3_1	103	110	PF00069	0.769
MOD_GSK3_1	134	141	PF00069	0.697
MOD_GSK3_1	155	162	PF00069	0.675
MOD_GSK3_1	209	216	PF00069	0.528
MOD_GSK3_1	230	237	PF00069	0.576
MOD_GSK3_1	266	273	PF00069	0.580
MOD_GSK3_1	337	344	PF00069	0.757
MOD_GSK3_1	412	419	PF00069	0.720
MOD_GSK3_1	437	444	PF00069	0.805
MOD_GSK3_1	451	458	PF00069	0.590
MOD_GSK3_1	459	466	PF00069	0.640
MOD_GSK3_1	477	484	PF00069	0.541
MOD_GSK3_1	603	610	PF00069	0.758
MOD_GSK3_1	654	661	PF00069	0.775
MOD_GSK3_1	662	669	PF00069	0.739
MOD_GSK3_1	690	697	PF00069	0.674
MOD_GSK3_1	743	750	PF00069	0.587
MOD_GSK3_1	777	784	PF00069	0.673
MOD_GSK3_1	851	858	PF00069	0.812
MOD_GSK3_1	918	925	PF00069	0.721
MOD_GSK3_1	930	937	PF00069	0.608
MOD_N-GLC_1	123	128	PF02516	0.711
MOD_N-GLC_1	455	460	PF02516	0.673
MOD_N-GLC_1	734	739	PF02516	0.584
MOD_N-GLC_2	497	499	PF02516	0.535
MOD_NEK2_1	103	108	PF00069	0.759
MOD_NEK2_1	134	139	PF00069	0.697
MOD_NEK2_1	201	206	PF00069	0.681
MOD_NEK2_1	394	399	PF00069	0.705
MOD_NEK2_1	583	588	PF00069	0.662
MOD_NEK2_1	668	673	PF00069	0.671
MOD_NEK2_1	679	684	PF00069	0.606
MOD_NEK2_1	694	699	PF00069	0.518
MOD_NEK2_1	711	716	PF00069	0.607
MOD_NEK2_1	777	782	PF00069	0.720
MOD_NEK2_2	5	10	PF00069	0.537
MOD_OFUCOSY	728	733	PF10250	0.575
MOD_PIKK_1	213	219	PF00454	0.561
MOD_PIKK_1	930	936	PF00454	0.553
MOD_PKA_1	149	155	PF00069	0.550
MOD_PKA_2	149	155	PF00069	0.653
MOD_PKA_2	407	413	PF00069	0.521
MOD_PKA_2	537	543	PF00069	0.633
MOD_PKA_2	597	603	PF00069	0.596
MOD_PKA_2	607	613	PF00069	0.563
MOD_PKA_2	651	657	PF00069	0.579
MOD_PKA_2	729	735	PF00069	0.657
MOD_PKA_2	930	936	PF00069	0.640
MOD_PKB_1	148	156	PF00069	0.545
MOD_Plk_1	497	503	PF00069	0.793
MOD_Plk_1	584	590	PF00069	0.531
MOD_Plk_1	711	717	PF00069	0.734
MOD_Plk_1	80	86	PF00069	0.810
MOD_Plk_1	871	877	PF00069	0.553
MOD_Plk_4	126	132	PF00069	0.745
MOD_Plk_4	155	161	PF00069	0.735
MOD_Plk_4	337	343	PF00069	0.504
MOD_Plk_4	394	400	PF00069	0.706
MOD_Plk_4	642	648	PF00069	0.807
MOD_Plk_4	668	674	PF00069	0.571
MOD_Plk_4	711	717	PF00069	0.734
MOD_Plk_4	81	87	PF00069	0.561
MOD_Plk_4	851	857	PF00069	0.560
MOD_Plk_4	919	925	PF00069	0.722
MOD_ProDKin_1	142	148	PF00069	0.685
MOD_ProDKin_1	22	28	PF00069	0.805
MOD_ProDKin_1	419	425	PF00069	0.706
MOD_ProDKin_1	45	51	PF00069	0.824
MOD_ProDKin_1	464	470	PF00069	0.782
MOD_ProDKin_1	500	506	PF00069	0.572
MOD_ProDKin_1	611	617	PF00069	0.597
MOD_ProDKin_1	68	74	PF00069	0.807
MOD_ProDKin_1	734	740	PF00069	0.682
MOD_ProDKin_1	804	810	PF00069	0.776
MOD_ProDKin_1	844	850	PF00069	0.653
MOD_ProDKin_1	89	95	PF00069	0.772
MOD_ProDKin_1	901	907	PF00069	0.772
MOD_ProDKin_1	966	972	PF00069	0.795
TRG_DiLeu_BaEn_1	172	177	PF01217	0.762
TRG_DiLeu_BaEn_1	283	288	PF01217	0.463
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.787
TRG_DiLeu_LyEn_5	172	177	PF01217	0.548
TRG_ENDOCYTIC_2	1014	1017	PF00928	0.714
TRG_ENDOCYTIC_2	1022	1025	PF00928	0.548
TRG_ER_diArg_1	148	151	PF00400	0.579
TRG_NLS_MonoExtN_4	146	152	PF00514	0.576
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	829	833	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4K1	Leishmania donovani	66%	100%
A4I6S5	Leishmania infantum	66%	100%
E9B1U7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4Q6B5	Leishmania major	65%	99%